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The map label for this gene is holA [H]

Identifier: 238893707

GI number: 238893707

Start: 1567895

End: 1568926

Strand: Reverse

Name: holA [H]

Synonym: KP1_1627

Alternate gene names: 238893707

Gene position: 1568926-1567895 (Counterclockwise)

Preceding gene: 238893708

Following gene: 238893706

Centisome position: 29.89

GC content: 61.63

Gene sequence:

>1032_bases
ATGATTCGGTTGTACCCGGAACAGCTCCGCGCGCAGCTCACTGAAGGGCTGCGCGCGGCCTATCTGCTGCTTGGCAACGA
TCCCCTGCTGTTGCAGGAAAGCCAGGACGCCATTCGCGAAGCTGCTGCCGCGCAGGGATTTACCGAGCACCATACTTTTT
CAATCGACAACAGCACCGACTGGCAGGCGATTTTCGCCTTAAGCCAGGCGATGAGCCTGTTTGCCAGCCGGCAAACCCTG
CTGTTGATCCTACCGGAAAACGGCCCCAACGCGGCGATCAATGAACAGCTCGCCACGCTGGTTGGCCTGCTGCACGACGA
CCTGCTGCTGATAGTTCGCGGAAATAAGCTGACCAAAGCCCAGGAGAATGCCGCATGGCTCACCGCCCTGGCTCAGCGCG
CAGTCCAGGTCAGTTGCCAGACGCCGGAATACGCGCAGCTGCCGCGCTGGCTGGCCGCCCGTGCCAAACAGCATCAGCTG
CAGCTCGACGACGCGGCCAGTCAGCTGCTGTGCTACTGTTACGAAGGCAATCTGCTGGCGCTGGCGCAGGCGCTGGAGCG
TCTGGCGCTGCTCTGGCCGGACGGTAAGCTAACCCTGCCCCGCGTTGAGCAAGCGGTAAACGATGCCGCGCACTTTACGC
CTTACCATTGGGTCGATGCCCTACTGGCCGGCAAAAGTAAGCGCGTGCTGCACGTCCTGCAGCAGTTACGCCTTGAAGGC
TGCGAGCCGGCGATCCTGCTGCGTACTTTGCAGCGGGAGCTGCTGCTGCTGGTTACCCTCAAGCGCCAGGCGACGCACAC
GCCGCTGCGCTCGCTGTTTGATAAACATCGGGTCTGGCAAAACCGCCGTCAGCTGCTCAGCGACGCTCTCACGCGCCTGA
GCGGGGAACAGCTACGCCAGGCGGTGACCCTTCTGACCCGCGCGGAGCTCACCTTTAAACAGGATTACGGGCACGACGTC
TGGCCCGAACTGGAAAGTCTTTCGTTGTTGCTCTGCCACAAAGCCCTGGCGGACGTTTTTATTGATGGTTGA

Upstream 100 bases:

>100_bases
TAGCGGATGTTGAAGCAACCCAGCAGGAAGAGAAACCGGTCGCCAGCAGCGCGGCGCCGGCTTCCTCGGGTAACCGCGTC
TCCACCACGCTGGGTCAATG

Downstream 100 bases:

>100_bases
TATGACTCAGTTACAGGCAATCTATGGCGGCACCTTCGATCCGGTGCATTACGGTCACCTTAAGCCGGTTGAGATCCTGG
CGAATCAGATTGGCCTGAGC

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MIRLYPEQLRAQLTEGLRAAYLLLGNDPLLLQESQDAIREAAAAQGFTEHHTFSIDNSTDWQAIFALSQAMSLFASRQTL
LLILPENGPNAAINEQLATLVGLLHDDLLLIVRGNKLTKAQENAAWLTALAQRAVQVSCQTPEYAQLPRWLAARAKQHQL
QLDDAASQLLCYCYEGNLLALAQALERLALLWPDGKLTLPRVEQAVNDAAHFTPYHWVDALLAGKSKRVLHVLQQLRLEG
CEPAILLRTLQRELLLLVTLKRQATHTPLRSLFDKHRVWQNRRQLLSDALTRLSGEQLRQAVTLLTRAELTFKQDYGHDV
WPELESLSLLLCHKALADVFIDG

Sequences:

>Translated_343_residues
MIRLYPEQLRAQLTEGLRAAYLLLGNDPLLLQESQDAIREAAAAQGFTEHHTFSIDNSTDWQAIFALSQAMSLFASRQTL
LLILPENGPNAAINEQLATLVGLLHDDLLLIVRGNKLTKAQENAAWLTALAQRAVQVSCQTPEYAQLPRWLAARAKQHQL
QLDDAASQLLCYCYEGNLLALAQALERLALLWPDGKLTLPRVEQAVNDAAHFTPYHWVDALLAGKSKRVLHVLQQLRLEG
CEPAILLRTLQRELLLLVTLKRQATHTPLRSLFDKHRVWQNRRQLLSDALTRLSGEQLRQAVTLLTRAELTFKQDYGHDV
WPELESLSLLLCHKALADVFIDG
>Mature_343_residues
MIRLYPEQLRAQLTEGLRAAYLLLGNDPLLLQESQDAIREAAAAQGFTEHHTFSIDNSTDWQAIFALSQAMSLFASRQTL
LLILPENGPNAAINEQLATLVGLLHDDLLLIVRGNKLTKAQENAAWLTALAQRAVQVSCQTPEYAQLPRWLAARAKQHQL
QLDDAASQLLCYCYEGNLLALAQALERLALLWPDGKLTLPRVEQAVNDAAHFTPYHWVDALLAGKSKRVLHVLQQLRLEG
CEPAILLRTLQRELLLLVTLKRQATHTPLRSLFDKHRVWQNRRQLLSDALTRLSGEQLRQAVTLLTRAELTFKQDYGHDV
WPELESLSLLLCHKALADVFIDG

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=343, Percent_Identity=84.8396501457726, Blast_Score=568, Evalue=1e-163,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 38613; Mature: 38613

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRLYPEQLRAQLTEGLRAAYLLLGNDPLLLQESQDAIREAAAAQGFTEHHTFSIDNSTD
CCEECHHHHHHHHHHHHHHEEEEECCCCEEEECHHHHHHHHHHHCCCCCCCEEECCCCCC
WQAIFALSQAMSLFASRQTLLLILPENGPNAAINEQLATLVGLLHDDLLLIVRGNKLTKA
HHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCHH
QENAAWLTALAQRAVQVSCQTPEYAQLPRWLAARAKQHQLQLDDAASQLLCYCYEGNLLA
HHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHCCCCHHH
LAQALERLALLWPDGKLTLPRVEQAVNDAAHFTPYHWVDALLAGKSKRVLHVLQQLRLEG
HHHHHHHHHEECCCCCEEHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCC
CEPAILLRTLQRELLLLVTLKRQATHTPLRSLFDKHRVWQNRRQLLSDALTRLSGEQLRQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
AVTLLTRAELTFKQDYGHDVWPELESLSLLLCHKALADVFIDG
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIRLYPEQLRAQLTEGLRAAYLLLGNDPLLLQESQDAIREAAAAQGFTEHHTFSIDNSTD
CCEECHHHHHHHHHHHHHHEEEEECCCCEEEECHHHHHHHHHHHCCCCCCCEEECCCCCC
WQAIFALSQAMSLFASRQTLLLILPENGPNAAINEQLATLVGLLHDDLLLIVRGNKLTKA
HHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCHH
QENAAWLTALAQRAVQVSCQTPEYAQLPRWLAARAKQHQLQLDDAASQLLCYCYEGNLLA
HHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHCCCCHHH
LAQALERLALLWPDGKLTLPRVEQAVNDAAHFTPYHWVDALLAGKSKRVLHVLQQLRLEG
HHHHHHHHHEECCCCCEEHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCC
CEPAILLRTLQRELLLLVTLKRQATHTPLRSLFDKHRVWQNRRQLLSDALTRLSGEQLRQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
AVTLLTRAELTFKQDYGHDVWPELESLSLLLCHKALADVFIDG
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]