Click here to switch to the map view.

The map label for this gene is pheP [H]

Identifier: 238893561

GI number: 238893561

Start: 1409266

End: 1410675

Strand: Direct

Name: pheP [H]

Synonym: KP1_1467

Alternate gene names: 238893561

Gene position: 1409266-1410675 (Clockwise)

Preceding gene: 238893560

Following gene: 238893562

Centisome position: 26.85

GC content: 59.43

Gene sequence:

>1410_bases
GTGCCCCTTCACAAAAACACACAGGGGAACGACGTGAAAGACGCGTCAACGTCGTCGGAGACCGTCACGGAAAGTGGCCC
GACGCTTCATCGCGGTTTACAGAACCGACACATTCAACTTATCGCCCTTGGCGGCGCCATTGGCACCGGCCTGTTTCTCG
GCATTGGTCCCGCTATCCAGATGGCCGGTCCGGCGGTCTTACTGGGCTACGCCGTGGCCGGGATTGTCGCTTTTCTGATC
ATGCGCCAGCTGGGCGAAATGGTGGTGGAAGAGCCAGTATCCGGTTCCTTTGCCCACTTTGCCTATAAGTACTGGGGGCC
GTTCGCCGGCTTTCTCTCCGGCTGGAACTACTGGGTGATGTTCGTGCTGGTAGGGATGGCGGAGCTGACCGCCGCCGGGA
TCTATATGCAGTACTGGCTTCCCGACGTGCCCACCTGGGTTTGGGCGGCGGCTTTCTTCATCATTATTAACGCCGTCAAC
CTGGTCAACGTACGCTTGTATGGCGAAGCGGAGTTCTGGTTCGCGCTGATCAAGGTGCTGGCGATTATCGGCATGATTGC
CTTCGGCCTGTGGATGCTGTTCGGCGGCCACGGCGGCAGCAAAGCCGGGTTCGACAATCTGTGGAAACACGGCGGCTTCC
TCGCCACCGGCTGGCACGGACTTATTCTGTCGCTGGCGGTGATCATGTTCTCCTTCGGCGGGCTGGAGCTTATCGGCATC
ACCGCCGCCGAAGCGCAAAACCCGGAAAAGAGCATTCCCAAAGCGGTCAATCAGGTGGTCTATCGTATCCTGCTGTTCTA
TATCGGTTCGCTGGTGGTGCTGCTGGCGCTCTACCCGTGGGTGGAGATCAAATCCGACAGCAGCCCGTTTGTGATGATTT
TCCATAATCTGGACAGCAACCTGGTGGCCTCCGCGCTGAACTTCGTCATTCTGGTGGCCTCGCTGTCGGTGTATAACAGC
GGCGTGTACTCCAACAGCCGGATGCTGTTCGGCCTGTCGGTGCAGGGTAATGCGCCGAAATTTCTCGCCCGCGTCAGCAA
GCGCGGCGTGCCGGTGAACTCCCTGCTGCTCTCCGGAATTATCACTTCGCTGGTCGTGGTGCTGAACTACCTGCTGCCGC
ATGAAGCGCTGGGGCTGCTGATGGCCCTGGTGGTGGCGACGTTGTTGCTGAACTGGATCATGATCTGTATGGCGCACCTG
AAGTTCCGCGCCGCCCAGCGCCGCAAAGGGCGCGAATCGAAGTTCAAAGCGCTGCTGGCGCCCGCCAGCAACTACTTCTG
CATTGCTTTCCTTGGGCTGATCCTGGCGCTGATGTGCACTATCGACGGCATGCGTCTGTCGGCGATCCTGCTGCCGGTGT
GGATCCTGTTCCTGTTTATCGCCTTCAAACTGCTGCGCCGCCCGGCGTAA

Upstream 100 bases:

>100_bases
GCGTCTCAATGAGCTACGACTTCTGACGCTAAAAAAAGCGGGGCGGGCGGCTGACGCTCGCCCCACGCAACTTGCGACAA
TCCCCCCTAAGTGATAAAAG

Downstream 100 bases:

>100_bases
GCGAGATGCCCCGCCGTCCGGCGGGGCTGCCTGCCTTTTTATTGTGATCCTCTTCGCAGGCGGCGCATTTGCCTGGCGAT
CTTCTTTTTGTAATCGATTA

Product: phenylalanine transporter

Products: Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MPLHKNTQGNDVKDASTSSETVTESGPTLHRGLQNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYAVAGIVAFLI
MRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWLPDVPTWVWAAAFFIIINAVN
LVNVRLYGEAEFWFALIKVLAIIGMIAFGLWMLFGGHGGSKAGFDNLWKHGGFLATGWHGLILSLAVIMFSFGGLELIGI
TAAEAQNPEKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEIKSDSSPFVMIFHNLDSNLVASALNFVILVASLSVYNS
GVYSNSRMLFGLSVQGNAPKFLARVSKRGVPVNSLLLSGIITSLVVVLNYLLPHEALGLLMALVVATLLLNWIMICMAHL
KFRAAQRRKGRESKFKALLAPASNYFCIAFLGLILALMCTIDGMRLSAILLPVWILFLFIAFKLLRRPA

Sequences:

>Translated_469_residues
MPLHKNTQGNDVKDASTSSETVTESGPTLHRGLQNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYAVAGIVAFLI
MRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWLPDVPTWVWAAAFFIIINAVN
LVNVRLYGEAEFWFALIKVLAIIGMIAFGLWMLFGGHGGSKAGFDNLWKHGGFLATGWHGLILSLAVIMFSFGGLELIGI
TAAEAQNPEKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEIKSDSSPFVMIFHNLDSNLVASALNFVILVASLSVYNS
GVYSNSRMLFGLSVQGNAPKFLARVSKRGVPVNSLLLSGIITSLVVVLNYLLPHEALGLLMALVVATLLLNWIMICMAHL
KFRAAQRRKGRESKFKALLAPASNYFCIAFLGLILALMCTIDGMRLSAILLPVWILFLFIAFKLLRRPA
>Mature_468_residues
PLHKNTQGNDVKDASTSSETVTESGPTLHRGLQNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYAVAGIVAFLIM
RQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWLPDVPTWVWAAAFFIIINAVNL
VNVRLYGEAEFWFALIKVLAIIGMIAFGLWMLFGGHGGSKAGFDNLWKHGGFLATGWHGLILSLAVIMFSFGGLELIGIT
AAEAQNPEKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEIKSDSSPFVMIFHNLDSNLVASALNFVILVASLSVYNSG
VYSNSRMLFGLSVQGNAPKFLARVSKRGVPVNSLLLSGIITSLVVVLNYLLPHEALGLLMALVVATLLLNWIMICMAHLK
FRAAQRRKGRESKFKALLAPASNYFCIAFLGLILALMCTIDGMRLSAILLPVWILFLFIAFKLLRRPA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=433, Percent_Identity=25.635103926097, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI110347453, Length=357, Percent_Identity=25.7703081232493, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI258645169, Length=428, Percent_Identity=21.9626168224299, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4507047, Length=425, Percent_Identity=22.3529411764706, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI115648063, Length=376, Percent_Identity=23.6702127659574, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI115648022, Length=376, Percent_Identity=23.6702127659574, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1786789, Length=457, Percent_Identity=87.527352297593, Blast_Score=810, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=446, Percent_Identity=62.780269058296, Blast_Score=592, Evalue=1e-170,
Organism=Escherichia coli, GI48994972, Length=430, Percent_Identity=43.4883720930233, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1786602, Length=450, Percent_Identity=44, Blast_Score=347, Evalue=7e-97,
Organism=Escherichia coli, GI1790653, Length=452, Percent_Identity=38.0530973451327, Blast_Score=333, Evalue=2e-92,
Organism=Escherichia coli, GI87081915, Length=428, Percent_Identity=37.3831775700935, Blast_Score=298, Evalue=5e-82,
Organism=Escherichia coli, GI87081708, Length=447, Percent_Identity=35.5704697986577, Blast_Score=272, Evalue=4e-74,
Organism=Escherichia coli, GI1788480, Length=404, Percent_Identity=37.8712871287129, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI1789017, Length=421, Percent_Identity=35.6294536817102, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI87081869, Length=344, Percent_Identity=25.5813953488372, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082023, Length=388, Percent_Identity=22.680412371134, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI2367353, Length=386, Percent_Identity=22.5388601036269, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=378, Percent_Identity=20.8994708994709, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320772, Length=465, Percent_Identity=35.2688172043011, Blast_Score=254, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6324061, Length=446, Percent_Identity=34.7533632286996, Blast_Score=242, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6324059, Length=452, Percent_Identity=34.7345132743363, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6324990, Length=485, Percent_Identity=32.5773195876289, Blast_Score=217, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6319824, Length=453, Percent_Identity=30.6843267108168, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6324924, Length=451, Percent_Identity=31.7073170731707, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6321629, Length=429, Percent_Identity=30.7692307692308, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6322892, Length=415, Percent_Identity=33.7349397590361, Blast_Score=200, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6320717, Length=491, Percent_Identity=28.1059063136456, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324553, Length=392, Percent_Identity=32.1428571428571, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321053, Length=470, Percent_Identity=30.2127659574468, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319543, Length=410, Percent_Identity=30.9756097560976, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320251, Length=491, Percent_Identity=26.2729124236253, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6322967, Length=399, Percent_Identity=29.3233082706767, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6319608, Length=428, Percent_Identity=28.9719626168224, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319542, Length=485, Percent_Identity=25.7731958762887, Blast_Score=169, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6324981, Length=430, Percent_Identity=30.9302325581395, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6320364, Length=504, Percent_Identity=25.7936507936508, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24666159, Length=439, Percent_Identity=22.5512528473804, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI221512776, Length=439, Percent_Identity=22.5512528473804, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24667468, Length=428, Percent_Identity=24.7663551401869, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161077963, Length=452, Percent_Identity=23.0088495575221, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51207; Mature: 51075

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLHKNTQGNDVKDASTSSETVTESGPTLHRGLQNRHIQLIALGGAIGTGLFLGIGPAIQ
CCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHCCHHHH
MAGPAVLLGYAVAGIVAFLIMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYWVM
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
FVLVGMAELTAAGIYMQYWLPDVPTWVWAAAFFIIINAVNLVNVRLYGEAEFWFALIKVL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHH
AIIGMIAFGLWMLFGGHGGSKAGFDNLWKHGGFLATGWHGLILSLAVIMFSFGGLELIGI
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEECHHHHHHHHHHHHHHCCCEEEEEE
TAAEAQNPEKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEIKSDSSPFVMIFHNLDSN
EHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEEECCCHH
LVASALNFVILVASLSVYNSGVYSNSRMLFGLSVQGNAPKFLARVSKRGVPVNSLLLSGI
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHH
ITSLVVVLNYLLPHEALGLLMALVVATLLLNWIMICMAHLKFRAAQRRKGRESKFKALLA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
PASNYFCIAFLGLILALMCTIDGMRLSAILLPVWILFLFIAFKLLRRPA
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PLHKNTQGNDVKDASTSSETVTESGPTLHRGLQNRHIQLIALGGAIGTGLFLGIGPAIQ
CCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHCCHHHH
MAGPAVLLGYAVAGIVAFLIMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYWVM
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
FVLVGMAELTAAGIYMQYWLPDVPTWVWAAAFFIIINAVNLVNVRLYGEAEFWFALIKVL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHH
AIIGMIAFGLWMLFGGHGGSKAGFDNLWKHGGFLATGWHGLILSLAVIMFSFGGLELIGI
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEECHHHHHHHHHHHHHHCCCEEEEEE
TAAEAQNPEKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEIKSDSSPFVMIFHNLDSN
EHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEEECCCHH
LVASALNFVILVASLSVYNSGVYSNSRMLFGLSVQGNAPKFLARVSKRGVPVNSLLLSGI
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHH
ITSLVVVLNYLLPHEALGLLMALVVATLLLNWIMICMAHLKFRAAQRRKGRESKFKALLA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
PASNYFCIAFLGLILALMCTIDGMRLSAILLPVWILFLFIAFKLLRRPA
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] + L-phenylalanine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1711024; 8905232; 9278503; 8626334 [H]