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The map label for this gene is guaC [H]

Identifier: 238893084

GI number: 238893084

Start: 910633

End: 911676

Strand: Direct

Name: guaC [H]

Synonym: KP1_0928

Alternate gene names: 238893084

Gene position: 910633-911676 (Clockwise)

Preceding gene: 238893083

Following gene: 238893089

Centisome position: 17.35

GC content: 56.99

Gene sequence:

>1044_bases
ATGCGTATTGAAGAAGATCTGAAGCTTGGTTTCAAAGACGTTCTTATCCGCCCGAAACGCTCTACCCTCAAAAGCCGTTC
TGATGTTGAGCTGGAACGTGAATTCACCTTTAAACATTCAGGCCTGACCTGGTCCGGCGTGCCGATTATTGCGGCTAACA
TGGATACCGTCGGCACCTTCAGCATGGCTAAAGCGCTGGCCACTTTTGGTATTCTGACCGCGGTACATAAGCACTACACC
GCTGAAGAATGGCTGGCGTTTACCCAGGGCGCATCCGCAGACGTACTCAAGCATGTGATGGTTTCCACCGGCACGTCCGA
TGCGGATTTCGAAAAAACCCAGCAGATCCTCTCTCAGAACCCACAGCTGAATTTTGTGTGTATCGACGTCGCCAACGGCT
ACTCCGAGCACTTTGTACAGTTCGTGGCGAAGGCGCGCGAAGCCTGGCCGCAAAAAACTATCATCGCCGGGAACGTGGTC
ACCGGTGAAATGTGCGAAGAGCTGATCCTCTCCGGCGCCGATATCGTCAAAGTTGGCATCGGCCCGGGATCCGTCTGCAC
CACCCGCGTTAAGACCGGGGTCGGCTATCCGCAGCTCTCCGCCGTGATTGAGTGTGCCGATGCGGCGCACGGCCTTGGCG
GCCAGATCATCAGCGACGGCGGTTGCACCATGCCGGGCGATGTGGCGAAAGCCTTCGGCGGCGGCGCTGATTTCGTGATG
CTTGGCGGCATGCTGGCGGGCCATGAAGAGAGCGGCGGAACCATCGTTGAAGAAAACGGAGAGAAATTCATGCTGTTCTA
CGGCATGAGCTCCGAGTCGGCGATGACCCGCCATGTGGGCGGTGTCGCGAAATACCGCGCGGCGGAAGGCAAAACCGTTA
AGCTGCCTTTGCGTGGACCAGTGGAGAATACCGCACGTGATATTCTCGGCGGCCTGCGTTCTGCCTGCACCTACGTTGGC
GCCTCGCGTCTGAAAGAGCTGACCAAGCGTACGACCTTTATCCGCGTTCAGGAACAAGAGAACCGGGTATTCAATAGCCT
GTAA

Upstream 100 bases:

>100_bases
AAGTGAAAATCGCAGTCTTGCGCGGGCCTGATTCGCGCGTATGATAACGTCACTGGAGTTGTGCTCTCACATTCATGCCA
TTAACCCCAGGAATTCGCAC

Downstream 100 bases:

>100_bases
TCGGCTGCGCTGGCGCCTGCGCGGCGCCAGTGTTTCTCATCCTCCCGCCCCGCCAATGGCATCGCCCAGGTGAAAAACGG
GCAAATACATTGCCACCACC

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MRIEEDLKLGFKDVLIRPKRSTLKSRSDVELEREFTFKHSGLTWSGVPIIAANMDTVGTFSMAKALATFGILTAVHKHYT
AEEWLAFTQGASADVLKHVMVSTGTSDADFEKTQQILSQNPQLNFVCIDVANGYSEHFVQFVAKAREAWPQKTIIAGNVV
TGEMCEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIISDGGCTMPGDVAKAFGGGADFVM
LGGMLAGHEESGGTIVEENGEKFMLFYGMSSESAMTRHVGGVAKYRAAEGKTVKLPLRGPVENTARDILGGLRSACTYVG
ASRLKELTKRTTFIRVQEQENRVFNSL

Sequences:

>Translated_347_residues
MRIEEDLKLGFKDVLIRPKRSTLKSRSDVELEREFTFKHSGLTWSGVPIIAANMDTVGTFSMAKALATFGILTAVHKHYT
AEEWLAFTQGASADVLKHVMVSTGTSDADFEKTQQILSQNPQLNFVCIDVANGYSEHFVQFVAKAREAWPQKTIIAGNVV
TGEMCEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIISDGGCTMPGDVAKAFGGGADFVM
LGGMLAGHEESGGTIVEENGEKFMLFYGMSSESAMTRHVGGVAKYRAAEGKTVKLPLRGPVENTARDILGGLRSACTYVG
ASRLKELTKRTTFIRVQEQENRVFNSL
>Mature_347_residues
MRIEEDLKLGFKDVLIRPKRSTLKSRSDVELEREFTFKHSGLTWSGVPIIAANMDTVGTFSMAKALATFGILTAVHKHYT
AEEWLAFTQGASADVLKHVMVSTGTSDADFEKTQQILSQNPQLNFVCIDVANGYSEHFVQFVAKAREAWPQKTIIAGNVV
TGEMCEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIISDGGCTMPGDVAKAFGGGADFVM
LGGMLAGHEESGGTIVEENGEKFMLFYGMSSESAMTRHVGGVAKYRAAEGKTVKLPLRGPVENTARDILGGLRSACTYVG
ASRLKELTKRTTFIRVQEQENRVFNSL

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541956, Length=343, Percent_Identity=69.0962099125364, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI50541954, Length=344, Percent_Identity=68.8953488372093, Blast_Score=507, Evalue=1e-144,
Organism=Homo sapiens, GI50541952, Length=344, Percent_Identity=68.8953488372093, Blast_Score=507, Evalue=1e-144,
Organism=Homo sapiens, GI50541948, Length=344, Percent_Identity=68.8953488372093, Blast_Score=507, Evalue=1e-144,
Organism=Homo sapiens, GI156104880, Length=344, Percent_Identity=66.2790697674419, Blast_Score=489, Evalue=1e-138,
Organism=Homo sapiens, GI66933016, Length=244, Percent_Identity=27.8688524590164, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI217035148, Length=244, Percent_Identity=28.6885245901639, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI217035150, Length=244, Percent_Identity=28.6885245901639, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI217035146, Length=244, Percent_Identity=28.6885245901639, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI156616279, Length=244, Percent_Identity=28.6885245901639, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI217035152, Length=244, Percent_Identity=28.6885245901639, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI34328930, Length=244, Percent_Identity=28.6885245901639, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI34328928, Length=244, Percent_Identity=28.6885245901639, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1786293, Length=347, Percent_Identity=92.2190201729107, Blast_Score=664, Evalue=0.0,
Organism=Escherichia coli, GI1788855, Length=221, Percent_Identity=37.5565610859729, Blast_Score=128, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17560440, Length=343, Percent_Identity=65.3061224489796, Blast_Score=494, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI71994385, Length=174, Percent_Identity=35.0574712643678, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71994389, Length=168, Percent_Identity=35.1190476190476, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322012, Length=237, Percent_Identity=31.6455696202532, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6323464, Length=235, Percent_Identity=31.4893617021277, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323585, Length=235, Percent_Identity=31.4893617021277, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6319352, Length=120, Percent_Identity=36.6666666666667, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641071, Length=248, Percent_Identity=29.0322580645161, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24641073, Length=248, Percent_Identity=29.0322580645161, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28571163, Length=248, Percent_Identity=29.0322580645161, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005993
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 37279; Mature: 37279

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEEDLKLGFKDVLIRPKRSTLKSRSDVELEREFTFKHSGLTWSGVPIIAANMDTVGTF
CCCCHHHHCCHHHHEECCCHHHHCCCCCCEEEHHEEEEECCCEECCCEEEEECCCCHHHH
SMAKALATFGILTAVHKHYTAEEWLAFTQGASADVLKHVMVSTGTSDADFEKTQQILSQN
HHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCC
PQLNFVCIDVANGYSEHFVQFVAKAREAWPQKTIIAGNVVTGEMCEELILSGADIVKVGI
CCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCEEHHHHHHHHHCCCCEEEEEC
GPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIISDGGCTMPGDVAKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHCCCCCHHH
LGGMLAGHEESGGTIVEENGEKFMLFYGMSSESAMTRHVGGVAKYRAAEGKTVKLPLRGP
HCCCCCCCCCCCCEEEECCCCEEEEEEECCCCHHHHHHHCCHHHHCCCCCCEEEEECCCC
VENTARDILGGLRSACTYVGASRLKELTKRTTFIRVQEQENRVFNSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHCCC
>Mature Secondary Structure
MRIEEDLKLGFKDVLIRPKRSTLKSRSDVELEREFTFKHSGLTWSGVPIIAANMDTVGTF
CCCCHHHHCCHHHHEECCCHHHHCCCCCCEEEHHEEEEECCCEECCCEEEEECCCCHHHH
SMAKALATFGILTAVHKHYTAEEWLAFTQGASADVLKHVMVSTGTSDADFEKTQQILSQN
HHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCC
PQLNFVCIDVANGYSEHFVQFVAKAREAWPQKTIIAGNVVTGEMCEELILSGADIVKVGI
CCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCEEHHHHHHHHHCCCCEEEEEC
GPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIISDGGCTMPGDVAKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHCCCCCHHH
LGGMLAGHEESGGTIVEENGEKFMLFYGMSSESAMTRHVGGVAKYRAAEGKTVKLPLRGP
HCCCCCCCCCCCCEEEECCCCEEEEEEECCCCHHHHHHHCCHHHHCCCCCCEEEEECCCC
VENTARDILGGLRSACTYVGASRLKELTKRTTFIRVQEQENRVFNSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA