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The map label for this gene is ctaB [H]

Identifier: 238028695

GI number: 238028695

Start: 3594190

End: 3595092

Strand: Reverse

Name: ctaB [H]

Synonym: bglu_1g31590

Alternate gene names: 238028695

Gene position: 3595092-3594190 (Counterclockwise)

Preceding gene: 238028696

Following gene: 238028694

Centisome position: 92.03

GC content: 66.33

Gene sequence:

>903_bases
ATGGAATCCTCGCTTTCCCAGTCCTCCGGCAGCCGCCTGTCGCAATATTTCGCGCTGACCAAGCCGCGCGTCACGCAACT
CGCGGTGTTCTGCGCCGTGATCGGGATGTTCCTCGCCACGCCCGGCATGGTGCCGCTGCGCCCGCTGATCGGCGGCACGA
TCGGCATCTGGCTGCTGGCCGGCGCCGCGTTCGCGATCAACTGTCTCGTCGAGCAGAAGATCGACGCGAAGATGCGCCGC
ACCGCATGGCGGCCTTCCGCGCGCGGCGAGATCACCACGCCGCAGATCCTGGCCTTCTCGACGGTGCTCGGCGGCGTCGG
CGCGTGGACGCTCTACACCTTCACGAATCCGCTGACGATGTGGCTGACGATCGCCACCTTCGTCGGCTACGCGGTCGTCT
ACACGCTGCTGCTCAAACCCGCCACGCCGCAGAACATCGTGATCGGCGGCGCGTCCGGCGCGATGCCGCCGGCGCTCGGC
TGGGCCGCCGTGACGGGCACCGTGCCCGGCGACGCGTGGATCCTGGTGCTGATCATCTTCGTCTGGACCCCGCCGCACTT
CTGGGTGCTCGCGCTCTACCGGATCAAGGACTACGAGAACTCGGGCCTGCCGATGCTGCCCGTCACGCACGGCGAGAAGT
TCACGCGGCTGCACATCCTGCTCTACACGCTCATCCTGTTCGTCGTGACGATGATGCCGTTCATCTCGGGCATGAGCGGC
GTGGTCTATCTGGCGAGCGCGGTGCTGCTCGGTGCGGTGTTCATCGCCTACGCGTGGAAGGTCTACGTCGACTATTCCGA
TGCGCTCGCGCGCCGCGCGTTCCGCTACTCGATCGTCTATCTCTCGCTGCTGTTCATGGCGCTGCTCGTCGATCATTACC
TGCGCCCGCTGCTCGGCTTCTGA

Upstream 100 bases:

>100_bases
TGTTGCTCGTCATGTTAAACTTTCGAATCCTTTCAAGCCGTCCCGGCCGCGTCGCGCTTCGCGCGCGCGACATCGCGCCC
GCCTGACGCTCCCCACGCCC

Downstream 100 bases:

>100_bases
GCGCGCCGCGATGATGCCGCGCCCCATCCCGTCCACGCGGCGGCGCTGGCTGGCCGCCTGCGCCGCGGCCGGCGCGCTGC
TGCTCGGCGGCTGCAGCCGC

Product: protoheme IX farnesyltransferase

Products: heme O; pyrophosphate [C]

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MESSLSQSSGSRLSQYFALTKPRVTQLAVFCAVIGMFLATPGMVPLRPLIGGTIGIWLLAGAAFAINCLVEQKIDAKMRR
TAWRPSARGEITTPQILAFSTVLGGVGAWTLYTFTNPLTMWLTIATFVGYAVVYTLLLKPATPQNIVIGGASGAMPPALG
WAAVTGTVPGDAWILVLIIFVWTPPHFWVLALYRIKDYENSGLPMLPVTHGEKFTRLHILLYTLILFVVTMMPFISGMSG
VVYLASAVLLGAVFIAYAWKVYVDYSDALARRAFRYSIVYLSLLFMALLVDHYLRPLLGF

Sequences:

>Translated_300_residues
MESSLSQSSGSRLSQYFALTKPRVTQLAVFCAVIGMFLATPGMVPLRPLIGGTIGIWLLAGAAFAINCLVEQKIDAKMRR
TAWRPSARGEITTPQILAFSTVLGGVGAWTLYTFTNPLTMWLTIATFVGYAVVYTLLLKPATPQNIVIGGASGAMPPALG
WAAVTGTVPGDAWILVLIIFVWTPPHFWVLALYRIKDYENSGLPMLPVTHGEKFTRLHILLYTLILFVVTMMPFISGMSG
VVYLASAVLLGAVFIAYAWKVYVDYSDALARRAFRYSIVYLSLLFMALLVDHYLRPLLGF
>Mature_300_residues
MESSLSQSSGSRLSQYFALTKPRVTQLAVFCAVIGMFLATPGMVPLRPLIGGTIGIWLLAGAAFAINCLVEQKIDAKMRR
TAWRPSARGEITTPQILAFSTVLGGVGAWTLYTFTNPLTMWLTIATFVGYAVVYTLLLKPATPQNIVIGGASGAMPPALG
WAAVTGTVPGDAWILVLIIFVWTPPHFWVLALYRIKDYENSGLPMLPVTHGEKFTRLHILLYTLILFVVTMMPFISGMSG
VVYLASAVLLGAVFIAYAWKVYVDYSDALARRAFRYSIVYLSLLFMALLVDHYLRPLLGF

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=256, Percent_Identity=30.078125, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786631, Length=280, Percent_Identity=32.8571428571429, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71998235, Length=286, Percent_Identity=29.3706293706294, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6325085, Length=215, Percent_Identity=32.093023255814, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI19921064, Length=283, Percent_Identity=29.3286219081272, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.- [C]

Molecular weight: Translated: 32911; Mature: 32911

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESSLSQSSGSRLSQYFALTKPRVTQLAVFCAVIGMFLATPGMVPLRPLIGGTIGIWLLA
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GAAFAINCLVEQKIDAKMRRTAWRPSARGEITTPQILAFSTVLGGVGAWTLYTFTNPLTM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHEECCCHHHH
WLTIATFVGYAVVYTLLLKPATPQNIVIGGASGAMPPALGWAAVTGTVPGDAWILVLIIF
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHEECCCCCHHHHHHHHHH
VWTPPHFWVLALYRIKDYENSGLPMLPVTHGEKFTRLHILLYTLILFVVTMMPFISGMSG
HHCCCHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
VVYLASAVLLGAVFIAYAWKVYVDYSDALARRAFRYSIVYLSLLFMALLVDHYLRPLLGF
HHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MESSLSQSSGSRLSQYFALTKPRVTQLAVFCAVIGMFLATPGMVPLRPLIGGTIGIWLLA
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GAAFAINCLVEQKIDAKMRRTAWRPSARGEITTPQILAFSTVLGGVGAWTLYTFTNPLTM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHEECCCHHHH
WLTIATFVGYAVVYTLLLKPATPQNIVIGGASGAMPPALGWAAVTGTVPGDAWILVLIIF
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHEECCCCCHHHHHHHHHH
VWTPPHFWVLALYRIKDYENSGLPMLPVTHGEKFTRLHILLYTLILFVVTMMPFISGMSG
HHCCCHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
VVYLASAVLLGAVFIAYAWKVYVDYSDALARRAFRYSIVYLSLLFMALLVDHYLRPLLGF
HHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protoheme; farnesyl-PP [C]

Specific reaction: protoheme + farnesyl-PP = heme O + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA