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The map label for this gene is fsr [H]

Identifier: 238027763

GI number: 238027763

Start: 2377401

End: 2378648

Strand: Direct

Name: fsr [H]

Synonym: bglu_1g21870

Alternate gene names: 238027763

Gene position: 2377401-2378648 (Clockwise)

Preceding gene: 238027761

Following gene: 238027766

Centisome position: 60.86

GC content: 69.55

Gene sequence:

>1248_bases
ATGCAAACCAGTCTCGACACCCCCCCGTCCGTGACCGGCAGCGCGCCCGCCGCCACGGCCGCGGCGCCCGCTCGCACCGA
TTACCCGGTGCTCGGCGCGATCAGCTTCTCGCACCTGCTCAACGACATGATTCAGTCGTTGATCCTCGCGATCTATCCGA
TGCTGAAGGCCGACTTCGCGCTGTCGTTCGCGCAGATCGGCCTGATCACGCTGACCTACCAGATCACCGCCTCGCTGCTG
CAGCCGCTGGTCGGGCTCTATACCGACAAGCGGCCGCTGCCGTTCTCGCTGCCGGTGGGCATGGGCTTCACGCTGTCGGG
GCTGCTGCTGATGTCGGCCGCGCCGAGCTTCGGCCTGCTGCTGGTGGCCGCCGCGCTGGTCGGCTGCGGCTCGTCGGTGT
TCCATCCGGAATCGTCGCGCGTCGCGCGGCTGGCCTCGGGCGGCCGCCATGGGCTCGCCCAGTCGCTGTTCCAGGTGGGC
GGCAACGCCGGCTCCTCGCTCGGGCCGCTGCTGGCCGCGCTGGTGATCATTCCGCACGGGCGGCCCAGCATCGCCTGGGT
GTCGGTGGCCGCGCTGGTGGCGATCGTCGTGCTGACCCGGATCGGCCGCTGGTACCGGCGCCAGCCCGCGCGCCATAAAA
AGACGGCCGGCGCGCGCCATGCGTCGCTGTCGTCGCGGCAGGTCGCGTTCGCGCTCGCCGTGCTGATGGTGCTGGTGTTC
TCGAAGTACTTTTACCTGGCCAGCATCAACAGCTACTTCACCTTCTACCTGATCGACAAGTTCCACCTGAGCGTGCAGGC
CGCCCAGCTGCACCTGTTCGTGTTCCTCGCGGCGGTGGCGGCCGGCACCGTGATCGGCGGCCCGATCGGCGACCGCATCG
GCCGCAAGTACGTGATCTGGGCCTCGATTCTCGGCGTCGCGCCGTTCACGCTGGCGCTGCCGCACGCGAACCTGCTCTGG
ACCAGCGTGCTGACCGTGATCATCGGCCTGGTGCTGGCCTCGGCGTTCTCGGCGATCCTCGTCTACGCGCAGGAGCTGAT
TCCCGGCAAGGTCGGGACCGTGGCGGGCCTGTTCTTCGGGCTGTCGTTCGGAATGGGCGGGATCGGCGCGGCCGTGCTCG
GCGATATTGCCGACGCGAGGGGCGTGAGCTACGTCTACCAGCTCTGCGCGTACCTGCCGCTGCTCGGCGTGCTGACGGTG
CTGCTGCCCGACGTGGAGGGAAAGCGGGCGGCCGGCCGCGCCGCCTGA

Upstream 100 bases:

>100_bases
CTTGTCATGACAATTCACGCAAGCCAACCTACACTGCCTTCGCAATCTCAAAAATCGACCCACCCGCCCGGCCCCGGCCG
GGCCCCCAGCCCGCTCGCTC

Downstream 100 bases:

>100_bases
CGGCGCGGCGGCACTCGCGCGCCGCGCCTTCATCGAAGGCGGGCGCCGGCCTGACCGGGGGCGGCCCGAACCGGCCGCCG
GCGCGGCCGGCGGCACGCCT

Product: Fosmidomycin resistance protein

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MQTSLDTPPSVTGSAPAATAAAPARTDYPVLGAISFSHLLNDMIQSLILAIYPMLKADFALSFAQIGLITLTYQITASLL
QPLVGLYTDKRPLPFSLPVGMGFTLSGLLLMSAAPSFGLLLVAAALVGCGSSVFHPESSRVARLASGGRHGLAQSLFQVG
GNAGSSLGPLLAALVIIPHGRPSIAWVSVAALVAIVVLTRIGRWYRRQPARHKKTAGARHASLSSRQVAFALAVLMVLVF
SKYFYLASINSYFTFYLIDKFHLSVQAAQLHLFVFLAAVAAGTVIGGPIGDRIGRKYVIWASILGVAPFTLALPHANLLW
TSVLTVIIGLVLASAFSAILVYAQELIPGKVGTVAGLFFGLSFGMGGIGAAVLGDIADARGVSYVYQLCAYLPLLGVLTV
LLPDVEGKRAAGRAA

Sequences:

>Translated_415_residues
MQTSLDTPPSVTGSAPAATAAAPARTDYPVLGAISFSHLLNDMIQSLILAIYPMLKADFALSFAQIGLITLTYQITASLL
QPLVGLYTDKRPLPFSLPVGMGFTLSGLLLMSAAPSFGLLLVAAALVGCGSSVFHPESSRVARLASGGRHGLAQSLFQVG
GNAGSSLGPLLAALVIIPHGRPSIAWVSVAALVAIVVLTRIGRWYRRQPARHKKTAGARHASLSSRQVAFALAVLMVLVF
SKYFYLASINSYFTFYLIDKFHLSVQAAQLHLFVFLAAVAAGTVIGGPIGDRIGRKYVIWASILGVAPFTLALPHANLLW
TSVLTVIIGLVLASAFSAILVYAQELIPGKVGTVAGLFFGLSFGMGGIGAAVLGDIADARGVSYVYQLCAYLPLLGVLTV
LLPDVEGKRAAGRAA
>Mature_415_residues
MQTSLDTPPSVTGSAPAATAAAPARTDYPVLGAISFSHLLNDMIQSLILAIYPMLKADFALSFAQIGLITLTYQITASLL
QPLVGLYTDKRPLPFSLPVGMGFTLSGLLLMSAAPSFGLLLVAAALVGCGSSVFHPESSRVARLASGGRHGLAQSLFQVG
GNAGSSLGPLLAALVIIPHGRPSIAWVSVAALVAIVVLTRIGRWYRRQPARHKKTAGARHASLSSRQVAFALAVLMVLVF
SKYFYLASINSYFTFYLIDKFHLSVQAAQLHLFVFLAAVAAGTVIGGPIGDRIGRKYVIWASILGVAPFTLALPHANLLW
TSVLTVIIGLVLASAFSAILVYAQELIPGKVGTVAGLFFGLSFGMGGIGAAVLGDIADARGVSYVYQLCAYLPLLGVLTV
LLPDVEGKRAAGRAA

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=407, Percent_Identity=66.0933660933661, Blast_Score=503, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43401; Mature: 43401

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTSLDTPPSVTGSAPAATAAAPARTDYPVLGAISFSHLLNDMIQSLILAIYPMLKADFA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSFAQIGLITLTYQITASLLQPLVGLYTDKRPLPFSLPVGMGFTLSGLLLMSAAPSFGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHCCCCHHHH
LVAAALVGCGSSVFHPESSRVARLASGGRHGLAQSLFQVGGNAGSSLGPLLAALVIIPHG
HHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
RPSIAWVSVAALVAIVVLTRIGRWYRRQPARHKKTAGARHASLSSRQVAFALAVLMVLVF
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHH
SKYFYLASINSYFTFYLIDKFHLSVQAAQLHLFVFLAAVAAGTVIGGPIGDRIGRKYVIW
HHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHH
ASILGVAPFTLALPHANLLWTSVLTVIIGLVLASAFSAILVYAQELIPGKVGTVAGLFFG
HHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LSFGMGGIGAAVLGDIADARGVSYVYQLCAYLPLLGVLTVLLPDVEGKRAAGRAA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MQTSLDTPPSVTGSAPAATAAAPARTDYPVLGAISFSHLLNDMIQSLILAIYPMLKADFA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSFAQIGLITLTYQITASLLQPLVGLYTDKRPLPFSLPVGMGFTLSGLLLMSAAPSFGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHCCCCHHHH
LVAAALVGCGSSVFHPESSRVARLASGGRHGLAQSLFQVGGNAGSSLGPLLAALVIIPHG
HHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
RPSIAWVSVAALVAIVVLTRIGRWYRRQPARHKKTAGARHASLSSRQVAFALAVLMVLVF
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHH
SKYFYLASINSYFTFYLIDKFHLSVQAAQLHLFVFLAAVAAGTVIGGPIGDRIGRKYVIW
HHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHH
ASILGVAPFTLALPHANLLWTSVLTVIIGLVLASAFSAILVYAQELIPGKVGTVAGLFFG
HHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LSFGMGGIGAAVLGDIADARGVSYVYQLCAYLPLLGVLTVLLPDVEGKRAAGRAA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]