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The map label for this gene is purK [H]

Identifier: 238028509

GI number: 238028509

Start: 3367226

End: 3368419

Strand: Reverse

Name: purK [H]

Synonym: bglu_1g29730

Alternate gene names: 238028509

Gene position: 3368419-3367226 (Counterclockwise)

Preceding gene: 238028510

Following gene: 238028508

Centisome position: 86.23

GC content: 73.28

Gene sequence:

>1194_bases
ATGACTGCACACTCCACTCCGGTTTCACCGATCCTGCCCGGCGCCTGGCTCGGCATGGTCGGCGGCGGCCAGCTCGGCCG
CATGTTCTGCTTCGCGGCGCAGGCGATGGGCTATCGCGTCGCCGTGCTCGATCCCGACGCGGCAAGCCCCGCCGGCTCGG
TGGCCGACCGCCACCTGCGCGCGGCCTACGACGACGAGGCGGCGCTCGCCGAACTCGCCGCGCTGTGCGCGGCCGTGTCG
ACCGAATTCGAAAACGTGCCGGCCGCGAGCCTCGAGTTCCTGGCCCGCACCACCTTCGTCGCGCCGGCCGGGCGCTGCGT
GGCGATCGCGCAGGACCGGATCGCCGAGAAGCGCTTCATCGCTGGCTCGGGCGTGCCGGTCGCGCCGCACGTCGTGATCG
AATCGGCCGACGCGCTGGCCGCGCTTGGCGACGCCGAGCTCGACGCGGTGCTGCCCGGCATCCTGAAGACGGCGCGCCTG
GGCTACGACGGCAAGGGCCAGGTGCGCGTGGCGACGGCCGCCGAGGTGCGCGCCGCGTTCGCCTCGCTGCGCGGCGTGCC
GTGCGTGCTGGAGAAGCGCCTGGCGCTCAAGTACGAAGTGTCGGCGCTGATCGCGCGCGGCGTCGACGGCCGCTCGGCCG
CGTTCCCGCTCGCGCAGAACACGCATCATCAAGGCATCCTGTCGCTGACGGTGGTGCCGGCGCCGGCCGCCGACGCCGCG
CTGGCCGCCGCCGCGCAGCAGGCCGCGGTGCGGATCGCCGATTCGCTCGACTATGTCGGCGTGCTCTGCGTCGAGTTCTT
CGTGCTGGAGGACGGCAGCCTGGTCGCCAATGAGATGGCGCCGCGCCCGCACAACTCCGGCCACTACACGGTCGATGCCT
GTTCGGCCAGCCAGTTCGAGCAGCAGGTGCGCGCGATGACGCGGCTGCCGCTCGGCAACCCGCGCCAGCATTCGCCGGCG
GCGATGCTGAACGTGCTCGGCGACATCTGGTTCGCCGACGGCGCGAGCGAGGCGGTCACGCCGCCGTGGGAGCGCGTGGC
GGCGATGCCGGCCGCGCACCTGCACCTGTACGGCAAGCAAGAGGCGCGCGTGGGCCGCAAGATGGGCCACGTGAACTTCA
CCGCCGAGACGCTCGACGCGGCGCTCGAGGCCGCGCACGACTGCGCGCGGCTGCTGCGCGTGCCGCTCGACTGA

Upstream 100 bases:

>100_bases
AAGCCGCGCATGCGATGGTGCTGCCGCCGCTGTAAGCGGCGCGGCTCCCGAAGTCCCACGGCGGCGCGCCCGACGGCGCC
CGCCGCGCTCGATCACTGAC

Downstream 100 bases:

>100_bases
GGGGCGCGCCACGATGACTTCCGACGCCCGCCCGACGCCCGCCGGCAGCGCGCCCGACGCATCCGGCCCGCACGGCGTGC
CGGCCGCGCGGATCGACGAG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MTAHSTPVSPILPGAWLGMVGGGQLGRMFCFAAQAMGYRVAVLDPDAASPAGSVADRHLRAAYDDEAALAELAALCAAVS
TEFENVPAASLEFLARTTFVAPAGRCVAIAQDRIAEKRFIAGSGVPVAPHVVIESADALAALGDAELDAVLPGILKTARL
GYDGKGQVRVATAAEVRAAFASLRGVPCVLEKRLALKYEVSALIARGVDGRSAAFPLAQNTHHQGILSLTVVPAPAADAA
LAAAAQQAAVRIADSLDYVGVLCVEFFVLEDGSLVANEMAPRPHNSGHYTVDACSASQFEQQVRAMTRLPLGNPRQHSPA
AMLNVLGDIWFADGASEAVTPPWERVAAMPAAHLHLYGKQEARVGRKMGHVNFTAETLDAALEAAHDCARLLRVPLD

Sequences:

>Translated_397_residues
MTAHSTPVSPILPGAWLGMVGGGQLGRMFCFAAQAMGYRVAVLDPDAASPAGSVADRHLRAAYDDEAALAELAALCAAVS
TEFENVPAASLEFLARTTFVAPAGRCVAIAQDRIAEKRFIAGSGVPVAPHVVIESADALAALGDAELDAVLPGILKTARL
GYDGKGQVRVATAAEVRAAFASLRGVPCVLEKRLALKYEVSALIARGVDGRSAAFPLAQNTHHQGILSLTVVPAPAADAA
LAAAAQQAAVRIADSLDYVGVLCVEFFVLEDGSLVANEMAPRPHNSGHYTVDACSASQFEQQVRAMTRLPLGNPRQHSPA
AMLNVLGDIWFADGASEAVTPPWERVAAMPAAHLHLYGKQEARVGRKMGHVNFTAETLDAALEAAHDCARLLRVPLD
>Mature_396_residues
TAHSTPVSPILPGAWLGMVGGGQLGRMFCFAAQAMGYRVAVLDPDAASPAGSVADRHLRAAYDDEAALAELAALCAAVST
EFENVPAASLEFLARTTFVAPAGRCVAIAQDRIAEKRFIAGSGVPVAPHVVIESADALAALGDAELDAVLPGILKTARLG
YDGKGQVRVATAAEVRAAFASLRGVPCVLEKRLALKYEVSALIARGVDGRSAAFPLAQNTHHQGILSLTVVPAPAADAAL
AAAAQQAAVRIADSLDYVGVLCVEFFVLEDGSLVANEMAPRPHNSGHYTVDACSASQFEQQVRAMTRLPLGNPRQHSPAA
MLNVLGDIWFADGASEAVTPPWERVAAMPAAHLHLYGKQEARVGRKMGHVNFTAETLDAALEAAHDCARLLRVPLD

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=372, Percent_Identity=34.9462365591398, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1788155, Length=385, Percent_Identity=27.012987012987, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324702, Length=374, Percent_Identity=32.8877005347594, Blast_Score=201, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 41488; Mature: 41357

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAHSTPVSPILPGAWLGMVGGGQLGRMFCFAAQAMGYRVAVLDPDAASPAGSVADRHLR
CCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHH
AAYDDEAALAELAALCAAVSTEFENVPAASLEFLARTTFVAPAGRCVAIAQDRIAEKRFI
HHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHEE
AGSGVPVAPHVVIESADALAALGDAELDAVLPGILKTARLGYDGKGQVRVATAAEVRAAF
CCCCCCCCCHHEEECCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHH
ASLRGVPCVLEKRLALKYEVSALIARGVDGRSAAFPLAQNTHHQGILSLTVVPAPAADAA
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHH
LAAAAQQAAVRIADSLDYVGVLCVEFFVLEDGSLVANEMAPRPHNSGHYTVDACSASQFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCCCCCCCCEEEEECCHHHHH
QQVRAMTRLPLGNPRQHSPAAMLNVLGDIWFADGASEAVTPPWERVAAMPAAHLHLYGKQ
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHEEEECCH
EARVGRKMGHVNFTAETLDAALEAAHDCARLLRVPLD
HHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TAHSTPVSPILPGAWLGMVGGGQLGRMFCFAAQAMGYRVAVLDPDAASPAGSVADRHLR
CCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHH
AAYDDEAALAELAALCAAVSTEFENVPAASLEFLARTTFVAPAGRCVAIAQDRIAEKRFI
HHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHEE
AGSGVPVAPHVVIESADALAALGDAELDAVLPGILKTARLGYDGKGQVRVATAAEVRAAF
CCCCCCCCCHHEEECCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHH
ASLRGVPCVLEKRLALKYEVSALIARGVDGRSAAFPLAQNTHHQGILSLTVVPAPAADAA
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHH
LAAAAQQAAVRIADSLDYVGVLCVEFFVLEDGSLVANEMAPRPHNSGHYTVDACSASQFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCCCCCCCCEEEEECCHHHHH
QQVRAMTRLPLGNPRQHSPAAMLNVLGDIWFADGASEAVTPPWERVAAMPAAHLHLYGKQ
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHEEEECCH
EARVGRKMGHVNFTAETLDAALEAAHDCARLLRVPLD
HHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]