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The map label for this gene is cyoE [H]

Identifier: 238893375

GI number: 238893375

Start: 1215038

End: 1215970

Strand: Reverse

Name: cyoE [H]

Synonym: KP1_1258

Alternate gene names: 238893375

Gene position: 1215970-1215038 (Counterclockwise)

Preceding gene: 238893376

Following gene: 238893374

Centisome position: 23.17

GC content: 56.06

Gene sequence:

>933_bases
GTGGAACCTGAACTACAACATGATGATGCACTAAGAGCGGCGAGTATGTTTAAGCAATACCTGCAAGTAACGAAACCAGG
CATTATTTTTGGCAACCTGATCTCCGTGATCGGCGGTTTCCTGCTGGCCTCCAAAGGCCACATCGACTATCCGCTGTTCG
TCTGGACGCTCCTTGGAGTATCCCTGGTGGTCGCCTCGGGTTGTGTATTCAACAACTACATCGACCGGGACATCGATCGT
AAGATGGAACGGACGAAAAACCGGGTGCTGGTCAAAGGGCTGATCTCGCCAGAAGCTTCGCTGGTGTACGCCACCTTGCT
GGGTATTGCTGGCTTCATGCTGCTGTGGTTCGGCGCTAACCCGCTGGCCTGCTGGCTGGGGGTGATGGGGTTCGTGGTTT
ATGTCGGCGTCTACAGCCTGTACATGAAACGCCACTCCGTCTACGGCACGCTGATTGGCTCACTCTCCGGCGCTGCGCCG
CCGGTGATTGGCTACTGCGCGGTCACCGGTGATTTCGACAGCGGTGCGGCGATCCTGCTGGCTATCTTTAGCCTGTGGCA
GATGCCTCACTCCTACGCCATCGCGATTTTCCGCTTTAAGGATTATCAGGCGGCGAATATTCCGGTGCTGCCGGTGGTGA
AAGGCATTTCGGTCGCCAAAAACCATATTACGCTGTACATCGTCGCCTTTGCCGTGGCAACCTTGATGCTCTCGCTGGGC
GGCTACGCCGGGTATAAATACCTGGTCGTGGCGGCAGCGGTCAGCGTCTGGTGGCTGGGCATGGCGCTGCGTGGCTATAA
AGTGGCCGATGATAAAGTCTGGGCGCGTAAGCTGTTCGTCTTTTCTATCGTCGCCATCACCGCGCTGTCCGTGATGATGT
CCGTTGACTTTATGGTGCCGGATTCACATAGTCTGCTGGCTTACGTGAGATAA

Upstream 100 bases:

>100_bases
TGCATATGAACAGCAAGTCCGATGAAGGTTGGAACCTGACCGCATTTATCTTCACCGTAATCATCATTGCGATCGTGGTT
GTCGGCTCCATCTGGATTAT

Downstream 100 bases:

>100_bases
TTACGCACTCCAGTACGCTCTAAGGCCCCGTTTTTACGGGGCTTTTCTTTTCTGTTCCCTTACCGGATTCTTTCTCATTT
CATACTTCCCTCCCCTCCCC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MEPELQHDDALRAASMFKQYLQVTKPGIIFGNLISVIGGFLLASKGHIDYPLFVWTLLGVSLVVASGCVFNNYIDRDIDR
KMERTKNRVLVKGLISPEASLVYATLLGIAGFMLLWFGANPLACWLGVMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAP
PVIGYCAVTGDFDSGAAILLAIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVVKGISVAKNHITLYIVAFAVATLMLSLG
GYAGYKYLVVAAAVSVWWLGMALRGYKVADDKVWARKLFVFSIVAITALSVMMSVDFMVPDSHSLLAYVR

Sequences:

>Translated_310_residues
MEPELQHDDALRAASMFKQYLQVTKPGIIFGNLISVIGGFLLASKGHIDYPLFVWTLLGVSLVVASGCVFNNYIDRDIDR
KMERTKNRVLVKGLISPEASLVYATLLGIAGFMLLWFGANPLACWLGVMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAP
PVIGYCAVTGDFDSGAAILLAIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVVKGISVAKNHITLYIVAFAVATLMLSLG
GYAGYKYLVVAAAVSVWWLGMALRGYKVADDKVWARKLFVFSIVAITALSVMMSVDFMVPDSHSLLAYVR
>Mature_310_residues
MEPELQHDDALRAASMFKQYLQVTKPGIIFGNLISVIGGFLLASKGHIDYPLFVWTLLGVSLVVASGCVFNNYIDRDIDR
KMERTKNRVLVKGLISPEASLVYATLLGIAGFMLLWFGANPLACWLGVMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAP
PVIGYCAVTGDFDSGAAILLAIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVVKGISVAKNHITLYIVAFAVATLMLSLG
GYAGYKYLVVAAAVSVWWLGMALRGYKVADDKVWARKLFVFSIVAITALSVMMSVDFMVPDSHSLLAYVR

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=168, Percent_Identity=37.5, Blast_Score=111, Evalue=8e-25,
Organism=Escherichia coli, GI1786631, Length=294, Percent_Identity=95.2380952380952, Blast_Score=564, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI71998235, Length=225, Percent_Identity=29.7777777777778, Blast_Score=97, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6325085, Length=190, Percent_Identity=31.0526315789474, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19921064, Length=273, Percent_Identity=29.6703296703297, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 33892; Mature: 33892

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS00943 UBIA ; PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPELQHDDALRAASMFKQYLQVTKPGIIFGNLISVIGGFLLASKGHIDYPLFVWTLLGV
CCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
SLVVASGCVFNNYIDRDIDRKMERTKNRVLVKGLISPEASLVYATLLGIAGFMLLWFGAN
HHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
PLACWLGVMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTGDFDSGAAILL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHH
AIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVVKGISVAKNHITLYIVAFAVATLMLSLG
HHHHHHHCCCHHEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GYAGYKYLVVAAAVSVWWLGMALRGYKVADDKVWARKLFVFSIVAITALSVMMSVDFMVP
CCCHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
DSHSLLAYVR
CCCCEEEEEC
>Mature Secondary Structure
MEPELQHDDALRAASMFKQYLQVTKPGIIFGNLISVIGGFLLASKGHIDYPLFVWTLLGV
CCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
SLVVASGCVFNNYIDRDIDRKMERTKNRVLVKGLISPEASLVYATLLGIAGFMLLWFGAN
HHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
PLACWLGVMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTGDFDSGAAILL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHH
AIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVVKGISVAKNHITLYIVAFAVATLMLSLG
HHHHHHHCCCHHEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GYAGYKYLVVAAAVSVWWLGMALRGYKVADDKVWARKLFVFSIVAITALSVMMSVDFMVP
CCCHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
DSHSLLAYVR
CCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA