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The map label for this gene is phbA [H]

Identifier: 238028775

GI number: 238028775

Start: 3679313

End: 3680506

Strand: Direct

Name: phbA [H]

Synonym: bglu_1g32390

Alternate gene names: 238028775

Gene position: 3679313-3680506 (Clockwise)

Preceding gene: 238028774

Following gene: 238028776

Centisome position: 94.18

GC content: 73.37

Gene sequence:

>1194_bases
ATGACGACTGCTGAACGTGATCCGGTCGTGATCGCCGCGGCGGCACGCACGCCGATCGCGGGCTTCCAGGGCGGCTTCGC
GCCGCTCACCGCGCCGCAGCTCGGCAGCGCCGCGATCGCCGCGGCACTGCAGCGCGCCGGCCTCGCGCCCGAGCAGGTCG
AGGAAGTGGTGATGGGCTGCGTGCTGCCCGCCGGGCAGGGCCAGGCGCCCGCGCGGCAGGCCGCGCTCGGCGCGAAGCTG
CCGCTCGCGGCCGGCTGCACCACCGTCAACAAGATGTGCGGCTCGGGCATGCGCGCGGCGATGTTCGCGCACGACATGCT
GCTGGCCGGCTCGGCCGAGGTGATCGTGGCGGGCGGCATGGAGAGCATGACCAACGCGCCGTACCTGCTGCCGAAGGCGC
GCGGCGGGATGCGCATGGGCCATGGCGAGGTGCTCGACCACATGTTCCTCGACGGGCTCGAGGACGCCTACGAGCGCGGC
CGGCTGATGGGCACCTTCGCCGACGAGTGCGCGGCCGAATACGGCTTCACGCGCGAGGCGCAGGACGCCTTTGCGATCGA
GTCGCTGGCGCGCGCCAGGCGCGCCAACGAGGACGGTTCGTTTTCCTGGGAAATGGTGCCGGTGAGCGTCGCCTCCCGCA
AGGGCGAGACCGTGGTGACGCGCGACGAGCAGCCGTTCAGCGCGAAGCCGGAGAAGATTCCCACGCTGAAGCCGGCGTTC
GGGCCGAACGGCACCGTGACGGCCGCCAATGCCTCGTCGATCTCCGACGGCGCGGCCGCGCTGGTGATGATGCGCGCCTC
CACGGCCGAGCGGCTCGGCACCACGCCGATCGCGCGCGTGGTGGCCCACAGCACCTTCGCGCAGGCACCCTCGCGCTTCA
CCACGGCGCCGGTGGGGGCGCTGCGGCGCCTGTTCGAGCGCACCGGCTGGCGGCCGTCCGACGTCGACCTGTTCGAGATC
AACGAGGCGTTCGCCGTGGTGGCGATGGCCGCCATGAAGGAGCACGGGCTGGCGCACGAACGCGTCAACGTCAACGGCGG
CGCCTGCGCGCTCGGCCATCCGATCGGCGCCTCGGGCGCGCGCATCGTCGCCACGCTGCTCGGCGCGCTGCGCGCGCGCG
GCGGCAAGCGCGGCATGGCGAGCCTCTGCATCGGCGGCGGCGAGGCCACGGCGCTGGCCGTCGAACTGTACTGA

Upstream 100 bases:

>100_bases
GGGCGTGCACTGTCGGCGGACAACGATATGGTCGCGGCCGATGCGGCGAAGCTCGCCGACGTCGCCGAACAGGTCGCGAA
TACTCTGATGGAGACGAAAC

Downstream 100 bases:

>100_bases
TCGGCCTCGACCCGGAGACTCATCGATGAAAACCGTCCTGATCGTCGGCGCGTCGCGCGGCCTGGGCAGGGAGTTTGTCC
GCCAGTACCGGCGTGACGGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MTTAERDPVVIAAAARTPIAGFQGGFAPLTAPQLGSAAIAAALQRAGLAPEQVEEVVMGCVLPAGQGQAPARQAALGAKL
PLAAGCTTVNKMCGSGMRAAMFAHDMLLAGSAEVIVAGGMESMTNAPYLLPKARGGMRMGHGEVLDHMFLDGLEDAYERG
RLMGTFADECAAEYGFTREAQDAFAIESLARARRANEDGSFSWEMVPVSVASRKGETVVTRDEQPFSAKPEKIPTLKPAF
GPNGTVTAANASSISDGAAALVMMRASTAERLGTTPIARVVAHSTFAQAPSRFTTAPVGALRRLFERTGWRPSDVDLFEI
NEAFAVVAMAAMKEHGLAHERVNVNGGACALGHPIGASGARIVATLLGALRARGGKRGMASLCIGGGEATALAVELY

Sequences:

>Translated_397_residues
MTTAERDPVVIAAAARTPIAGFQGGFAPLTAPQLGSAAIAAALQRAGLAPEQVEEVVMGCVLPAGQGQAPARQAALGAKL
PLAAGCTTVNKMCGSGMRAAMFAHDMLLAGSAEVIVAGGMESMTNAPYLLPKARGGMRMGHGEVLDHMFLDGLEDAYERG
RLMGTFADECAAEYGFTREAQDAFAIESLARARRANEDGSFSWEMVPVSVASRKGETVVTRDEQPFSAKPEKIPTLKPAF
GPNGTVTAANASSISDGAAALVMMRASTAERLGTTPIARVVAHSTFAQAPSRFTTAPVGALRRLFERTGWRPSDVDLFEI
NEAFAVVAMAAMKEHGLAHERVNVNGGACALGHPIGASGARIVATLLGALRARGGKRGMASLCIGGGEATALAVELY
>Mature_396_residues
TTAERDPVVIAAAARTPIAGFQGGFAPLTAPQLGSAAIAAALQRAGLAPEQVEEVVMGCVLPAGQGQAPARQAALGAKLP
LAAGCTTVNKMCGSGMRAAMFAHDMLLAGSAEVIVAGGMESMTNAPYLLPKARGGMRMGHGEVLDHMFLDGLEDAYERGR
LMGTFADECAAEYGFTREAQDAFAIESLARARRANEDGSFSWEMVPVSVASRKGETVVTRDEQPFSAKPEKIPTLKPAFG
PNGTVTAANASSISDGAAALVMMRASTAERLGTTPIARVVAHSTFAQAPSRFTTAPVGALRRLFERTGWRPSDVDLFEIN
EAFAVVAMAAMKEHGLAHERVNVNGGACALGHPIGASGARIVATLLGALRARGGKRGMASLCIGGGEATALAVELY

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=389, Percent_Identity=46.2724935732648, Blast_Score=331, Evalue=7e-91,
Organism=Homo sapiens, GI148539872, Length=396, Percent_Identity=45.2020202020202, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=35.969387755102, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI4501853, Length=398, Percent_Identity=36.9346733668342, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=31.2056737588652, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI194353979, Length=88, Percent_Identity=51.1363636363636, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1788554, Length=388, Percent_Identity=48.1958762886598, Blast_Score=317, Evalue=7e-88,
Organism=Escherichia coli, GI87082165, Length=388, Percent_Identity=44.0721649484536, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI1787663, Length=397, Percent_Identity=36.5239294710327, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=36.6583541147132, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1788683, Length=415, Percent_Identity=28.9156626506024, Blast_Score=141, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17535921, Length=389, Percent_Identity=44.7300771208226, Blast_Score=307, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI25147385, Length=385, Percent_Identity=40.7792207792208, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI133906874, Length=388, Percent_Identity=37.8865979381443, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI17535917, Length=389, Percent_Identity=33.1619537275064, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=423, Percent_Identity=30.9692671394799, Blast_Score=168, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=393, Percent_Identity=43.5114503816794, Blast_Score=306, Evalue=5e-84,
Organism=Saccharomyces cerevisiae, GI6322031, Length=391, Percent_Identity=32.7365728900256, Blast_Score=176, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24655093, Length=388, Percent_Identity=44.8453608247423, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI24640423, Length=389, Percent_Identity=46.5295629820051, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI17648125, Length=396, Percent_Identity=33.8383838383838, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17137578, Length=423, Percent_Identity=29.0780141843972, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41054; Mature: 40922

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAERDPVVIAAAARTPIAGFQGGFAPLTAPQLGSAAIAAALQRAGLAPEQVEEVVMGC
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
VLPAGQGQAPARQAALGAKLPLAAGCTTVNKMCGSGMRAAMFAHDMLLAGSAEVIVAGGM
HCCCCCCCCCHHHHHHCCCCCHHHCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCH
ESMTNAPYLLPKARGGMRMGHGEVLDHMFLDGLEDAYERGRLMGTFADECAAEYGFTREA
HHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCCCH
QDAFAIESLARARRANEDGSFSWEMVPVSVASRKGETVVTRDEQPFSAKPEKIPTLKPAF
HHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCC
GPNGTVTAANASSISDGAAALVMMRASTAERLGTTPIARVVAHSTFAQAPSRFTTAPVGA
CCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHH
LRRLFERTGWRPSDVDLFEINEAFAVVAMAAMKEHGLAHERVNVNGGACALGHPIGASGA
HHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCHHEEECCCCEEECCCCCCCCHH
RIVATLLGALRARGGKRGMASLCIGGGEATALAVELY
HHHHHHHHHHHHCCCCCCCHHEEECCCCEEEEEEEEC
>Mature Secondary Structure 
TTAERDPVVIAAAARTPIAGFQGGFAPLTAPQLGSAAIAAALQRAGLAPEQVEEVVMGC
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
VLPAGQGQAPARQAALGAKLPLAAGCTTVNKMCGSGMRAAMFAHDMLLAGSAEVIVAGGM
HCCCCCCCCCHHHHHHCCCCCHHHCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCH
ESMTNAPYLLPKARGGMRMGHGEVLDHMFLDGLEDAYERGRLMGTFADECAAEYGFTREA
HHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCCCH
QDAFAIESLARARRANEDGSFSWEMVPVSVASRKGETVVTRDEQPFSAKPEKIPTLKPAF
HHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCC
GPNGTVTAANASSISDGAAALVMMRASTAERLGTTPIARVVAHSTFAQAPSRFTTAPVGA
CCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHH
LRRLFERTGWRPSDVDLFEINEAFAVVAMAAMKEHGLAHERVNVNGGACALGHPIGASGA
HHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCHHEEECCCCEEECCCCCCCCHH
RIVATLLGALRARGGKRGMASLCIGGGEATALAVELY
HHHHHHHHHHHHCCCCCCCHHEEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2670935; 2670936 [H]