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The map label for this gene is fadA [H]

Identifier: 238892441

GI number: 238892441

Start: 204296

End: 205459

Strand: Reverse

Name: fadA [H]

Synonym: KP1_0202

Alternate gene names: 238892441

Gene position: 205459-204296 (Counterclockwise)

Preceding gene: 238892442

Following gene: 238892438

Centisome position: 3.91

GC content: 60.82

Gene sequence:

>1164_bases
ATGGAACAGGTTGTCATTGTCGATGCAATTCGCACCCCGATGGGCCGTTCGAAGGGCGGCGCATTTCGCCACGTGCGCGC
GGAAGACCTCTCCGCGCACCTGATGCGTAGCCTGCTGTCGCGCAATCCGTCGCTTGAGGCAAGCGCGATAGACGATATCT
ACTGGGGTTGCGTGCAGCAAACCCTCGAGCAGGGTTTTAACATCGCCCGAAACGCGGCGCTGCTGGCGGAGATCCCGCAT
TCGGTACCAGCAAATACGGTCAACCGTCTGTGCGGTTCTTCCATGCAGGCGCTGCACGATGCGACCCGTATGATCATGAC
CGGCGATGCCAGCGTCTGCCTGATTGGCGGCGTCGAGCACATGGGCCATGTGCCAATGAGCCATGGCGTCGATTTCCATC
CGGGCCTCAGCCGCAACGTGGCAAAGGCGGCAGGGATGATGGGGCTGACTGCGGAGATGCTGGCGCGTCTGCACGGTATT
AGCCGCGAGATGCAGGATCAGTTCGCCGCGCGCTCTCACGCTCGTGCCTGGGCCGCAACCCAGTCCGGCGCATTCAAAGC
GGAGATTATCCCCACCGGCGGCCACGATGCCGATGGCGTACTCAAGTCCTTTAACTATGACGAGGTGATCCGCCCGGAAA
CCACCGTCGAGACGCTGTCCACGCTTAAACCGGCGTTTGACCCGGTGACCGGTACGGTAACGGCGGGTACCTCTTCCGCC
CTTTCCGATGGCGCAGCGGCGATGCTGCTGATGAGCGAAAGCCGCGCTCGCGAGCTGGGGCTGAAGCCGCGCGCTCGCGT
CCGTTCAATGGCGGTGGTCGGCTGCGACCCGTCCATTATGGGTTATGGCCCGGTTCCGGCCTCAAAGCTGGCGCTGAAAA
AAGCGGGCTTATCCACCAGCGATATCGACGTTTTTGAAATGAATGAAGCATTTGCCGCGCAGATCCTACCGTGTATTAAA
GATCTGGGCTTAATGGAGCAGATCGATGAGAAGATCAACCTCAACGGCGGGGCGATCGCGCTCGGTCATCCGCTGGGCTG
TTCCGGGGCGCGTATTAGCACCACGCTGATCAACCAGATGGAGCGCAAAGACGCTCAGTTCGGCCTCGCCACCATGTGTA
TCGGCCTGGGACAAGGGATCGCTACCGTGTTTGAGCGGGTTTAA

Upstream 100 bases:

>100_bases
AGCCGGTCTTCGTGACAAAGCGCGCCATAACGAAGCGTATTATCCCCAGGTAGAGCCAGCCCGTCCGGTTGGCGCTCTGA
AAACGGCTTAAGGAGTCACA

Downstream 100 bases:

>100_bases
GCGAAAGGGTATCTCAACGCCATTGCCACCAGAACCTGGCGGCTATGGCGAAGAGAGCAGGTTTAGTTGCCGTTCTTCCC
GCCTGTCAGGGGCGGGTTTT

Product: 3-ketoacyl-CoA thiolase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MEQVVIVDAIRTPMGRSKGGAFRHVRAEDLSAHLMRSLLSRNPSLEASAIDDIYWGCVQQTLEQGFNIARNAALLAEIPH
SVPANTVNRLCGSSMQALHDATRMIMTGDASVCLIGGVEHMGHVPMSHGVDFHPGLSRNVAKAAGMMGLTAEMLARLHGI
SREMQDQFAARSHARAWAATQSGAFKAEIIPTGGHDADGVLKSFNYDEVIRPETTVETLSTLKPAFDPVTGTVTAGTSSA
LSDGAAAMLLMSESRARELGLKPRARVRSMAVVGCDPSIMGYGPVPASKLALKKAGLSTSDIDVFEMNEAFAAQILPCIK
DLGLMEQIDEKINLNGGAIALGHPLGCSGARISTTLINQMERKDAQFGLATMCIGLGQGIATVFERV

Sequences:

