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The map label for this gene is ubiB [H]

Identifier: 238892433

GI number: 238892433

Start: 197120

End: 198760

Strand: Direct

Name: ubiB [H]

Synonym: KP1_0194

Alternate gene names: 238892433

Gene position: 197120-198760 (Clockwise)

Preceding gene: 238892432

Following gene: 238892434

Centisome position: 3.76

GC content: 56.61

Gene sequence:

>1641_bases
ATGACGCCAGGAGAATTACGGCGACTGTATTTCATCATCCACACCTTTTTGAGCTACGGGCTCGATGAGCTCATCCCCAA
AATGCGGATCACGCTGCCGCTGCGTATCTGGCGGCGGATGCTGTTCTGGATGCCAAACCGCCATCAGGATCAGCCTCTTG
GCGCCCGCCTTCGGCTGGCGCTCCAGGAGTTGGGGCCGGTGTGGATAAAATTCGGCCAGATGCTTTCCACCCGCCGGGAT
CTCTTTCCGCCGCATATTGCCGATCAGCTGGCGCTGTTGCAGGACCGCGTGGCGCCCTTTGAAGGGAAGCTCGCGCAGCA
GCAGATAGAGAAAGCGATGGGGGGGCTGCCGGTCGAGACCTGGTTTGATGATTTCTCCGTTGAGCCGTTAGCCTCGGCGT
CCATCGCCCAGGTGCATACCGCGCGTCTGAAGGAGAATGGCAAAGAGGTGGTGATCAAGGTTATCCGCCCGGATATTTTG
CCGATCATTAAAGCGGACATGAAGCTCATCTACCGCCTGGCGCGCTGGGTACCGCGTCTGCTGCCTGACGGTCGCCGTCT
GCGCCCGCAGGAGGTAGTTCGTGAATATGAAAAAACGCTGCTGGATGAGCTGAACCTGCTGCGGGAATCCGCCAACGCTA
TTCAGCTGCGGCGTAATTTCGAAGACAGCCCGATGCTGTACGTGCCGGAGGTGTACCCCGACTACTGCAGCGAAAGCATG
ATGGTAATGGAGCGCATTTACGGTATCCCGGTGTCCGATGTGGAGGCGCTGGAGGCCCAGGGCACCAATATGCAGCTGCT
GGCGGAGCGGGGCGTGCAGGTCTTCTTCACCCAGGTGTTCCGCGACAGCTTCTTCCATGCCGATATGCATCCTGGCAACA
TATTCGTCAGCTACGAGCATCCGGAAGATCCGCAGTATATCGGCATCGACTGCGGTATTGTCGGCTCACTGAACAAAGAA
GATAAGCGCTATCTGGCGGAAAACTTTATCGCCTTTTTCAACCGCGATTATCGTAAAGTTGCCGAGCTGCACGTCGATTC
CGGTTGGGTTCCGCCCGATACCAACGTTGAAGAGTTTGAGTTCGCGATCCGCACGGTCTGCGAGCCGATCTTTGAGAAGC
CGCTGGCGGAGATCTCCTTCGGCCACGTGCTGCTTAATCTGTTCAATACCGCGCGGCGTTTCAATATGGAAGTCCAGCCG
CAGCTCGTTTTACTACAGAAGACATTACTTTACGTAGAAGGGGTAGGCCGGCAGCTCTATCCTCAGTTAGACTTGTGGAA
AACGGCGAAGCCTTTCCTCGAGTCGTGGATCAAAGATCAGGTCGGCATTCCGGCGCTGGTGCGCGCGTTTAAAGACAAAG
CGCCGTTCTGGATCGAAAGAATGCCGGAAATACCTGAGCTGGTGTATCAGAGCCTGCAGCAGAGCAAACAGCTGCAGACC
AGCGTCGATACTATTGTGCGGGATATGCATGTGCGTCATGTGCGCCAGGGCCAATCCCGTTACCTGTTTGGTATAGGCGC
GGTTTTATTGCTCAGTGGTACGCTGCTCTTTATCCATCGCCCTGAGTGGGGAATGATGCCCGGTTGGCTGATGGCCGGCG
GTGTGGTGACCTGGCTTATTGGCTGGCGGAAAACCCACTGA

Upstream 100 bases:

>100_bases
CGCCGGGGCCGCTGGAGCTGGCCTGGTTTGCTGAAGAGACAACGGCTATTGAGCGCGCGCTGGCCGCACTGGAAAAACGG
CTGGAAACGCTGGAGGGCAA

Downstream 100 bases:

>100_bases
TCGGTTCGCCTCTTCATGACGCAGGCTTATTTGCGCAAAATCATGTCGGCGGCCTGACGAAGAGGCGGCTCGCAGGATGG
CGTGTATAATGCGTCCACAC

Product: putative ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MTPGELRRLYFIIHTFLSYGLDELIPKMRITLPLRIWRRMLFWMPNRHQDQPLGARLRLALQELGPVWIKFGQMLSTRRD
LFPPHIADQLALLQDRVAPFEGKLAQQQIEKAMGGLPVETWFDDFSVEPLASASIAQVHTARLKENGKEVVIKVIRPDIL
PIIKADMKLIYRLARWVPRLLPDGRRLRPQEVVREYEKTLLDELNLLRESANAIQLRRNFEDSPMLYVPEVYPDYCSESM
MVMERIYGIPVSDVEALEAQGTNMQLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHPEDPQYIGIDCGIVGSLNKE
DKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQP
QLVLLQKTLLYVEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALVRAFKDKAPFWIERMPEIPELVYQSLQQSKQLQT
SVDTIVRDMHVRHVRQGQSRYLFGIGAVLLLSGTLLFIHRPEWGMMPGWLMAGGVVTWLIGWRKTH

