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The map label for this gene is hssS [H]

Identifier: 238028082

GI number: 238028082

Start: 2890115

End: 2892052

Strand: Reverse

Name: hssS [H]

Synonym: bglu_1g25330

Alternate gene names: 238028082

Gene position: 2892052-2890115 (Counterclockwise)

Preceding gene: 238028083

Following gene: 238028081

Centisome position: 74.03

GC content: 71.67

Gene sequence:

>1938_bases
ATGCCCGGCTCGCGGCTGCTGAGACGGGCGCTGCCGGCGGCGCTACGGCGGCTCGGCACCTACCAGAAGATCCGCATCGG
ATTCCTGGTCGTCGCGGCGATCATCGCGCTGCTGTGCGCCACCATCATCGCCGGCAACGTCGACCGCTTCCGCAAGAGCA
GCGGCGATCTGCAGGGCTTCGAGCTGGCGCGCAGCGCGATGGCGGCGGCCAGCATCGTGTCGGCCGAGCGCGGGCCGATG
AACAACCTGCTGGTCGACCCGCAGCGCGACGACGCGCGCGAGCGCGCCGAACTGGCGGTGGCGCGGGCCGCCTCCGACCA
CGCGTTGCTGCGCTTTCGGGTGCTCGCCGCGCAGCAGGGCGCGCGCGGCGACGAGCAGGCGGCACGCGCGCCGGCGCTGA
TCGACGCGGTCGGTCTGCAACTGGCGCGGGCGCGCCGCGAGGCCGACGCGCTGGCCGCGCGCGCGCCGGTGCAACGCGAA
GCGGGACAGCTGCGGCGGGTGCAGGCCGAGATGTTCGCCGTCGTCGACGCGCTGACGCCGTTGAGCGACGATCTGCTGAT
TCGGCTGACACGCAACAATCCCGACGTGGCGGGGGCGGTGATCCTGGCGCGTCAGGCCGGCGACCTGCGCGAATATTCGG
GGCGCCTCGGCTCCAAGCTGGTCGCCGCGCTGTTCGCGCAAGTGCCGCTCGCCGACCAGCCGCTGATGGAAATCGCGCAC
CTGAGCGGCCAGATCGACGAACTGCGCACGCTGATCGCCAGCACCATCAAGCCCTATCTCGACGATGCCCTGCTCGCGCG
CGACTTTCGCCAGCTGCGCGGTTCGATGGGCGGCGGGCTGATGCCGCTCGCCGGCTCGATCGTCGCCCAGGGCCGCGACG
GCGTCTACGCCATGAGCGCGGCCGATTTCTCGCGGCAGGCGGTGCTGTATTTCCGCGCCTCCGAGCTGCTGCGCGACCGC
GCGATGGCGATCGCGAGCCGCGAGGCGGTGGCGTCGCGCGACCTCGCGCGGGCCAGGGTGGTGGTGTCGGTGGCCATGGC
GCTGCTGAGCCTCGTGATCCTGCTGGTGTTCGCGCGGGGCGCGCAGAACGCGCTGCTCAAGCCGCTCGGCGTGCTCGGCA
AGCGCATCGCCGCGCTCGGCGACGGCGACCGTGCCGCGGCGATCCGCCCGCCCGCCGCGGCCGGCCCCGAACTGGTGCGC
GTGTATCGCGCGTTCGAGACGCTGCGCCAGGCCCAGCTGCGTCGCGAGGTGCTGGAGCGCCAGCGCAGCGACATGCTGAT
GCTGTTCTCGCACGACATGCGCGCGCCGCTGACCTCGCTGATTACGCTTGCCGGCGCGTCCGGGCCTGCTGCCGGCGACG
ACACGCGGCAGCGGCTGGAGAAGGTCGAGAAGCTCGCGCGCCACACGCTGGCGATGGCCGACGGCTTCGTGCAGGTGTCA
CGAGCCGAGGCCAGCGAATTCGAGTCGATCCCGGTCAATCTCAGCGACCTGCTCAACGAGGCCCGCGACACGATCTGGCC
GGTCGCGCACGACCGGCAGGTGGCGATCGACGACGTGCCGCGCCGCGACGACGCGATCGTCCACGGCGACCCCGCACTGT
TGTCGCGGGCCTTGGTCAACCTGTTGAGCAACGCGGTGAAATACACCATGCCGCACACCCGCGTCGAGTGCGCGGTGGAC
ATCGTCGACAATCGCTCGGCGGTGCGCTGCACGATTCGCGATCACGGTTATGGCATCGACCAGGAAGCGCAGTGCCATCT
GTTCGAGCGTTACCGGCGCTTCCGGCTCGAAGGCCAGCCGGAGACCAGCGGCGTCGGGCTCGGCCTGGCTTTCGTGAAGG
CGGTGATCATGCGCCACCGCGGCGAGATCCGCGTGCAGAGCGCCGCCTGGCAGGGCACCACCGTGACGATCACGCTGCCG
GTGGCCCGCGAGGCCTAG

Upstream 100 bases:

>100_bases
GGCGGGCCGGTGCCACGGCGCGCCGCCGCCGCGGCCGGTGCCGCTTCGCGACCGGTCCGGCCCGCGCGCCGGGCCGCCCG
GGGTGGCGGAGGGCGGCGTC

Downstream 100 bases:

>100_bases
CCCGGCTGCCGCCACGGCATGTCAGGAAGCGATGATTCCTATATTAAATGCCGGTATTAAGTGCCGGGAGTTGATATTTA
TATTGAAAATATTGCCGATT

Product: two-component regulatory system sensor kinase protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 645; Mature: 644

Protein sequence:

>645_residues
MPGSRLLRRALPAALRRLGTYQKIRIGFLVVAAIIALLCATIIAGNVDRFRKSSGDLQGFELARSAMAAASIVSAERGPM
NNLLVDPQRDDARERAELAVARAASDHALLRFRVLAAQQGARGDEQAARAPALIDAVGLQLARARREADALAARAPVQRE
AGQLRRVQAEMFAVVDALTPLSDDLLIRLTRNNPDVAGAVILARQAGDLREYSGRLGSKLVAALFAQVPLADQPLMEIAH
LSGQIDELRTLIASTIKPYLDDALLARDFRQLRGSMGGGLMPLAGSIVAQGRDGVYAMSAADFSRQAVLYFRASELLRDR
AMAIASREAVASRDLARARVVVSVAMALLSLVILLVFARGAQNALLKPLGVLGKRIAALGDGDRAAAIRPPAAAGPELVR
VYRAFETLRQAQLRREVLERQRSDMLMLFSHDMRAPLTSLITLAGASGPAAGDDTRQRLEKVEKLARHTLAMADGFVQVS
RAEASEFESIPVNLSDLLNEARDTIWPVAHDRQVAIDDVPRRDDAIVHGDPALLSRALVNLLSNAVKYTMPHTRVECAVD
IVDNRSAVRCTIRDHGYGIDQEAQCHLFERYRRFRLEGQPETSGVGLGLAFVKAVIMRHRGEIRVQSAAWQGTTVTITLP
VAREA

Sequences:

>Translated_645_residues
MPGSRLLRRALPAALRRLGTYQKIRIGFLVVAAIIALLCATIIAGNVDRFRKSSGDLQGFELARSAMAAASIVSAERGPM
NNLLVDPQRDDARERAELAVARAASDHALLRFRVLAAQQGARGDEQAARAPALIDAVGLQLARARREADALAARAPVQRE
AGQLRRVQAEMFAVVDALTPLSDDLLIRLTRNNPDVAGAVILARQAGDLREYSGRLGSKLVAALFAQVPLADQPLMEIAH
LSGQIDELRTLIASTIKPYLDDALLARDFRQLRGSMGGGLMPLAGSIVAQGRDGVYAMSAADFSRQAVLYFRASELLRDR
AMAIASREAVASRDLARARVVVSVAMALLSLVILLVFARGAQNALLKPLGVLGKRIAALGDGDRAAAIRPPAAAGPELVR
VYRAFETLRQAQLRREVLERQRSDMLMLFSHDMRAPLTSLITLAGASGPAAGDDTRQRLEKVEKLARHTLAMADGFVQVS
RAEASEFESIPVNLSDLLNEARDTIWPVAHDRQVAIDDVPRRDDAIVHGDPALLSRALVNLLSNAVKYTMPHTRVECAVD
IVDNRSAVRCTIRDHGYGIDQEAQCHLFERYRRFRLEGQPETSGVGLGLAFVKAVIMRHRGEIRVQSAAWQGTTVTITLP
VAREA
>Mature_644_residues
PGSRLLRRALPAALRRLGTYQKIRIGFLVVAAIIALLCATIIAGNVDRFRKSSGDLQGFELARSAMAAASIVSAERGPMN
NLLVDPQRDDARERAELAVARAASDHALLRFRVLAAQQGARGDEQAARAPALIDAVGLQLARARREADALAARAPVQREA
GQLRRVQAEMFAVVDALTPLSDDLLIRLTRNNPDVAGAVILARQAGDLREYSGRLGSKLVAALFAQVPLADQPLMEIAHL
SGQIDELRTLIASTIKPYLDDALLARDFRQLRGSMGGGLMPLAGSIVAQGRDGVYAMSAADFSRQAVLYFRASELLRDRA
MAIASREAVASRDLARARVVVSVAMALLSLVILLVFARGAQNALLKPLGVLGKRIAALGDGDRAAAIRPPAAAGPELVRV
YRAFETLRQAQLRREVLERQRSDMLMLFSHDMRAPLTSLITLAGASGPAAGDDTRQRLEKVEKLARHTLAMADGFVQVSR
AEASEFESIPVNLSDLLNEARDTIWPVAHDRQVAIDDVPRRDDAIVHGDPALLSRALVNLLSNAVKYTMPHTRVECAVDI
VDNRSAVRCTIRDHGYGIDQEAQCHLFERYRRFRLEGQPETSGVGLGLAFVKAVIMRHRGEIRVQSAAWQGTTVTITLPV
AREA

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=307, Percent_Identity=28.9902280130293, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1788713, Length=235, Percent_Identity=31.4893617021277, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789149, Length=254, Percent_Identity=27.9527559055118, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790346, Length=260, Percent_Identity=26.9230769230769, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1790436, Length=252, Percent_Identity=25.7936507936508, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=27.1186440677966, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 70005; Mature: 69874

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGSRLLRRALPAALRRLGTYQKIRIGFLVVAAIIALLCATIIAGNVDRFRKSSGDLQGF
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHH
ELARSAMAAASIVSAERGPMNNLLVDPQRDDARERAELAVARAASDHALLRFRVLAAQQG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
ARGDEQAARAPALIDAVGLQLARARREADALAARAPVQREAGQLRRVQAEMFAVVDALTP
CCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
LSDDLLIRLTRNNPDVAGAVILARQAGDLREYSGRLGSKLVAALFAQVPLADQPLMEIAH
CCCCEEEEEECCCCCHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LSGQIDELRTLIASTIKPYLDDALLARDFRQLRGSMGGGLMPLAGSIVAQGRDGVYAMSA
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEC
ADFSRQAVLYFRASELLRDRAMAIASREAVASRDLARARVVVSVAMALLSLVILLVFARG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AQNALLKPLGVLGKRIAALGDGDRAAAIRPPAAAGPELVRVYRAFETLRQAQLRREVLER
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QRSDMLMLFSHDMRAPLTSLITLAGASGPAAGDDTRQRLEKVEKLARHTLAMADGFVQVS
HHCCEEEEECCHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAEASEFESIPVNLSDLLNEARDTIWPVAHDRQVAIDDVPRRDDAIVHGDPALLSRALVN
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEECCHHHHHHHHHH
LLSNAVKYTMPHTRVECAVDIVDNRSAVRCTIRDHGYGIDQEAQCHLFERYRRFRLEGQP
HHHHHHHHCCCCCHHEEEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCC
ETSGVGLGLAFVKAVIMRHRGEIRVQSAAWQGTTVTITLPVAREA
CCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCC
>Mature Secondary Structure 
PGSRLLRRALPAALRRLGTYQKIRIGFLVVAAIIALLCATIIAGNVDRFRKSSGDLQGF
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHH
ELARSAMAAASIVSAERGPMNNLLVDPQRDDARERAELAVARAASDHALLRFRVLAAQQG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
ARGDEQAARAPALIDAVGLQLARARREADALAARAPVQREAGQLRRVQAEMFAVVDALTP
CCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
LSDDLLIRLTRNNPDVAGAVILARQAGDLREYSGRLGSKLVAALFAQVPLADQPLMEIAH
CCCCEEEEEECCCCCHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LSGQIDELRTLIASTIKPYLDDALLARDFRQLRGSMGGGLMPLAGSIVAQGRDGVYAMSA
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEC
ADFSRQAVLYFRASELLRDRAMAIASREAVASRDLARARVVVSVAMALLSLVILLVFARG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AQNALLKPLGVLGKRIAALGDGDRAAAIRPPAAAGPELVRVYRAFETLRQAQLRREVLER
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QRSDMLMLFSHDMRAPLTSLITLAGASGPAAGDDTRQRLEKVEKLARHTLAMADGFVQVS
HHCCEEEEECCHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAEASEFESIPVNLSDLLNEARDTIWPVAHDRQVAIDDVPRRDDAIVHGDPALLSRALVN
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEECCHHHHHHHHHH
LLSNAVKYTMPHTRVECAVDIVDNRSAVRCTIRDHGYGIDQEAQCHLFERYRRFRLEGQP
HHHHHHHHCCCCCHHEEEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCC
ETSGVGLGLAFVKAVIMRHRGEIRVQSAAWQGTTVTITLPVAREA
CCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA