Click here to switch to the map view.

The map label for this gene is fes [H]

Identifier: 238893634

GI number: 238893634

Start: 1491504

End: 1492712

Strand: Direct

Name: fes [H]

Synonym: KP1_1548

Alternate gene names: 238893634

Gene position: 1491504-1492712 (Clockwise)

Preceding gene: 238893631

Following gene: 238893635

Centisome position: 28.42

GC content: 67.66

Gene sequence:

>1209_bases
ATGTTAAGGACAGGAAGCGAGGAGTGGTGGCAAACCCTGCGGGGGCCGCAGTGCCGCGCAGTGGATGACGCCATCGAGGT
AACGTTCTGGTGGCGGGACCCGGCGGGGGATGAAACCTGCTCTCCCCATCGTCGGGTATGGCTCTATATCACCGGCGTGA
CCGACCACCATCAGAATGCGCGGCCGCAATCGCTGCAACGTCTCCCCGGGACCGACGCCTGGTTCTGGCGCACTACGCTG
TCGCCGACCTGGCGCGGCAGCTACTGTTTTATTCCCTCCGACCGTGACGATGATTTTTCCCCTGAGGTGTTCAGCGCTGA
TGCGCCCGACCGCGCGCTGCTACGCGAAGGCTGGCGCAAACTGCTGCCGCGGGCGATAGCCGATCCGCTGAACCCGCACA
GCTGGCTGGGCGGACGCGGCCATGGCGTGTCCGCCCTGGAGATGCCGCAGGCCCCCGCGCAGCCCGGCTGGGACCCGCTT
AATGAGGCACATCCTGCCGCCCGTTGCCTTGAGTGGCGCAGCGCGCGTCTGGGCAACCATCGCCGGGTCTGGATCTACAC
CCCTGGCGAGGCCGTCGACCCGCAAACGCGGCCGCTGGCGATCCTGCTCGACGGCCAGTTCTGGGCCGAGAGCATGCCGG
TGTGGTCGCCGCTGGCCGCCCTGACCCGCGAGGGGAGACTGCCGCCGGCGGTCTACCTGCTGATCGACGCGATCGACAAC
CAGCGCCGCGGGGTTGAGCTGCCCTGTCACCGCGATTTCTGGCTGGCGGTGCAGGAGGAGCTCCTGCCGCTGGTCCACGG
CTATGCCCCGTTCAGCGACCGCCCGGATCGGACGGTGGTGGCCGGGCAAAGCTTCGGCGGTCTGGCGGCGATGTTCGCCG
CTCTCAACTGGCCGCAGCGCTTTGGCTGCGTGCTCAGCCAGTCAGGCTCCTACTGGTGGCCGCACCGCGATGGCCGCGGG
ATGGGCTTTATCGGCGAACAGCTTCGCCAGGGTGAGGTGTCCGCGGCCGGGCTGCGCGTCTGGCTGGAAGCGGGCCAACG
CGAACCGATCATTTTTCGCGCGAACCAGGCGCTACTGGCGCAACTCACCACAACACAGCAGACGATTTTCTGGCGTCAGG
TTGACGGCGGGCATGATGCGCTTTGCTGGCGCGGCGGGCTGACGGCAGGGCTTATCCAGCTCTGGCAGCCTCTGCTGTCG
CACCCTTAG

Upstream 100 bases:

>100_bases
CTAATACGCTATTGCAAATGCAAATAGTTATCAATAATATTATCAATAAATAATGACAATTAATTAAAAAAGTCACGCTA
TACATAGGGTTAATGACAGA

Downstream 100 bases:

>100_bases
CATCGCGTTTTACGACAGGAGTTTGATATGCAATTCAGTAACCCCTTCGACAATCCGCAAGGGCAGTTTTACATTCTGCG
CAATGATCAGCAGCAGTACA

Product: enterobactin/ferric enterobactin esterase

Products: Fe [C]

Alternate protein names: Ferric enterobactin esterase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MLRTGSEEWWQTLRGPQCRAVDDAIEVTFWWRDPAGDETCSPHRRVWLYITGVTDHHQNARPQSLQRLPGTDAWFWRTTL
SPTWRGSYCFIPSDRDDDFSPEVFSADAPDRALLREGWRKLLPRAIADPLNPHSWLGGRGHGVSALEMPQAPAQPGWDPL
NEAHPAARCLEWRSARLGNHRRVWIYTPGEAVDPQTRPLAILLDGQFWAESMPVWSPLAALTREGRLPPAVYLLIDAIDN
QRRGVELPCHRDFWLAVQEELLPLVHGYAPFSDRPDRTVVAGQSFGGLAAMFAALNWPQRFGCVLSQSGSYWWPHRDGRG
MGFIGEQLRQGEVSAAGLRVWLEAGQREPIIFRANQALLAQLTTTQQTIFWRQVDGGHDALCWRGGLTAGLIQLWQPLLS
HP

Sequences:

>Translated_402_residues
MLRTGSEEWWQTLRGPQCRAVDDAIEVTFWWRDPAGDETCSPHRRVWLYITGVTDHHQNARPQSLQRLPGTDAWFWRTTL
SPTWRGSYCFIPSDRDDDFSPEVFSADAPDRALLREGWRKLLPRAIADPLNPHSWLGGRGHGVSALEMPQAPAQPGWDPL
NEAHPAARCLEWRSARLGNHRRVWIYTPGEAVDPQTRPLAILLDGQFWAESMPVWSPLAALTREGRLPPAVYLLIDAIDN
QRRGVELPCHRDFWLAVQEELLPLVHGYAPFSDRPDRTVVAGQSFGGLAAMFAALNWPQRFGCVLSQSGSYWWPHRDGRG
MGFIGEQLRQGEVSAAGLRVWLEAGQREPIIFRANQALLAQLTTTQQTIFWRQVDGGHDALCWRGGLTAGLIQLWQPLLS
HP
>Mature_402_residues
MLRTGSEEWWQTLRGPQCRAVDDAIEVTFWWRDPAGDETCSPHRRVWLYITGVTDHHQNARPQSLQRLPGTDAWFWRTTL
SPTWRGSYCFIPSDRDDDFSPEVFSADAPDRALLREGWRKLLPRAIADPLNPHSWLGGRGHGVSALEMPQAPAQPGWDPL
NEAHPAARCLEWRSARLGNHRRVWIYTPGEAVDPQTRPLAILLDGQFWAESMPVWSPLAALTREGRLPPAVYLLIDAIDN
QRRGVELPCHRDFWLAVQEELLPLVHGYAPFSDRPDRTVVAGQSFGGLAAMFAALNWPQRFGCVLSQSGSYWWPHRDGRG
MGFIGEQLRQGEVSAAGLRVWLEAGQREPIIFRANQALLAQLTTTQQTIFWRQVDGGHDALCWRGGLTAGLIQLWQPLLS
HP

Specific function: Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use [H]

COG id: COG2382

COG function: function code P; Enterochelin esterase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fes family [H]

Homologues:

Organism=Escherichia coli, GI1786799, Length=375, Percent_Identity=67.2, Blast_Score=510, Evalue=1e-146,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021764
- InterPro:   IPR000801
- InterPro:   IPR014756 [H]

Pfam domain/function: PF11806 DUF3327; PF00756 Esterase [H]

EC number: NA

Molecular weight: Translated: 45487; Mature: 45487

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRTGSEEWWQTLRGPQCRAVDDAIEVTFWWRDPAGDETCSPHRRVWLYITGVTDHHQNA
CCCCCCHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCC
RPQSLQRLPGTDAWFWRTTLSPTWRGSYCFIPSDRDDDFSPEVFSADAPDRALLREGWRK
CHHHHHHCCCCCCEEEEEECCCCCCCCEEECCCCCCCCCCCCEECCCCCHHHHHHHHHHH
LLPRAIADPLNPHSWLGGRGHGVSALEMPQAPAQPGWDPLNEAHPAARCLEWRSARLGNH
HHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCHHCCHHHHHHHHHHHHCCCC
RRVWIYTPGEAVDPQTRPLAILLDGQFWAESMPVWSPLAALTREGRLPPAVYLLIDAIDN
CEEEEECCCCCCCCCCCCEEEEECCCHHHCCCCCHHHHHHHHHCCCCCCEEEEEEEHHCC
QRRGVELPCHRDFWLAVQEELLPLVHGYAPFSDRPDRTVVAGQSFGGLAAMFAALNWPQR
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCHHH
FGCVLSQSGSYWWPHRDGRGMGFIGEQLRQGEVSAAGLRVWLEAGQREPIIFRANQALLA
HHHHEECCCCEECCCCCCCCCCHHHHHHHCCCCCHHHHHHEEECCCCCCEEEECCHHHHH
QLTTTQQTIFWRQVDGGHDALCWRGGLTAGLIQLWQPLLSHP
HHHHCCEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLRTGSEEWWQTLRGPQCRAVDDAIEVTFWWRDPAGDETCSPHRRVWLYITGVTDHHQNA
CCCCCCHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCC
RPQSLQRLPGTDAWFWRTTLSPTWRGSYCFIPSDRDDDFSPEVFSADAPDRALLREGWRK
CHHHHHHCCCCCCEEEEEECCCCCCCCEEECCCCCCCCCCCCEECCCCCHHHHHHHHHHH
LLPRAIADPLNPHSWLGGRGHGVSALEMPQAPAQPGWDPLNEAHPAARCLEWRSARLGNH
HHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCHHCCHHHHHHHHHHHHCCCC
RRVWIYTPGEAVDPQTRPLAILLDGQFWAESMPVWSPLAALTREGRLPPAVYLLIDAIDN
CEEEEECCCCCCCCCCCCEEEEECCCHHHCCCCCHHHHHHHHHCCCCCCEEEEEEEHHCC
QRRGVELPCHRDFWLAVQEELLPLVHGYAPFSDRPDRTVVAGQSFGGLAAMFAALNWPQR
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCHHH
FGCVLSQSGSYWWPHRDGRGMGFIGEQLRQGEVSAAGLRVWLEAGQREPIIFRANQALLA
HHHHEECCCCEECCCCCCCCCCHHHHHHHCCCCCHHHHHHEEECCCCCCEEEECCHHHHH
QLTTTQQTIFWRQVDGGHDALCWRGGLTAGLIQLWQPLLSHP
HHHHCCEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ferrienterobactin [C]

Specific reaction: ferrienterobactin = Fe [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2974033; 9278503; 8905232 [H]