Sequences:

>Translated_546_residues
MTPGELRRLYFIIHTFLSYGLDELIPKMRITLPLRIWRRMLFWMPNRHQDQPLGARLRLALQELGPVWIKFGQMLSTRRD
LFPPHIADQLALLQDRVAPFEGKLAQQQIEKAMGGLPVETWFDDFSVEPLASASIAQVHTARLKENGKEVVIKVIRPDIL
PIIKADMKLIYRLARWVPRLLPDGRRLRPQEVVREYEKTLLDELNLLRESANAIQLRRNFEDSPMLYVPEVYPDYCSESM
MVMERIYGIPVSDVEALEAQGTNMQLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHPEDPQYIGIDCGIVGSLNKE
DKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQP
QLVLLQKTLLYVEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALVRAFKDKAPFWIERMPEIPELVYQSLQQSKQLQT
SVDTIVRDMHVRHVRQGQSRYLFGIGAVLLLSGTLLFIHRPEWGMMPGWLMAGGVVTWLIGWRKTH
>Mature_545_residues
TPGELRRLYFIIHTFLSYGLDELIPKMRITLPLRIWRRMLFWMPNRHQDQPLGARLRLALQELGPVWIKFGQMLSTRRDL
FPPHIADQLALLQDRVAPFEGKLAQQQIEKAMGGLPVETWFDDFSVEPLASASIAQVHTARLKENGKEVVIKVIRPDILP
IIKADMKLIYRLARWVPRLLPDGRRLRPQEVVREYEKTLLDELNLLRESANAIQLRRNFEDSPMLYVPEVYPDYCSESMM
VMERIYGIPVSDVEALEAQGTNMQLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHPEDPQYIGIDCGIVGSLNKED
KRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQ
LVLLQKTLLYVEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALVRAFKDKAPFWIERMPEIPELVYQSLQQSKQLQTS
VDTIVRDMHVRHVRQGQSRYLFGIGAVLLLSGTLLFIHRPEWGMMPGWLMAGGVVTWLIGWRKTH

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=272, Percent_Identity=29.7794117647059, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI32261307, Length=313, Percent_Identity=23.6421725239617, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI40254938, Length=256, Percent_Identity=28.125, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI34147522, Length=211, Percent_Identity=29.8578199052133, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI217035081, Length=205, Percent_Identity=28.780487804878, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI2367309, Length=545, Percent_Identity=88.9908256880734, Blast_Score=1018, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17559152, Length=286, Percent_Identity=26.5734265734266, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32565180, Length=304, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6325148, Length=441, Percent_Identity=23.5827664399093, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323282, Length=250, Percent_Identity=26, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321319, Length=199, Percent_Identity=28.643216080402, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24662575, Length=232, Percent_Identity=31.8965517241379, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI22024280, Length=252, Percent_Identity=30.952380952381, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63466; Mature: 63335

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPGELRRLYFIIHTFLSYGLDELIPKMRITLPLRIWRRMLFWMPNRHQDQPLGARLRLA
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LQELGPVWIKFGQMLSTRRDLFPPHIADQLALLQDRVAPFEGKLAQQQIEKAMGGLPVET
HHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHH
WFDDFSVEPLASASIAQVHTARLKENGKEVVIKVIRPDILPIIKADMKLIYRLARWVPRL
HHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LPDGRRLRPQEVVREYEKTLLDELNLLRESANAIQLRRNFEDSPMLYVPEVYPDYCSESM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHH
MVMERIYGIPVSDVEALEAQGTNMQLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEH
HHHHHHHCCCCCHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEECC
PEDPQYIGIDCGIVGSLNKEDKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFE
CCCCCEEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
FAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGVGRQLY
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHC
PQLDLWKTAKPFLESWIKDQVGIPALVRAFKDKAPFWIERMPEIPELVYQSLQQSKQLQT
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHH
SVDTIVRDMHVRHVRQGQSRYLFGIGAVLLLSGTLLFIHRPEWGMMPGWLMAGGVVTWLI
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHH
GWRKTH
HHHCCC
>Mature Secondary Structure 
TPGELRRLYFIIHTFLSYGLDELIPKMRITLPLRIWRRMLFWMPNRHQDQPLGARLRLA
CCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LQELGPVWIKFGQMLSTRRDLFPPHIADQLALLQDRVAPFEGKLAQQQIEKAMGGLPVET
HHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHH
WFDDFSVEPLASASIAQVHTARLKENGKEVVIKVIRPDILPIIKADMKLIYRLARWVPRL
HHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LPDGRRLRPQEVVREYEKTLLDELNLLRESANAIQLRRNFEDSPMLYVPEVYPDYCSESM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHH
MVMERIYGIPVSDVEALEAQGTNMQLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEH
HHHHHHHCCCCCHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEECC
PEDPQYIGIDCGIVGSLNKEDKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFE
CCCCCEEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
FAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGVGRQLY
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHC
PQLDLWKTAKPFLESWIKDQVGIPALVRAFKDKAPFWIERMPEIPELVYQSLQQSKQLQT
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHH
SVDTIVRDMHVRHVRQGQSRYLFGIGAVLLLSGTLLFIHRPEWGMMPGWLMAGGVVTWLI
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHH
GWRKTH
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA