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The map label for this gene is cytR [H]

Identifier: 238892337

GI number: 238892337

Start: 86398

End: 87426

Strand: Reverse

Name: cytR [H]

Synonym: KP1_0091

Alternate gene names: 238892337

Gene position: 87426-86398 (Counterclockwise)

Preceding gene: 238892338

Following gene: 238892336

Centisome position: 1.67

GC content: 56.46

Gene sequence:

>1029_bases
GTGAAGCCCAAAAAACAAGTGGTTGCCGCCACCATGAAAGACGTCGCCCTCAAGGCAAACGTTTCCACGGCAACCGTGTC
CCGAGCGTTGATGAACCCTGATAAGGTGTCGCAAGCCACCCGTAACCGGGTCGAGCAGGCGGCGCTGGAAGTCGGCTATT
TACCGCAGTCGCTCGGACGCAATATGAAGCGCAACGAATCGCGGACGATCCTCGTGATCGTCCCGGATATCTGCGATCCC
TTCTTTAGTGAAGTGATCCGCGGTATTGAAGTCACTGCCGCCGAGCACGGCTATCTGGTGTTAATCGGCGATTGCGCCCA
CCAGAATCAGAAAGAAAAAACCTTTATCGACCTTATCATCACCAAGCAGATCGACGGCATGGTGCTGCTCAGCTCGCGCT
TGCCGTTTGACGCCAGCGTGGAAGAGCAGCGCAATTTGCCGCCAATGGTCATGTCGAATGAGTTTGCGCCGGAGCTGGAG
CTGCCCACCGTCCATATCGATAACCTGACGGCGGCCTTTAACGCGGTAAATTATCTCCACGAGCTGGGACATCAGCGTAT
CGGCTGTATCGCCGGCCCGGAAGATATGCCGTTGTGCCATTATCGCCTGCAGGGTTATGTGCAGGCGCTGCGCCGCAGCG
GTATCACCGTCGATCCGCACTATATTGCTCGCGGCAACTTTACCTTCGAAGCCGGCGCCAATGCGCTGGAGCAGCTGCTG
GCGCAGCCGGTGCCGCCCACGGCGGTCTTTTGCCATAGCGATGTGATGGCGCTGGGCGCCTTATCGCTGGCAAAACGTCG
CGGTCTGAAAGTACCGGACGACCTGTCAATTGTCGGCTTCGATAACATCGCGTTGTCTGAATTTTGCGATCCGCCGTTGA
CCACGGTTTCACAGCCACGGTTTGATATTGGCCGTGAAGGAATGCTGCTATTACTGGAGCAAATGCAGGGGCATAACGTG
AACAGCGGCTCGCGTCTGCTCGATTGCGAACTGATTGTTCGCGGCAGTACGCAAAAAATCAGACGATAA

Upstream 100 bases:

>100_bases
ATGAAAATTCTGTAACTCACTGCCGCGACTATCTGATAAAAATGATGCAGCAGTTAGCGCCCAAGGGAAATGCCAGCGCC
ATTCAGCGAGGAGAAACCAG

Downstream 100 bases:

>100_bases
CCATCAGGCTTTCGGGCCTGCTCTTCTGGTCAAAGGCCCGCCGCTTAAGTAACATGGCGGGCTGACGAACGAATATAAGA
CAGCGAAACGATAGTGGCAC

Product: DNA-binding transcriptional regulator CytR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKPKKQVVAATMKDVALKANVSTATVSRALMNPDKVSQATRNRVEQAALEVGYLPQSLGRNMKRNESRTILVIVPDICDP
FFSEVIRGIEVTAAEHGYLVLIGDCAHQNQKEKTFIDLIITKQIDGMVLLSSRLPFDASVEEQRNLPPMVMSNEFAPELE
LPTVHIDNLTAAFNAVNYLHELGHQRIGCIAGPEDMPLCHYRLQGYVQALRRSGITVDPHYIARGNFTFEAGANALEQLL
AQPVPPTAVFCHSDVMALGALSLAKRRGLKVPDDLSIVGFDNIALSEFCDPPLTTVSQPRFDIGREGMLLLLEQMQGHNV
NSGSRLLDCELIVRGSTQKIRR

Sequences:

>Translated_342_residues
MKPKKQVVAATMKDVALKANVSTATVSRALMNPDKVSQATRNRVEQAALEVGYLPQSLGRNMKRNESRTILVIVPDICDP
FFSEVIRGIEVTAAEHGYLVLIGDCAHQNQKEKTFIDLIITKQIDGMVLLSSRLPFDASVEEQRNLPPMVMSNEFAPELE
LPTVHIDNLTAAFNAVNYLHELGHQRIGCIAGPEDMPLCHYRLQGYVQALRRSGITVDPHYIARGNFTFEAGANALEQLL
AQPVPPTAVFCHSDVMALGALSLAKRRGLKVPDDLSIVGFDNIALSEFCDPPLTTVSQPRFDIGREGMLLLLEQMQGHNV
NSGSRLLDCELIVRGSTQKIRR
>Mature_342_residues
MKPKKQVVAATMKDVALKANVSTATVSRALMNPDKVSQATRNRVEQAALEVGYLPQSLGRNMKRNESRTILVIVPDICDP
FFSEVIRGIEVTAAEHGYLVLIGDCAHQNQKEKTFIDLIITKQIDGMVLLSSRLPFDASVEEQRNLPPMVMSNEFAPELE
LPTVHIDNLTAAFNAVNYLHELGHQRIGCIAGPEDMPLCHYRLQGYVQALRRSGITVDPHYIARGNFTFEAGANALEQLL
AQPVPPTAVFCHSDVMALGALSLAKRRGLKVPDDLSIVGFDNIALSEFCDPPLTTVSQPRFDIGREGMLLLLEQMQGHNV
NSGSRLLDCELIVRGSTQKIRR

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=340, Percent_Identity=84.4117647058823, Blast_Score=610, Evalue=1e-176,
Organism=Escherichia coli, GI1787948, Length=341, Percent_Identity=33.1378299120235, Blast_Score=207, Evalue=6e-55,
Organism=Escherichia coli, GI1790194, Length=330, Percent_Identity=33.6363636363636, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1788474, Length=308, Percent_Identity=34.4155844155844, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1789202, Length=290, Percent_Identity=33.7931034482759, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1789068, Length=330, Percent_Identity=32.1212121212121, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI48994940, Length=322, Percent_Identity=29.5031055900621, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1787580, Length=315, Percent_Identity=29.5238095238095, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1790715, Length=319, Percent_Identity=28.2131661442006, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786540, Length=343, Percent_Identity=28.2798833819242, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1787906, Length=305, Percent_Identity=25.5737704918033, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789456, Length=340, Percent_Identity=26.7647058823529, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1786268, Length=311, Percent_Identity=22.508038585209, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1790689, Length=321, Percent_Identity=23.98753894081, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37736; Mature: 37736

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPKKQVVAATMKDVALKANVSTATVSRALMNPDKVSQATRNRVEQAALEVGYLPQSLGR
CCCHHHHHHHHHHHHHEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHCC
NMKRNESRTILVIVPDICDPFFSEVIRGIEVTAAEHGYLVLIGDCAHQNQKEKTFIDLII
CCCCCCCCEEEEEECCCCCHHHHHHHCCEEEEEECCCEEEEEECCCCCCCCCHHEEEEEE
TKQIDGMVLLSSRLPFDASVEEQRNLPPMVMSNEFAPELELPTVHIDNLTAAFNAVNYLH
EECCCCEEEEECCCCCCCCCHHHCCCCCEEECCCCCCCCCCCEEEECCHHHHHHHHHHHH
ELGHQRIGCIAGPEDMPLCHYRLQGYVQALRRSGITVDPHYIARGNFTFEAGANALEQLL
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEECCCEEECCCEEEHHHHHHHHHHH
AQPVPPTAVFCHSDVMALGALSLAKRRGLKVPDDLSIVGFDNIALSEFCDPPLTTVSQPR
HCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHCCCCCCCCCCCC
FDIGREGMLLLLEQMQGHNVNSGSRLLDCELIVRGSTQKIRR
CCCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEEECCHHHHCC
>Mature Secondary Structure
MKPKKQVVAATMKDVALKANVSTATVSRALMNPDKVSQATRNRVEQAALEVGYLPQSLGR
CCCHHHHHHHHHHHHHEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHCC
NMKRNESRTILVIVPDICDPFFSEVIRGIEVTAAEHGYLVLIGDCAHQNQKEKTFIDLII
CCCCCCCCEEEEEECCCCCHHHHHHHCCEEEEEECCCEEEEEECCCCCCCCCHHEEEEEE
TKQIDGMVLLSSRLPFDASVEEQRNLPPMVMSNEFAPELELPTVHIDNLTAAFNAVNYLH
EECCCCEEEEECCCCCCCCCHHHCCCCCEEECCCCCCCCCCCEEEECCHHHHHHHHHHHH
ELGHQRIGCIAGPEDMPLCHYRLQGYVQALRRSGITVDPHYIARGNFTFEAGANALEQLL
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEECCCEEECCCEEEHHHHHHHHHHH
AQPVPPTAVFCHSDVMALGALSLAKRRGLKVPDDLSIVGFDNIALSEFCDPPLTTVSQPR
HCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHCCCCCCCCCCCC
FDIGREGMLLLLEQMQGHNVNSGSRLLDCELIVRGSTQKIRR
CCCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]