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The map label for this gene is cysM [H]

Identifier: 238893396

GI number: 238893396

Start: 1236832

End: 1237884

Strand: Reverse

Name: cysM [H]

Synonym: KP1_1280

Alternate gene names: 238893396

Gene position: 1237884-1236832 (Counterclockwise)

Preceding gene: 238893402

Following gene: 238893394

Centisome position: 23.59

GC content: 60.97

Gene sequence:

>1053_bases
ATGAATAGCGCCTGGGTTAAACATGCCATTAGCGAAATCAACGCTGACTATCAGCGCTCCGCCGACACGCACCTGATCCG
TCTGCCGCTGCCCGCTTTTCCGGGCATCCACCTGTATCTGAAAGATGAAAGCCCCCACCCCACCGGCAGCCTGAAGCATC
GCCTGGCGCGGTCGCTGTTTCTCTATGGCTTGTGCAACGGCTGGATCAAAGAAGGCACGCCAATTATAGAGTCCTCCTCA
GGGTCAACCGCCGTTTCGGAGGCCTATTTCGCCCGCCTGCTGGGGCTGCCGTTTATCGCTGTGATGCCCTCCTGCACCGC
CAGACGCAAAATCGAACAGATCGAGTTCTACGGCGGACGCTGCCATTTTGTGCAGAGCGCCGGCGAAATCTACGCGGCTT
CCGAAACGCTGGCCCGCGAGCTGAACGGCCATTATATGGATCAGTTTACCTTCGCCGAGCGGGCCACCGACTGGCGCGGC
AACAACAATATCGCCGACAGTATTTTCCGCCAGATGAGCCATGAGCCGCACCCGCAGCCGTCATGGATCGTCATGAGCGC
CGGCACCGGCGGCACCTCAGCAACCATTGGCCGCTATATTCGCAGCCAGGGCTACGAGACGCAGCTGATGGTCGTTGATC
CGCAGAATTCGGTGTTCCTCGATTACTGGCAGACCCGCGACGCCAGCCTGCGCAGCCCGGTCGGCAGCAAAATTGAAGGC
ATAGGACGGCCGCGCGTCGAGCCGTCGTTTATTCCCGACGTTGTCGATGAGATGCTGCGCGTGCCGGATGCGGCGAGCGT
AGCCACCGCCCTGTGGCTGGAAACGCAGCTTGGGCGCAAGGTCGGCGCCTCGACCGGCACCAATATGTGGGGCGTATTGC
AGCTGGCCGCGCGGATGCGCGAAGAAGGTCGCACCGGCTCGATAGTGACACTCCTGTGCGACAGCGGTGAGCGTTACCTG
GAAAGCTATTACAACCCGCAGTGGGTGGCGGACAATATCGGCGATATTGCGCCCTGGCAGGCGGAGATCGCCGGTCTGGT
CGAAAGGCGATAA

Upstream 100 bases:

>100_bases
AAAATTTTGCTCTCATAATGGTAATCCACAGGTTAAATGGCAACAATTTTTCCTGCGCTTTCCGCTAAGCTAGGCACAAA
ATGACAAACAGGAAATCACG

Downstream 100 bases:

>100_bases
AAAAAGCCAGATAGAAGCCTATCTGGCTTGCTGGAAGGGTCTCTCTATTCGGGGGAATAAGGAAGATCAGGATTATCCAG
CCAATGAGTTAAAAAATGGG

Product: putative cysteine synthase/cystathionine beta-synthase

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MNSAWVKHAISEINADYQRSADTHLIRLPLPAFPGIHLYLKDESPHPTGSLKHRLARSLFLYGLCNGWIKEGTPIIESSS
GSTAVSEAYFARLLGLPFIAVMPSCTARRKIEQIEFYGGRCHFVQSAGEIYAASETLARELNGHYMDQFTFAERATDWRG
NNNIADSIFRQMSHEPHPQPSWIVMSAGTGGTSATIGRYIRSQGYETQLMVVDPQNSVFLDYWQTRDASLRSPVGSKIEG
IGRPRVEPSFIPDVVDEMLRVPDAASVATALWLETQLGRKVGASTGTNMWGVLQLAARMREEGRTGSIVTLLCDSGERYL
ESYYNPQWVADNIGDIAPWQAEIAGLVERR

Sequences:

>Translated_350_residues
MNSAWVKHAISEINADYQRSADTHLIRLPLPAFPGIHLYLKDESPHPTGSLKHRLARSLFLYGLCNGWIKEGTPIIESSS
GSTAVSEAYFARLLGLPFIAVMPSCTARRKIEQIEFYGGRCHFVQSAGEIYAASETLARELNGHYMDQFTFAERATDWRG
NNNIADSIFRQMSHEPHPQPSWIVMSAGTGGTSATIGRYIRSQGYETQLMVVDPQNSVFLDYWQTRDASLRSPVGSKIEG
IGRPRVEPSFIPDVVDEMLRVPDAASVATALWLETQLGRKVGASTGTNMWGVLQLAARMREEGRTGSIVTLLCDSGERYL
ESYYNPQWVADNIGDIAPWQAEIAGLVERR
>Mature_350_residues
MNSAWVKHAISEINADYQRSADTHLIRLPLPAFPGIHLYLKDESPHPTGSLKHRLARSLFLYGLCNGWIKEGTPIIESSS
GSTAVSEAYFARLLGLPFIAVMPSCTARRKIEQIEFYGGRCHFVQSAGEIYAASETLARELNGHYMDQFTFAERATDWRG
NNNIADSIFRQMSHEPHPQPSWIVMSAGTGGTSATIGRYIRSQGYETQLMVVDPQNSVFLDYWQTRDASLRSPVGSKIEG
IGRPRVEPSFIPDVVDEMLRVPDAASVATALWLETQLGRKVGASTGTNMWGVLQLAARMREEGRTGSIVTLLCDSGERYL
ESYYNPQWVADNIGDIAPWQAEIAGLVERR

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=317, Percent_Identity=23.6593059936909, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI295821200, Length=317, Percent_Identity=23.6593059936909, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4557415, Length=317, Percent_Identity=23.6593059936909, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI2367138, Length=312, Percent_Identity=25.6410256410256, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71996324, Length=352, Percent_Identity=32.6704545454545, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17539800, Length=356, Percent_Identity=31.7415730337079, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17539640, Length=356, Percent_Identity=29.2134831460674, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17535051, Length=299, Percent_Identity=27.0903010033445, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI32566674, Length=289, Percent_Identity=26.643598615917, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562970, Length=292, Percent_Identity=26.027397260274, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI115535073, Length=303, Percent_Identity=27.7227722772277, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=25.7575757575758, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24643623, Length=317, Percent_Identity=26.4984227129338, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20129101, Length=317, Percent_Identity=26.4984227129338, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 38927; Mature: 38927

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSAWVKHAISEINADYQRSADTHLIRLPLPAFPGIHLYLKDESPHPTGSLKHRLARSLF
CCCHHHHHHHHHHCCHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
LYGLCNGWIKEGTPIIESSSGSTAVSEAYFARLLGLPFIAVMPSCTARRKIEQIEFYGGR
HHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHEECCE
CHFVQSAGEIYAASETLARELNGHYMDQFTFAERATDWRGNNNIADSIFRQMSHEPHPQP
EEEECCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCC
SWIVMSAGTGGTSATIGRYIRSQGYETQLMVVDPQNSVFLDYWQTRDASLRSPVGSKIEG
CEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHC
IGRPRVEPSFIPDVVDEMLRVPDAASVATALWLETQLGRKVGASTGTNMWGVLQLAARMR
CCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
EEGRTGSIVTLLCDSGERYLESYYNPQWVADNIGDIAPWQAEIAGLVERR
HCCCCCCEEEEEECCCHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MNSAWVKHAISEINADYQRSADTHLIRLPLPAFPGIHLYLKDESPHPTGSLKHRLARSLF
CCCHHHHHHHHHHCCHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
LYGLCNGWIKEGTPIIESSSGSTAVSEAYFARLLGLPFIAVMPSCTARRKIEQIEFYGGR
HHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHEECCE
CHFVQSAGEIYAASETLARELNGHYMDQFTFAERATDWRGNNNIADSIFRQMSHEPHPQP
EEEECCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCC
SWIVMSAGTGGTSATIGRYIRSQGYETQLMVVDPQNSVFLDYWQTRDASLRSPVGSKIEG
CEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHC
IGRPRVEPSFIPDVVDEMLRVPDAASVATALWLETQLGRKVGASTGTNMWGVLQLAARMR
CCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
EEGRTGSIVTLLCDSGERYLESYYNPQWVADNIGDIAPWQAEIAGLVERR
HCCCCCCEEEEEECCCHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9034314; 10688204 [H]