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The map label for this gene is tpa [H]

Identifier: 238893604

GI number: 238893604

Start: 1457883

End: 1459220

Strand: Direct

Name: tpa [H]

Synonym: KP1_1518

Alternate gene names: 238893604

Gene position: 1457883-1459220 (Clockwise)

Preceding gene: 238893602

Following gene: 238893613

Centisome position: 27.78

GC content: 63.6

Gene sequence:

>1338_bases
ATGAAGCTGGCAATTCACAACGAGGTCGCGGTAAGCAATGACGAAGTTCGGCAATTAGATCGCGCCTATGTGTTTCATTC
ATGGTCGATGCAGGGCAATCTCAACCCGCTGGTCATCGCCGGGGCGCAAGGCTGCGAGCTATGGGATTATGAGGGGAACA
CCTGGCTCGATTTCAGCAGCCAGCTGGTGAACGTCAACATTGGCTATCAGCACCCTCGGGTACTGGCGGCCATGAAGGCG
CAGCTGGAGACCCTGGTCACCATCGCGCCCGCCACCGCCAACCTTGCCCGCGGCGAAGCGGCGAAGCGCATCGTCGACCT
GGCGCCGGCGGGCTTCAGTAAGGTGTTCTTCACTAACGCCGGGGCGGATGCCAATGAGAACGCGATTCGTATGGCGCGGC
TCTATACCGGGCGCGACAAGGTGCTGTCGGCCTATCGTTCCTATCATGGCAATACCGGCAGCGCGATCGCCGCTACCGGC
GACTGGCGCCGGGTGCCGAATGAGTTCTCCCGCGGCCACGTTCACTTCTTCAACCCCTACCTTTACCGCAGCGAGTTCAA
CGCCGCGACTGAGGAAGAGGAGTGCCAGCGCGCGCTGGCGCATCTGCGGCGGATCATTGAATGCGAGGGGCCGACGGCCA
TCGCGGCGATCCTGCTGGAGTCCATCCCCGGCACCGCCGGGATCCTCGTGCCGCCGGCAGGCTATATGCAGGGCGTGCGC
GCCCTGACCAACGAGTTTGGCATCGTGCTGATCCTCGATGAGGTGATGGCCGGCTTTGGCCGCACCGGCAGCTGGTTCGC
CTTCGAGCAGGATGGCGTGGTGCCGGATCTGGTGACCTTTGCCAAGGGGGTTAACGCCGGCTACGTGCCGGCGGGCGGGG
TGCTGATTAGCGAGCCGATTGCCCGCTACTTTGACGACCACTTCTTTGCCGGGGGGCTGACCTACTCCGGCCATCCGCTG
GCGATGGCGGCGATTGTCGCCACCATCGACGCGATGAAAGAGGAGAAGGTGGTTGAGAACGCGGCCTCTATCGGCAACGA
GGTGCTGCGCCCCGGTCTCGAGGCGCTGGCGGAGAAGCACGCCATTATCGGCGAGGTGCGCGGTCGCGGCCTGTTCCAGG
CGCTGGAGCTGGTGAGCAGCCGTGAACAAAAAACGCCGCTGACCGCCGCCGACATGGCCGCGATCAAAGGGGCCCTGACC
GAAGCCGGGCTGCTGGCCTTTGTGGTGGAGAACCGCATTCACGTGGTCCCGCCGTGCACCATTACTGCTGAGCAGGTGGC
GCAAGGGCTGGCGATTTTTGATGCGGTCTTTGCTCGCTTTGCCAGTCTGGCGAAGTAG

Upstream 100 bases:

>100_bases
GACACCGTGTCACATCGTTATGCGCGCACTGGCTCTATCCGATTTGCGCGGCCAAGGCCAATGATGAAGCCAACCACTAC
GACATGAGAGAGGGCAGGGT

Downstream 100 bases:

