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The map label for this gene is ldcC [H]

Identifier: 238893182

GI number: 238893182

Start: 1022104

End: 1024257

Strand: Direct

Name: ldcC [H]

Synonym: KP1_1043

Alternate gene names: 238893182

Gene position: 1022104-1024257 (Clockwise)

Preceding gene: 238893181

Following gene: 238893183

Centisome position: 19.47

GC content: 58.17

Gene sequence:

>2154_bases
GTGAATATCATCGCCATCATGGGGCCTCACGGCGTCTACCACAAAGACGAGCCGATCAAAGAACTGGAAGCGGCGCTGCA
GCGCCAGGGCTTCCAGACCATCTGGCCGCAAAACAGCGCCGACCTGCTGCAGTTTATCGAGCACAACCCGCGCATCTGCG
GGGTGATCTTCGACTGGGATGAATACAGCGTCGATCTGTGCAGCGATATCAATCAGCTCAATGAATACCTTCCTCTGTAC
GCCTTTATTAACGCCCACTCGACGATGGATGTCAGCAGTCAGGATTTGCGCATGACGCTGTGGTTCTTCGAATATGCGCT
GGGACTCTCCGAAGAGATCGCCACCCGCATTGGGCAGTACACCCGCGAGTACCTGGAGAATATCACTCCGCCGTTTACCC
GCGCGCTGTTCAACTATGTCCAGGAGGGAAAATATACCTTCTGTACGCCGGGCCATATGGGCGGCAGCGCCTATCAGAAA
AGCCCGGTGGGCTGCCTGTTCTATGATTTTTTTGGCGGGAATACGCTGAAGGCGGATGTCTCGATTTCGGTCACCGAGCT
GGGCTCCCTGCTGGATCATACCGGCCCGCACCTGGAGGCGGAGGAGTATATCGCGCGCGCCTTTGGCGCCGAGCAAAGCT
ATATGGTGACCAACGGCACCTCGACGTCCAATAAAATTGTCGGCATGTACTCGGCGCCCGCCGGCAGCACCCTGCTGATT
GACCGTAACTGTCACAAATCGCTGGCCCACCTGCTGATGATGAGCGATGTGGTTCCCCTGTGGCTGAAGCCGACCCGCAA
CGCGCTGGGGATCCTCGGCGGTATCCCCCGGCGCGAATTTACCCGCGACAGCATTCAGCAGAAAGTGCGCGACACGGGCG
GGGCGCAGTGGCCCGTGCATGCGGTGATCACCAACTCCACCTACGATGGTCTGCTCTATAACACCACCTGGCTTAAGGAG
ACGCTCGATGTCCCGTCGATCCATTTCGATTCCGCCTGGGTGCCCTATACCCATTTCCATCCGATATATCAGGGGAAAAG
CGGTATGAGCGGGGAGCGGATCCCCGGGAAAGTCATCTTCGAGACGCAGTCGACGCATAAGATGCTGGCCGCGCTGTCGC
AGGCCTCGCTGATCCACATTAAAGGCAACTATGATGAAGAGACCTTTAACGAAGCCTTTATGATGCATACCTCTACGTCG
CCGAGCTACCCCATCGTCGCGTCGATTGAGACCGCGGCGGCGATGCTGCGCGGCAACTCCGGTAAACGTCTGATCCAGCG
CTCCATTGAGCGGGCGCTGGACTTCCGCAAAGAGGTGCAGCGACTGCGCGAGGAGTCGGACGGCTGGTTCTTTGATATCT
GGCAGCCGGAAGCCGTGGATAAAGCCGAGTGCTGGCCGGTAGCGCCGGGCGAGGACTGGCACGGTTTCAAAGATGCCGAT
GCGGATCATATGTATCTCGATCCGGTGAAGGTCACCATTCTGACGCCGGGCATGGACGAGCAGGGGAATATGGATGAAGA
GGGGATCCCGGCGGCGCTGGTGGCGAAGTTCCTCGACGAGCGGGGCGTGGTGGTAGAGAAAACAGGCCCCTACAATCTGC
TGTTCCTGTTCAGTATCGGCATCGATAAAACCCGGGCGATGGGGCTGCTGCGCGGCCTGACCGAGTTTAAACGCGCCTAC
GATCTCAATCTGCGGGTGAAAAATATGCTGCCGGATCTGTACGCCGAAGATCCCGACTTCTACCGCAACATGCGGATCCA
GGATCTGGCGCAGGGGATCCACCGCTTGATCCGTCAGCATCAGCTGCCGCAGCTGATGCTCAGCGCCTTTGACGTCCTGC
CGGAAATGAAAATGACGCCGCATCACGCCTGGCAGCGCCAGATCAAGGGGGAGGTGGAAACTATTGAACTGGAGAACCTG
GTGGGGCGGATTTCGGCCAACATGATCCTCCCTTATCCGCCGGGGGTTCCGCTGCTGATGCCGGGAGAGATGATCACCGA
GGAAAGCCGGGCGGTGCTCGATTTTCTGCTGATGCTTTGCTCTATCGGCCGTCATTACCCGGGCTTTGAGACCGATATTC
ACGGCGCCAAGCGCGATGAGGACGGTGTATATCGGGTACGAGTCTTAAAAAATGACGAAAGGCTTGCGCGTTAA

