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The map label for this gene is ubiE [H]

Identifier: 238892431

GI number: 238892431

Start: 195749

End: 196504

Strand: Direct

Name: ubiE [H]

Synonym: KP1_0191

Alternate gene names: 238892431

Gene position: 195749-196504 (Clockwise)

Preceding gene: 238892430

Following gene: 238892432

Centisome position: 3.73

GC content: 53.04

Gene sequence:

>756_bases
ATGGTTGAGGATTCACAAGAAACGACGCACTTTGGCTTTCAGACGGTCGCTAAAGAGCAGAAAGCAGATATGGTGGCGCA
TGTATTCCATTCTGTCGCCGCAAAATATGATGTGATGAACGACCTGATGTCGTTTGGGATCCATCGTTTGTGGAAGCGTT
TCACCATCGACTGCAGCGGCGTACGACGCGGGCAGACCGTGCTGGATTTGGCTGGTGGTACCGGTGATTTGACGGCCAAG
TTCTCCCGCCTGGTAGGGGAAACCGGCCGCGTCATGCTTGCTGATATCAATGATTCTATGCTCAAAATGGGCCGCGAAAA
GCTGCGCAATATCGGCATCGTAGGCAACGTTGAGTATGTTCAGGCCAACGCGGAAGCCCTGCCTTTTGCTGATAATACCT
TTGACTGCATCACCATCTCTTTCGGTCTGCGTAACGTGACCGACAAAGAGAAAGCGCTGCGTTCGATGTACCGCGTGCTG
AAGCCGGGCGGACGTCTGCTGGTGCTGGAGTTTTCTAAACCCATTATCGAACCGCTGAGCAAAGCCTACGACGCTTACTC
CTTCCATATCCTGCCGAAGGTGGGCGAGCTGGTGGCAAAAGATGGCGACAGCTATCGCTACCTGGCGGAATCTATTCGTA
TGCATCCGGACCAGGAAACCCTGAAAGGGATGATGCAGGATGCGGGCTTCGAAAACGTGGATTACTACAACCTGACGGCG
GGTATCGTTGCTTTGCATCGCGGTTACAAGTTCTGA

Upstream 100 bases:

>100_bases
CGTAGCCGGGAGGCGGCTCCGCCATGCTGAAACGTATGGGAAATGCGCTGAGTCTGATACACTCAGTGAACATTTTCTTG
AAAAGCAAGCAGGCATAGAG

Downstream 100 bases:

>100_bases
CAGGAGGGACGCTATGCCTTTCACACCCCTGGTTACCGCTGGCATTGAAACGGCGCTGAATACTTTCCTCTGGCGCGACA
AAGCGCTTAAACCCGCTCGC

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MVEDSQETTHFGFQTVAKEQKADMVAHVFHSVAAKYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAK
FSRLVGETGRVMLADINDSMLKMGREKLRNIGIVGNVEYVQANAEALPFADNTFDCITISFGLRNVTDKEKALRSMYRVL
KPGGRLLVLEFSKPIIEPLSKAYDAYSFHILPKVGELVAKDGDSYRYLAESIRMHPDQETLKGMMQDAGFENVDYYNLTA
GIVALHRGYKF

Sequences:

>Translated_251_residues
MVEDSQETTHFGFQTVAKEQKADMVAHVFHSVAAKYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAK
FSRLVGETGRVMLADINDSMLKMGREKLRNIGIVGNVEYVQANAEALPFADNTFDCITISFGLRNVTDKEKALRSMYRVL
KPGGRLLVLEFSKPIIEPLSKAYDAYSFHILPKVGELVAKDGDSYRYLAESIRMHPDQETLKGMMQDAGFENVDYYNLTA
GIVALHRGYKF
>Mature_251_residues
MVEDSQETTHFGFQTVAKEQKADMVAHVFHSVAAKYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAK
FSRLVGETGRVMLADINDSMLKMGREKLRNIGIVGNVEYVQANAEALPFADNTFDCITISFGLRNVTDKEKALRSMYRVL
KPGGRLLVLEFSKPIIEPLSKAYDAYSFHILPKVGELVAKDGDSYRYLAESIRMHPDQETLKGMMQDAGFENVDYYNLTA
GIVALHRGYKF

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=282, Percent_Identity=43.9716312056738, Blast_Score=234, Evalue=7e-62,
Organism=Escherichia coli, GI48994983, Length=251, Percent_Identity=92.0318725099602, Blast_Score=494, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17557039, Length=247, Percent_Identity=46.9635627530364, Blast_Score=228, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6323526, Length=268, Percent_Identity=44.0298507462687, Blast_Score=187, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24641702, Length=263, Percent_Identity=43.7262357414449, Blast_Score=233, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 28148; Mature: 28148

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEDSQETTHFGFQTVAKEQKADMVAHVFHSVAAKYDVMNDLMSFGIHRLWKRFTIDCSG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VRRGQTVLDLAGGTGDLTAKFSRLVGETGRVMLADINDSMLKMGREKLRNIGIVGNVEYV
CCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCEE
QANAEALPFADNTFDCITISFGLRNVTDKEKALRSMYRVLKPGGRLLVLEFSKPIIEPLS
ECCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHH
KAYDAYSFHILPKVGELVAKDGDSYRYLAESIRMHPDQETLKGMMQDAGFENVDYYNLTA
HHHCCCEEEECHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEHHHH
GIVALHRGYKF
HHHHHHCCCCC
>Mature Secondary Structure
MVEDSQETTHFGFQTVAKEQKADMVAHVFHSVAAKYDVMNDLMSFGIHRLWKRFTIDCSG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VRRGQTVLDLAGGTGDLTAKFSRLVGETGRVMLADINDSMLKMGREKLRNIGIVGNVEYV
CCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCEE
QANAEALPFADNTFDCITISFGLRNVTDKEKALRSMYRVLKPGGRLLVLEFSKPIIEPLS
ECCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHH
KAYDAYSFHILPKVGELVAKDGDSYRYLAESIRMHPDQETLKGMMQDAGFENVDYYNLTA
HHHCCCEEEECHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEHHHH
GIVALHRGYKF
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA