Click here to switch to the map view.

The map label for this gene is ilvD [H]

Identifier: 238892374

GI number: 238892374

Start: 132209

End: 134059

Strand: Direct

Name: ilvD [H]

Synonym: KP1_0132

Alternate gene names: 238892374

Gene position: 132209-134059 (Clockwise)

Preceding gene: 238892373

Following gene: 238892375

Centisome position: 2.52

GC content: 60.4

Gene sequence:

>1851_bases
ATGCCTAAGTACCGTTCCGCCACCACCACACATGGCCGCAACATGGCGGGCGCCCGCGCGTTGTGGCGCGCAACCGGAAT
GACCGATGCCGATTTCGGCAAACCGATTATCGCCGTCGTTAACTCCTTTACCCAGTTTGTCCCCGGGCACGTGCACCTGC
GCGATCTCGGCAAACTGGTTGCCGAGCAGATTGAAGCCGCCGGTGGTGTGGCCAAAGAATTCAACACCATCGCAGTGGAT
GATGGGATCGCTATGGGCCACGGGGGTATGCTCTATTCACTGCCATCCCGCGAGCTGATCGCCGACTCGGTGGAGTATAT
GGTTAACGCCCACTGCGCTGATGCCATGGTTTGTATCTCCAACTGCGACAAAATCACCCCGGGGATGCTGATGGCCTCCC
TGCGTTTGAATATTCCGGTGATCTTTGTTTCCGGCGGCCCGATGGAAGCCGGGAAGACCAAGCTGTCAGATAAAATCATC
AAGCTTGACCTGGTGGATGCGATGATTCAGGGGGCGGATCCGAAAGTGTCCGACGAGCAGAGTAATCAGGTGGAACGCTC
CGCCTGCCCGACCTGCGGCTCCTGTTCCGGGATGTTCACGGCGAACTCCATGAACTGCCTGACCGAAGCGCTGGGCCTGT
CGCAGCCGGGCAACGGCTCTCTGCTGGCGACCCACGCCGATCGTAAGGAGCTGTTCCTAAACGCCGGGAAACGTATCGTG
GAGCTGACCAAACGCTATTACGAGCAGGATGACGCTTCCGCGCTGCCGCGCAATATCGCCAGCAAGGCGGCCTTTGAGAA
CGCTATGACGCTGGATATCGCCATGGGCGGCTCCACCAATACCGTTCTGCACCTGCTGGCGGCGGCGCAGGAAGCTGATA
TCGACTTCACCATGAGCGATATCGATAAGCTCTCCCGCAAAGTGCCGCAGCTGTGTAAGGTGGCGCCGAGCACGCAGAAA
TACCATATGGAAGATGTGCATCGCGCCGGCGGCGTGCTGGGCATTCTGGGCGAGCTGGACCGAGCCGGGCTGCTGAATCG
CGAGGTCAAAAACGTCCTTGGCCTGACGCTGCCGCAGACCCTGGAACAGTACGATGTGATGGTGACCCAGGACGACGCGG
TGAAAAAAATGTTCCGCGCCGGCCCGGCGGGCATCCGTACCACCCAGGCGTTCTCGCAAGACTGCCGCTGGGATACCCTG
GATGACGATCGCGCCGAAGGCTGTATCCGTTCTCTGGAACACGCTTACAGCAAGGACGGCGGCCTGGCGGTGCTGTACGG
CAATTTCGCGGAAAACGGTTGTATCGTGAAAACCGCCGGCGTGGACGACAGCATCCTGAAATTTACCGGTCCGGCGAAAG
TATATGAGAGCCAGGACGATGCGGTTGAGGCCATCCTCGGCGGTAAAGTCGTGGAAGGCGACGTCGTGGTGATCCGCTAC
GAAGGGCCGAAAGGCGGGCCGGGGATGCAGGAAATGCTTTACCCCACCAGCTTCCTGAAATCGATGGGGCTGGGCAAAGC
GTGCGCGCTGATCACCGATGGCCGTTTCTCCGGCGGCACCTCAGGGCTCTCTATCGGTCACGTCTCTCCGGAAGCGGCGA
GCGGCGGCAACATTGCGCTCATTGAAGATGGCGACATGATCGCGATTGATATTCCGAACCGCAGCATCCAGCTGCAGCTG
AGCGATGCGGAAATTGCGGCGCGTCGTGAAGCCCAGGAAGCGCGTGGCGACCAGGCGTGGACGCCGAAGAATCGCCAGCG
TCAGGTCTCCTTTGCCCTTCGCGCCTACGCCAGCCTGGCGACCAGCGCCGACAAAGGCGCGGTACGCGATAAATCCAAGC
TGGGTGGCTAA

Upstream 100 bases:

>100_bases
AGAAGATAAATGGGGCTGGTTGGATCCGGTAAGTAAGTAATTAAAAATGGGACGGCACGCACCGTCCCATTTAATAAACA
CAGATGGGAGTAAAAAGAGC

Downstream 100 bases:

>100_bases
TCATGGCGGATTCACAACCCTTGTCCGGCGCTCCTGAGGGCGCCGAGTACCTGCGAGCAGTGCTGCGCGCGCCGGTTTAT
GAAGCGGTGCAGAAAACGCC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 616; Mature: 615

Protein sequence:

>616_residues
MPKYRSATTTHGRNMAGARALWRATGMTDADFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEAAGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKII
KLDLVDAMIQGADPKVSDEQSNQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKELFLNAGKRIV
ELTKRYYEQDDASALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEADIDFTMSDIDKLSRKVPQLCKVAPSTQK
YHMEDVHRAGGVLGILGELDRAGLLNREVKNVLGLTLPQTLEQYDVMVTQDDAVKKMFRAGPAGIRTTQAFSQDCRWDTL
DDDRAEGCIRSLEHAYSKDGGLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVEGDVVVIRY
EGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGNIALIEDGDMIAIDIPNRSIQLQL
SDAEIAARREAQEARGDQAWTPKNRQRQVSFALRAYASLATSADKGAVRDKSKLGG

Sequences:

>Translated_616_residues
MPKYRSATTTHGRNMAGARALWRATGMTDADFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEAAGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKII
KLDLVDAMIQGADPKVSDEQSNQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKELFLNAGKRIV
ELTKRYYEQDDASALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEADIDFTMSDIDKLSRKVPQLCKVAPSTQK
YHMEDVHRAGGVLGILGELDRAGLLNREVKNVLGLTLPQTLEQYDVMVTQDDAVKKMFRAGPAGIRTTQAFSQDCRWDTL
DDDRAEGCIRSLEHAYSKDGGLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVEGDVVVIRY
EGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGNIALIEDGDMIAIDIPNRSIQLQL
SDAEIAARREAQEARGDQAWTPKNRQRQVSFALRAYASLATSADKGAVRDKSKLGG
>Mature_615_residues
PKYRSATTTHGRNMAGARALWRATGMTDADFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEAAGGVAKEFNTIAVDD
GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKIIK
LDLVDAMIQGADPKVSDEQSNQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKELFLNAGKRIVE
LTKRYYEQDDASALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEADIDFTMSDIDKLSRKVPQLCKVAPSTQKY
HMEDVHRAGGVLGILGELDRAGLLNREVKNVLGLTLPQTLEQYDVMVTQDDAVKKMFRAGPAGIRTTQAFSQDCRWDTLD
DDRAEGCIRSLEHAYSKDGGLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVEGDVVVIRYE
GPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGNIALIEDGDMIAIDIPNRSIQLQLS
DAEIAARREAQEARGDQAWTPKNRQRQVSFALRAYASLATSADKGAVRDKSKLGG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=616, Percent_Identity=96.4285714285714, Blast_Score=1233, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=539, Percent_Identity=29.1280148423006, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI2367371, Length=570, Percent_Identity=29.2982456140351, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1786464, Length=520, Percent_Identity=30, Blast_Score=173, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6322476, Length=615, Percent_Identity=37.8861788617886, Blast_Score=344, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65707; Mature: 65575

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKYRSATTTHGRNMAGARALWRATGMTDADFGKPIIAVVNSFTQFVPGHVHLRDLGKLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AEQIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKIIKLDLVDAMIQGADPKVSDEQ
CCCCCCHHHHHHHEECCCEEEEEECCCCCCCCHHHHHHHEEHHHHHHHHCCCCCCCCCCH
SNQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKELFLNAGKRIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHCCHHHH
ELTKRYYEQDDASALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEADIDFTMSD
HHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEHHH
IDKLSRKVPQLCKVAPSTQKYHMEDVHRAGGVLGILGELDRAGLLNREVKNVLGLTLPQT
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHH
LEQYDVMVTQDDAVKKMFRAGPAGIRTTQAFSQDCRWDTLDDDRAEGCIRSLEHAYSKDG
HHHHCEEEECCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
GLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVEGDVVVIRY
CEEEEECCCCCCCCEEEECCCCCCHHEECCCHHHHCCCHHHHHHHHCCEEEECCEEEEEE
EGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGNIAL
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCEEE
IEDGDMIAIDIPNRSIQLQLSDAEIAARREAQEARGDQAWTPKNRQRQVSFALRAYASLA
EECCCEEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
TSADKGAVRDKSKLGG
CCCCCCCCCCHHHCCC
>Mature Secondary Structure 
PKYRSATTTHGRNMAGARALWRATGMTDADFGKPIIAVVNSFTQFVPGHVHLRDLGKLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AEQIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKIIKLDLVDAMIQGADPKVSDEQ
CCCCCCHHHHHHHEECCCEEEEEECCCCCCCCHHHHHHHEEHHHHHHHHCCCCCCCCCCH
SNQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKELFLNAGKRIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHCCHHHH
ELTKRYYEQDDASALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEADIDFTMSD
HHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEHHH
IDKLSRKVPQLCKVAPSTQKYHMEDVHRAGGVLGILGELDRAGLLNREVKNVLGLTLPQT
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHH
LEQYDVMVTQDDAVKKMFRAGPAGIRTTQAFSQDCRWDTLDDDRAEGCIRSLEHAYSKDG
HHHHCEEEECCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
GLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVEGDVVVIRY
CEEEEECCCCCCCCEEEECCCCCCHHEECCCHHHHCCCHHHHHHHHCCEEEECCEEEEEE
EGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGNIAL
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCEEE
IEDGDMIAIDIPNRSIQLQLSDAEIAARREAQEARGDQAWTPKNRQRQVSFALRAYASLA
EECCCEEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
TSADKGAVRDKSKLGG
CCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA