| Definition | Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome. |
|---|---|
| Accession | NC_012731 |
| Length | 5,248,520 |
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The map label for this gene is metL [H]
Identifier: 238892342
GI number: 238892342
Start: 92087
End: 94519
Strand: Direct
Name: metL [H]
Synonym: KP1_0096
Alternate gene names: 238892342
Gene position: 92087-94519 (Clockwise)
Preceding gene: 238892341
Following gene: 238892344
Centisome position: 1.75
GC content: 62.52
Gene sequence:
>2433_bases ATGAGTGTGATTGCGCAGGCAGGGGCGAAGGGTCGTCAGCTGCACAAATTTGGTGGGAGTAGTTTAGCGGATGCGAAATG TTACCTGCGCGTCGCGGGGATCATGAAGGAGTATTCGCAGGCGGGGGATATGATGGTCGTCTCCGCCGCTGGCAGCACCA CCAACCAGCTGATCAGCTGGCTTAAGCTTAGCCAGAGCGATCGCCTTGCTGCGCATCAGGTTCAGCAGTCGCTTCGCCGC TATCACACCGAGCTGATTGGCGGTCTGCTGGAGCCTGCGGCGGCGGATACGTTGATAGCCGCCTTTATCCACGACCTTGA GCGTCTGGCTGGTCTGCTGGACGGCGGGGTTTCCGAAGCGGTCTATGCGGAAGTAGTCGGCCATGGGGAAGTGTGGTCCG CGCGCCTGATGGCGGCGGTTCTCAATCAGCTGGGTATGGAAGCCGCCTGGCTGGACGCGCGCGCGTTCCTGCGCGCGGAA CGCGCCGCGCAGCCGCAGGTGGATGAAGGATTATCCTATCCGCTGCTGCAGCAGCTGATGGCGCAGCATCCTAACAAACG TCTGGTGGTGACCGGCTTTATCTCCCGTAACCAGGCCGGCGAAACCGTCCTGCTGGGCCGTAACGGGTCTGACTACTCTG CCACCCAGATCGGCGCGCTGGCGGGTGCCTCCCGGGTCACTATCTGGAGCGACGTTGCCGGGGTGTACAGCGCGGATCCG CGCAAGGTGAAAGACGCCTGCCTGCTGCCGCTGCTGCGTCTGGACGAAGCCAGCGAGCTGGCGCGCCTGGCCGCGCCGGT GCTCCATGCCCGCACGCTACAGCCGGTTTCCGCCAGTGATATCGATCTGCAGTTACGCTGCAGCTACACGCCGGAACAGG GTTCCACGCGCATTGAGCGCGTGCTGGCCTCCGGTACCGGCGCACGGATTGTCACCAGCCATGACGACGTCTGCCTGGTG GAGTTCCAGGTGCCGGCCGGTCACGATTTCAAACTGGCGCATAAAGAGCTGGACGCTCTGCTCAAACGCGCCCAGCTGCG CCCGTTAGCCGTTGGCGTCCATGCCGACCGTAAGCTGCTGCAGTTCTGCTATACCTCCGAGGTGGCCGACAGCGCGCTGA AATTGCTCGATGAAGCCGGTCTGCCGGGCGAGCTGCGTCTGCGTCAGAAGCTGGCGCTGGTGGCGATGGTGGGCGCGGGA GTCACCCGTAACCCGCTGCACTGCCACCGTTTCTGGCAGCAGCTCAAAGGGCAGCCGGTGGAGTTCACCTGGCAGTCTGA AGAGGGGATCAGCCTGGTGGCGGTGCTACGCGCCGGGCCGACGGAAAGCCTGATCCAGGGGCTGCATCAGTCCTTGTTTC GCGCCGAAAAGCGTATTGGCCTGATGCTGTTCGGCAAAGGGAACATTGGTTCCCGCTGGCTGGAGCTTTTCGCCCGTGAA CAAACTACGCTCTCGGCGCGTACCGGTTTCGAGTTTATTCTCGCCGGCGTAGTCGACAGTAAACGCAGCCTGCTGAATTA CGACGGGCTGGATGCCAGCCGGGCGCTGGCTTTCTTCAACGATGAAGCGGTGGAGCAGGATGAAGAGTCGCTGTTCCTGT GGATGCGCGCGCACCCGTATGATGATTTAGTGGTGCTGGACGTCACCGCCAGCGAACAGCTGGCCGACCAGTATCTTGAT TTCGCCAGCCATGGCTTCCACGTCATTAGCGCTAACAAGCTGGCGGGTGCCAGCAGCAGTGATAAATATCGTCAGATCCA CGACGCGTTTGAGAAGACTGGGCGCCACTGGCTATATAACGCCACCGTGGGCGCCGGCTTGCCGGTGAACCATACGGTGC GCGACCTGATCGACAGCGGCGATACTATTCTCGGCCTGAGCGGTATCTTCTCGGGAACGCTATCCTGGCTGTTCCTGCAG TTCGATGGCACCGTGCCGTTCACCGACCTGGTGGATCAGGCGTGGCAGCAGGGGCTGACCGAGCCGGATCCGCGCGTCGA TCTGTCCGGTAAGGATGTGATGCGTAAGCTGGTGATCCTCGCGCGGGAAGCGGGCTATGACATCGAACCGGATCAGGTGC GTGTGGAATCACTGGTGCCGGCGCACTGTGAAGAGGGGTCGGTCGATCACTTCTTTGAGAATGGCGAAGAGCTGAACGAG CAGATGCTGCAGCGTCTGGAAGCGGCCCGCGAGATGGGGCTGGTGCTCCGCTACGTGGCGCGCTTTGATGCCAACGGCAA AGCACGCGTCGGTGTGGAAGCGGTACGCGAAGAGCACCCGCTGGCGGCGCTGCTGCCGTGCGATAACGTGTTTGCCATCG AAAGCCGCTGGTATCGCGATAACCCGCTGGTGATCCGCGGGCCCGGCGCCGGGCGCGATGTGACCGCCGGGGCAATCCAG TCGGATATTAACCGCCTGGCGCAGCTGCTGTAA
Upstream 100 bases:
>100_bases TTTCAGAAACGCTCCTGCGTATATCGACCGGTATTGAAGATGGTGAAGATTTAATTGCCGACCTGGAAAATGGCTTCCGG GCAGCAAACGAGGAATAAAG
Downstream 100 bases:
>100_bases GCGTCGCGTTATACTCTTGAACCAGTGAGGCCACTATTTGCGTTACGCGCCCTGCGGAATACAGGGCGCTCTGCGCAAAC GCGGGTCTGTTTTCCAGCCA
Product: bifunctional aspartate kinase II/homoserine dehydrogenase II
Products: NA
Alternate protein names: Aspartokinase II/homoserine dehydrogenase II; AKII-HDII; Aspartokinase; Homoserine dehydrogenase [H]
Number of amino acids: Translated: 810; Mature: 809
Protein sequence:
>810_residues MSVIAQAGAKGRQLHKFGGSSLADAKCYLRVAGIMKEYSQAGDMMVVSAAGSTTNQLISWLKLSQSDRLAAHQVQQSLRR YHTELIGGLLEPAAADTLIAAFIHDLERLAGLLDGGVSEAVYAEVVGHGEVWSARLMAAVLNQLGMEAAWLDARAFLRAE RAAQPQVDEGLSYPLLQQLMAQHPNKRLVVTGFISRNQAGETVLLGRNGSDYSATQIGALAGASRVTIWSDVAGVYSADP RKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSASDIDLQLRCSYTPEQGSTRIERVLASGTGARIVTSHDDVCLV EFQVPAGHDFKLAHKELDALLKRAQLRPLAVGVHADRKLLQFCYTSEVADSALKLLDEAGLPGELRLRQKLALVAMVGAG VTRNPLHCHRFWQQLKGQPVEFTWQSEEGISLVAVLRAGPTESLIQGLHQSLFRAEKRIGLMLFGKGNIGSRWLELFARE QTTLSARTGFEFILAGVVDSKRSLLNYDGLDASRALAFFNDEAVEQDEESLFLWMRAHPYDDLVVLDVTASEQLADQYLD FASHGFHVISANKLAGASSSDKYRQIHDAFEKTGRHWLYNATVGAGLPVNHTVRDLIDSGDTILGLSGIFSGTLSWLFLQ FDGTVPFTDLVDQAWQQGLTEPDPRVDLSGKDVMRKLVILAREAGYDIEPDQVRVESLVPAHCEEGSVDHFFENGEELNE QMLQRLEAAREMGLVLRYVARFDANGKARVGVEAVREEHPLAALLPCDNVFAIESRWYRDNPLVIRGPGAGRDVTAGAIQ SDINRLAQLL
Sequences:
>Translated_810_residues MSVIAQAGAKGRQLHKFGGSSLADAKCYLRVAGIMKEYSQAGDMMVVSAAGSTTNQLISWLKLSQSDRLAAHQVQQSLRR YHTELIGGLLEPAAADTLIAAFIHDLERLAGLLDGGVSEAVYAEVVGHGEVWSARLMAAVLNQLGMEAAWLDARAFLRAE RAAQPQVDEGLSYPLLQQLMAQHPNKRLVVTGFISRNQAGETVLLGRNGSDYSATQIGALAGASRVTIWSDVAGVYSADP RKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSASDIDLQLRCSYTPEQGSTRIERVLASGTGARIVTSHDDVCLV EFQVPAGHDFKLAHKELDALLKRAQLRPLAVGVHADRKLLQFCYTSEVADSALKLLDEAGLPGELRLRQKLALVAMVGAG VTRNPLHCHRFWQQLKGQPVEFTWQSEEGISLVAVLRAGPTESLIQGLHQSLFRAEKRIGLMLFGKGNIGSRWLELFARE QTTLSARTGFEFILAGVVDSKRSLLNYDGLDASRALAFFNDEAVEQDEESLFLWMRAHPYDDLVVLDVTASEQLADQYLD FASHGFHVISANKLAGASSSDKYRQIHDAFEKTGRHWLYNATVGAGLPVNHTVRDLIDSGDTILGLSGIFSGTLSWLFLQ FDGTVPFTDLVDQAWQQGLTEPDPRVDLSGKDVMRKLVILAREAGYDIEPDQVRVESLVPAHCEEGSVDHFFENGEELNE QMLQRLEAAREMGLVLRYVARFDANGKARVGVEAVREEHPLAALLPCDNVFAIESRWYRDNPLVIRGPGAGRDVTAGAIQ SDINRLAQLL >Mature_809_residues SVIAQAGAKGRQLHKFGGSSLADAKCYLRVAGIMKEYSQAGDMMVVSAAGSTTNQLISWLKLSQSDRLAAHQVQQSLRRY HTELIGGLLEPAAADTLIAAFIHDLERLAGLLDGGVSEAVYAEVVGHGEVWSARLMAAVLNQLGMEAAWLDARAFLRAER AAQPQVDEGLSYPLLQQLMAQHPNKRLVVTGFISRNQAGETVLLGRNGSDYSATQIGALAGASRVTIWSDVAGVYSADPR KVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSASDIDLQLRCSYTPEQGSTRIERVLASGTGARIVTSHDDVCLVE FQVPAGHDFKLAHKELDALLKRAQLRPLAVGVHADRKLLQFCYTSEVADSALKLLDEAGLPGELRLRQKLALVAMVGAGV TRNPLHCHRFWQQLKGQPVEFTWQSEEGISLVAVLRAGPTESLIQGLHQSLFRAEKRIGLMLFGKGNIGSRWLELFAREQ TTLSARTGFEFILAGVVDSKRSLLNYDGLDASRALAFFNDEAVEQDEESLFLWMRAHPYDDLVVLDVTASEQLADQYLDF ASHGFHVISANKLAGASSSDKYRQIHDAFEKTGRHWLYNATVGAGLPVNHTVRDLIDSGDTILGLSGIFSGTLSWLFLQF DGTVPFTDLVDQAWQQGLTEPDPRVDLSGKDVMRKLVILAREAGYDIEPDQVRVESLVPAHCEEGSVDHFFENGEELNEQ MLQRLEAAREMGLVLRYVARFDANGKARVGVEAVREEHPLAALLPCDNVFAIESRWYRDNPLVIRGPGAGRDVTAGAIQS DINRLAQLL
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0527
COG function: function code E; Aspartokinases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the homoserine dehydrogenase family [H]
Homologues:
Organism=Escherichia coli, GI1790376, Length=810, Percent_Identity=90.8641975308642, Blast_Score=1521, Evalue=0.0, Organism=Escherichia coli, GI1786183, Length=825, Percent_Identity=31.8787878787879, Blast_Score=348, Evalue=7e-97, Organism=Escherichia coli, GI1790455, Length=288, Percent_Identity=31.9444444444444, Blast_Score=120, Evalue=4e-28, Organism=Saccharomyces cerevisiae, GI6322599, Length=370, Percent_Identity=32.972972972973, Blast_Score=164, Evalue=7e-41, Organism=Saccharomyces cerevisiae, GI6320893, Length=309, Percent_Identity=26.8608414239482, Blast_Score=82, Evalue=4e-16,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001048 - InterPro: IPR005106 - InterPro: IPR001341 - InterPro: IPR018042 - InterPro: IPR011147 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF00696 AA_kinase; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =2.7.2.4; =1.1.1.3 [H]
Molecular weight: Translated: 88715; Mature: 88584
Theoretical pI: Translated: 5.78; Mature: 5.78
Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00324 ASPARTOKINASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 1.5 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSVIAQAGAKGRQLHKFGGSSLADAKCYLRVAGIMKEYSQAGDMMVVSAAGSTTNQLISW CCCCHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHH LKLSQSDRLAAHQVQQSLRRYHTELIGGLLEPAAADTLIAAFIHDLERLAGLLDGGVSEA HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH VYAEVVGHGEVWSARLMAAVLNQLGMEAAWLDARAFLRAERAAQPQVDEGLSYPLLQQLM HHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHH AQHPNKRLVVTGFISRNQAGETVLLGRNGSDYSATQIGALAGASRVTIWSDVAGVYSADP HHCCCCEEEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHCCCCEEEEHHHHCHHCCCCC RKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSASDIDLQLRCSYTPEQGSTRIER HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCHHHHHH VLASGTGARIVTSHDDVCLVEFQVPAGHDFKLAHKELDALLKRAQLRPLAVGVHADRKLL HHHCCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHH QFCYTSEVADSALKLLDEAGLPGELRLRQKLALVAMVGAGVTRNPLHCHRFWQQLKGQPV HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCE EFTWQSEEGISLVAVLRAGPTESLIQGLHQSLFRAEKRIGLMLFGKGNIGSRWLELFARE EEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHH QTTLSARTGFEFILAGVVDSKRSLLNYDGLDASRALAFFNDEAVEQDEESLFLWMRAHPY HHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHCCCCCCEEEEEECCCC DDLVVLDVTASEQLADQYLDFASHGFHVISANKLAGASSSDKYRQIHDAFEKTGRHWLYN CCEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEE ATVGAGLPVNHTVRDLIDSGDTILGLSGIFSGTLSWLFLQFDGTVPFTDLVDQAWQQGLT ECCCCCCCCCHHHHHHHCCCCCEEEHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHCCCC EPDPRVDLSGKDVMRKLVILAREAGYDIEPDQVRVESLVPAHCEEGSVDHFFENGEELNE CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHEEHHHHCCCCCCCCCHHHHHCCHHHHHH QMLQRLEAAREMGLVLRYVARFDANGKARVGVEAVREEHPLAALLPCDNVFAIESRWYRD HHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHCCCCCEEEECCCCEEEECCCEECC NPLVIRGPGAGRDVTAGAIQSDINRLAQLL CCEEEECCCCCCCCHHHHHHHHHHHHHHHC >Mature Secondary Structure SVIAQAGAKGRQLHKFGGSSLADAKCYLRVAGIMKEYSQAGDMMVVSAAGSTTNQLISW CCCHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHH LKLSQSDRLAAHQVQQSLRRYHTELIGGLLEPAAADTLIAAFIHDLERLAGLLDGGVSEA HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH VYAEVVGHGEVWSARLMAAVLNQLGMEAAWLDARAFLRAERAAQPQVDEGLSYPLLQQLM HHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHH AQHPNKRLVVTGFISRNQAGETVLLGRNGSDYSATQIGALAGASRVTIWSDVAGVYSADP HHCCCCEEEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHCCCCEEEEHHHHCHHCCCCC RKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSASDIDLQLRCSYTPEQGSTRIER HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCHHHHHH VLASGTGARIVTSHDDVCLVEFQVPAGHDFKLAHKELDALLKRAQLRPLAVGVHADRKLL HHHCCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHH QFCYTSEVADSALKLLDEAGLPGELRLRQKLALVAMVGAGVTRNPLHCHRFWQQLKGQPV HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCE EFTWQSEEGISLVAVLRAGPTESLIQGLHQSLFRAEKRIGLMLFGKGNIGSRWLELFARE EEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHH QTTLSARTGFEFILAGVVDSKRSLLNYDGLDASRALAFFNDEAVEQDEESLFLWMRAHPY HHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHCCCCCCEEEEEECCCC DDLVVLDVTASEQLADQYLDFASHGFHVISANKLAGASSSDKYRQIHDAFEKTGRHWLYN CCEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEE ATVGAGLPVNHTVRDLIDSGDTILGLSGIFSGTLSWLFLQFDGTVPFTDLVDQAWQQGLT ECCCCCCCCCHHHHHHHCCCCCEEEHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHCCCC EPDPRVDLSGKDVMRKLVILAREAGYDIEPDQVRVESLVPAHCEEGSVDHFFENGEELNE CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHEEHHHHCCCCCCCCCHHHHHCCHHHHHH QMLQRLEAAREMGLVLRYVARFDANGKARVGVEAVREEHPLAALLPCDNVFAIESRWYRD HHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHCCCCCEEEECCCCEEEECCCEECC NPLVIRGPGAGRDVTAGAIQSDINRLAQLL CCEEEECCCCCCCCHHHHHHHHHHHHHHHC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 6298218; 8346018; 9278503 [H]