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The map label for this gene is ilvY [H]

Identifier: 238892376

GI number: 238892376

Start: 135603

End: 136577

Strand: Reverse

Name: ilvY [H]

Synonym: KP1_0134

Alternate gene names: 238892376

Gene position: 136577-135603 (Counterclockwise)

Preceding gene: 238892378

Following gene: 238892370

Centisome position: 2.6

GC content: 59.9

Gene sequence:

>975_bases
ATGACAGGAATTTTATTGCGGAAATTGATATATTCACAACGTCACGTTGCATTTTATGAAATACAAAACCGGGGAGTACG
CGCCGTGGATTTACGCGATCTGAAAACCTTTCTGCATCTGGCGGAAAGCCGCCATTTTGGCCGCAGCGCGCGGGCCATGC
ACGTCAGCCCGTCGACGCTTTCGCGCCAGATCCAGCGTCTGGAAGAGGACCTCGGCCAGCCGCTGTTCGTGCGAGATAAT
CGCACGGTGACCCTTACCGAAGCCGGGGAAGAGTTACGTACCTTTGCCCAACAGACTTTATTGCAGTATCAGCAGCTTCG
TCACGTCATCGATCAGCAGGGCCCTTCGCTCTCCGGCGAGCTGCACATCTTCTGCTCCGTCACCGCCGCCTATAGCCATC
TGCCGCCGATCCTCGACCGCTTTCGCGCCGCGCACCCCTCGGTGGAGATCAAGCTCTCGACCGGCGACGCCGCCGACGCT
ATGGAGAAGGTCGTCACCGGCGAAGCCGACCTGGCGATTGCCGGTAAGCCGGAGACTCTGCCAGGGTCGGTGGCGTTTTC
GATGCTGGAGAACCTCGCCGTGGTGTTAATTGCCCCGGCCCTTCCCTGCCCGGTGCGCAACCAGGTGACCGTCGAGCGCC
CCGACTGGTCGACAGTGCCCTTTATCATGGCCGACCAGGGGCCGGTACGTCGGCGCATCGAGCTGTGGTTTCGGCGGCAT
AAAATCAGCAATCCGTCGATCTACGCCACCGTCGGCGGGCACGAAGCGATGGTGTCGATGGTCGCCCTGGGATGCGGCGT
GGCGCTGCTGCCGGAAGTGGTGCTGGAGAACAGTCCGGAGCCGGTACGCAACAGGGTGATGATCCTGGAGCGCAGCGATG
AGCAAACGCCGTTTGAGCTGGGCGTTTGCGCACAAAAAAAGCGGCTGCATGAGCCGCTTATTGATGCTTTCTGGAAAATT
CTTCCCAACCACTAA

Upstream 100 bases:

>100_bases
CGCAGGTTCAGTGTATTAAAGTAGTTAGCCATGTCTGTAACTCCGTGATGTTGTGTCGTGCTTATTGTTCGGTTCGCTTT
TGCGAGAATGAACTTACTAT

Downstream 100 bases:

>100_bases
CCCGCGAGGAAAAAGCGGAATGCCGGGTTATGCGTTTCGTCGTGGCACTCATAGCCCAGCTCATTAAGACGAGTTTCAAA
GTCCGGCTCGTGCTCGCCCA

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MTGILLRKLIYSQRHVAFYEIQNRGVRAVDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDN
RTVTLTEAGEELRTFAQQTLLQYQQLRHVIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAAHPSVEIKLSTGDAADA
MEKVVTGEADLAIAGKPETLPGSVAFSMLENLAVVLIAPALPCPVRNQVTVERPDWSTVPFIMADQGPVRRRIELWFRRH
KISNPSIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEQTPFELGVCAQKKRLHEPLIDAFWKI
LPNH

Sequences:

>Translated_324_residues
MTGILLRKLIYSQRHVAFYEIQNRGVRAVDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDN
RTVTLTEAGEELRTFAQQTLLQYQQLRHVIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAAHPSVEIKLSTGDAADA
MEKVVTGEADLAIAGKPETLPGSVAFSMLENLAVVLIAPALPCPVRNQVTVERPDWSTVPFIMADQGPVRRRIELWFRRH
KISNPSIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEQTPFELGVCAQKKRLHEPLIDAFWKI
LPNH
>Mature_323_residues
TGILLRKLIYSQRHVAFYEIQNRGVRAVDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNR
TVTLTEAGEELRTFAQQTLLQYQQLRHVIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAAHPSVEIKLSTGDAADAM
EKVVTGEADLAIAGKPETLPGSVAFSMLENLAVVLIAPALPCPVRNQVTVERPDWSTVPFIMADQGPVRRRIELWFRRHK
ISNPSIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEQTPFELGVCAQKKRLHEPLIDAFWKIL
PNH

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=296, Percent_Identity=95.9459459459459, Blast_Score=566, Evalue=1e-163,
Organism=Escherichia coli, GI1790399, Length=261, Percent_Identity=29.5019157088123, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI157672245, Length=182, Percent_Identity=32.967032967033, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788297, Length=246, Percent_Identity=28.8617886178862, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788887, Length=254, Percent_Identity=28.3464566929134, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787806, Length=256, Percent_Identity=25, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI145693105, Length=167, Percent_Identity=29.940119760479, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787879, Length=247, Percent_Identity=27.1255060728745, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI2367136, Length=253, Percent_Identity=26.8774703557312, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788481, Length=249, Percent_Identity=25.7028112449799, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787601, Length=145, Percent_Identity=28.9655172413793, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790262, Length=303, Percent_Identity=26.7326732673267, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1788296, Length=225, Percent_Identity=29.7777777777778, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788706, Length=154, Percent_Identity=31.8181818181818, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787530, Length=249, Percent_Identity=23.6947791164659, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788748, Length=302, Percent_Identity=21.8543046357616, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI145693193, Length=123, Percent_Identity=34.9593495934959, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI48994962, Length=212, Percent_Identity=26.4150943396226, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789440, Length=168, Percent_Identity=26.1904761904762, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787589, Length=194, Percent_Identity=28.3505154639175, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 36311; Mature: 36180

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGILLRKLIYSQRHVAFYEIQNRGVRAVDLRDLKTFLHLAESRHFGRSARAMHVSPSTL
CCHHHHHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHCCCCCCCEEECCHHHH
SRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRTFAQQTLLQYQQLRHVIDQQGPSLSGE
HHHHHHHHHHCCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LHIFCSVTAAYSHLPPILDRFRAAHPSVEIKLSTGDAADAMEKVVTGEADLAIAGKPETL
EEEEEEEHHHHHCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCEEECCCCCCC
PGSVAFSMLENLAVVLIAPALPCPVRNQVTVERPDWSTVPFIMADQGPVRRRIELWFRRH
CHHHHHHHHHHHEEEEEECCCCCCCCCCEEEECCCCCCCCEEEECCCHHHHHHHHHHHHH
KISNPSIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEQTPFEL
CCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHH
GVCAQKKRLHEPLIDAFWKILPNH
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TGILLRKLIYSQRHVAFYEIQNRGVRAVDLRDLKTFLHLAESRHFGRSARAMHVSPSTL
CHHHHHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHCCCCCCCEEECCHHHH
SRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRTFAQQTLLQYQQLRHVIDQQGPSLSGE
HHHHHHHHHHCCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LHIFCSVTAAYSHLPPILDRFRAAHPSVEIKLSTGDAADAMEKVVTGEADLAIAGKPETL
EEEEEEEHHHHHCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCEEECCCCCCC
PGSVAFSMLENLAVVLIAPALPCPVRNQVTVERPDWSTVPFIMADQGPVRRRIELWFRRH
CHHHHHHHHHHHEEEEEECCCCCCCCCCEEEECCCCCCCCEEEECCCHHHHHHHHHHHHH
KISNPSIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEQTPFEL
CCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHH
GVCAQKKRLHEPLIDAFWKILPNH
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3003115; 1379743; 9278503; 3550695 [H]