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The map label for this gene is codB [H]

Identifier: 238893666

GI number: 238893666

Start: 1527625

End: 1528887

Strand: Reverse

Name: codB [H]

Synonym: KP1_1584

Alternate gene names: 238893666

Gene position: 1528887-1527625 (Counterclockwise)

Preceding gene: 238893670

Following gene: 238893665

Centisome position: 29.13

GC content: 63.74

Gene sequence:

>1263_bases
ATGTCAAACAACAATGATTTTCCCCTCGTCGAAGCGCCCGCCGCCGGACGCAAAGGCGTATTTTCCATCGCCATGGTGTT
GTTCAGCTTTACCTTTTTCACCGGCACGATGTTCGCCGGCGGTAAACTCGGCGTCTCCTTTTCCATCGTCAATCTGCTGT
GGATAGCCGTCATCGGCAACGCCTTGCTGGCCCTCTATGCCGCGTCGCTGGGCTGGATCGCCGCGCGCAGCGGCCTGAAT
ACGGTGCTGATGGGCCGGTTCTGCTTCGGGGAGATTGGCAGCAAGCTGGCCGATTTTATTCTTGGCTTTGCCGAGCTGGG
CTGGTACGCCTGGGGCACCGCCACGGTCGCTATCTCGTTGGTGAAGATCCTCGCTCTGCCCGAGGCGCTGACCCAGCCGT
TGATGGTGCTGTTTGGTATTCTGTTCTGCGTCACCGCGCTGGTGGGCTACAGGGGGCTGGACGCGCTGTCGCGCCTGTCG
GTGCCATTGATGTTTGTGCTGCTGATGGTCTCCATGTATCTGGCGCTGCACCACGCCGGCGGCTGGCAGGCGATGACCCG
TATTGCGCCGAGCGACACCATGACCTGGTCGGCGGCCATCACCATGGTCTTCGGCACTTTCGCCAGCGGCGCCACCCAGG
CGACAAACTGGACCCGGCTGGCCAACTCCAGCCGGACCGCCATTCTCGCCAGCATGGGCAGCTTCCTCATCGGCAACGGG
CTGATGATCGTCGCCGGCGCCTGGTGCGCTATCGTCTATCAACAGGCCGATATCGTCGAAGTGCTGATCCTGCAGGGGCT
GTCGGTCGCCGCGGTGATCATGCTCTGTCTCAACCTGCTGACCATCCAGGGCCCTACCATCTATAACGTCTCTGCCGCCG
CCTGCCATCTGCTGCGCAGCGAACGTCGCCGGACGCTGACCCTCGCCGCCGCCGGGGTGGGCATTGTGCTCGCCATCGGC
GGGATGTACGAAATGCTGATCCCGTTCCTCGTGCTGCTGGGCAGTATTATTCCGCCCATCGGCGGGGTGATCCTCGCCGA
CTACTGGTTCGCCCGCGGCGGACGCTATCCCCTGCTGCAGAACGCCCGCCTGCCGCGTTTTAACTGGCTGGGACTCGGCG
CCTACGCCGCCGGCGCGGTGGTGGCCTATCTGTCACCGTGGATCGCGCCGCTGGTGGGGATCACCGTCTCCGCGCTGGTC
TATATCGCCCTGACCCTGCTAAGCAAACGCCAGCCTGCCGCCGTCGCGGAGCAGGAGCCATGA

Upstream 100 bases:

>100_bases
ATGTTGCACACCGCGCGCTATTCCCCGTGCCCGGTTTTTCCTGGCACATCTCTTGCTACTTCCGGCAATCACCGCCCATC
TACCAGCCAGAGGTTCCAGG

Downstream 100 bases:

>100_bases
GCCTGACGGTCAGCGAACTGCTGGCCCTTGAGGGTCTCTCCGCCCTGCGTCTGCGGGCGGGAAAGCAAGGGCTGCAGCGG
GCCGTACGCTGGTACTACGT

Product: cytosine permease

Products: Proton [Cytoplasm]; cytosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSNNNDFPLVEAPAAGRKGVFSIAMVLFSFTFFTGTMFAGGKLGVSFSIVNLLWIAVIGNALLALYAASLGWIAARSGLN
TVLMGRFCFGEIGSKLADFILGFAELGWYAWGTATVAISLVKILALPEALTQPLMVLFGILFCVTALVGYRGLDALSRLS
VPLMFVLLMVSMYLALHHAGGWQAMTRIAPSDTMTWSAAITMVFGTFASGATQATNWTRLANSSRTAILASMGSFLIGNG
LMIVAGAWCAIVYQQADIVEVLILQGLSVAAVIMLCLNLLTIQGPTIYNVSAAACHLLRSERRRTLTLAAAGVGIVLAIG
GMYEMLIPFLVLLGSIIPPIGGVILADYWFARGGRYPLLQNARLPRFNWLGLGAYAAGAVVAYLSPWIAPLVGITVSALV
YIALTLLSKRQPAAVAEQEP

Sequences:

>Translated_420_residues
MSNNNDFPLVEAPAAGRKGVFSIAMVLFSFTFFTGTMFAGGKLGVSFSIVNLLWIAVIGNALLALYAASLGWIAARSGLN
TVLMGRFCFGEIGSKLADFILGFAELGWYAWGTATVAISLVKILALPEALTQPLMVLFGILFCVTALVGYRGLDALSRLS
VPLMFVLLMVSMYLALHHAGGWQAMTRIAPSDTMTWSAAITMVFGTFASGATQATNWTRLANSSRTAILASMGSFLIGNG
LMIVAGAWCAIVYQQADIVEVLILQGLSVAAVIMLCLNLLTIQGPTIYNVSAAACHLLRSERRRTLTLAAAGVGIVLAIG
GMYEMLIPFLVLLGSIIPPIGGVILADYWFARGGRYPLLQNARLPRFNWLGLGAYAAGAVVAYLSPWIAPLVGITVSALV
YIALTLLSKRQPAAVAEQEP
>Mature_419_residues
SNNNDFPLVEAPAAGRKGVFSIAMVLFSFTFFTGTMFAGGKLGVSFSIVNLLWIAVIGNALLALYAASLGWIAARSGLNT
VLMGRFCFGEIGSKLADFILGFAELGWYAWGTATVAISLVKILALPEALTQPLMVLFGILFCVTALVGYRGLDALSRLSV
PLMFVLLMVSMYLALHHAGGWQAMTRIAPSDTMTWSAAITMVFGTFASGATQATNWTRLANSSRTAILASMGSFLIGNGL
MIVAGAWCAIVYQQADIVEVLILQGLSVAAVIMLCLNLLTIQGPTIYNVSAAACHLLRSERRRTLTLAAAGVGIVLAIGG
MYEMLIPFLVLLGSIIPPIGGVILADYWFARGGRYPLLQNARLPRFNWLGLGAYAAGAVVAYLSPWIAPLVGITVSALVY
IALTLLSKRQPAAVAEQEP

Specific function: Required for cytosine transport into the cell [H]

COG id: COG1457

COG function: function code F; Purine-cytosine permease and related proteins

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine-cytosine permease family [H]

Homologues:

Organism=Escherichia coli, GI1786530, Length=420, Percent_Identity=33.5714285714286, Blast_Score=206, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001248
- InterPro:   IPR012681 [H]

Pfam domain/function: PF02133 Transp_cyt_pur [H]

EC number: NA

Molecular weight: Translated: 44598; Mature: 44466

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNNDFPLVEAPAAGRKGVFSIAMVLFSFTFFTGTMFAGGKLGVSFSIVNLLWIAVIGN
CCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ALLALYAASLGWIAARSGLNTVLMGRFCFGEIGSKLADFILGFAELGWYAWGTATVAISL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKILALPEALTQPLMVLFGILFCVTALVGYRGLDALSRLSVPLMFVLLMVSMYLALHHAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GWQAMTRIAPSDTMTWSAAITMVFGTFASGATQATNWTRLANSSRTAILASMGSFLIGNG
CHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCC
LMIVAGAWCAIVYQQADIVEVLILQGLSVAAVIMLCLNLLTIQGPTIYNVSAAACHLLRS
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHH
ERRRTLTLAAAGVGIVLAIGGMYEMLIPFLVLLGSIIPPIGGVILADYWFARGGRYPLLQ
HHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCC
NARLPRFNWLGLGAYAAGAVVAYLSPWIAPLVGITVSALVYIALTLLSKRQPAAVAEQEP
CCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SNNNDFPLVEAPAAGRKGVFSIAMVLFSFTFFTGTMFAGGKLGVSFSIVNLLWIAVIGN
CCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ALLALYAASLGWIAARSGLNTVLMGRFCFGEIGSKLADFILGFAELGWYAWGTATVAISL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKILALPEALTQPLMVLFGILFCVTALVGYRGLDALSRLSVPLMFVLLMVSMYLALHHAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GWQAMTRIAPSDTMTWSAAITMVFGTFASGATQATNWTRLANSSRTAILASMGSFLIGNG
CHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCC
LMIVAGAWCAIVYQQADIVEVLILQGLSVAAVIMLCLNLLTIQGPTIYNVSAAACHLLRS
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHH
ERRRTLTLAAAGVGIVLAIGGMYEMLIPFLVLLGSIIPPIGGVILADYWFARGGRYPLLQ
HHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCC
NARLPRFNWLGLGAYAAGAVVAYLSPWIAPLVGITVSALVYIALTLLSKRQPAAVAEQEP
CCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; cytosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + cytosine [Periplasm] = Proton [Cytoplasm] + cytosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]