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The map label for this gene is modE [H]

Identifier: 238893790

GI number: 238893790

Start: 1660324

End: 1661112

Strand: Reverse

Name: modE [H]

Synonym: KP1_1719

Alternate gene names: 238893790

Gene position: 1661112-1660324 (Counterclockwise)

Preceding gene: 238893795

Following gene: 238893789

Centisome position: 31.65

GC content: 61.6

Gene sequence:

>789_bases
ATGCAGGCCGAAATTCTTCTCACCCTTAAGCTACAGCAGCGCCTGTTTGCCGATCCGCGGCGGATCGCCCTGCTCAAACA
AATTGACCAGACCGGTTCGATAAGCCAGGGGGCGAAGCATGCGGGTATCAGCTATAAGAGCGCTTGGGATGCCATCAATG
AGATGAACCAGCTCAGCGAACATCCGTTGGTGGATCGCGCCACCGGCGGAAAGGGCGGCGGCGGCGCGGTGCTGACCCGC
TACGGGCAGCGTCTGATCCAGCTGTACGATCTGCTGGCGCAGATCCAGCAGAAAGCGTTTGATGTACTCAGCGATGACGA
TGCCCTGCCGCTGGATAGCCTGCTGGCGGCCATCTCGCGCTTTTCCCTGCAGACCAGCGCCCGCAACCAGTGGTTCGGCA
CCATTACCGGCCGCGATCGCCAGCAGGTGCAGCAGCACGTGGAAGTACTGTTGGCTGACGGAAAAACCCGCCTGAACATC
GCCATCACCGCGCAAAGCGCTGAGAAGCTGGGACTCGATGAGGGCCAGGAGGTGCTGGTCCTGCTCAAAGCGCCATGGGT
CGGCATCACCCTCGATCCCGCAGCAGCCCGCCAGGCCGATAACCAGCTGTCGGGACGTATCAGTCATATCGAATGCGGGT
CCGGCCAGTGCGAAGTACTGATGACCCTGGCGGACGGTCAAACCCTGTGCGCCACCCTGCCACAGGCGCAGGCCGCTGGC
CTGGCGGAAGGAACGGAGGCGATCGCTTACTTCAATGCCGATCGCATCATTCTCGCGACGTTATGCTGA

Upstream 100 bases:

>100_bases
ACACGTCCCATTTGTGCGGTGGGTAATGACCAACCGCGCAGAGAGGTTTTGCAAGTGGGCGACTATCGGTCACAATACCC
TTTTTTGTCAGGAAACGATT

Downstream 100 bases:

>100_bases
CCCCATTGACATTACGCGCCTGAAGTCGTATCCCTGATGCACATCGCTGCAAAAAATGGGATACATCATGTCATCATTGC
AAATTTCGCAAGGCACGTTT

Product: DNA-binding transcriptional regulator ModE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MQAEILLTLKLQQRLFADPRRIALLKQIDQTGSISQGAKHAGISYKSAWDAINEMNQLSEHPLVDRATGGKGGGGAVLTR
YGQRLIQLYDLLAQIQQKAFDVLSDDDALPLDSLLAAISRFSLQTSARNQWFGTITGRDRQQVQQHVEVLLADGKTRLNI
AITAQSAEKLGLDEGQEVLVLLKAPWVGITLDPAAARQADNQLSGRISHIECGSGQCEVLMTLADGQTLCATLPQAQAAG
LAEGTEAIAYFNADRIILATLC

Sequences:

>Translated_262_residues
MQAEILLTLKLQQRLFADPRRIALLKQIDQTGSISQGAKHAGISYKSAWDAINEMNQLSEHPLVDRATGGKGGGGAVLTR
YGQRLIQLYDLLAQIQQKAFDVLSDDDALPLDSLLAAISRFSLQTSARNQWFGTITGRDRQQVQQHVEVLLADGKTRLNI
AITAQSAEKLGLDEGQEVLVLLKAPWVGITLDPAAARQADNQLSGRISHIECGSGQCEVLMTLADGQTLCATLPQAQAAG
LAEGTEAIAYFNADRIILATLC
>Mature_262_residues
MQAEILLTLKLQQRLFADPRRIALLKQIDQTGSISQGAKHAGISYKSAWDAINEMNQLSEHPLVDRATGGKGGGGAVLTR
YGQRLIQLYDLLAQIQQKAFDVLSDDDALPLDSLLAAISRFSLQTSARNQWFGTITGRDRQQVQQHVEVLLADGKTRLNI
AITAQSAEKLGLDEGQEVLVLLKAPWVGITLDPAAARQADNQLSGRISHIECGSGQCEVLMTLADGQTLCATLPQAQAAG
LAEGTEAIAYFNADRIILATLC

Specific function: The modE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA reg

COG id: COG2005

COG function: function code R; N-terminal domain of molybdenum-binding protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the modE family [H]

Homologues:

Organism=Escherichia coli, GI1786976, Length=262, Percent_Identity=81.2977099236641, Blast_Score=390, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR004606
- InterPro:   IPR008995
- InterPro:   IPR003725
- InterPro:   IPR016462
- InterPro:   IPR005116
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03459 TOBE [H]

EC number: NA

Molecular weight: Translated: 28259; Mature: 28259

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAEILLTLKLQQRLFADPRRIALLKQIDQTGSISQGAKHAGISYKSAWDAINEMNQLSE
CCCEEEEEEEHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHC
HPLVDRATGGKGGGGAVLTRYGQRLIQLYDLLAQIQQKAFDVLSDDDALPLDSLLAAISR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
FSLQTSARNQWFGTITGRDRQQVQQHVEVLLADGKTRLNIAITAQSAEKLGLDEGQEVLV
HHHHHCCCCCEEEEECCCCHHHHHHHHHEEHCCCCEEEEEEEEECCHHHCCCCCCCEEEE
LLKAPWVGITLDPAAARQADNQLSGRISHIECGSGQCEVLMTLADGQTLCATLPQAQAAG
EEECCEEEEEECHHHHHHCCHHHHCCEEEEECCCCCEEEEEEECCCCEEEHHCCCHHHCC
LAEGTEAIAYFNADRIILATLC
CCCCCCEEEEECCCEEEEEECC
>Mature Secondary Structure
MQAEILLTLKLQQRLFADPRRIALLKQIDQTGSISQGAKHAGISYKSAWDAINEMNQLSE
CCCEEEEEEEHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHC
HPLVDRATGGKGGGGAVLTRYGQRLIQLYDLLAQIQQKAFDVLSDDDALPLDSLLAAISR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
FSLQTSARNQWFGTITGRDRQQVQQHVEVLLADGKTRLNIAITAQSAEKLGLDEGQEVLV
HHHHHCCCCCEEEEECCCCHHHHHHHHHEEHCCCCEEEEEEEEECCHHHCCCCCCCEEEE
LLKAPWVGITLDPAAARQADNQLSGRISHIECGSGQCEVLMTLADGQTLCATLPQAQAAG
EEECCEEEEEECHHHHHHCCHHHHCCEEEEECCCCCEEEEEEECCCCEEEHHCCCHHHCC
LAEGTEAIAYFNADRIILATLC
CCCCCCEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]