>Translated_387_residues
MEQVVIVDAIRTPMGRSKGGAFRHVRAEDLSAHLMRSLLSRNPSLEASAIDDIYWGCVQQTLEQGFNIARNAALLAEIPH
SVPANTVNRLCGSSMQALHDATRMIMTGDASVCLIGGVEHMGHVPMSHGVDFHPGLSRNVAKAAGMMGLTAEMLARLHGI
SREMQDQFAARSHARAWAATQSGAFKAEIIPTGGHDADGVLKSFNYDEVIRPETTVETLSTLKPAFDPVTGTVTAGTSSA
LSDGAAAMLLMSESRARELGLKPRARVRSMAVVGCDPSIMGYGPVPASKLALKKAGLSTSDIDVFEMNEAFAAQILPCIK
DLGLMEQIDEKINLNGGAIALGHPLGCSGARISTTLINQMERKDAQFGLATMCIGLGQGIATVFERV
>Mature_387_residues
MEQVVIVDAIRTPMGRSKGGAFRHVRAEDLSAHLMRSLLSRNPSLEASAIDDIYWGCVQQTLEQGFNIARNAALLAEIPH
SVPANTVNRLCGSSMQALHDATRMIMTGDASVCLIGGVEHMGHVPMSHGVDFHPGLSRNVAKAAGMMGLTAEMLARLHGI
SREMQDQFAARSHARAWAATQSGAFKAEIIPTGGHDADGVLKSFNYDEVIRPETTVETLSTLKPAFDPVTGTVTAGTSSA
LSDGAAAMLLMSESRARELGLKPRARVRSMAVVGCDPSIMGYGPVPASKLALKKAGLSTSDIDVFEMNEAFAAQILPCIK
DLGLMEQIDEKINLNGGAIALGHPLGCSGARISTTLINQMERKDAQFGLATMCIGLGQGIATVFERV

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=43.6868686868687, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI167614485, Length=395, Percent_Identity=39.746835443038, Blast_Score=254, Evalue=8e-68,
Organism=Homo sapiens, GI148539872, Length=398, Percent_Identity=40.2010050251256, Blast_Score=245, Evalue=4e-65,
Organism=Homo sapiens, GI4504327, Length=429, Percent_Identity=34.7319347319347, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4557237, Length=402, Percent_Identity=34.8258706467662, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI194353979, Length=393, Percent_Identity=31.5521628498728, Blast_Score=152, Evalue=8e-37,
Organism=Escherichia coli, GI48994986, Length=387, Percent_Identity=92.5064599483204, Blast_Score=742, Evalue=0.0,
Organism=Escherichia coli, GI1787663, Length=405, Percent_Identity=46.1728395061728, Blast_Score=326, Evalue=1e-90,
Organism=Escherichia coli, GI87082165, Length=401, Percent_Identity=41.645885286783, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1788554, Length=401, Percent_Identity=42.8927680798005, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI1788683, Length=422, Percent_Identity=34.3601895734597, Blast_Score=188, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=40.8977556109726, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17551802, Length=430, Percent_Identity=33.953488372093, Blast_Score=200, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI17535921, Length=403, Percent_Identity=33.2506203473945, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI25147385, Length=395, Percent_Identity=31.1392405063291, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17535917, Length=388, Percent_Identity=27.8350515463918, Blast_Score=111, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6322031, Length=392, Percent_Identity=39.2857142857143, Blast_Score=232, Evalue=8e-62,
Organism=Saccharomyces cerevisiae, GI6325229, Length=408, Percent_Identity=34.5588235294118, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24655093, Length=402, Percent_Identity=40.0497512437811, Blast_Score=261, Evalue=8e-70,
Organism=Drosophila melanogaster, GI17648125, Length=402, Percent_Identity=39.3034825870647, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI17137578, Length=429, Percent_Identity=34.4988344988345, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24640423, Length=402, Percent_Identity=32.089552238806, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41050; Mature: 41050

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQVVIVDAIRTPMGRSKGGAFRHVRAEDLSAHLMRSLLSRNPSLEASAIDDIYWGCVQQ
CCCEEEEEHHCCCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TLEQGFNIARNAALLAEIPHSVPANTVNRLCGSSMQALHDATRMIMTGDASVCLIGGVEH
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHEEECCCCEEEEECHHH
MGHVPMSHGVDFHPGLSRNVAKAAGMMGLTAEMLARLHGISREMQDQFAARSHARAWAAT
HCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QSGAFKAEIIPTGGHDADGVLKSFNYDEVIRPETTVETLSTLKPAFDPVTGTVTAGTSSA
CCCCEEEEEEECCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCHH
LSDGAAAMLLMSESRARELGLKPRARVRSMAVVGCDPSIMGYGPVPASKLALKKAGLSTS
HCCCHHEEEHHHHHHHHHCCCCCHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHCCCCCC
DIDVFEMNEAFAAQILPCIKDLGLMEQIDEKINLNGGAIALGHPLGCSGARISTTLINQM
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHH
ERKDAQFGLATMCIGLGQGIATVFERV
HHHHHHHHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure
MEQVVIVDAIRTPMGRSKGGAFRHVRAEDLSAHLMRSLLSRNPSLEASAIDDIYWGCVQQ
CCCEEEEEHHCCCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TLEQGFNIARNAALLAEIPHSVPANTVNRLCGSSMQALHDATRMIMTGDASVCLIGGVEH
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHEEECCCCEEEEECHHH
MGHVPMSHGVDFHPGLSRNVAKAAGMMGLTAEMLARLHGISREMQDQFAARSHARAWAAT
HCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QSGAFKAEIIPTGGHDADGVLKSFNYDEVIRPETTVETLSTLKPAFDPVTGTVTAGTSSA
CCCCEEEEEEECCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCHH
LSDGAAAMLLMSESRARELGLKPRARVRSMAVVGCDPSIMGYGPVPASKLALKKAGLSTS
HCCCHHEEEHHHHHHHHHCCCCCHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHCCCCCC
DIDVFEMNEAFAAQILPCIKDLGLMEQIDEKINLNGGAIALGHPLGCSGARISTTLINQM
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHH
ERKDAQFGLATMCIGLGQGIATVFERV
HHHHHHHHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA