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The map label for this gene is pcp [H]

Identifier: 238893756

GI number: 238893756

Start: 1623674

End: 1624318

Strand: Direct

Name: pcp [H]

Synonym: KP1_1680

Alternate gene names: 238893756

Gene position: 1623674-1624318 (Clockwise)

Preceding gene: 238893755

Following gene: 238893757

Centisome position: 30.94

GC content: 59.38

Gene sequence:

>645_bases
ATGGCTGGCGTATTGATTACCGGTTTTGAGCCGTTCGGCGGCGAAACGGTTAATCCTTCATGGGAAGTGGTTAAGCAGCT
GGATGGCATGATTATTCGCGGACAGCAGGTGGTGGCTAAACAATTACCCTGCGTATTCGGCGAAGCGCTGACGGTGCTGA
AGGCGGCGCTGGAAACCTATCAACCGCGGCTGACGATTGCCGTCGGACAGGCCGGCGGCCGTGTCGATATTACCGTCGAA
CGTGTAGCGATCAATGTCGATGATGCGCGGATCCCCGACAATAAAGGCCAGCAACCGATCGACGAGCCGATCGTCGCTAA
TGGCCCTGCGGCCTGCTTCAGTACGCTGCCGATCAAAGCGATCGTCAGCGCGCTGCGCCAGCAGGGGATCCCGGCCTCGG
TGTCGCAAACCGCGGGCACCTTCGTCTGCAATCACGTGATGTATGGTTTGCTGCATCAGCTGCAGGGAAAAAGCGGGCAG
AAGGGCGGTTTTATCCATATTCCTTATCTGCCTGAACAGGCGGCGGCCCACCCGGGGCAGGCGAGTATGTCGGTCGCGAC
GGTACGCGCGGCGCTGGAAACGGCGATTGCCGTCGCCCTTGAACAGGATGACGATGTCAAAATTGGCGGCGGCGCCACCC
ATTAA

Upstream 100 bases:

>100_bases
TAAAAACGCGGTGATTAAAGCACAGATACCGACCGGTATCCTGCTGCTTATCGTCAATGTATTCTTACTCTATTTCCTGA
TGTTCCTGTAAGGAGGGATG

Downstream 100 bases:

>100_bases
CAGAAGGATGACAGTATGCCGGAAGGTCCGGAGATCCGCCGTGCGGCGGATAAACTGGAGGCGGCAATCAAAGGCGAACC
CTTAACCAACGTCTGGTTCG

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase [H]

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MAGVLITGFEPFGGETVNPSWEVVKQLDGMIIRGQQVVAKQLPCVFGEALTVLKAALETYQPRLTIAVGQAGGRVDITVE
RVAINVDDARIPDNKGQQPIDEPIVANGPAACFSTLPIKAIVSALRQQGIPASVSQTAGTFVCNHVMYGLLHQLQGKSGQ
KGGFIHIPYLPEQAAAHPGQASMSVATVRAALETAIAVALEQDDDVKIGGGATH

Sequences:

>Translated_214_residues
MAGVLITGFEPFGGETVNPSWEVVKQLDGMIIRGQQVVAKQLPCVFGEALTVLKAALETYQPRLTIAVGQAGGRVDITVE
RVAINVDDARIPDNKGQQPIDEPIVANGPAACFSTLPIKAIVSALRQQGIPASVSQTAGTFVCNHVMYGLLHQLQGKSGQ
KGGFIHIPYLPEQAAAHPGQASMSVATVRAALETAIAVALEQDDDVKIGGGATH
>Mature_213_residues
AGVLITGFEPFGGETVNPSWEVVKQLDGMIIRGQQVVAKQLPCVFGEALTVLKAALETYQPRLTIAVGQAGGRVDITVER
VAINVDDARIPDNKGQQPIDEPIVANGPAACFSTLPIKAIVSALRQQGIPASVSQTAGTFVCNHVMYGLLHQLQGKSGQK
GGFIHIPYLPEQAAAHPGQASMSVATVRAALETAIAVALEQDDDVKIGGGATH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline [H]

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family [H]

Homologues:

Organism=Homo sapiens, GI8923198, Length=204, Percent_Identity=28.4313725490196, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000816
- InterPro:   IPR016125 [H]

Pfam domain/function: PF01470 Peptidase_C15 [H]

EC number: =3.4.19.3 [H]

Molecular weight: Translated: 22384; Mature: 22253

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS01333 PYRASE_GLU ; PS01334 PYRASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGVLITGFEPFGGETVNPSWEVVKQLDGMIIRGQQVVAKQLPCVFGEALTVLKAALETY
CCCEEEECCCCCCCCCCCCHHHHHHHHCCEEEECHHHHHHHCCHHHHHHHHHHHHHHHHC
QPRLTIAVGQAGGRVDITVERVAINVDDARIPDNKGQQPIDEPIVANGPAACFSTLPIKA
CCEEEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHH
IVSALRQQGIPASVSQTAGTFVCNHVMYGLLHQLQGKSGQKGGFIHIPYLPEQAAAHPGQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHCCCCC
ASMSVATVRAALETAIAVALEQDDDVKIGGGATH
CHHHHHHHHHHHHHHHHHEECCCCCEEECCCCCC
>Mature Secondary Structure 
AGVLITGFEPFGGETVNPSWEVVKQLDGMIIRGQQVVAKQLPCVFGEALTVLKAALETY
CCEEEECCCCCCCCCCCCHHHHHHHHCCEEEECHHHHHHHCCHHHHHHHHHHHHHHHHC
QPRLTIAVGQAGGRVDITVERVAINVDDARIPDNKGQQPIDEPIVANGPAACFSTLPIKA
CCEEEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHH
IVSALRQQGIPASVSQTAGTFVCNHVMYGLLHQLQGKSGQKGGFIHIPYLPEQAAAHPGQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHCCCCC
ASMSVATVRAALETAIAVALEQDDDVKIGGGATH
CHHHHHHHHHHHHHHHHHEECCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA