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The map label for this gene is fsr [H]

Identifier: 238893448

GI number: 238893448

Start: 1291203

End: 1292423

Strand: Reverse

Name: fsr [H]

Synonym: KP1_1338

Alternate gene names: 238893448

Gene position: 1292423-1291203 (Counterclockwise)

Preceding gene: 238893450

Following gene: 238893447

Centisome position: 24.62

GC content: 57.49

Gene sequence:

>1221_bases
ATGGCAATCAATCAGACCGCTCAACCCTTGTCCGGCCCCGCTGCGCCGCCGCAAAAAGCACGCACCTCGTTTGGCATCTT
AGGCGCGATCAGCCTGTCCCATTTGCTTAACGATATGATCCAGTCGCTTATTCTCGCTATCTACCCGCTGCTGCAGGCGG
AGTTCTCCCTTACCTTCGTGCAGATCGGCATGATCACCCTGACCTTCCAGCTCACCTCATCGCTATTCCAGCCGGTGATT
GGCTACATCACCGATAAACGCTCGATGCCGTGGTCGCTGCCGGTGGGCATGTGCTTCACCCTCTGCGGTTTGATTCTCCT
CGCGCTGGCCGGTAGCTTCGGCATGGTGCTGCTGGCCGCCGCGCTGGTAGGTACCGGCTCCTCGGTTTTCCATCCGGAAT
CATCCCGCGTGGCGCGGATGGCCTCCGGCGGCCGTCACGGCCTGGCCCAGTCGCTGTTCCAGGTGGGCGGCAATTTCGGC
AGCTCGCTTGGCCCATTGCTGGCGGCGGTGATCATCGCCCCGTACGGCAAAGGCAACGTCGCCTGGTTTGTGCTGGCCGC
TCTGCTGGCTATTGTCGTGCTGTCGCAAATCAGCCGCTGGTATGCCGCGCAGCATCGAATGAATAAGGGCAAACCGAAAC
CGGCCATCGTTAATCCGCTGCCGCGCAAGAAGGTCATTCTGGCGGTAGGCATTCTGCTGATGCTGATTTTCTCGAAATAT
TTCTATATGGCGAGCATCAGCAGCTATTACACCTTTTATCTGATGCATAAATTCGGCTTAACGGTGCAAAACGCCCAGCT
TCATCTGTTTGCCTTCCTGTTCGCAGTGGCTGCCGGGACGGTGATTGGCGGGCCTGTTGGCGACAAAATTGGGCGTAAGT
ATGTGATTTGGGGCTCTATCCTCGGCGTAGCGCCTTTCACCCTCGTTTTACCCTACGCCAGCCTTGAATGGACGGGTATT
TTGACGGTGATCATTGGTTTTATCCTCGCCTCGGCCTTTTCCGCTATTCTGGTCTATGCGCAGGAACTGCTGCCGGGACG
CATCGGCATGGTTTCTGGCCTGTTTTTCGGCTTCGCCTTTGGCATGGGCGGCCTTGGCGCCGCGGTGTTAGGCCTGCTGG
CGGACCATACCAGCATCGATCTGGTTTATAAAATCTGCGCCTTCCTGCCGCTGCTGGGATTCCTGACGATATTCCTTCCT
GATAACCGGCAAAAAGCCTGA

Upstream 100 bases:

>100_bases
CAGCCCGTTCGTCATATTTCCCATGCAGTAGCCGGGAAAATCAGGGCAGTCGCCATGGCGGACAAAAGACGAAAGCTATA
TAAAAAAGTGACGTGAACCT

Downstream 100 bases:

>100_bases
TTATTCGGCGGCCAAAGTGCAACCCTGGCCGCCGTTAACCCTTGTGTCATCAGCCTGTTCCACGATTTCCCCCCGCCATT
TTCCCTTCTGTGCCTTTTCA

Product: fosmidomycin resistance protein

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MAINQTAQPLSGPAAPPQKARTSFGILGAISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVI
GYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAAALVGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFG
SSLGPLLAAVIIAPYGKGNVAWFVLAALLAIVVLSQISRWYAAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLIFSKY
FYMASISSYYTFYLMHKFGLTVQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYASLEWTGI
LTVIIGFILASAFSAILVYAQELLPGRIGMVSGLFFGFAFGMGGLGAAVLGLLADHTSIDLVYKICAFLPLLGFLTIFLP
DNRQKA

Sequences:

>Translated_406_residues
MAINQTAQPLSGPAAPPQKARTSFGILGAISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVI
GYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAAALVGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFG
SSLGPLLAAVIIAPYGKGNVAWFVLAALLAIVVLSQISRWYAAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLIFSKY
FYMASISSYYTFYLMHKFGLTVQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYASLEWTGI
LTVIIGFILASAFSAILVYAQELLPGRIGMVSGLFFGFAFGMGGLGAAVLGLLADHTSIDLVYKICAFLPLLGFLTIFLP
DNRQKA
>Mature_405_residues
AINQTAQPLSGPAAPPQKARTSFGILGAISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIG
YITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAAALVGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGS
SLGPLLAAVIIAPYGKGNVAWFVLAALLAIVVLSQISRWYAAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLIFSKYF
YMASISSYYTFYLMHKFGLTVQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYASLEWTGIL
TVIIGFILASAFSAILVYAQELLPGRIGMVSGLFFGFAFGMGGLGAAVLGLLADHTSIDLVYKICAFLPLLGFLTIFLPD
NRQKA

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=405, Percent_Identity=89.3827160493827, Blast_Score=691, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43314; Mature: 43183

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAINQTAQPLSGPAAPPQKARTSFGILGAISLSHLLNDMIQSLILAIYPLLQAEFSLTFV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHH
ALVGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNV
HHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCH
AWFVLAALLAIVVLSQISRWYAAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLIFSKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FYMASISSYYTFYLMHKFGLTVQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSI
HHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHCCCCCCCCCHHHCCEEEEEHHH
LGVAPFTLVLPYASLEWTGILTVIIGFILASAFSAILVYAQELLPGRIGMVSGLFFGFAF
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GMGGLGAAVLGLLADHTSIDLVYKICAFLPLLGFLTIFLPDNRQKA
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AINQTAQPLSGPAAPPQKARTSFGILGAISLSHLLNDMIQSLILAIYPLLQAEFSLTFV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHH
ALVGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNV
HHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCH
AWFVLAALLAIVVLSQISRWYAAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLIFSKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FYMASISSYYTFYLMHKFGLTVQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSI
HHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHCCCCCCCCCHHHCCEEEEEHHH
LGVAPFTLVLPYASLEWTGILTVIIGFILASAFSAILVYAQELLPGRIGMVSGLFFGFAF
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GMGGLGAAVLGLLADHTSIDLVYKICAFLPLLGFLTIFLPDNRQKA
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]