Click here to switch to the map view.

The map label for this gene is hslU [H]

Identifier: 238028912

GI number: 238028912

Start: 3838802

End: 3840136

Strand: Direct

Name: hslU [H]

Synonym: bglu_1g33770

Alternate gene names: 238028912

Gene position: 3838802-3840136 (Clockwise)

Preceding gene: 238028911

Following gene: 238028915

Centisome position: 98.27

GC content: 64.94

Gene sequence:

>1335_bases
ATGACCCCTGCCGAGATCGTCTCGGAACTCGACAAGCACATCATCGGCCAGGCCAAGGCGAAGAAGGCGGTGGCCGTCGC
GCTGCGCAACCGCTGGCGCCGCCAGCAGGTGGCCGAGCCGCTGCGCCAGGAAATCACGCCGAAGAACATCCTGATGATCG
GCCCGACCGGCGTCGGCAAGACCGAGATCGCGCGGCGCCTGGCCAAGCTCGCCGACGCGCCGTTCATCAAGATCGAGGCG
ACCAAGTTCACCGAGGTCGGCTACGTCGGGCGCGACGTGGACAGCATCGTGCGCGACCTGATCGAGATCTCGGTCAAGCA
GACGCGCGAGACGGAGATGCGCAAGGTGCGCTCGAAGGCCCAGGACCAGGCCGAGGACCGCATCCTCGACATCCTGCTGC
CGCAGCCGCGCGCGGTCGGCTTCGGCTCGAACGCCGAGTCCGCCAACGAGGACAATAACGCCACCCGCCAGACCTTCCGC
AAGCGGCTGCGCGAGGGCGCGCTCGACGACAAGGAAATCGAGCTCGACATCGAGCAGCCGCAGGCCGGCATGGACATCAT
GGCGCCGCCGGGCATGGAAGAGATGACCGAGCAGATCCGCTCGATGTTCTCGAATCTCGGCGGCGGCAAGAAAACCCGCC
GCAAGGTGAAGATCAAGGAAGCGCTGAAGCTGCTGACCGACGAGGAAGCCGGCAAGCTGCTCAATGACGAGGAAGTGAAG
ACGAAGGCCGTGCAGAACGTCGAGCAGAACGGCATCGTGTTCCTCGACGAGATCGACAAGATCGCCTCGCGCAACCACGA
GGGGGGCGGCGGCGAGGTCTCGCGCCAGGGCGTGCAGCGCGATCTGCTGCCGCTCGTGGAGGGCACCACGGTCAACACCA
AGTACGGGATGATCCGCACCGATCACATCCTGTTCATCGCGAGCGGCGCGTTCCATCTGTCCAAGCCGAGCGACCTGATT
CCGGAACTGCAGGGGCGCTTTCCGATTCGCGTCGAACTCGACTCGCTGTCGGTCGAGGATTTCGAATCGATCCTGGTGGC
CACCGACGCCAGCCTCGTCAAGCAATACCAGGCGCTGCTCGCCACCGAGGAAGTGCAGCTCGAATTCGCCGCAGACGGCA
TCCGGCGCCTGGCCGAGGTCGCGTTCTCGGTCAACGAGAAGACCGAGAACATCGGCGCGCGGCGGCTCTATACCGTGATC
GAGAAGCTGCTCGAGGACGTGTCGTTCGCGGCCGGCAATCATGCGGGCCAGAGCGTCACGATCGACGCGGGGTATGTCGA
TCGTGCGCTCGGCGAAGTGTCGAAGGATGAAGACCTGTCGCGCTACGTGCTGTAA

Upstream 100 bases:

>100_bases
ATCGTCGCCAAGGCGCTGACGATCGCGGGCGACATGTGCATCTACACGAATCACAACCACATCATCGAAACGATCGAGTA
AGGACGCTTCCATGAGCACC

Downstream 100 bases:

>100_bases
GCCGGCGGCGACTCGCCGGGGCAGGTGGCGGACCGGACGGGCGGCCCTGCGCAGGCGGGCCCGCCCGCTTTTTTTGTTTT
TTGCGATAACGCGGGCGCAA

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTPAEIVSELDKHIIGQAKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIKIEA
TKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVRSKAQDQAEDRILDILLPQPRAVGFGSNAESANEDNNATRQTFR
KRLREGALDDKEIELDIEQPQAGMDIMAPPGMEEMTEQIRSMFSNLGGGKKTRRKVKIKEALKLLTDEEAGKLLNDEEVK
TKAVQNVEQNGIVFLDEIDKIASRNHEGGGGEVSRQGVQRDLLPLVEGTTVNTKYGMIRTDHILFIASGAFHLSKPSDLI
PELQGRFPIRVELDSLSVEDFESILVATDASLVKQYQALLATEEVQLEFAADGIRRLAEVAFSVNEKTENIGARRLYTVI
EKLLEDVSFAAGNHAGQSVTIDAGYVDRALGEVSKDEDLSRYVL

Sequences:

>Translated_444_residues
MTPAEIVSELDKHIIGQAKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIKIEA
TKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVRSKAQDQAEDRILDILLPQPRAVGFGSNAESANEDNNATRQTFR
KRLREGALDDKEIELDIEQPQAGMDIMAPPGMEEMTEQIRSMFSNLGGGKKTRRKVKIKEALKLLTDEEAGKLLNDEEVK
TKAVQNVEQNGIVFLDEIDKIASRNHEGGGGEVSRQGVQRDLLPLVEGTTVNTKYGMIRTDHILFIASGAFHLSKPSDLI
PELQGRFPIRVELDSLSVEDFESILVATDASLVKQYQALLATEEVQLEFAADGIRRLAEVAFSVNEKTENIGARRLYTVI
EKLLEDVSFAAGNHAGQSVTIDAGYVDRALGEVSKDEDLSRYVL
>Mature_443_residues
TPAEIVSELDKHIIGQAKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIKIEAT
KFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVRSKAQDQAEDRILDILLPQPRAVGFGSNAESANEDNNATRQTFRK
RLREGALDDKEIELDIEQPQAGMDIMAPPGMEEMTEQIRSMFSNLGGGKKTRRKVKIKEALKLLTDEEAGKLLNDEEVKT
KAVQNVEQNGIVFLDEIDKIASRNHEGGGGEVSRQGVQRDLLPLVEGTTVNTKYGMIRTDHILFIASGAFHLSKPSDLIP
ELQGRFPIRVELDSLSVEDFESILVATDASLVKQYQALLATEEVQLEFAADGIRRLAEVAFSVNEKTENIGARRLYTVIE
KLLEDVSFAAGNHAGQSVTIDAGYVDRALGEVSKDEDLSRYVL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=444, Percent_Identity=63.7387387387387, Blast_Score=578, Evalue=1e-166,
Organism=Escherichia coli, GI1786642, Length=102, Percent_Identity=47.0588235294118, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71982905, Length=251, Percent_Identity=33.0677290836653, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71982908, Length=251, Percent_Identity=33.0677290836653, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24648291, Length=121, Percent_Identity=38.0165289256198, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24648289, Length=121, Percent_Identity=38.0165289256198, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 49299; Mature: 49168

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPAEIVSELDKHIIGQAKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCH
TEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVRSKA
HHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDQAEDRILDILLPQPRAVGFGSNAESANEDNNATRQTFRKRLREGALDDKEIELDIEQP
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCC
QAGMDIMAPPGMEEMTEQIRSMFSNLGGGKKTRRKVKIKEALKLLTDEEAGKLLNDEEVK
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHH
TKAVQNVEQNGIVFLDEIDKIASRNHEGGGGEVSRQGVQRDLLPLVEGTTVNTKYGMIRT
HHHHHHHHCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCEEEE
DHILFIASGAFHLSKPSDLIPELQGRFPIRVELDSLSVEDFESILVATDASLVKQYQALL
CEEEEEEECCCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHH
ATEEVQLEFAADGIRRLAEVAFSVNEKTENIGARRLYTVIEKLLEDVSFAAGNHAGQSVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
IDAGYVDRALGEVSKDEDLSRYVL
EECCHHHHHHHCCCCCCCHHHHCC
>Mature Secondary Structure 
TPAEIVSELDKHIIGQAKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCH
TEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVRSKA
HHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDQAEDRILDILLPQPRAVGFGSNAESANEDNNATRQTFRKRLREGALDDKEIELDIEQP
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCC
QAGMDIMAPPGMEEMTEQIRSMFSNLGGGKKTRRKVKIKEALKLLTDEEAGKLLNDEEVK
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHH
TKAVQNVEQNGIVFLDEIDKIASRNHEGGGGEVSRQGVQRDLLPLVEGTTVNTKYGMIRT
HHHHHHHHCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCEEEE
DHILFIASGAFHLSKPSDLIPELQGRFPIRVELDSLSVEDFESILVATDASLVKQYQALL
CEEEEEEECCCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHH
ATEEVQLEFAADGIRRLAEVAFSVNEKTENIGARRLYTVIEKLLEDVSFAAGNHAGQSVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
IDAGYVDRALGEVSKDEDLSRYVL
EECCHHHHHHHCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA