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The map label for this gene is alkJ [H]

Identifier: 238028893

GI number: 238028893

Start: 3818152

End: 3819828

Strand: Reverse

Name: alkJ [H]

Synonym: bglu_1g33580

Alternate gene names: 238028893

Gene position: 3819828-3818152 (Counterclockwise)

Preceding gene: 238028896

Following gene: 238028886

Centisome position: 97.78

GC content: 71.32

Gene sequence:

>1677_bases
ATGCAGTACGACTATCTGATCGTGGGCGGCGGCTCGGGCGGCGCGAGCCTCGCCGCGCGTCTTGCCGACGCCTGCCCCGA
TGCCACCGTCGCGCTGATCGAGGCGGGCGGCAGCAATCAGCGCAACCTGCTGGTCAATCTGCCGGTCGGCATCGCCGCGC
TGGTGCCGTACCGGCTCGGCACCAACTACGGCTACCAGACGGAGCCGCAGGCCGGGCTCGGCGGGCGGCGCGGCTACCAG
CCGCGCGGGCGCGGGCTGGGCGGATCGAGCGCGATCAACGCGATGATCTACACGCGCGGCCACCCGCTCGACTACGACGA
ATGGGCCGCGCTCGGCTGCACCGGCTGGGGCTGGCAGGACGTGCTGCCCTACTTTCGCCGCGCCGAGGGCAACCAGCGCG
GCGCGAGCGAATGGCACGGCGCCGATGGCCCGCTGACGGTGTCCGATCTGCGCTTTCGCAATCCGTTCGCCCAACGATTC
ATCGATGCGGCACACGCGGCCGGCTATCCGCTCAACGACGATTTCAACGGCCCCGAGCAGGAAGGCGTCGGCTTCTACCA
GGTCACGCATCGCGACGGCGCGCGCTGCAGCGTCGCGCGCGCCTATCTATATGACCAGCCGCGCCCCAACCTGCAGATCC
TGACCGGCGCGACCGCGCTGCGCGTGGCGTTCGACGGCAAGCGCGCGGTCGGCGTCACGCTCGAGCGCGGCGGCAGGATC
GAGACGCTCGGCGCGCGCGCCGAGGTGATCCTGGCGGCCGGCGCGTTCAACTCGCCGCAGCTGCTGATGTGTTCGGGCAT
CGGCCCGGGCGAGTCGCTGCGCGCGCACGGCATCGAGGTGCTTCACGACGCGCCCGAGGTCGGCCGCAACCTGATCGACC
ATATCGACTTCATCATCAACAAGCGCGTGGATTCGACGGAGCTGGTGGGGATCTGCCTGCGCGGGCTCGCCAAGATGGCG
CCGCAGCTGTGGCGCTGGCTCTCGAAACGCGACGGCATGATGTCGAGCAACGTCGCCGAGGCGGGCGGCTTCCTCAAGAG
CGAGCCGGGACTCGACCGTCCCGACCTGCAACTGCATTTCTGCACCGCGCTCGTCGACGATCACAACCGCCGCATGCACT
GGGGCTTCGGCTATTCGCTGCACGTCTGCGCGCTGCGGCCCTGGAGCCGCGGCACCGTCACGCTGGCGAGCGCCGACGCG
CGCGAGGCGCCGCGCATCGACCCGCGCTTCCTGAGCGACGCGCGCGATCTCGAACTGCTGATGAAGGGCGCGAAGGTGAT
CCGCCGGATTCTGGCGGCCCAGCCGCTCGCCTCGCAGGGCGGGCGCGAACTCTATACCGACCCGGCCGACGACGACGACG
CGCTGCGCGCGGCCATCGTCGCGCACGCGGACACCATCTACCACCCGGTCGGCACCTGCCGGATGGGCGGCGACCCGGCT
TCGGTCGTCGATCCGCAACTGCGCGTGCGCGGCGTGACGGGGCTGCGCGTGGTCGATGCGTCGGTGATGCCGACGCTGAT
CGGCGGCAATACCAACGCCCCCTCGGTGATGATCGGCGAGCGCGCGGCCGATTTCATCGCGGCCGCACGACGTGGGAGCG
TGCCGCAGCCCATCGAGAGCGTGGCGCCCATGGCGGCCGCCGCGGGCGCGTGGATGTCGCGCGGCGCAGCCGGGTAG

Upstream 100 bases:

>100_bases
ACGCGTCGCGTTCCTACAATGCGCGAACATTACAAGCGATAGCGCCGCTCGCCGCATCCGGCGAAGCCGGTCACTGTTCA
TGACATGAAGGAGACATGAC

Downstream 100 bases:

>100_bases
GGCGCAGATGGCTGAGTGCGGACCGGGGTGAGGCCGGCGGGTGGCAGGCCGGCGGAGCCGCCGCCCGCAGCGGGCGGGCT
GCCGGCGTAACTGCGCGGGC

Product: GMC family oxidoreductase

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: NA

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MQYDYLIVGGGSGGASLAARLADACPDATVALIEAGGSNQRNLLVNLPVGIAALVPYRLGTNYGYQTEPQAGLGGRRGYQ
PRGRGLGGSSAINAMIYTRGHPLDYDEWAALGCTGWGWQDVLPYFRRAEGNQRGASEWHGADGPLTVSDLRFRNPFAQRF
IDAAHAAGYPLNDDFNGPEQEGVGFYQVTHRDGARCSVARAYLYDQPRPNLQILTGATALRVAFDGKRAVGVTLERGGRI
ETLGARAEVILAAGAFNSPQLLMCSGIGPGESLRAHGIEVLHDAPEVGRNLIDHIDFIINKRVDSTELVGICLRGLAKMA
PQLWRWLSKRDGMMSSNVAEAGGFLKSEPGLDRPDLQLHFCTALVDDHNRRMHWGFGYSLHVCALRPWSRGTVTLASADA
REAPRIDPRFLSDARDLELLMKGAKVIRRILAAQPLASQGGRELYTDPADDDDALRAAIVAHADTIYHPVGTCRMGGDPA
SVVDPQLRVRGVTGLRVVDASVMPTLIGGNTNAPSVMIGERAADFIAAARRGSVPQPIESVAPMAAAAGAWMSRGAAG

Sequences:

>Translated_558_residues
MQYDYLIVGGGSGGASLAARLADACPDATVALIEAGGSNQRNLLVNLPVGIAALVPYRLGTNYGYQTEPQAGLGGRRGYQ
PRGRGLGGSSAINAMIYTRGHPLDYDEWAALGCTGWGWQDVLPYFRRAEGNQRGASEWHGADGPLTVSDLRFRNPFAQRF
IDAAHAAGYPLNDDFNGPEQEGVGFYQVTHRDGARCSVARAYLYDQPRPNLQILTGATALRVAFDGKRAVGVTLERGGRI
ETLGARAEVILAAGAFNSPQLLMCSGIGPGESLRAHGIEVLHDAPEVGRNLIDHIDFIINKRVDSTELVGICLRGLAKMA
PQLWRWLSKRDGMMSSNVAEAGGFLKSEPGLDRPDLQLHFCTALVDDHNRRMHWGFGYSLHVCALRPWSRGTVTLASADA
REAPRIDPRFLSDARDLELLMKGAKVIRRILAAQPLASQGGRELYTDPADDDDALRAAIVAHADTIYHPVGTCRMGGDPA
SVVDPQLRVRGVTGLRVVDASVMPTLIGGNTNAPSVMIGERAADFIAAARRGSVPQPIESVAPMAAAAGAWMSRGAAG
>Mature_558_residues
MQYDYLIVGGGSGGASLAARLADACPDATVALIEAGGSNQRNLLVNLPVGIAALVPYRLGTNYGYQTEPQAGLGGRRGYQ
PRGRGLGGSSAINAMIYTRGHPLDYDEWAALGCTGWGWQDVLPYFRRAEGNQRGASEWHGADGPLTVSDLRFRNPFAQRF
IDAAHAAGYPLNDDFNGPEQEGVGFYQVTHRDGARCSVARAYLYDQPRPNLQILTGATALRVAFDGKRAVGVTLERGGRI
ETLGARAEVILAAGAFNSPQLLMCSGIGPGESLRAHGIEVLHDAPEVGRNLIDHIDFIINKRVDSTELVGICLRGLAKMA
PQLWRWLSKRDGMMSSNVAEAGGFLKSEPGLDRPDLQLHFCTALVDDHNRRMHWGFGYSLHVCALRPWSRGTVTLASADA
REAPRIDPRFLSDARDLELLMKGAKVIRRILAAQPLASQGGRELYTDPADDDDALRAAIVAHADTIYHPVGTCRMGGDPA
SVVDPQLRVRGVTGLRVVDASVMPTLIGGNTNAPSVMIGERAADFIAAARRGSVPQPIESVAPMAAAAGAWMSRGAAG

Specific function: Converts aliphatic medium-chain-length alcohols into aldehydes. May be linked to the electron transfer chain [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=536, Percent_Identity=42.910447761194, Blast_Score=389, Evalue=1e-108,
Organism=Escherichia coli, GI1786503, Length=542, Percent_Identity=40.0369003690037, Blast_Score=342, Evalue=5e-95,
Organism=Caenorhabditis elegans, GI17532301, Length=554, Percent_Identity=36.101083032491, Blast_Score=332, Evalue=3e-91,
Organism=Drosophila melanogaster, GI45551458, Length=573, Percent_Identity=36.4746945898778, Blast_Score=322, Evalue=4e-88,
Organism=Drosophila melanogaster, GI45549471, Length=573, Percent_Identity=36.1256544502618, Blast_Score=322, Evalue=4e-88,
Organism=Drosophila melanogaster, GI24642042, Length=572, Percent_Identity=37.0629370629371, Blast_Score=312, Evalue=3e-85,
Organism=Drosophila melanogaster, GI24642037, Length=574, Percent_Identity=38.6759581881533, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24642055, Length=581, Percent_Identity=36.8330464716007, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24642048, Length=579, Percent_Identity=35.0604490500864, Blast_Score=298, Evalue=9e-81,
Organism=Drosophila melanogaster, GI24642035, Length=591, Percent_Identity=35.8714043993232, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24650267, Length=581, Percent_Identity=35.6282271944923, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI17137792, Length=571, Percent_Identity=34.3257443082312, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI24642059, Length=580, Percent_Identity=33.6206896551724, Blast_Score=281, Evalue=7e-76,
Organism=Drosophila melanogaster, GI24642039, Length=572, Percent_Identity=34.965034965035, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI18859995, Length=565, Percent_Identity=34.8672566371681, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI18859993, Length=579, Percent_Identity=32.1243523316062, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24642051, Length=570, Percent_Identity=30.7017543859649, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24642057, Length=585, Percent_Identity=30.0854700854701, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24645930, Length=574, Percent_Identity=29.0940766550523, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 59690; Mature: 59690

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYDYLIVGGGSGGASLAARLADACPDATVALIEAGGSNQRNLLVNLPVGIAALVPYRLG
CCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHC
TNYGYQTEPQAGLGGRRGYQPRGRGLGGSSAINAMIYTRGHPLDYDEWAALGCTGWGWQD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEEEECCCCCCHHHHHCCCCCCCCHHH
VLPYFRRAEGNQRGASEWHGADGPLTVSDLRFRNPFAQRFIDAAHAAGYPLNDDFNGPEQ
HHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHH
EGVGFYQVTHRDGARCSVARAYLYDQPRPNLQILTGATALRVAFDGKRAVGVTLERGGRI
HCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCEEEEEEECCCEEEEEEECCCCEE
ETLGARAEVILAAGAFNSPQLLMCSGIGPGESLRAHGIEVLHDAPEVGRNLIDHIDFIIN
EEECCCEEEEEEECCCCCCCEEEEECCCCCCCHHHCCHHHHHCCHHHHHHHHHHHHHHHH
KRVDSTELVGICLRGLAKMAPQLWRWLSKRDGMMSSNVAEAGGFLKSEPGLDRPDLQLHF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCEEEE
CTALVDDHNRRMHWGFGYSLHVCALRPWSRGTVTLASADAREAPRIDPRFLSDARDLELL
EEEHHCCCCCEEEEECCCEEEEEEECCCCCCEEEEEECCCCCCCCCCHHHHCCHHHHHHH
MKGAKVIRRILAAQPLASQGGRELYTDPADDDDALRAAIVAHADTIYHPVGTCRMGGDPA
HHHHHHHHHHHHCCCHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCH
SVVDPQLRVRGVTGLRVVDASVMPTLIGGNTNAPSVMIGERAADFIAAARRGSVPQPIES
HHCCCCCEEECCCCEEEECCCCCCEEECCCCCCCEEEECHHHHHHHHHHHCCCCCCCHHH
VAPMAAAAGAWMSRGAAG
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQYDYLIVGGGSGGASLAARLADACPDATVALIEAGGSNQRNLLVNLPVGIAALVPYRLG
CCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHC
TNYGYQTEPQAGLGGRRGYQPRGRGLGGSSAINAMIYTRGHPLDYDEWAALGCTGWGWQD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEEEECCCCCCHHHHHCCCCCCCCHHH
VLPYFRRAEGNQRGASEWHGADGPLTVSDLRFRNPFAQRFIDAAHAAGYPLNDDFNGPEQ
HHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHH
EGVGFYQVTHRDGARCSVARAYLYDQPRPNLQILTGATALRVAFDGKRAVGVTLERGGRI
HCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCEEEEEEECCCEEEEEEECCCCEE
ETLGARAEVILAAGAFNSPQLLMCSGIGPGESLRAHGIEVLHDAPEVGRNLIDHIDFIIN
EEECCCEEEEEEECCCCCCCEEEEECCCCCCCHHHCCHHHHHCCHHHHHHHHHHHHHHHH
KRVDSTELVGICLRGLAKMAPQLWRWLSKRDGMMSSNVAEAGGFLKSEPGLDRPDLQLHF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCEEEE
CTALVDDHNRRMHWGFGYSLHVCALRPWSRGTVTLASADAREAPRIDPRFLSDARDLELL
EEEHHCCCCCEEEEECCCEEEEEEECCCCCCEEEEEECCCCCCCCCCHHHHCCHHHHHHH
MKGAKVIRRILAAQPLASQGGRELYTDPADDDDALRAAIVAHADTIYHPVGTCRMGGDPA
HHHHHHHHHHHHCCCHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCH
SVVDPQLRVRGVTGLRVVDASVMPTLIGGNTNAPSVMIGERAADFIAAARRGSVPQPIES
HHCCCCCEEECCCCEEEECCCCCCEEECCCCCCCEEEECHHHHHHHHHHHCCCCCCCHHH
VAPMAAAAGAWMSRGAAG
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11390693 [H]