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The map label for this gene is pepQ [H]

Identifier: 238892443

GI number: 238892443

Start: 207850

End: 209181

Strand: Direct

Name: pepQ [H]

Synonym: KP1_0204

Alternate gene names: 238892443

Gene position: 207850-209181 (Clockwise)

Preceding gene: 238892440

Following gene: 238892444

Centisome position: 3.96

GC content: 55.26

Gene sequence:

>1332_bases
ATGGAATCCCTGGCCGCGCTCTATAAAAATCATATTGTTACCCTACAAGAACGTACCCGCGACGTCCTGGCCCGTTTTCA
AATGGATGCTCTGCTGATTCACTCCGGCGAGCTGGTTAACGTCTTCCTTGATGACCATCCGTACCCGTTCAAGGTCAATC
CGCAGTTCAAAGCCTGGGTGCCTGTGACTCAGGTGCCTAACTGCTGGCTGCTGGTGGACGGTGTGAATAAACCGAAGCTG
TGGTTCTATCTGCCGGTAGATTACTGGCATAACGTTGAGCCGTTGCCGACCTCTTTCTGGACCGAAGAGATAGACGTGAT
CGCGCTACCGAAGGCCGATGGCATCGGCAGCCAGCTGCCTGCTGCTCGCGGTAATATTGGCTATATCGGTCCGGTGCCTG
AGCGCGCGCTGGGCCTGGGTATCGCCGCGGATAAGATCAACCCGAAAGGGGTTATCGACTACCTGCATTACTACCGGGCT
TACAAAACCGATTACGAGCTGGCCTGCATGCGTGAAGCGCAGAAGTCGGCGGTGAATGGTCATCGTGCGGCCTACGAAGC
TTTCCAGTCGGGGATGAGCGAATTCGATATCAACCAGGCCTATCTCACCGCCACCGGCCATCGTGATACCGACGTGCCTT
ACAGCAATATTGTCGCGCTGAATGAGCATGCCTCCGTCCTGCACTACACCAAACTGGACCATCGTGCCCCGGCGGAGATG
CGCAGTTTCCTGCTCGACGCCGGTGCGGAATATAACGGCTATGCCGCAGATCTGACGCGCACCTGGGCGGCGCACGGCGA
TAACGACTTTGCCCATCTGATCAAAGACGTTAACGATGAGCAGCAGGCGCTGATTAGTACCATGAAGGCCGGTACCAGTT
ACATTGATTACCATATCCAGTTCCATCAGCGTATCGCGAAGCTGTTGCGTAAACACCAGTTGGTTACCGACATGAGCGAA
GAGGCGATGGTGGAGAATGACCTGACCGGGCCGTTTATGCCGCACGGGATTGGCCATCCGCTGGGTCTGCAGGTGCACGA
TGTCGCTGGCTTTATGCAGGATGACACCGGTACGCATCTGGCGGCGCCGTCGAAATACCCGTATCTGCGCTGCACCCGTA
TTATCGAGCCGCGGATGGTGTTAACTATTGAACCCGGCATCTACTTCATTGAGTCGTTACTGGCGCCGTGGCGTGAAGGC
CCGTTTAGCAAGCACTTTAACTGGCAAAAAATTGACGCCATGAAGCCGTTCGGTGGGATCCGTATCGAAGATAACGTGGT
GATTCACGAAAACAGTATCGAAAATATGACGCGCGATCTGAAGCTGGCCTGA

Upstream 100 bases:

>100_bases
ATAATTGCTGGTCGGATCACATCCGGCGGAAATCACCCGCACGCAGGTCGATGTGCTAAGATGCGGTGTATCACGATCCC
ATAAAAGCAAAGGATAAAAG

Downstream 100 bases:

>100_bases
TGGAGAGCTGGTTAATCCCGGCGGCGCCGGTTACCGTCGTTGAGGAGATTAAAAAAAGCCGTTTTATCACGCTGTTGGCG
CATACCGACGGCGTGGCGGC

Product: proline dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MESLAALYKNHIVTLQERTRDVLARFQMDALLIHSGELVNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKL
WFYLPVDYWHNVEPLPTSFWTEEIDVIALPKADGIGSQLPAARGNIGYIGPVPERALGLGIAADKINPKGVIDYLHYYRA
YKTDYELACMREAQKSAVNGHRAAYEAFQSGMSEFDINQAYLTATGHRDTDVPYSNIVALNEHASVLHYTKLDHRAPAEM
RSFLLDAGAEYNGYAADLTRTWAAHGDNDFAHLIKDVNDEQQALISTMKAGTSYIDYHIQFHQRIAKLLRKHQLVTDMSE
EAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDTGTHLAAPSKYPYLRCTRIIEPRMVLTIEPGIYFIESLLAPWREG
PFSKHFNWQKIDAMKPFGGIRIEDNVVIHENSIENMTRDLKLA

Sequences:

>Translated_443_residues
MESLAALYKNHIVTLQERTRDVLARFQMDALLIHSGELVNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKL
WFYLPVDYWHNVEPLPTSFWTEEIDVIALPKADGIGSQLPAARGNIGYIGPVPERALGLGIAADKINPKGVIDYLHYYRA
YKTDYELACMREAQKSAVNGHRAAYEAFQSGMSEFDINQAYLTATGHRDTDVPYSNIVALNEHASVLHYTKLDHRAPAEM
RSFLLDAGAEYNGYAADLTRTWAAHGDNDFAHLIKDVNDEQQALISTMKAGTSYIDYHIQFHQRIAKLLRKHQLVTDMSE
EAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDTGTHLAAPSKYPYLRCTRIIEPRMVLTIEPGIYFIESLLAPWREG
PFSKHFNWQKIDAMKPFGGIRIEDNVVIHENSIENMTRDLKLA
>Mature_443_residues
MESLAALYKNHIVTLQERTRDVLARFQMDALLIHSGELVNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKL
WFYLPVDYWHNVEPLPTSFWTEEIDVIALPKADGIGSQLPAARGNIGYIGPVPERALGLGIAADKINPKGVIDYLHYYRA
YKTDYELACMREAQKSAVNGHRAAYEAFQSGMSEFDINQAYLTATGHRDTDVPYSNIVALNEHASVLHYTKLDHRAPAEM
RSFLLDAGAEYNGYAADLTRTWAAHGDNDFAHLIKDVNDEQQALISTMKAGTSYIDYHIQFHQRIAKLLRKHQLVTDMSE
EAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDTGTHLAAPSKYPYLRCTRIIEPRMVLTIEPGIYFIESLLAPWREG
PFSKHFNWQKIDAMKPFGGIRIEDNVVIHENSIENMTRDLKLA

Specific function: Splits dipeptides with a prolyl residue in the C- terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=454, Percent_Identity=28.8546255506608, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI260593665, Length=355, Percent_Identity=30.9859154929577, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI260593663, Length=316, Percent_Identity=30.6962025316456, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI11559925, Length=303, Percent_Identity=26.7326732673267, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790282, Length=443, Percent_Identity=89.6162528216704, Blast_Score=849, Evalue=0.0,
Organism=Escherichia coli, GI1789275, Length=301, Percent_Identity=31.2292358803987, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1788728, Length=296, Percent_Identity=26.0135135135135, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17508215, Length=291, Percent_Identity=33.6769759450172, Blast_Score=135, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6321118, Length=286, Percent_Identity=29.3706293706294, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320922, Length=302, Percent_Identity=28.1456953642384, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357079, Length=294, Percent_Identity=30.6122448979592, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI19920384, Length=293, Percent_Identity=27.6450511945392, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR001131
- InterPro:   IPR022846 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 50171; Mature: 50171

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESLAALYKNHIVTLQERTRDVLARFQMDALLIHSGELVNVFLDDHPYPFKVNPQFKAWV
CCHHHHHHHCCEEEHHHHHHHHHHHHHHCEEEEECCCEEEEEECCCCCCEEECCCCEEEE
PVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPTSFWTEEIDVIALPKADGIGSQLP
CCCCCCCCEEEEECCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
AARGNIGYIGPVPERALGLGIAADKINPKGVIDYLHYYRAYKTDYELACMREAQKSAVNG
CCCCCCCCCCCCCHHHHCCCEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
HRAAYEAFQSGMSEFDINQAYLTATGHRDTDVPYSNIVALNEHASVLHYTKLDHRAPAEM
HHHHHHHHHCCHHHCCCCEEEEEECCCCCCCCCHHHEEEECCCCCEEEEECCCCCCHHHH
RSFLLDAGAEYNGYAADLTRTWAAHGDNDFAHLIKDVNDEQQALISTMKAGTSYIDYHIQ
HHHHHHCCCCCCCEEHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCEEEEHHH
FHQRIAKLLRKHQLVTDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDTGTHL
HHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHHCCCCCCEE
AAPSKYPYLRCTRIIEPRMVLTIEPGIYFIESLLAPWREGPFSKHFNWQKIDAMKPFGGI
CCCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCE
RIEDNVVIHENSIENMTRDLKLA
EEECCEEEECCCHHHHHHHCCCC
>Mature Secondary Structure
MESLAALYKNHIVTLQERTRDVLARFQMDALLIHSGELVNVFLDDHPYPFKVNPQFKAWV
CCHHHHHHHCCEEEHHHHHHHHHHHHHHCEEEEECCCEEEEEECCCCCCEEECCCCEEEE
PVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPTSFWTEEIDVIALPKADGIGSQLP
CCCCCCCCEEEEECCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
AARGNIGYIGPVPERALGLGIAADKINPKGVIDYLHYYRAYKTDYELACMREAQKSAVNG
CCCCCCCCCCCCCHHHHCCCEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
HRAAYEAFQSGMSEFDINQAYLTATGHRDTDVPYSNIVALNEHASVLHYTKLDHRAPAEM
HHHHHHHHHCCHHHCCCCEEEEEECCCCCCCCCHHHEEEECCCCCEEEEECCCCCCHHHH
RSFLLDAGAEYNGYAADLTRTWAAHGDNDFAHLIKDVNDEQQALISTMKAGTSYIDYHIQ
HHHHHHCCCCCCCEEHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCEEEEHHH
FHQRIAKLLRKHQLVTDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDTGTHL
HHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHHCCCCCCEE
AAPSKYPYLRCTRIIEPRMVLTIEPGIYFIESLLAPWREGPFSKHFNWQKIDAMKPFGGI
CCCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCE
RIEDNVVIHENSIENMTRDLKLA
EEECCEEEECCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA