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The map label for this gene is apbA [H]

Identifier: 238893363

GI number: 238893363

Start: 1202047

End: 1202958

Strand: Reverse

Name: apbA [H]

Synonym: KP1_1245

Alternate gene names: 238893363

Gene position: 1202958-1202047 (Counterclockwise)

Preceding gene: 238893365

Following gene: 238893362

Centisome position: 22.92

GC content: 57.46

Gene sequence:

>912_bases
ATGAAAGTAACCGTACTGGGATGCGGTGCGCTGGGACAACTATGGCTGACCGCGTTGTACAAACAGGGACATGAAGTCCA
GGGCTGGCTGCGCGTACCGCAGCCATTCTGTAGCGTCAACGTCATTGAAACCGATGGCTCAGTGTTCAACGAATCGCTGA
CGGCCAACGACCCCGATTTTCTCGCCAGCAGCGAGCTGCTGATCGTCACCTTAAAGGCCTGGCAGGTGTCGAATGCGGTA
AAGCACCTGGCCGGGATCCTGCCGGACACCACGCCAATTGTGCTGATTCATAACGGCATGGGCACCGTCGAGGAGCTGCG
CGGCGTGAAACAGCCGTTGCTGCTGGCCTCCACGACCCAGGCGGCGCGGCGCGATGGGAATGTCATCATCCACGTTGCCC
AGGGCACCACGCATATCGGACCGGCAAAAAGCTACGAGGGGGACTACAGCTATCTCGCAGAAGTTCTGCAGAGCGTGCTG
CCGGATGTCGCCTGGCATAACAATATCCACTCGGCCATCTGGCGCAAGCTGGCGGTTAACTGCGTGATTAACCCTCTGAC
CGCGCTCAAAGGGTGTAAAAACGGCGATCTGCGCGACTATACGCAGGAAGTTGCGGCCATTTGTCGCGAGGTGGCGGCGG
TGATGGAGCGCGAAGGTATTCATACCTCGGCGGAAAACCTGCTATTTTATGTCGAACAGGTAATTGAAAGTACGGCAGAA
AATATCTCTTCCATGCTGCAGGACGTTCGCGCCCAGCGGCATACAGAGATCGACTACATCACCGGTTTTCTGCTCAACCG
CGCCCGCGCCCACGGCGTCGCCGTACCGGAAAACGCCCGCTTATTTGAATTGATCAAGCGTAAGGAGAATGAATATGAGC
GCGTCGGCACTGATTTGCCTCGCCCCTGGTAG

Upstream 100 bases:

>100_bases
AACGCTCGCGCTATTTTCCCCGTGATGTCCGACGATGCGAAAAGCGACGAGATAGACTTTAGCCATCAGCGCCTGGGATA
GCGGCAGATGAGGAGGAACA

Downstream 100 bases:

>100_bases
CGAAGAGACCGAAGCGGTCACCACTATCGACCTGCTGGTCCGCGGCGGAGTAAAGGTGACCACCGCCAGCGTCGCCAGCG
ACGGCAGCCTGACCATCGTC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MKVTVLGCGALGQLWLTALYKQGHEVQGWLRVPQPFCSVNVIETDGSVFNESLTANDPDFLASSELLIVTLKAWQVSNAV
KHLAGILPDTTPIVLIHNGMGTVEELRGVKQPLLLASTTQAARRDGNVIIHVAQGTTHIGPAKSYEGDYSYLAEVLQSVL
PDVAWHNNIHSAIWRKLAVNCVINPLTALKGCKNGDLRDYTQEVAAICREVAAVMEREGIHTSAENLLFYVEQVIESTAE
NISSMLQDVRAQRHTEIDYITGFLLNRARAHGVAVPENARLFELIKRKENEYERVGTDLPRPW

Sequences:

>Translated_303_residues
MKVTVLGCGALGQLWLTALYKQGHEVQGWLRVPQPFCSVNVIETDGSVFNESLTANDPDFLASSELLIVTLKAWQVSNAV
KHLAGILPDTTPIVLIHNGMGTVEELRGVKQPLLLASTTQAARRDGNVIIHVAQGTTHIGPAKSYEGDYSYLAEVLQSVL
PDVAWHNNIHSAIWRKLAVNCVINPLTALKGCKNGDLRDYTQEVAAICREVAAVMEREGIHTSAENLLFYVEQVIESTAE
NISSMLQDVRAQRHTEIDYITGFLLNRARAHGVAVPENARLFELIKRKENEYERVGTDLPRPW
>Mature_303_residues
MKVTVLGCGALGQLWLTALYKQGHEVQGWLRVPQPFCSVNVIETDGSVFNESLTANDPDFLASSELLIVTLKAWQVSNAV
KHLAGILPDTTPIVLIHNGMGTVEELRGVKQPLLLASTTQAARRDGNVIIHVAQGTTHIGPAKSYEGDYSYLAEVLQSVL
PDVAWHNNIHSAIWRKLAVNCVINPLTALKGCKNGDLRDYTQEVAAICREVAAVMEREGIHTSAENLLFYVEQVIESTAE
NISSMLQDVRAQRHTEIDYITGFLLNRARAHGVAVPENARLFELIKRKENEYERVGTDLPRPW

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=303, Percent_Identity=77.5577557755775, Blast_Score=506, Evalue=1e-145,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33528; Mature: 33528

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVTVLGCGALGQLWLTALYKQGHEVQGWLRVPQPFCSVNVIETDGSVFNESLTANDPDF
CEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEECCCHHHHCCCCCCCCCH
LASSELLIVTLKAWQVSNAVKHLAGILPDTTPIVLIHNGMGTVEELRGVKQPLLLASTTQ
HCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHCCCCCHHHHHHHH
AARRDGNVIIHVAQGTTHIGPAKSYEGDYSYLAEVLQSVLPDVAWHNNIHSAIWRKLAVN
HHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
CVINPLTALKGCKNGDLRDYTQEVAAICREVAAVMEREGIHTSAENLLFYVEQVIESTAE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
NISSMLQDVRAQRHTEIDYITGFLLNRARAHGVAVPENARLFELIKRKENEYERVGTDLP
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
RPW
CCC
>Mature Secondary Structure
MKVTVLGCGALGQLWLTALYKQGHEVQGWLRVPQPFCSVNVIETDGSVFNESLTANDPDF
CEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEECCCHHHHCCCCCCCCCH
LASSELLIVTLKAWQVSNAVKHLAGILPDTTPIVLIHNGMGTVEELRGVKQPLLLASTTQ
HCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHCCCCCHHHHHHHH
AARRDGNVIIHVAQGTTHIGPAKSYEGDYSYLAEVLQSVLPDVAWHNNIHSAIWRKLAVN
HHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
CVINPLTALKGCKNGDLRDYTQEVAAICREVAAVMEREGIHTSAENLLFYVEQVIESTAE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
NISSMLQDVRAQRHTEIDYITGFLLNRARAHGVAVPENARLFELIKRKENEYERVGTDLP
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
RPW
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]