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The map label for this gene is menA [H]

Identifier: 238892333

GI number: 238892333

Start: 82380

End: 83306

Strand: Reverse

Name: menA [H]

Synonym: KP1_0085

Alternate gene names: 238892333

Gene position: 83306-82380 (Counterclockwise)

Preceding gene: 238892334

Following gene: 238892332

Centisome position: 1.59

GC content: 59.33

Gene sequence:

>927_bases
ATAACTATGACTGATATCAGCCGTTCACAGGCGTGGCTGGAAAGCCTGCGTCCTAAAACGTTACCGCTGGCATTTGCCGC
GATTATTGTTGGCACCGTCCTTGCCTGGGAGCAGGGCCATTTTGATCCCTGGGTTGCCCTGCTGGCGCTGATCACCGCCG
GCTTGCTGCAAATTCTTTCCAACCTCGCCAATGACTACGGCGACGCGGTTAAGGGGAGCGATAAACCGGATCGCATCGGG
CCGCTGCGCGGGATGCAGAAAGGGGTGATTACCCCCCAGCAGATGAAGCGCGCTCTGATCGTCACCGTCGTACTCATCTG
CCTGTTTGGTCTGGCGCTGCTGTGCGCCGCCTGGCAGAGCGTCGGCGATTTCATCGGCTTCCTCGCCCTGGGAGGCCTGT
CTATCGTGGCCGCCATCACCTACACGGTGGGCACCCGTCCGTATGGATATATTGGTCTGGGTGATATCTCAGTACTCGTT
TTCTTCGGCTGGCTGAGCGTCCTCGGCAGCTGGTATCTGCAAGCCCATAATGTGGAAGCGGCCATTTTTCTGCCGGCGAC
AGCCTGCGGTCTGCTGGCGACCGCCGTGCTGAACATCAATAATCTGCGCGATATCGACAGCGACCGGCAGAACGGGAAGA
ACACCCTCGCCGTGCGCCTGGGCCCGGTCAATGCCCGCCGCTATCATGCCTGCCTGCTGCTCGGCGCCCTGCTGTGTCTG
GCGCTGTTTAACCTGCTGACGCTGCATTCAGCCTGGGGCTGGCTGTTTATTCTCGCCACGCCGCTGCTGGTGAAACAGGC
GCGCTACGTCCTGCGCGAATCCGATCCGCTGGCGATGCGGCCAATGCTCGAAAAGACGGTCAAAGGGGCCTTACTGACCA
ACCTGCTGTTTGTTATCGGAATTATTGCCAGTAAGCTGATGGCTTAA

Upstream 100 bases:

>100_bases
GGTGGCAGATGAAGATCTGAGCCGTTTTATCCTATAATCCGGTGCAATGCATTTTCATCACTGTTGATGGGGGCTATCGC
CCCCATTTTTATTGGCTAAA

Downstream 100 bases:

>100_bases
CTGACAAATATCAATTAACAATTGATGATTTTGCCAACAATGCGATTCGCGGGATATACTAAAAACTCTCGCAGCAACTG
AACGTTAAGCCTATGAAATA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTMTDISRSQAWLESLRPKTLPLAFAAIIVGTVLAWEQGHFDPWVALLALITAGLLQILSNLANDYGDAVKGSDKPDRIG
PLRGMQKGVITPQQMKRALIVTVVLICLFGLALLCAAWQSVGDFIGFLALGGLSIVAAITYTVGTRPYGYIGLGDISVLV
FFGWLSVLGSWYLQAHNVEAAIFLPATACGLLATAVLNINNLRDIDSDRQNGKNTLAVRLGPVNARRYHACLLLGALLCL
ALFNLLTLHSAWGWLFILATPLLVKQARYVLRESDPLAMRPMLEKTVKGALLTNLLFVIGIIASKLMA

Sequences:

>Translated_308_residues
MTMTDISRSQAWLESLRPKTLPLAFAAIIVGTVLAWEQGHFDPWVALLALITAGLLQILSNLANDYGDAVKGSDKPDRIG
PLRGMQKGVITPQQMKRALIVTVVLICLFGLALLCAAWQSVGDFIGFLALGGLSIVAAITYTVGTRPYGYIGLGDISVLV
FFGWLSVLGSWYLQAHNVEAAIFLPATACGLLATAVLNINNLRDIDSDRQNGKNTLAVRLGPVNARRYHACLLLGALLCL
ALFNLLTLHSAWGWLFILATPLLVKQARYVLRESDPLAMRPMLEKTVKGALLTNLLFVIGIIASKLMA
>Mature_307_residues
TMTDISRSQAWLESLRPKTLPLAFAAIIVGTVLAWEQGHFDPWVALLALITAGLLQILSNLANDYGDAVKGSDKPDRIGP
LRGMQKGVITPQQMKRALIVTVVLICLFGLALLCAAWQSVGDFIGFLALGGLSIVAAITYTVGTRPYGYIGLGDISVLVF
FGWLSVLGSWYLQAHNVEAAIFLPATACGLLATAVLNINNLRDIDSDRQNGKNTLAVRLGPVNARRYHACLLLGALLCLA
LFNLLTLHSAWGWLFILATPLLVKQARYVLRESDPLAMRPMLEKTVKGALLTNLLFVIGIIASKLMA

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=304, Percent_Identity=28.6184210526316, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1790365, Length=305, Percent_Identity=83.6065573770492, Blast_Score=518, Evalue=1e-148,
Organism=Drosophila melanogaster, GI17737429, Length=293, Percent_Identity=26.2798634812287, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 33323; Mature: 33192

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMTDISRSQAWLESLRPKTLPLAFAAIIVGTVLAWEQGHFDPWVALLALITAGLLQILS
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
NLANDYGDAVKGSDKPDRIGPLRGMQKGVITPQQMKRALIVTVVLICLFGLALLCAAWQS
HHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGDFIGFLALGGLSIVAAITYTVGTRPYGYIGLGDISVLVFFGWLSVLGSWYLQAHNVEA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCE
AIFLPATACGLLATAVLNINNLRDIDSDRQNGKNTLAVRLGPVNARRYHACLLLGALLCL
EEEEHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
ALFNLLTLHSAWGWLFILATPLLVKQARYVLRESDPLAMRPMLEKTVKGALLTNLLFVIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IIASKLMA
HHHHHHCC
>Mature Secondary Structure 
TMTDISRSQAWLESLRPKTLPLAFAAIIVGTVLAWEQGHFDPWVALLALITAGLLQILS
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
NLANDYGDAVKGSDKPDRIGPLRGMQKGVITPQQMKRALIVTVVLICLFGLALLCAAWQS
HHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGDFIGFLALGGLSIVAAITYTVGTRPYGYIGLGDISVLVFFGWLSVLGSWYLQAHNVEA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCE
AIFLPATACGLLATAVLNINNLRDIDSDRQNGKNTLAVRLGPVNARRYHACLLLGALLCL
EEEEHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
ALFNLLTLHSAWGWLFILATPLLVKQARYVLRESDPLAMRPMLEKTVKGALLTNLLFVIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IIASKLMA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]