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The map label for this gene is iscS [H]

Identifier: 238028020

GI number: 238028020

Start: 2804027

End: 2805250

Strand: Reverse

Name: iscS [H]

Synonym: bglu_1g24700

Alternate gene names: 238028020

Gene position: 2805250-2804027 (Counterclockwise)

Preceding gene: 238028021

Following gene: 238028019

Centisome position: 71.81

GC content: 64.46

Gene sequence:

>1224_bases
ATGAACAACGATATTCCTCACCTGCCCATCTACATGGACTACAGCGCGACGACCCCGGTCGATCCGCGCGTGGTCGACAA
GATGGTGCCGTACCTGCGCGAGCAGTTCGGCAACCCTGCGTCGCGCAGCCACGCTTACGGCTGGGATGCCGAACGCGCGG
TGGAAGAGGCGCGTGAACAGGTGGCGGCGCTCGTGAACGCGGACCCGCGCGAGATCATCTGGACCTCCGGCGCGACCGAA
TCCGACAATCTCGCGATCAAGGGTGCGGCGCACTTCTATCAGGGCAAGGGCAAGCACGTCATCACGGTGAAGACCGAGCA
CAAGGCCGTGCTCGATACTTGCCGCGAACTCGAGCGCGAAGGCTTCGAGCTCACCTATCTCGACGTGAAGGACGACGGCC
TGATCGACCTCGAAGTGTTCAAGGCCGCGCTGCGCCCCGACACGATCCTGGTGTCGGTGATGCACGTCAACAACGAGATC
GGCGTGATCCAGGACATCGAGACGATCGGCGAGATCTGCCGCGAGAAGGGCATCGTGTTCCACGTCGACGCGGCGCAGTC
GACCGGCAAGGTGGCGATCGATCTGGCGAAGCTGAAGGTCGATCTGATGTCGTTCTCGGCCCACAAGACCTATGGCCCGA
AGGGGATCGGCGCGCTCTACGTGCGCCGCAAGCCGCGCGTGCGGATCGAGGCGCAGATGCACGGCGGCGGTCACGAGCGC
GGCATGCGTTCGGGCACGCTGGCGACGCACCAGATCGTCGGCATGGGCGAGGCGTTCCGTATCGCGCGCGAGGAAATGGC
GGTCGAGAACGAGCGGGTGCGCGCGTTGCGCGACAAGCTGCTGCGCGGCCTCTCGCAGATCGAGGAAACCTACGTGAACG
GCGACATGGAGCACCGGGTTCCGCACAACCTCAACATCAGCTTCAACTTCGTCGAAGGCGAATCGCTGATCATGGCGATC
AAGGATGTCGCGGTGTCGTCCGGCTCGGCTTGCACCTCGGCGTCGCTGGAGCCTTCCTACGTGCTGCGCGCGCTCGGCCG
CAACGACGAGCTCGCCCACAGCTCGATCCGCTTCACGGTCGGCCGCTTCACGACCGAGCAGGACGTGGACTACGTGATCA
AGCTGCTGCAGGGCAAGATCGCCAAGCTGCGGGACCTGTCGCCGCTCTGGGAAATGCACAAGGACGGCATCGACCTCTCG
ACGATCGAGTGGGCCGCACACTGA

Upstream 100 bases:

>100_bases
CATCGCGAGTTCTTGACGCTGACGCGCGGCTGCCCGCGCGCATCGCCTGTCTACACAAAAAAGAATCGTCCCTGCATTGA
ATGAATACCCGGAGCGCCAG

Downstream 100 bases:

>100_bases
ATGAAGGTTGCGCGGCCCGGCGCCGCGTACACGTAACGCACAGGAGTCGAACATGTCTTACAGCAACAAGGTTCTGGATC
ACTACGAAAACCCGCGCAAC

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MNNDIPHLPIYMDYSATTPVDPRVVDKMVPYLREQFGNPASRSHAYGWDAERAVEEAREQVAALVNADPREIIWTSGATE
SDNLAIKGAAHFYQGKGKHVITVKTEHKAVLDTCRELEREGFELTYLDVKDDGLIDLEVFKAALRPDTILVSVMHVNNEI
GVIQDIETIGEICREKGIVFHVDAAQSTGKVAIDLAKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
GMRSGTLATHQIVGMGEAFRIAREEMAVENERVRALRDKLLRGLSQIEETYVNGDMEHRVPHNLNISFNFVEGESLIMAI
KDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEQDVDYVIKLLQGKIAKLRDLSPLWEMHKDGIDLS
TIEWAAH

Sequences:

>Translated_407_residues
MNNDIPHLPIYMDYSATTPVDPRVVDKMVPYLREQFGNPASRSHAYGWDAERAVEEAREQVAALVNADPREIIWTSGATE
SDNLAIKGAAHFYQGKGKHVITVKTEHKAVLDTCRELEREGFELTYLDVKDDGLIDLEVFKAALRPDTILVSVMHVNNEI
GVIQDIETIGEICREKGIVFHVDAAQSTGKVAIDLAKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
GMRSGTLATHQIVGMGEAFRIAREEMAVENERVRALRDKLLRGLSQIEETYVNGDMEHRVPHNLNISFNFVEGESLIMAI
KDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEQDVDYVIKLLQGKIAKLRDLSPLWEMHKDGIDLS
TIEWAAH
>Mature_407_residues
MNNDIPHLPIYMDYSATTPVDPRVVDKMVPYLREQFGNPASRSHAYGWDAERAVEEAREQVAALVNADPREIIWTSGATE
SDNLAIKGAAHFYQGKGKHVITVKTEHKAVLDTCRELEREGFELTYLDVKDDGLIDLEVFKAALRPDTILVSVMHVNNEI
GVIQDIETIGEICREKGIVFHVDAAQSTGKVAIDLAKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
GMRSGTLATHQIVGMGEAFRIAREEMAVENERVRALRDKLLRGLSQIEETYVNGDMEHRVPHNLNISFNFVEGESLIMAI
KDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEQDVDYVIKLLQGKIAKLRDLSPLWEMHKDGIDLS
TIEWAAH

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=400, Percent_Identity=58.75, Blast_Score=520, Evalue=1e-147,
Organism=Homo sapiens, GI156713448, Length=418, Percent_Identity=32.0574162679426, Blast_Score=191, Evalue=1e-48,
Organism=Escherichia coli, GI48994898, Length=402, Percent_Identity=73.8805970149254, Blast_Score=634, Evalue=0.0,
Organism=Escherichia coli, GI1787970, Length=225, Percent_Identity=27.1111111111111, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1789175, Length=229, Percent_Identity=28.3842794759825, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25143064, Length=401, Percent_Identity=60.3491271820449, Blast_Score=512, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17533177, Length=324, Percent_Identity=31.1728395061728, Blast_Score=138, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6319831, Length=399, Percent_Identity=57.6441102756892, Blast_Score=505, Evalue=1e-144,
Organism=Drosophila melanogaster, GI20129463, Length=400, Percent_Identity=57.25, Blast_Score=483, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45369; Mature: 45369

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNDIPHLPIYMDYSATTPVDPRVVDKMVPYLREQFGNPASRSHAYGWDAERAVEEAREQ
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
VAALVNADPREIIWTSGATESDNLAIKGAAHFYQGKGKHVITVKTEHKAVLDTCRELERE
HHHHHCCCCHHEEEECCCCCCCCEEEEECHHHCCCCCCEEEEEECCHHHHHHHHHHHHHC
GFELTYLDVKDDGLIDLEVFKAALRPDTILVSVMHVNNEIGVIQDIETIGEICREKGIVF
CCEEEEEEECCCCEEEHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEE
HVDAAQSTGKVAIDLAKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
EEECCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHC
GMRSGTLATHQIVGMGEAFRIAREEMAVENERVRALRDKLLRGLSQIEETYVNGDMEHRV
CCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PHNLNISFNFVEGESLIMAIKDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTV
CCCCCEEEEEECCCEEEEEEHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEE
GRFTTEQDVDYVIKLLQGKIAKLRDLSPLWEMHKDGIDLSTIEWAAH
ECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEECCC
>Mature Secondary Structure
MNNDIPHLPIYMDYSATTPVDPRVVDKMVPYLREQFGNPASRSHAYGWDAERAVEEAREQ
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
VAALVNADPREIIWTSGATESDNLAIKGAAHFYQGKGKHVITVKTEHKAVLDTCRELERE
HHHHHCCCCHHEEEECCCCCCCCEEEEECHHHCCCCCCEEEEEECCHHHHHHHHHHHHHC
GFELTYLDVKDDGLIDLEVFKAALRPDTILVSVMHVNNEIGVIQDIETIGEICREKGIVF
CCEEEEEEECCCCEEEHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEE
HVDAAQSTGKVAIDLAKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
EEECCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHC
GMRSGTLATHQIVGMGEAFRIAREEMAVENERVRALRDKLLRGLSQIEETYVNGDMEHRV
CCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PHNLNISFNFVEGESLIMAIKDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTV
CCCCCEEEEEECCCEEEEEEHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEE
GRFTTEQDVDYVIKLLQGKIAKLRDLSPLWEMHKDGIDLSTIEWAAH
ECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA