Click here to switch to the map view.

The map label for this gene is pcaK [H]

Identifier: 238893367

GI number: 238893367

Start: 1206719

End: 1208128

Strand: Reverse

Name: pcaK [H]

Synonym: KP1_1250

Alternate gene names: 238893367

Gene position: 1208128-1206719 (Counterclockwise)

Preceding gene: 238893368

Following gene: 238893366

Centisome position: 23.02

GC content: 60.57

Gene sequence:

>1410_bases
ATGCCGCGCAGCCCTACCTGCGCGCCTGCGCATAAGGAATACGCTATGACACAGACTCAACGCCTGGATGTCAGAGAGTT
AATAAATCGTAACCCGCTGAGCCGATTTCAGAAGCTGATTATATTTCTCGGCTTTTGCGTCATCGCTCTCGATGGTTTTG
ATATCGCGATCATGGGCTTTATCGCCCCGACGCTAAAGCTGGAATGGGGGGTAAGCAACCACCAGCTGGGTCTGGTGATC
AGCGCCGCGCTGATCGGCCTCGCGCTGGGGGCGATTTTCTCCGGCCCGCTCGCCGACTGGCTGGGACGTAAGAAAATCAT
CATCAACAGCGTTTTCTTCTTCGGTTTCTGGACCATCGCCACCGCCTTCTCGCACAACGTAGAACAGATGATGTTCTTTC
GCTTTATGACTGGCCTCGGGCTGGGCGCCGCGATGCCGAATATCGGGACGCTGGTGTCGGAATACGCCCCGGAACGCCAG
CGTTCATTTATTATCACCGTCATCTTTTGCGGCTTCACCTTCGGCGCGGCGGCGGGAGGATTTTCGGCATCGTGGCTGAT
CCCCCAGTTTGGCTGGCACTCGCTGATGGCGCTCGGCGGTATTCTGCCGCTGCTGTTTGCCCCCCTGCTCATCTGGCTGC
TGCCGGAATCGGTTCGTTTTCTGGTGATCAAACAAGCGCCCGCGGCGCGCATACGCGCCATTCTTAACCGTCTCTATCCC
GGACAAATCAGCGACAATGTGACGTTTATCCTGCCGGCGCAGCCAGCGGCCGGCAACGCGATGCGCATTGTCCTCTCCCG
CCAGTACGGTTTCGGCTCGCTGATGCTATGGCTGGTCTACTTTATGGGGCTGTTCCTGGTCTATATCCTCGGCAGCTGGC
TGCCAACGCTGGTTAAAGCGGTAGGAATGACCGTTAGCCAGGCGGCCATCATGACGGCGATCTACCAGGCGGGCGGCACC
CTCGGCTCGTTGTTTGCCGGCTGGCTGATGGACAGGATCAACCCCCATCGCGCGCTGGGGATAATCTACGCCGTTGGCGG
CCTGTTCACCATGGCGATGGGCTACGCCGCGGGCAGCTTTGCCTTGCTCTGTATGCTGGCGTTTATCAGCGGCGCCTGCC
TGAACGGCGCCAATACCGGCATGAACGCCCTCTCCGCCCGCTACTACCCTACACAGGCGCGGGCGACGGGCTCCAGCTGG
ATGCACGGCGTCGGGCGCATCGGCGCCATTCTCAGCGCCTTTGCCGGCGCCGAGATGATGGCGCTCAACCTGCCCTTTGA
AAGCGTCTTTTTGATCCTCGGCATCCCGGCAGCCCTCACCGTCGCAGGCCTGGCGGCGAAGGGCATCTTTGCGGCCGGTC
ATCCTGCCGTCGCTTCAACTTCCCCCGCGTCTGTGCGCGGAGCGTCATAG

Upstream 100 bases:

>100_bases
ATGTCGGCCCTGCCGGCGACGCTGCCGGTCTCTCTCGAAGTGCCGCTTGACGGCGAGCAAGGCGCCCTGCCGCCTCTTCA
GCGGGCGCAGTTACTGTTCG

Downstream 100 bases:

>100_bases
CGGCATCTGGTTCCCGGTGCAATCGGCGGATTGCACCGCCTTCAGCAGCTAATAAAGAAAATTTATTTCATATTTTTTTG
AAACGAAAAAACGCCCGCAA

Product: 4-hydroxybenzoate transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MPRSPTCAPAHKEYAMTQTQRLDVRELINRNPLSRFQKLIIFLGFCVIALDGFDIAIMGFIAPTLKLEWGVSNHQLGLVI
SAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATAFSHNVEQMMFFRFMTGLGLGAAMPNIGTLVSEYAPERQ
RSFIITVIFCGFTFGAAAGGFSASWLIPQFGWHSLMALGGILPLLFAPLLIWLLPESVRFLVIKQAPAARIRAILNRLYP
GQISDNVTFILPAQPAAGNAMRIVLSRQYGFGSLMLWLVYFMGLFLVYILGSWLPTLVKAVGMTVSQAAIMTAIYQAGGT
LGSLFAGWLMDRINPHRALGIIYAVGGLFTMAMGYAAGSFALLCMLAFISGACLNGANTGMNALSARYYPTQARATGSSW
MHGVGRIGAILSAFAGAEMMALNLPFESVFLILGIPAALTVAGLAAKGIFAAGHPAVASTSPASVRGAS

Sequences:

>Translated_469_residues
MPRSPTCAPAHKEYAMTQTQRLDVRELINRNPLSRFQKLIIFLGFCVIALDGFDIAIMGFIAPTLKLEWGVSNHQLGLVI
SAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATAFSHNVEQMMFFRFMTGLGLGAAMPNIGTLVSEYAPERQ
RSFIITVIFCGFTFGAAAGGFSASWLIPQFGWHSLMALGGILPLLFAPLLIWLLPESVRFLVIKQAPAARIRAILNRLYP
GQISDNVTFILPAQPAAGNAMRIVLSRQYGFGSLMLWLVYFMGLFLVYILGSWLPTLVKAVGMTVSQAAIMTAIYQAGGT
LGSLFAGWLMDRINPHRALGIIYAVGGLFTMAMGYAAGSFALLCMLAFISGACLNGANTGMNALSARYYPTQARATGSSW
MHGVGRIGAILSAFAGAEMMALNLPFESVFLILGIPAALTVAGLAAKGIFAAGHPAVASTSPASVRGAS
>Mature_468_residues
PRSPTCAPAHKEYAMTQTQRLDVRELINRNPLSRFQKLIIFLGFCVIALDGFDIAIMGFIAPTLKLEWGVSNHQLGLVIS
AALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATAFSHNVEQMMFFRFMTGLGLGAAMPNIGTLVSEYAPERQR
SFIITVIFCGFTFGAAAGGFSASWLIPQFGWHSLMALGGILPLLFAPLLIWLLPESVRFLVIKQAPAARIRAILNRLYPG
QISDNVTFILPAQPAAGNAMRIVLSRQYGFGSLMLWLVYFMGLFLVYILGSWLPTLVKAVGMTVSQAAIMTAIYQAGGTL
GSLFAGWLMDRINPHRALGIIYAVGGLFTMAMGYAAGSFALLCMLAFISGACLNGANTGMNALSARYYPTQARATGSSWM
HGVGRIGAILSAFAGAEMMALNLPFESVFLILGIPAALTVAGLAAKGIFAAGHPAVASTSPASVRGAS

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=451, Percent_Identity=25.2771618625277, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI7662270, Length=357, Percent_Identity=22.6890756302521, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI213021148, Length=462, Percent_Identity=22.0779220779221, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI166064021, Length=376, Percent_Identity=25, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87081723, Length=388, Percent_Identity=33.2474226804124, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI87082231, Length=439, Percent_Identity=25.5125284738041, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082404, Length=398, Percent_Identity=25.1256281407035, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082159, Length=402, Percent_Identity=24.1293532338308, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1786229, Length=383, Percent_Identity=24.0208877284595, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788074, Length=452, Percent_Identity=25, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32564663, Length=436, Percent_Identity=26.605504587156, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24640198, Length=199, Percent_Identity=31.6582914572864, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24640196, Length=199, Percent_Identity=31.6582914572864, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24640200, Length=199, Percent_Identity=31.6582914572864, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19922874, Length=456, Percent_Identity=21.0526315789474, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50158; Mature: 50027

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRSPTCAPAHKEYAMTQTQRLDVRELINRNPLSRFQKLIIFLGFCVIALDGFDIAIMGF
CCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
IAPTLKLEWGVSNHQLGLVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIA
HHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHH
TAFSHNVEQMMFFRFMTGLGLGAAMPNIGTLVSEYAPERQRSFIITVIFCGFTFGAAAGG
HHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHCCHHHHHHEEHHHHHHHHHHHCCCC
FSASWLIPQFGWHSLMALGGILPLLFAPLLIWLLPESVRFLVIKQAPAARIRAILNRLYP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCC
GQISDNVTFILPAQPAAGNAMRIVLSRQYGFGSLMLWLVYFMGLFLVYILGSWLPTLVKA
CCCCCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGMTVSQAAIMTAIYQAGGTLGSLFAGWLMDRINPHRALGIIYAVGGLFTMAMGYAAGSF
HCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLCMLAFISGACLNGANTGMNALSARYYPTQARATGSSWMHGVGRIGAILSAFAGAEMM
HHHHHHHHHHCHHCCCCCCCHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHCCCCEE
ALNLPFESVFLILGIPAALTVAGLAAKGIFAAGHPAVASTSPASVRGAS
EEECCHHHHHHHHCCHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PRSPTCAPAHKEYAMTQTQRLDVRELINRNPLSRFQKLIIFLGFCVIALDGFDIAIMGF
CCCCCCCCCHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
IAPTLKLEWGVSNHQLGLVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIA
HHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHH
TAFSHNVEQMMFFRFMTGLGLGAAMPNIGTLVSEYAPERQRSFIITVIFCGFTFGAAAGG
HHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHCCHHHHHHEEHHHHHHHHHHHCCCC
FSASWLIPQFGWHSLMALGGILPLLFAPLLIWLLPESVRFLVIKQAPAARIRAILNRLYP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCC
GQISDNVTFILPAQPAAGNAMRIVLSRQYGFGSLMLWLVYFMGLFLVYILGSWLPTLVKA
CCCCCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGMTVSQAAIMTAIYQAGGTLGSLFAGWLMDRINPHRALGIIYAVGGLFTMAMGYAAGSF
HCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLCMLAFISGACLNGANTGMNALSARYYPTQARATGSSWMHGVGRIGAILSAFAGAEMM
HHHHHHHHHHCHHCCCCCCCHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHCCCCEE
ALNLPFESVFLILGIPAALTVAGLAAKGIFAAGHPAVASTSPASVRGAS
EEECCHHHHHHHHCCHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]