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The map label for this gene is hemN [H]

Identifier: 238892280

GI number: 238892280

Start: 30705

End: 32078

Strand: Direct

Name: hemN [H]

Synonym: KP1_0027

Alternate gene names: 238892280

Gene position: 30705-32078 (Clockwise)

Preceding gene: 238892279

Following gene: 238892284

Centisome position: 0.59

GC content: 55.39

Gene sequence:

>1374_bases
ATGTCTGAGCAGATAATCGACTGGGATCTGGCCCTGATCCAGAAATATAACTATTCCGGGCCGCGCTATACCTCGTATCC
CACCGCGCTGGAGTTTTCACCGCAATTTGGCGCGGCGGAATTCGATGCCGCTGTGGCCCGTTACCCACAGCGTCCCCTGT
CGCTGTACGTGCATATCCCGTTTTGCCATAAGCTGTGTTATTTCTGCGGCTGCAATAAGATAGTCACCCGCCAGCAGCAT
AAGGCCGATCAATATCTCGATGTCCTTGAACAGGAGATCATCCACCGCGCGCCGCTGTTTGCCACTCGCCAGGTGAAGCA
ACTGCACTGGGGGGGCGGCACGCCAACTTATCTCAATAAGGCGCAAATCAGTCGCCTGATGGATCTGTTGCGCAGCCATT
TTCATTTCAGCGCGGAAGCCGAGATCTCCATTGAGGTCGATCCGCGTGAGATCGAGCTGGATGTCCTCGATCATTTACGC
GCTGAGGGTTTCAACCGCCTGAGTATGGGCGTACAGGACTTCAATAAAGAGGTTCAGCGTCTGGTTAACCGTGAGCAGGA
CGAAGCGTTCATCTTTGATTTGCTCAACCATGCGCGGGAGATTGGTTTTACCTCGACCAATATCGACCTCATTTATGGCC
TGCCGAAGCAAACGCCGGAGAGCTTCGCCTTTACCCTGCAAAAGGTCGCCGAGCTCAATCCTGACCGCCTGAGCGTGTTT
AACTATGCGCATCTGCCCACGCTCTTTGCCGCTCAGCGGAAGATTAAAGATGCCGATCTGCCCTCCGCTGAGCAGAAGCT
GGAGATCCTGCAGGAAACCATCGGCTCGCTGACGACGGCAGGCTATCAGTTTATCGGCATGGACCATTTCGCCCGTCCCG
ATGATGAATTAGCGGTCGCGCAACGTCACGGCGTACTGCATCGTAATTTCCAGGGCTACACCACTCAGGGCGATACCGAT
CTGCTGGGGATGGGCGTTTCGGCGATCAGCATGATTGGCGACAGCTACGCCCAGAACCAAAAAGAGCTCAAGCAGTACTA
CCAGCAGGTAGCAGAGCAAGGGAACGCCCTGTGGCGCGGGATCGCGTTAACTCGCGATGACTGTCTGCGTCGCGACGTGA
TTAAAGCGTTGATCTGTAACTTCCAGCTGGATATCGCGGCGGTCGAGGCGCAGTGGGATGTGGATTTTGCGTCTTATTTC
GCCGAGGATCTGAAGCTGCTGGCGCCGCTGGCGCATGACGGGCTGGTGGCTGTGGATGATAAGGTCATTCAGGTGACGGC
GAAAGGCCGCCTGCTGATCCGCAACATCTGTATGTGCTTTGATGCCTACCTACGGCAAAAGGCCCGAATGCAGCAGTTCT
CACGGGTTATTTAA

Upstream 100 bases:

>100_bases
TGTCGCGGCGTCAGAAATGGCTGCGCAACCGGCTCATGACCCGCGGTGCGGTGGGGCCGGGACGGCGTACCCGTCGGCGG
CACCATCGGAAGGAGTGAGC

Downstream 100 bases:

>100_bases
TATTTTCCCCCTCTCCCGCAGGAGAGGGGGAACAATTAGCTGAACAGCCCGACCAGCGCAGCGCACAGCACGGCAGCGAC
TGCCGTTTGTGGCGTGTGAC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MSEQIIDWDLALIQKYNYSGPRYTSYPTALEFSPQFGAAEFDAAVARYPQRPLSLYVHIPFCHKLCYFCGCNKIVTRQQH
KADQYLDVLEQEIIHRAPLFATRQVKQLHWGGGTPTYLNKAQISRLMDLLRSHFHFSAEAEISIEVDPREIELDVLDHLR
AEGFNRLSMGVQDFNKEVQRLVNREQDEAFIFDLLNHAREIGFTSTNIDLIYGLPKQTPESFAFTLQKVAELNPDRLSVF
NYAHLPTLFAAQRKIKDADLPSAEQKLEILQETIGSLTTAGYQFIGMDHFARPDDELAVAQRHGVLHRNFQGYTTQGDTD
LLGMGVSAISMIGDSYAQNQKELKQYYQQVAEQGNALWRGIALTRDDCLRRDVIKALICNFQLDIAAVEAQWDVDFASYF
AEDLKLLAPLAHDGLVAVDDKVIQVTAKGRLLIRNICMCFDAYLRQKARMQQFSRVI

Sequences:

>Translated_457_residues
MSEQIIDWDLALIQKYNYSGPRYTSYPTALEFSPQFGAAEFDAAVARYPQRPLSLYVHIPFCHKLCYFCGCNKIVTRQQH
KADQYLDVLEQEIIHRAPLFATRQVKQLHWGGGTPTYLNKAQISRLMDLLRSHFHFSAEAEISIEVDPREIELDVLDHLR
AEGFNRLSMGVQDFNKEVQRLVNREQDEAFIFDLLNHAREIGFTSTNIDLIYGLPKQTPESFAFTLQKVAELNPDRLSVF
NYAHLPTLFAAQRKIKDADLPSAEQKLEILQETIGSLTTAGYQFIGMDHFARPDDELAVAQRHGVLHRNFQGYTTQGDTD
LLGMGVSAISMIGDSYAQNQKELKQYYQQVAEQGNALWRGIALTRDDCLRRDVIKALICNFQLDIAAVEAQWDVDFASYF
AEDLKLLAPLAHDGLVAVDDKVIQVTAKGRLLIRNICMCFDAYLRQKARMQQFSRVI
>Mature_456_residues
SEQIIDWDLALIQKYNYSGPRYTSYPTALEFSPQFGAAEFDAAVARYPQRPLSLYVHIPFCHKLCYFCGCNKIVTRQQHK
ADQYLDVLEQEIIHRAPLFATRQVKQLHWGGGTPTYLNKAQISRLMDLLRSHFHFSAEAEISIEVDPREIELDVLDHLRA
EGFNRLSMGVQDFNKEVQRLVNREQDEAFIFDLLNHAREIGFTSTNIDLIYGLPKQTPESFAFTLQKVAELNPDRLSVFN
YAHLPTLFAAQRKIKDADLPSAEQKLEILQETIGSLTTAGYQFIGMDHFARPDDELAVAQRHGVLHRNFQGYTTQGDTDL
LGMGVSAISMIGDSYAQNQKELKQYYQQVAEQGNALWRGIALTRDDCLRRDVIKALICNFQLDIAAVEAQWDVDFASYFA
EDLKLLAPLAHDGLVAVDDKVIQVTAKGRLLIRNICMCFDAYLRQKARMQQFSRVI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=247, Percent_Identity=28.3400809716599, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI87082341, Length=457, Percent_Identity=88.8402625820569, Blast_Score=846, Evalue=0.0,
Organism=Escherichia coli, GI1789325, Length=244, Percent_Identity=33.1967213114754, Blast_Score=129, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 52180; Mature: 52049

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQIIDWDLALIQKYNYSGPRYTSYPTALEFSPQFGAAEFDAAVARYPQRPLSLYVHIP
CCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEEECH
FCHKLCYFCGCNKIVTRQQHKADQYLDVLEQEIIHRAPLFATRQVKQLHWGGGTPTYLNK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCH
AQISRLMDLLRSHFHFSAEAEISIEVDPREIELDVLDHLRAEGFNRLSMGVQDFNKEVQR
HHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LVNREQDEAFIFDLLNHAREIGFTSTNIDLIYGLPKQTPESFAFTLQKVAELNPDRLSVF
HHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEHH
NYAHLPTLFAAQRKIKDADLPSAEQKLEILQETIGSLTTAGYQFIGMDHFARPDDELAVA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHH
QRHGVLHRNFQGYTTQGDTDLLGMGVSAISMIGDSYAQNQKELKQYYQQVAEQGNALWRG
HHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHH
IALTRDDCLRRDVIKALICNFQLDIAAVEAQWDVDFASYFAEDLKLLAPLAHDGLVAVDD
EECCHHHHHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHCCCEEEECC
KVIQVTAKGRLLIRNICMCFDAYLRQKARMQQFSRVI
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEQIIDWDLALIQKYNYSGPRYTSYPTALEFSPQFGAAEFDAAVARYPQRPLSLYVHIP
CCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEEECH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EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7768836; 8346018; 9278503 [H]