>100_bases
GGGAGGGGGCCGGATACTGTTGCCCGGCGGCGCGCTTGCCGGGCCTACGGGGTGTGAGCCTGTGAGTGGATCCTGTAGGC
CGGGTAAGGCGCAGCCGCCA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MKLAIHNEVAVSNDEVRQLDRAYVFHSWSMQGNLNPLVIAGAQGCELWDYEGNTWLDFSSQLVNVNIGYQHPRVLAAMKA
QLETLVTIAPATANLARGEAAKRIVDLAPAGFSKVFFTNAGADANENAIRMARLYTGRDKVLSAYRSYHGNTGSAIAATG
DWRRVPNEFSRGHVHFFNPYLYRSEFNAATEEEECQRALAHLRRIIECEGPTAIAAILLESIPGTAGILVPPAGYMQGVR
ALTNEFGIVLILDEVMAGFGRTGSWFAFEQDGVVPDLVTFAKGVNAGYVPAGGVLISEPIARYFDDHFFAGGLTYSGHPL
AMAAIVATIDAMKEEKVVENAASIGNEVLRPGLEALAEKHAIIGEVRGRGLFQALELVSSREQKTPLTAADMAAIKGALT
EAGLLAFVVENRIHVVPPCTITAEQVAQGLAIFDAVFARFASLAK

Sequences:

>Translated_445_residues
MKLAIHNEVAVSNDEVRQLDRAYVFHSWSMQGNLNPLVIAGAQGCELWDYEGNTWLDFSSQLVNVNIGYQHPRVLAAMKA
QLETLVTIAPATANLARGEAAKRIVDLAPAGFSKVFFTNAGADANENAIRMARLYTGRDKVLSAYRSYHGNTGSAIAATG
DWRRVPNEFSRGHVHFFNPYLYRSEFNAATEEEECQRALAHLRRIIECEGPTAIAAILLESIPGTAGILVPPAGYMQGVR
ALTNEFGIVLILDEVMAGFGRTGSWFAFEQDGVVPDLVTFAKGVNAGYVPAGGVLISEPIARYFDDHFFAGGLTYSGHPL
AMAAIVATIDAMKEEKVVENAASIGNEVLRPGLEALAEKHAIIGEVRGRGLFQALELVSSREQKTPLTAADMAAIKGALT
EAGLLAFVVENRIHVVPPCTITAEQVAQGLAIFDAVFARFASLAK
>Mature_445_residues
MKLAIHNEVAVSNDEVRQLDRAYVFHSWSMQGNLNPLVIAGAQGCELWDYEGNTWLDFSSQLVNVNIGYQHPRVLAAMKA
QLETLVTIAPATANLARGEAAKRIVDLAPAGFSKVFFTNAGADANENAIRMARLYTGRDKVLSAYRSYHGNTGSAIAATG
DWRRVPNEFSRGHVHFFNPYLYRSEFNAATEEEECQRALAHLRRIIECEGPTAIAAILLESIPGTAGILVPPAGYMQGVR
ALTNEFGIVLILDEVMAGFGRTGSWFAFEQDGVVPDLVTFAKGVNAGYVPAGGVLISEPIARYFDDHFFAGGLTYSGHPL
AMAAIVATIDAMKEEKVVENAASIGNEVLRPGLEALAEKHAIIGEVRGRGLFQALELVSSREQKTPLTAADMAAIKGALT
EAGLLAFVVENRIHVVPPCTITAEQVAQGLAIFDAVFARFASLAK

Specific function: Catalyzes the degradation of taurine into alanine and sulfoacetaldehyde. Can also transaminate hypotaurine (2- aminosulfinate), beta-alanine and with low activity cysteine and 3-aminopropanesulfonate. In addition to pyruvate, 2-ketobutyrate and oxaloaceta

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=408, Percent_Identity=32.3529411764706, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4557809, Length=442, Percent_Identity=28.2805429864253, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI24119277, Length=416, Percent_Identity=30.0480769230769, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI226442705, Length=408, Percent_Identity=32.1078431372549, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI226442709, Length=376, Percent_Identity=32.7127659574468, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI13994255, Length=432, Percent_Identity=27.3148148148148, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI284507298, Length=333, Percent_Identity=27.6276276276276, Blast_Score=119, Evalue=7e-27,
Organism=Escherichia coli, GI1789016, Length=414, Percent_Identity=34.2995169082126, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI145693181, Length=392, Percent_Identity=29.8469387755102, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1787560, Length=407, Percent_Identity=31.9410319410319, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1788044, Length=420, Percent_Identity=25.4761904761905, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1789759, Length=345, Percent_Identity=26.9565217391304, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1786991, Length=427, Percent_Identity=25.9953161592506, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1786349, Length=333, Percent_Identity=30.03003003003, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI32564660, Length=423, Percent_Identity=33.096926713948, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI25144271, Length=418, Percent_Identity=29.9043062200957, Blast_Score=174, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI71992977, Length=433, Percent_Identity=27.0207852193995, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI25144274, Length=305, Percent_Identity=30.1639344262295, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17541228, Length=368, Percent_Identity=25.8152173913043, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71981843, Length=154, Percent_Identity=29.2207792207792, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=444, Percent_Identity=30.8558558558559, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6324432, Length=416, Percent_Identity=24.7596153846154, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321456, Length=380, Percent_Identity=26.0526315789474, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324386, Length=488, Percent_Identity=22.5409836065574, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI161085790, Length=428, Percent_Identity=32.0093457943925, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI28574759, Length=413, Percent_Identity=32.4455205811138, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI21356575, Length=392, Percent_Identity=31.1224489795918, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI21357415, Length=413, Percent_Identity=28.3292978208232, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI281366494, Length=402, Percent_Identity=24.6268656716418, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24667139, Length=402, Percent_Identity=24.6268656716418, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24667143, Length=402, Percent_Identity=24.6268656716418, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.77 [H]

Molecular weight: Translated: 47991; Mature: 47991

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLAIHNEVAVSNDEVRQLDRAYVFHSWSMQGNLNPLVIAGAQGCELWDYEGNTWLDFSS
CEEEECCCEECCCHHHHHHHHHHEEEEECCCCCCCEEEEECCCCCEEEECCCCEEEECCC
QLVNVNIGYQHPRVLAAMKAQLETLVTIAPATANLARGEAAKRIVDLAPAGFSKVFFTNA
EEEEEEECCCCHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEECC
GADANENAIRMARLYTGRDKVLSAYRSYHGNTGSAIAATGDWRRVPNEFSRGHVHFFNPY
CCCCCCCCEEHHHHHCCHHHHHHHHHHHCCCCCCEEEECCCHHHCCHHHCCCCEEEECCE
LYRSEFNAATEEEECQRALAHLRRIIECEGPTAIAAILLESIPGTAGILVPPAGYMQGVR
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEECCHHHHHHHH
ALTNEFGIVLILDEVMAGFGRTGSWFAFEQDGVVPDLVTFAKGVNAGYVPAGGVLISEPI
HHHHCCCEEEEHHHHHHCCCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCEEHHHHH
ARYFDDHFFAGGLTYSGHPLAMAAIVATIDAMKEEKVVENAASIGNEVLRPGLEALAEKH
HHHHCCHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIIGEVRGRGLFQALELVSSREQKTPLTAADMAAIKGALTEAGLLAFVVENRIHVVPPCT
HHHHHHCCCHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
ITAEQVAQGLAIFDAVFARFASLAK
CCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLAIHNEVAVSNDEVRQLDRAYVFHSWSMQGNLNPLVIAGAQGCELWDYEGNTWLDFSS
CEEEECCCEECCCHHHHHHHHHHEEEEECCCCCCCEEEEECCCCCEEEECCCCEEEECCC
QLVNVNIGYQHPRVLAAMKAQLETLVTIAPATANLARGEAAKRIVDLAPAGFSKVFFTNA
EEEEEEECCCCHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEECC
GADANENAIRMARLYTGRDKVLSAYRSYHGNTGSAIAATGDWRRVPNEFSRGHVHFFNPY
CCCCCCCCEEHHHHHCCHHHHHHHHHHHCCCCCCEEEECCCHHHCCHHHCCCCEEEECCE
LYRSEFNAATEEEECQRALAHLRRIIECEGPTAIAAILLESIPGTAGILVPPAGYMQGVR
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEECCHHHHHHHH
ALTNEFGIVLILDEVMAGFGRTGSWFAFEQDGVVPDLVTFAKGVNAGYVPAGGVLISEPI
HHHHCCCEEEEHHHHHHCCCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCEEHHHHH
ARYFDDHFFAGGLTYSGHPLAMAAIVATIDAMKEEKVVENAASIGNEVLRPGLEALAEKH
HHHHCCHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIIGEVRGRGLFQALELVSSREQKTPLTAADMAAIKGALTEAGLLAFVVENRIHVVPPCT
HHHHHHCCCHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
ITAEQVAQGLAIFDAVFARFASLAK
CCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11082195 [H]