Upstream 100 bases:

>100_bases
ACTAAACACTAAGGGCCGGATTTTCCGGCCCTTTTTTTATGTGCGATGCGCCCGGGGGATTGCTATGATGCTTGACTTAG
GTGAATACCAGGAGGAAAGC

Downstream 100 bases:

>100_bases
CGGCGCGCACGAGTAACGTGGCTGGCTTAACAGAAGGAGTTTAACCATGCTGGGTTTGAAACGGGTTCACCATATTGCCA
TCATTGCGACCGACTACGCC

Product: lysine decarboxylase 2

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 717; Mature: 717

Protein sequence:

>717_residues
MNIIAIMGPHGVYHKDEPIKELEAALQRQGFQTIWPQNSADLLQFIEHNPRICGVIFDWDEYSVDLCSDINQLNEYLPLY
AFINAHSTMDVSSQDLRMTLWFFEYALGLSEEIATRIGQYTREYLENITPPFTRALFNYVQEGKYTFCTPGHMGGSAYQK
SPVGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARAFGAEQSYMVTNGTSTSNKIVGMYSAPAGSTLLI
DRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPRREFTRDSIQQKVRDTGGAQWPVHAVITNSTYDGLLYNTTWLKE
TLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERIPGKVIFETQSTHKMLAALSQASLIHIKGNYDEETFNEAFMMHTSTS
PSYPIVASIETAAAMLRGNSGKRLIQRSIERALDFRKEVQRLREESDGWFFDIWQPEAVDKAECWPVAPGEDWHGFKDAD
ADHMYLDPVKVTILTPGMDEQGNMDEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIGIDKTRAMGLLRGLTEFKRAY
DLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHRLIRQHQLPQLMLSAFDVLPEMKMTPHHAWQRQIKGEVETIELENL
VGRISANMILPYPPGVPLLMPGEMITEESRAVLDFLLMLCSIGRHYPGFETDIHGAKRDEDGVYRVRVLKNDERLAR

Sequences:

>Translated_717_residues
MNIIAIMGPHGVYHKDEPIKELEAALQRQGFQTIWPQNSADLLQFIEHNPRICGVIFDWDEYSVDLCSDINQLNEYLPLY
AFINAHSTMDVSSQDLRMTLWFFEYALGLSEEIATRIGQYTREYLENITPPFTRALFNYVQEGKYTFCTPGHMGGSAYQK
SPVGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARAFGAEQSYMVTNGTSTSNKIVGMYSAPAGSTLLI
DRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPRREFTRDSIQQKVRDTGGAQWPVHAVITNSTYDGLLYNTTWLKE
TLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERIPGKVIFETQSTHKMLAALSQASLIHIKGNYDEETFNEAFMMHTSTS
PSYPIVASIETAAAMLRGNSGKRLIQRSIERALDFRKEVQRLREESDGWFFDIWQPEAVDKAECWPVAPGEDWHGFKDAD
ADHMYLDPVKVTILTPGMDEQGNMDEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIGIDKTRAMGLLRGLTEFKRAY
DLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHRLIRQHQLPQLMLSAFDVLPEMKMTPHHAWQRQIKGEVETIELENL
VGRISANMILPYPPGVPLLMPGEMITEESRAVLDFLLMLCSIGRHYPGFETDIHGAKRDEDGVYRVRVLKNDERLAR
>Mature_717_residues
MNIIAIMGPHGVYHKDEPIKELEAALQRQGFQTIWPQNSADLLQFIEHNPRICGVIFDWDEYSVDLCSDINQLNEYLPLY
AFINAHSTMDVSSQDLRMTLWFFEYALGLSEEIATRIGQYTREYLENITPPFTRALFNYVQEGKYTFCTPGHMGGSAYQK
SPVGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARAFGAEQSYMVTNGTSTSNKIVGMYSAPAGSTLLI
DRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPRREFTRDSIQQKVRDTGGAQWPVHAVITNSTYDGLLYNTTWLKE
TLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERIPGKVIFETQSTHKMLAALSQASLIHIKGNYDEETFNEAFMMHTSTS
PSYPIVASIETAAAMLRGNSGKRLIQRSIERALDFRKEVQRLREESDGWFFDIWQPEAVDKAECWPVAPGEDWHGFKDAD
ADHMYLDPVKVTILTPGMDEQGNMDEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIGIDKTRAMGLLRGLTEFKRAY
DLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHRLIRQHQLPQLMLSAFDVLPEMKMTPHHAWQRQIKGEVETIELENL
VGRISANMILPYPPGVPLLMPGEMITEESRAVLDFLLMLCSIGRHYPGFETDIHGAKRDEDGVYRVRVLKNDERLAR

Specific function: LDC is constitutively but weakly expressed under various conditions [H]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1786384, Length=710, Percent_Identity=88.8732394366197, Blast_Score=1348, Evalue=0.0,
Organism=Escherichia coli, GI1790573, Length=714, Percent_Identity=69.327731092437, Blast_Score=1087, Evalue=0.0,
Organism=Escherichia coli, GI221142684, Length=735, Percent_Identity=35.5102040816327, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI87082193, Length=620, Percent_Identity=34.6774193548387, Blast_Score=337, Evalue=2e-93,
Organism=Escherichia coli, GI1786909, Length=691, Percent_Identity=31.4037626628075, Blast_Score=309, Evalue=5e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.18 [H]

Molecular weight: Translated: 81252; Mature: 81252

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIAIMGPHGVYHKDEPIKELEAALQRQGFQTIWPQNSADLLQFIEHNPRICGVIFDWD
CCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEECCCCHHHHHHHHHCCCCEEEEEECCC
EYSVDLCSDINQLNEYLPLYAFINAHSTMDVSSQDLRMTLWFFEYALGLSEEIATRIGQY
CCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
TREYLENITPPFTRALFNYVQEGKYTFCTPGHMGGSAYQKSPVGCLFYDFFGGNTLKADV
HHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEEE
SISVTELGSLLDHTGPHLEAEEYIARAFGAEQSYMVTNGTSTSNKIVGMYSAPAGSTLLI
EEEHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEECCCCCEEEE
DRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPRREFTRDSIQQKVRDTGGAQWPVH
ECCHHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEE
AVITNSTYDGLLYNTTWLKETLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERIPGKVIF
EEEECCCCCCEEEEHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
ETQSTHKMLAALSQASLIHIKGNYDEETFNEAFMMHTSTSPSYPIVASIETAAAMLRGNS
ECCHHHHHHHHHCCCCEEEEECCCCHHHHCCEEEEEECCCCCCCEEEEHHHHHHHHCCCC
GKRLIQRSIERALDFRKEVQRLREESDGWFFDIWQPEAVDKAECWPVAPGEDWHGFKDAD
CHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
ADHMYLDPVKVTILTPGMDEQGNMDEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEC
IDKTRAMGLLRGLTEFKRAYDLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHRLIRQH
CCHHHHHHHHHHHHHHHHHHCCCEEHHHHCCHHHCCCCHHHHCCCHHHHHHHHHHHHHHH
QLPQLMLSAFDVLPEMKMTPHHAWQRQIKGEVETIELENLVGRISANMILPYPPGVPLLM
CHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHCCEEEECCCCCCEEE
PGEMITEESRAVLDFLLMLCSIGRHYPGFETDIHGAKRDEDGVYRVRVLKNDERLAR
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECHHHHCC
>Mature Secondary Structure
MNIIAIMGPHGVYHKDEPIKELEAALQRQGFQTIWPQNSADLLQFIEHNPRICGVIFDWD
CCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEECCCCHHHHHHHHHCCCCEEEEEECCC
EYSVDLCSDINQLNEYLPLYAFINAHSTMDVSSQDLRMTLWFFEYALGLSEEIATRIGQY
CCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
TREYLENITPPFTRALFNYVQEGKYTFCTPGHMGGSAYQKSPVGCLFYDFFGGNTLKADV
HHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEEE
SISVTELGSLLDHTGPHLEAEEYIARAFGAEQSYMVTNGTSTSNKIVGMYSAPAGSTLLI
EEEHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEECCCCCEEEE
DRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPRREFTRDSIQQKVRDTGGAQWPVH
ECCHHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEE
AVITNSTYDGLLYNTTWLKETLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERIPGKVIF
EEEECCCCCCEEEEHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
ETQSTHKMLAALSQASLIHIKGNYDEETFNEAFMMHTSTSPSYPIVASIETAAAMLRGNS
ECCHHHHHHHHHCCCCEEEEECCCCHHHHCCEEEEEECCCCCCCEEEEHHHHHHHHCCCC
GKRLIQRSIERALDFRKEVQRLREESDGWFFDIWQPEAVDKAECWPVAPGEDWHGFKDAD
CHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
ADHMYLDPVKVTILTPGMDEQGNMDEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEC
IDKTRAMGLLRGLTEFKRAYDLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHRLIRQH
CCHHHHHHHHHHHHHHHHHHCCCEEHHHHCCHHHCCCCHHHHCCCHHHHHHHHHHHHHHH
QLPQLMLSAFDVLPEMKMTPHHAWQRQIKGEVETIELENLVGRISANMILPYPPGVPLLM
CHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHCCEEEECCCCCCEEE
PGEMITEESRAVLDFLLMLCSIGRHYPGFETDIHGAKRDEDGVYRVRVLKNDERLAR
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9226257; 9339543; 9278503; 9723924 [H]