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The map label for this gene is mrdA [H]

Identifier: 238028932

GI number: 238028932

Start: 3860124

End: 3862388

Strand: Direct

Name: mrdA [H]

Synonym: bglu_1g33970

Alternate gene names: 238028932

Gene position: 3860124-3862388 (Clockwise)

Preceding gene: 238028931

Following gene: 238028933

Centisome position: 98.81

GC content: 69.89

Gene sequence:

>2265_bases
ATGACCGAATTCAAGGACACCCAACAGCAGCTCTCGAAGTTCCGCCTGCGCGTCGCGGCGGCGGGGCTGTTCGTGTTCGT
CTGCTTCGGGCTGCTCGCGGTCCGCTTCTTCTACCTGCAGGTCTGGCAGCACGACAAGTACGCGCTGCAGGCCGACGAGA
ACCGCATCTCGGTCGCGCCGATCGTGCCGAATCGCGGCATCATCACCGACCGCAACGGCGTGGTGCTGGCGCGCAATTAT
TCGGCGTACACGCTCGAGATCACGCCGTCGAAGCTGACCGACACGCTCGACAACACCATCAACGCGCTCTCGGAGGTGAT
CCCGATCGACGCGCGTGATCGCCGCCGTTTCAAGAAGCTGCAGGAGGATTCGAAGAATTTCGAAAGCCTGCCGATTCGCA
CCCGCTTGAGCGACGAGGAAGTGGCGCGCTTCACGGCGCAGCGCTGGCGCTTTCCCGGCGTCGAGGTGCGCGCGCGGCTG
TTCCGGCAGTACCCGCTCGGCCCGACGGCCGCGCACGTGATCGGCTACATCGGCCGGATCTCGAAGCGCGATCAGGATCA
CATCGAGGCGATGAGCGAGGCGAACGACAGCGATCCCGAGCACTACGACCCGCGCCGTGACGCCAACAACTACAAGGGCA
CCGATTACATCGGCAAGATCGGCGTCGAGCAGAGCTACGAGACCGAGCTGCACGGCGTGACGGGCTTCGAGGAAGTCGAG
GTGACGGCGGGCGGCCGGCCGGTGCGCACCCTGTCGCGCACCCAGGCCACGCCGGGCGACAATCTCGTGCTGTCGATCGA
CATCGGGCTGCAGCAGGTGGCCGAGCAGGCGTTCGCCGGCAAGCGCGGCGCGCTGGTGGCGATCGAGCCGAGCACGGGCG
ACGTGCTCGCATTCGTGTCGTCGCCGAGCTTCGACCCGAACTCGTTCGTGGACGGCATCGACCAGCAGACCTGGGACGAG
CTCAACAACTCGCCCGACAAGCCGCTGCTGAACCGCCCGCTGCGCGGCACCTACCCGCCCGGCTCGACCTACAAGCCGTT
CATGGCGCTGGCCGGGCTCGAGCTGGGCAAGCGCACACCCAGCTGGGGCTTCCAGGATCCCGGCTACTTCACGTTCGGCG
GCCACACGTTCCGCAACGACGTGCGCTCGGGCCAGGGCTGGGTGGACATGAACCGCGCGATCATGGTGTCGAACGACACC
TATTTCTACATGCTCGCGCGCGACCTGGGCGTGACCAACATCGCGAACTTCATGAAGCCGTTCGGCTTCGGCCAGATCAC
CGGCATCGACGTGCAGGGCGAGGCGCGCGGCGTGCTGCCGTCGCCCGAATGGAAGCGCAAGACGTTCCGCAAGCCCGCGC
TGCAGAAGTGGTACGACGGCGAGACCATCAGCCTCGGGATCGGCCAGGGCTACAACTCGTTCACGATCCTGCAGCTCGCG
CACGCGGTGGCCACGCTGGCCGACAACGGCGTCGTGATGAAGCCCCATCTGGTCAAGGAGATCGAGGACCCGATCACGCG
CGTGCGGCACCTGACGGTGCCGAAGCAAAGCGCGGTGATCCCGCTCAAGCAGGCCAACATCGACGTGGTCAAGCGCGGCA
TGGAAAACGTCATCGAGAACCCGGCCGGCACGGCCTACAAGATCTTCCGCGGCGCCCCCTACACGGCGGCCGGCAAGACC
GGCACGGCGCAGGTGTTCTCGCTGCAGGGCTCGAACTACCACGGCCACCTGCTCGCCGAGCGGCTGCGCGATCACGCGCT
GTTCACCGCCTACGCGCCGGCCGACCATCCGCGCATCGCGCTCGCGCTGATCGTCGAGAACGGCGGCTGGGGCGCCCAGT
CGGCCGGCCCGATCGCGCGCAAGGTGCTCGACTTCTATCTGGTCGACCGCCAGAAGCCGGGCAGCGAGGCGGCCGCCGTG
GCCGCCGCCGCCTCGGCCACCGAGCCCGTCAGCGCGCCCGTGGTCGGCGATACGACGAAGCCGGTGGGCATCGCGGCCGG
CTTCACGGCGCTGCCGCAGCCGGTGCCGCCCGCCGCCGCGAGCGCGGCCGACGCGGCCTCGGGCGGCCTGCCGGACGGCG
CGGCCACGGGCGCATCCGGCCCGGCCGACTCCGCCGGCGCGGCCGCGCCCGCCGCGGCCAGCCTGCCGCCCGCGCGACGG
CTGCCGCGCAAGCCGCACCGCGCGCCCGCGAGCGCGGCGAGCGCCCCCGCCGCGACGCGCGACGAGCGCGTCCCCGCCCG
GCCCGCCGCCGGCACCGACGAATAA

Upstream 100 bases:

>100_bases
ACCCGCACGGCCGCCGCATGCCGAGCGCCCCGCCACCGGCCATCGCCGCGAGCCCCGACACCCGTGCGCAGCCGGCACGA
CCGCTTTTCTCCAGACTCGC

Downstream 100 bases:

>100_bases
CGGAGAAAGGCATGCAATTCGACAAGCGCGCCTGGCTCGACAAGGCAAAGCAGATGTTCGCGGGCTTCGACCGCCCGCTC
GCGCTGATCGTGTTCCTGCT

Product: Penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 754; Mature: 753

Protein sequence:

>754_residues
MTEFKDTQQQLSKFRLRVAAAGLFVFVCFGLLAVRFFYLQVWQHDKYALQADENRISVAPIVPNRGIITDRNGVVLARNY
SAYTLEITPSKLTDTLDNTINALSEVIPIDARDRRRFKKLQEDSKNFESLPIRTRLSDEEVARFTAQRWRFPGVEVRARL
FRQYPLGPTAAHVIGYIGRISKRDQDHIEAMSEANDSDPEHYDPRRDANNYKGTDYIGKIGVEQSYETELHGVTGFEEVE
VTAGGRPVRTLSRTQATPGDNLVLSIDIGLQQVAEQAFAGKRGALVAIEPSTGDVLAFVSSPSFDPNSFVDGIDQQTWDE
LNNSPDKPLLNRPLRGTYPPGSTYKPFMALAGLELGKRTPSWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNRAIMVSNDT
YFYMLARDLGVTNIANFMKPFGFGQITGIDVQGEARGVLPSPEWKRKTFRKPALQKWYDGETISLGIGQGYNSFTILQLA
HAVATLADNGVVMKPHLVKEIEDPITRVRHLTVPKQSAVIPLKQANIDVVKRGMENVIENPAGTAYKIFRGAPYTAAGKT
GTAQVFSLQGSNYHGHLLAERLRDHALFTAYAPADHPRIALALIVENGGWGAQSAGPIARKVLDFYLVDRQKPGSEAAAV
AAAASATEPVSAPVVGDTTKPVGIAAGFTALPQPVPPAAASAADAASGGLPDGAATGASGPADSAGAAAPAAASLPPARR
LPRKPHRAPASAASAPAATRDERVPARPAAGTDE

Sequences:

>Translated_754_residues
MTEFKDTQQQLSKFRLRVAAAGLFVFVCFGLLAVRFFYLQVWQHDKYALQADENRISVAPIVPNRGIITDRNGVVLARNY
SAYTLEITPSKLTDTLDNTINALSEVIPIDARDRRRFKKLQEDSKNFESLPIRTRLSDEEVARFTAQRWRFPGVEVRARL
FRQYPLGPTAAHVIGYIGRISKRDQDHIEAMSEANDSDPEHYDPRRDANNYKGTDYIGKIGVEQSYETELHGVTGFEEVE
VTAGGRPVRTLSRTQATPGDNLVLSIDIGLQQVAEQAFAGKRGALVAIEPSTGDVLAFVSSPSFDPNSFVDGIDQQTWDE
LNNSPDKPLLNRPLRGTYPPGSTYKPFMALAGLELGKRTPSWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNRAIMVSNDT
YFYMLARDLGVTNIANFMKPFGFGQITGIDVQGEARGVLPSPEWKRKTFRKPALQKWYDGETISLGIGQGYNSFTILQLA
HAVATLADNGVVMKPHLVKEIEDPITRVRHLTVPKQSAVIPLKQANIDVVKRGMENVIENPAGTAYKIFRGAPYTAAGKT
GTAQVFSLQGSNYHGHLLAERLRDHALFTAYAPADHPRIALALIVENGGWGAQSAGPIARKVLDFYLVDRQKPGSEAAAV
AAAASATEPVSAPVVGDTTKPVGIAAGFTALPQPVPPAAASAADAASGGLPDGAATGASGPADSAGAAAPAAASLPPARR
LPRKPHRAPASAASAPAATRDERVPARPAAGTDE
>Mature_753_residues
TEFKDTQQQLSKFRLRVAAAGLFVFVCFGLLAVRFFYLQVWQHDKYALQADENRISVAPIVPNRGIITDRNGVVLARNYS
AYTLEITPSKLTDTLDNTINALSEVIPIDARDRRRFKKLQEDSKNFESLPIRTRLSDEEVARFTAQRWRFPGVEVRARLF
RQYPLGPTAAHVIGYIGRISKRDQDHIEAMSEANDSDPEHYDPRRDANNYKGTDYIGKIGVEQSYETELHGVTGFEEVEV
TAGGRPVRTLSRTQATPGDNLVLSIDIGLQQVAEQAFAGKRGALVAIEPSTGDVLAFVSSPSFDPNSFVDGIDQQTWDEL
NNSPDKPLLNRPLRGTYPPGSTYKPFMALAGLELGKRTPSWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNRAIMVSNDTY
FYMLARDLGVTNIANFMKPFGFGQITGIDVQGEARGVLPSPEWKRKTFRKPALQKWYDGETISLGIGQGYNSFTILQLAH
AVATLADNGVVMKPHLVKEIEDPITRVRHLTVPKQSAVIPLKQANIDVVKRGMENVIENPAGTAYKIFRGAPYTAAGKTG
TAQVFSLQGSNYHGHLLAERLRDHALFTAYAPADHPRIALALIVENGGWGAQSAGPIARKVLDFYLVDRQKPGSEAAAVA
AAASATEPVSAPVVGDTTKPVGIAAGFTALPQPVPPAAASAADAASGGLPDGAATGASGPADSAGAAAPAAASLPPARRL
PRKPHRAPASAASAPAATRDERVPARPAAGTDE

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=645, Percent_Identity=39.8449612403101, Blast_Score=470, Evalue=1e-133,
Organism=Escherichia coli, GI1786272, Length=636, Percent_Identity=24.0566037735849, Blast_Score=126, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 81594; Mature: 81463

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFKDTQQQLSKFRLRVAAAGLFVFVCFGLLAVRFFYLQVWQHDKYALQADENRISVAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEE
IVPNRGIITDRNGVVLARNYSAYTLEITPSKLTDTLDNTINALSEVIPIDARDRRRFKKL
ECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QEDSKNFESLPIRTRLSDEEVARFTAQRWRFPGVEVRARLFRQYPLGPTAAHVIGYIGRI
HHHCCCHHCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
SKRDQDHIEAMSEANDSDPEHYDPRRDANNYKGTDYIGKIGVEQSYETELHGVTGFEEVE
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCCHHHCCCCCCCEEE
VTAGGRPVRTLSRTQATPGDNLVLSIDIGLQQVAEQAFAGKRGALVAIEPSTGDVLAFVS
EECCCCCHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEC
SPSFDPNSFVDGIDQQTWDELNNSPDKPLLNRPLRGTYPPGSTYKPFMALAGLELGKRTP
CCCCCCHHHHCCCCHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
SWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNRAIMVSNDTYFYMLARDLGVTNIANFMKP
CCCCCCCCEEEECCHHHHHHHCCCCCEEECCCEEEEECCCEEEEEECCCCHHHHHHHHCC
FGFGQITGIDVQGEARGVLPSPEWKRKTFRKPALQKWYDGETISLGIGQGYNSFTILQLA
CCCCCEEEEEECCCCCCCCCCCHHHHHHHCCHHHHHHCCCCEEEEECCCCCCCHHHHHHH
HAVATLADNGVVMKPHLVKEIEDPITRVRHLTVPKQSAVIPLKQANIDVVKRGMENVIEN
HHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCCCCCCCEEEHHHCCHHHHHHHHHHHHCC
PAGTAYKIFRGAPYTAAGKTGTAQVFSLQGSNYHGHLLAERLRDHALFTAYAPADHPRIA
CCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCEEEEEECCCCCCCEE
LALIVENGGWGAQSAGPIARKVLDFYLVDRQKPGSEAAAVAAAASATEPVSAPVVGDTTK
EEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
PVGIAAGFTALPQPVPPAAASAADAASGGLPDGAATGASGPADSAGAAAPAAASLPPARR
CCEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LPRKPHRAPASAASAPAATRDERVPARPAAGTDE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEFKDTQQQLSKFRLRVAAAGLFVFVCFGLLAVRFFYLQVWQHDKYALQADENRISVAP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEE
IVPNRGIITDRNGVVLARNYSAYTLEITPSKLTDTLDNTINALSEVIPIDARDRRRFKKL
ECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QEDSKNFESLPIRTRLSDEEVARFTAQRWRFPGVEVRARLFRQYPLGPTAAHVIGYIGRI
HHHCCCHHCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
SKRDQDHIEAMSEANDSDPEHYDPRRDANNYKGTDYIGKIGVEQSYETELHGVTGFEEVE
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCCHHHCCCCCCCEEE
VTAGGRPVRTLSRTQATPGDNLVLSIDIGLQQVAEQAFAGKRGALVAIEPSTGDVLAFVS
EECCCCCHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEC
SPSFDPNSFVDGIDQQTWDELNNSPDKPLLNRPLRGTYPPGSTYKPFMALAGLELGKRTP
CCCCCCHHHHCCCCHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
SWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNRAIMVSNDTYFYMLARDLGVTNIANFMKP
CCCCCCCCEEEECCHHHHHHHCCCCCEEECCCEEEEECCCEEEEEECCCCHHHHHHHHCC
FGFGQITGIDVQGEARGVLPSPEWKRKTFRKPALQKWYDGETISLGIGQGYNSFTILQLA
CCCCCEEEEEECCCCCCCCCCCHHHHHHHCCHHHHHHCCCCEEEEECCCCCCCHHHHHHH
HAVATLADNGVVMKPHLVKEIEDPITRVRHLTVPKQSAVIPLKQANIDVVKRGMENVIEN
HHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCCCCCCCEEEHHHCCHHHHHHHHHHHHCC
PAGTAYKIFRGAPYTAAGKTGTAQVFSLQGSNYHGHLLAERLRDHALFTAYAPADHPRIA
CCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCEEEEEECCCCCCCEE
LALIVENGGWGAQSAGPIARKVLDFYLVDRQKPGSEAAAVAAAASATEPVSAPVVGDTTK
EEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
PVGIAAGFTALPQPVPPAAASAADAASGGLPDGAATGASGPADSAGAAAPAAASLPPARR
CCEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LPRKPHRAPASAASAPAATRDERVPARPAAGTDE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]