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The map label for this gene is cyp18 [H]

Identifier: 238027923

GI number: 238027923

Start: 2598698

End: 2599189

Strand: Direct

Name: cyp18 [H]

Synonym: bglu_1g23650

Alternate gene names: 238027923

Gene position: 2598698-2599189 (Clockwise)

Preceding gene: 238027922

Following gene: 238027924

Centisome position: 66.52

GC content: 60.37

Gene sequence:

>492_bases
ATGGTTGAACTGCATACGAACCACGGCGTGATCAAGCTCGAACTCGACGCCGCCAAGGCACCGAAGACGGTGGAGAACTT
CCTGAACTACGTGAAGGCCGGCCACTACGACGGCACGGTGTTCCATCGCGTCATCAACGGCTTCATGATCCAGGGCGGCG
GTTTCGAGCCGGGCATGAAGCAGAAGCCCACCGAAGCGCCGATCGACAACGAGGCGAACAACGGCCTGAAGAACGACAAC
TACACGGTCGCGATGGCGCGCACCAACGATCCGCACTCGGCGACCGCGCAATTCTTCATCAACGTCAACGACAACGACTT
TCTGAACCACTCGTCGCCGACGCCGCAAGGCTGGGGCTACGCCGTATTCGGCAAGGTGGTCGAAGGCCAGGACGTGGTGG
ACAAGATCAAGAGCGTCAAGACGGGCAGCAAGGGCTTCCACCAGGACGTGCCGAACGACGACGTGGTGATCGAAAAGGCC
GTGGTGGTCTGA

Upstream 100 bases:

>100_bases
CGTCAGCAAGTAAACCCCGGGCGCGCTGCGCCCTGCCACGCGGCCGCGTCGTCCCGACCGGCCGCGTGCCGTTTCACCCA
CCTCTAAAGAAGGAACCATC

Downstream 100 bases:

>100_bases
CGCGTTACGCAGACGCATCCCGATGCTGCAGGAAGCACCACCGCGAAGCGTCTCCGGGGGCGTGCCGGGCGAGCATGGGC
TCGCGCACGCGGCACGCCCC

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MVELHTNHGVIKLELDAAKAPKTVENFLNYVKAGHYDGTVFHRVINGFMIQGGGFEPGMKQKPTEAPIDNEANNGLKNDN
YTVAMARTNDPHSATAQFFINVNDNDFLNHSSPTPQGWGYAVFGKVVEGQDVVDKIKSVKTGSKGFHQDVPNDDVVIEKA
VVV

Sequences:

>Translated_163_residues
MVELHTNHGVIKLELDAAKAPKTVENFLNYVKAGHYDGTVFHRVINGFMIQGGGFEPGMKQKPTEAPIDNEANNGLKNDN
YTVAMARTNDPHSATAQFFINVNDNDFLNHSSPTPQGWGYAVFGKVVEGQDVVDKIKSVKTGSKGFHQDVPNDDVVIEKA
VVV
>Mature_163_residues
MVELHTNHGVIKLELDAAKAPKTVENFLNYVKAGHYDGTVFHRVINGFMIQGGGFEPGMKQKPTEAPIDNEANNGLKNDN
YTVAMARTNDPHSATAQFFINVNDNDFLNHSSPTPQGWGYAVFGKVVEGQDVVDKIKSVKTGSKGFHQDVPNDDVVIEKA
VVV

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=163, Percent_Identity=33.1288343558282, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI24308049, Length=159, Percent_Identity=35.8490566037736, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI22547215, Length=163, Percent_Identity=31.9018404907975, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI22547212, Length=163, Percent_Identity=31.9018404907975, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI7657473, Length=163, Percent_Identity=31.9018404907975, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI19557636, Length=165, Percent_Identity=30.9090909090909, Blast_Score=78, Evalue=3e-15,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=67.9012345679012, Blast_Score=228, Evalue=2e-61,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=57.4074074074074, Blast_Score=174, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71980590, Length=147, Percent_Identity=35.3741496598639, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71980594, Length=147, Percent_Identity=35.3741496598639, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17532641, Length=166, Percent_Identity=33.1325301204819, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=143, Percent_Identity=34.965034965035, Blast_Score=76, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=163, Percent_Identity=30.0613496932515, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922912, Length=162, Percent_Identity=38.8888888888889, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24652460, Length=153, Percent_Identity=28.7581699346405, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI19922376, Length=165, Percent_Identity=27.8787878787879, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17986117, Length=165, Percent_Identity=30.3030303030303, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17824; Mature: 17824

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVELHTNHGVIKLELDAAKAPKTVENFLNYVKAGHYDGTVFHRVINGFMIQGGGFEPGMK
CEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCEEEECCCCCCCCC
QKPTEAPIDNEANNGLKNDNYTVAMARTNDPHSATAQFFINVNDNDFLNHSSPTPQGWGY
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCE
AVFGKVVEGQDVVDKIKSVKTGSKGFHQDVPNDDVVIEKAVVV
EEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MVELHTNHGVIKLELDAAKAPKTVENFLNYVKAGHYDGTVFHRVINGFMIQGGGFEPGMK
CEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCEEEECCCCCCCCC
QKPTEAPIDNEANNGLKNDNYTVAMARTNDPHSATAQFFINVNDNDFLNHSSPTPQGWGY
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCE
AVFGKVVEGQDVVDKIKSVKTGSKGFHQDVPNDDVVIEKAVVV
EEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]