| Definition | Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome. |
|---|---|
| Accession | NC_012731 |
| Length | 5,248,520 |
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The map label for this gene is mrcB [H]
Identifier: 238893147
GI number: 238893147
Start: 978213
End: 980765
Strand: Direct
Name: mrcB [H]
Synonym: KP1_1001
Alternate gene names: 238893147
Gene position: 978213-980765 (Clockwise)
Preceding gene: 238893146
Following gene: 238893148
Centisome position: 18.64
GC content: 61.38
Gene sequence:
>2553_bases ATGGCGGGAGATGACCGCGAGCCTATCGGACGTAAGGGAAGACCCTCACGTCCGACTAAACAGAAAGTCACCCGTCGCCG GGTCCGGGAAGAGGACTACGACGACGAGTATGATGACGATGATTATGAGGATGAGAAACCGGTGCCGAGAAAAGCCAAAG GCAAAGGTGGCAAGCCTCGTCGGAAGCGCAGCTGGCTGTGGCTGCTGGTCAAGCTGGGGATTGTCTTCGCGGTGCTGATT GCCGCCTATGGCGTCTACCTCGACCAGAAAATCCGCAGCCGCATTGACGGTAAAGTCTGGGAGCTGCCGGCCGCGGTCTA TGGCCGGATGGTCAACCTTGAGCCGGACATGCAGATCAGCAAAAACGAGATGGTGCGTCTGCTCAACGCCACGCAGTATC GCCAGGTCAGCGCGATGACGCGCCCCGGCGAATATACCGTGCAGGCTAACAGCATCGAGATGATCCGTCGTCCGTTCGAT TTCCCGGACAGTAAGGAAGGGCAGGTGCGCGCGCGTCTTACTTTCGACGGCGACCATCTTGAGACCATCGAGAATATGGA TAATAACCGCCAGTTCGGTTTCTTCCGCCTCGATCCGCGCCTTATCACCATGCTGCAGTCGCCGAACGGCGAGCAGCGCC TGTTCGTGAAGCGCAGCGGCTTCCCCGATCTGCTGGTGGATACCCTGCTGGCGACCGAAGACCGCCACTTCTATGAGCAC GATGGGATCAGTCTCTACTCCATCGGCCGCGCGGTGCTGGCGAACCTGACGGCAGGCCGAACGGTGCAGGGGGCGAGTAC CCTGACCCAACAGCTGGTGAAAAACCTGTTCCTCTCCAGCGAACGCTCCTACTGGCGTAAAGCCAACGAAGCGTATATGG CGCTGATCGTCGACGCCCGCTACAGCAAGGATCGCATCCTTGAGCTGTATATGAACGAGGTGTACCTCGGCCAGAGCGGC GATAACGAAATTCGCGGCTTCCCGCTGGCCAGCCTGTATTACTTCGGCCGTCCGGTGGAAGAGCTGAGCCTCGACCAGCA GGCGCTGCTGGTGGGGATGGTGAAAGGGGCGTCGGTCTATAACCCGTGGCGTAACCCGAAACTGGCCCTTGAACGACGCA ATCTGGTGCTGCGTCTGCTGCAGCAGCAGCAGGTTATCGACCAGGAGCTGTACGACATGCTCAGCGCCCGTCCGCTGGGC GTGCAGCCGCGCGGCGGGGTGATTTCACCGCAGCCGGCGTTTATGCAGATGGTTCGTCAGGAACTGCAGGCGAAGCTGGG CGATAAAGTGAAAGATCTCTCCGGCGTGAAGATCTTCACCACTTTCGACTCGGTGGCGCAGGATGCGGCGGAAAAAGCGG CCTCCGAAGGGATCCCGGTTCTGAAGAAACAGCGTAAGCTGGCAGACCTGGAAACCGCCATGGTGGTGGTTGACCGCTTC ACCGGCGAAGTGCGGGCGATGGTCGGCGGCGCGGAGCCGCAGTTCGCCGGTTATAACCGCGCGATGCAGGCCCGCCGATC GATTGGTTCTCTGGCCAAGCCGGCGACCTATCTGACCGCGCTGAGCCAGCCGAATCAGTATCGCCTGAATACCTGGATCG CCGATGCGCCGGTGACGATTCGCCTGTCCAACGGTCAGACGTGGTCCCCGCAGAACGACGATCGTCGTTTCAGCGGTCAG GTGATGCTGGTCGATGCCCTGACTCGCTCGATGAACGTCCCGACGGTTAACCTCGGGATGGCGCTGGGCTTGCCGGCGGT AGTCGATACCTGGACTAAACTGGGGGCGCCGAAGAATCAGCTCAACGCGGTGCCGTCGATGCTGCTTGGCGCGCTGAACC TGACGCCGATTGAAGTGGCCCAGGCCTTCCAGACCATCGCCAGCGGTGGGAACCGTGCGCCGCTTTCCGCGCTGCGGTCA GTGATTGCCGAAGATGGCACTGTGCTCTACCAGAGCTATCCGCAGGCGGAGCGCGCGGTGCCTGCCCAGGCGGCCTACAT GACGCTGTGGACTATGCAGCAGGTGGTGCAGCGCGGTACGGGGCGTCAGCTGGGGGCGAAGTATCCGGGCCTGCATCTGG CGGGGAAAACCGGGACCACCAACAATAACGTCGATACCTGGTTCGCCGGCATCGACGGTAGTCAGGTGACCATCACCTGG GTGGGTCGCGACAATAACCAGCCGACCAAACTGTACGGCGCCAGCGGCGCGATGTCGATTTACCAGCGCTATCTGGCGAA CCAGACGCCAACGCCGCTGGTGCTGACGGTGCCGGAAGACGTGGTTGATATGGGCGTGGACAGCAACGGCAACTTCGTCT GCAGCGGCGGTATGCGTTCGCTGCCGGTCTGGACCACGCAGCCGGATGCGCTGTGCCGTCAGGGCGAAATGATGCAACAG CAGCAGTTGCAGCAACAGGAAGCGAAAAATCCGTTTAATCAGTCCGGGCAGCAGCCGCCGCCGCAGCAGCAACAGCAGCA ACAGCCGCCGAAGCAGCAGGAAAAGAGCGACGGCGTCGCGGGCTGGATCAAGGATATGTTCGGCAGTAACTGA
Upstream 100 bases:
>100_bases ATAAGCAGCCTGGACGTTAATTTGAGAGATTTCTTCTTCCTCTGAACAGGGGAAGTATTGAGAATCAGGCCTTTGCGCCT GAACGTTGCGGAGAAAAAGC
Downstream 100 bases:
>100_bases TTTTGATCGCACGACCAGACCCCTTAATACGAAAGTATTAAGGGGTTTTTTTATGCCTGTAAAAAAGTTAACGGCTCTTT AACTCCATAATAACTATCTG
Product: penicillin-binding protein 1b
Products: NA
Alternate protein names: PBP-1b; PBP1b; Murein polymerase; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Peptidoglycan glycosyltransferase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 850; Mature: 849
Protein sequence:
>850_residues MAGDDREPIGRKGRPSRPTKQKVTRRRVREEDYDDEYDDDDYEDEKPVPRKAKGKGGKPRRKRSWLWLLVKLGIVFAVLI AAYGVYLDQKIRSRIDGKVWELPAAVYGRMVNLEPDMQISKNEMVRLLNATQYRQVSAMTRPGEYTVQANSIEMIRRPFD FPDSKEGQVRARLTFDGDHLETIENMDNNRQFGFFRLDPRLITMLQSPNGEQRLFVKRSGFPDLLVDTLLATEDRHFYEH DGISLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALIVDARYSKDRILELYMNEVYLGQSG DNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASVYNPWRNPKLALERRNLVLRLLQQQQVIDQELYDMLSARPLG VQPRGGVISPQPAFMQMVRQELQAKLGDKVKDLSGVKIFTTFDSVAQDAAEKAASEGIPVLKKQRKLADLETAMVVVDRF TGEVRAMVGGAEPQFAGYNRAMQARRSIGSLAKPATYLTALSQPNQYRLNTWIADAPVTIRLSNGQTWSPQNDDRRFSGQ VMLVDALTRSMNVPTVNLGMALGLPAVVDTWTKLGAPKNQLNAVPSMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRS VIAEDGTVLYQSYPQAERAVPAQAAYMTLWTMQQVVQRGTGRQLGAKYPGLHLAGKTGTTNNNVDTWFAGIDGSQVTITW VGRDNNQPTKLYGASGAMSIYQRYLANQTPTPLVLTVPEDVVDMGVDSNGNFVCSGGMRSLPVWTTQPDALCRQGEMMQQ QQLQQQEAKNPFNQSGQQPPPQQQQQQQPPKQQEKSDGVAGWIKDMFGSN
Sequences:
>Translated_850_residues MAGDDREPIGRKGRPSRPTKQKVTRRRVREEDYDDEYDDDDYEDEKPVPRKAKGKGGKPRRKRSWLWLLVKLGIVFAVLI AAYGVYLDQKIRSRIDGKVWELPAAVYGRMVNLEPDMQISKNEMVRLLNATQYRQVSAMTRPGEYTVQANSIEMIRRPFD FPDSKEGQVRARLTFDGDHLETIENMDNNRQFGFFRLDPRLITMLQSPNGEQRLFVKRSGFPDLLVDTLLATEDRHFYEH DGISLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALIVDARYSKDRILELYMNEVYLGQSG DNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASVYNPWRNPKLALERRNLVLRLLQQQQVIDQELYDMLSARPLG VQPRGGVISPQPAFMQMVRQELQAKLGDKVKDLSGVKIFTTFDSVAQDAAEKAASEGIPVLKKQRKLADLETAMVVVDRF TGEVRAMVGGAEPQFAGYNRAMQARRSIGSLAKPATYLTALSQPNQYRLNTWIADAPVTIRLSNGQTWSPQNDDRRFSGQ VMLVDALTRSMNVPTVNLGMALGLPAVVDTWTKLGAPKNQLNAVPSMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRS VIAEDGTVLYQSYPQAERAVPAQAAYMTLWTMQQVVQRGTGRQLGAKYPGLHLAGKTGTTNNNVDTWFAGIDGSQVTITW VGRDNNQPTKLYGASGAMSIYQRYLANQTPTPLVLTVPEDVVDMGVDSNGNFVCSGGMRSLPVWTTQPDALCRQGEMMQQ QQLQQQEAKNPFNQSGQQPPPQQQQQQQPPKQQEKSDGVAGWIKDMFGSN >Mature_849_residues AGDDREPIGRKGRPSRPTKQKVTRRRVREEDYDDEYDDDDYEDEKPVPRKAKGKGGKPRRKRSWLWLLVKLGIVFAVLIA AYGVYLDQKIRSRIDGKVWELPAAVYGRMVNLEPDMQISKNEMVRLLNATQYRQVSAMTRPGEYTVQANSIEMIRRPFDF PDSKEGQVRARLTFDGDHLETIENMDNNRQFGFFRLDPRLITMLQSPNGEQRLFVKRSGFPDLLVDTLLATEDRHFYEHD GISLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALIVDARYSKDRILELYMNEVYLGQSGD NEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASVYNPWRNPKLALERRNLVLRLLQQQQVIDQELYDMLSARPLGV QPRGGVISPQPAFMQMVRQELQAKLGDKVKDLSGVKIFTTFDSVAQDAAEKAASEGIPVLKKQRKLADLETAMVVVDRFT GEVRAMVGGAEPQFAGYNRAMQARRSIGSLAKPATYLTALSQPNQYRLNTWIADAPVTIRLSNGQTWSPQNDDRRFSGQV MLVDALTRSMNVPTVNLGMALGLPAVVDTWTKLGAPKNQLNAVPSMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSV IAEDGTVLYQSYPQAERAVPAQAAYMTLWTMQQVVQRGTGRQLGAKYPGLHLAGKTGTTNNNVDTWFAGIDGSQVTITWV GRDNNQPTKLYGASGAMSIYQRYLANQTPTPLVLTVPEDVVDMGVDSNGNFVCSGGMRSLPVWTTQPDALCRQGEMMQQQ QLQQQEAKNPFNQSGQQPPPQQQQQQQPPKQQEKSDGVAGWIKDMFGSN
Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal
COG id: COG0744
COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1786343, Length=852, Percent_Identity=86.8544600938967, Blast_Score=1410, Evalue=0.0, Organism=Escherichia coli, GI87082258, Length=249, Percent_Identity=34.9397590361446, Blast_Score=153, Evalue=4e-38, Organism=Escherichia coli, GI1788867, Length=580, Percent_Identity=27.5862068965517, Blast_Score=135, Evalue=1e-32, Organism=Escherichia coli, GI1789601, Length=127, Percent_Identity=37.007874015748, Blast_Score=79, Evalue=2e-15,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011813 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: =2.4.1.129 [H]
Molecular weight: Translated: 95030; Mature: 94898
Theoretical pI: Translated: 9.60; Mature: 9.60
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 3.4 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 3.3 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAGDDREPIGRKGRPSRPTKQKVTRRRVREEDYDDEYDDDDYEDEKPVPRKAKGKGGKPR CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC RKRSWLWLLVKLGIVFAVLIAAYGVYLDQKIRSRIDGKVWELPAAVYGRMVNLEPDMQIS HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHCEEECCCCCCCCC KNEMVRLLNATQYRQVSAMTRPGEYTVQANSIEMIRRPFDFPDSKEGQVRARLTFDGDHL HHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCCCCCCCCCCCEEEEEEECCHHH ETIENMDNNRQFGFFRLDPRLITMLQSPNGEQRLFVKRSGFPDLLVDTLLATEDRHFYEH HHHHCCCCCCCEEEEEECHHHHHEECCCCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHC DGISLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALIVDAR CCEEHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEEEECC YSKDRILELYMNEVYLGQSGDNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASVY CCHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCC NPWRNPKLALERRNLVLRLLQQQQVIDQELYDMLSARPLGVQPRGGVISPQPAFMQMVRQ CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH ELQAKLGDKVKDLSGVKIFTTFDSVAQDAAEKAASEGIPVLKKQRKLADLETAMVVVDRF HHHHHHCCHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH TGEVRAMVGGAEPQFAGYNRAMQARRSIGSLAKPATYLTALSQPNQYRLNTWIADAPVTI CCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEEECCCEEE RLSNGQTWSPQNDDRRFSGQVMLVDALTRSMNVPTVNLGMALGLPAVVDTWTKLGAPKNQ EECCCCCCCCCCCCCCCCCCEEEEEHHHHCCCCCEEECHHHHCCHHHHHHHHHCCCCHHH LNAVPSMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAEDGTVLYQSYPQAERAV HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEECCCCHHHCC PAQAAYMTLWTMQQVVQRGTGRQLGAKYPGLHLAGKTGTTNNNVDTWFAGIDGSQVTITW CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEECCCCCEEEEEE VGRDNNQPTKLYGASGAMSIYQRYLANQTPTPLVLTVPEDVVDMGVDSNGNFVCSGGMRS EECCCCCCCEEECCCHHHHHHHHHHCCCCCCCEEEECCHHHHHCCCCCCCCEEECCCCCC LPVWTTQPDALCRQGEMMQQQQLQQQEAKNPFNQSGQQPPPQQQQQQQPPKQQEKSDGVA CCEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHCCCCHHHHHCCCHH GWIKDMFGSN HHHHHHCCCC >Mature Secondary Structure AGDDREPIGRKGRPSRPTKQKVTRRRVREEDYDDEYDDDDYEDEKPVPRKAKGKGGKPR CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC RKRSWLWLLVKLGIVFAVLIAAYGVYLDQKIRSRIDGKVWELPAAVYGRMVNLEPDMQIS HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHCEEECCCCCCCCC KNEMVRLLNATQYRQVSAMTRPGEYTVQANSIEMIRRPFDFPDSKEGQVRARLTFDGDHL HHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCCCCCCCCCCCEEEEEEECCHHH ETIENMDNNRQFGFFRLDPRLITMLQSPNGEQRLFVKRSGFPDLLVDTLLATEDRHFYEH HHHHCCCCCCCEEEEEECHHHHHEECCCCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHC DGISLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALIVDAR CCEEHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEEEECC YSKDRILELYMNEVYLGQSGDNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASVY CCHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCC NPWRNPKLALERRNLVLRLLQQQQVIDQELYDMLSARPLGVQPRGGVISPQPAFMQMVRQ CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH ELQAKLGDKVKDLSGVKIFTTFDSVAQDAAEKAASEGIPVLKKQRKLADLETAMVVVDRF HHHHHHCCHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH TGEVRAMVGGAEPQFAGYNRAMQARRSIGSLAKPATYLTALSQPNQYRLNTWIADAPVTI CCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEEECCCEEE RLSNGQTWSPQNDDRRFSGQVMLVDALTRSMNVPTVNLGMALGLPAVVDTWTKLGAPKNQ EECCCCCCCCCCCCCCCCCCEEEEEHHHHCCCCCEEECHHHHCCHHHHHHHHHCCCCHHH LNAVPSMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAEDGTVLYQSYPQAERAV HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEECCCCHHHCC PAQAAYMTLWTMQQVVQRGTGRQLGAKYPGLHLAGKTGTTNNNVDTWFAGIDGSQVTITW CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEECCCCCEEEEEE VGRDNNQPTKLYGASGAMSIYQRYLANQTPTPLVLTVPEDVVDMGVDSNGNFVCSGGMRS EECCCCCCCEEECCCHHHHHHHHHHCCCCCCCEEEECCHHHHHCCCCCCCCEEECCCCCC LPVWTTQPDALCRQGEMMQQQQLQQQEAKNPFNQSGQQPPPQQQQQQQPPKQQEKSDGVA CCEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHCCCCHHHHHCCCHH GWIKDMFGSN HHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 3882429; 8202364; 9278503; 3920658; 8645198; 9244263; 3330753; 1885547; 10037771; 10564478; 9841666 [H]