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The map label for this gene is pdhR [H]

Identifier: 238027395

GI number: 238027395

Start: 1967847

End: 1968560

Strand: Reverse

Name: pdhR [H]

Synonym: bglu_1g17910

Alternate gene names: 238027395

Gene position: 1968560-1967847 (Counterclockwise)

Preceding gene: 238027399

Following gene: 238027394

Centisome position: 50.39

GC content: 70.45

Gene sequence:

>714_bases
ATGAAAACCCTCAACCAGACCGAGCGGATCGTGCGCGAGATCGAAACCCAGCTGATCGAGGGCGCTTGGGCGCCCGGCCA
GCGGATTCCGGGCGAGCGCAAGCTGGCCGAGGCGATGGGCGCGGCGCGCTCGACCGTGCGCACCGCGTTGCAGCGGCTCG
TCGCGCGAGGGCTGCTGGCGAGCCGGCCGATGTCGGGCTTCTACGTGTCGGACCGGCTCCAGACCGGGCTCATCTCGCCA
TGGCGGCAGCTCGTCAGCGAGCATCCCGAGCTGCGCCCCGACATGCTCGAATTCCGGCTGATGCTGGAAGGCACCACCGC
CTATCTGGCCGCGATACGCGCCACCGACGAGGATCTCGCGCGGATCGAGGCCGTCACCGACGCGATGGCCGTCGCGCATC
GCGCCGGCGACCATGCGGGCGGCTCCCGGCTCGACGGCGACTTCCACGCGGCGCTCGCGAGCGCCTCGCACAACGCGATG
CTGCGGCACCTGCAGGCCAGCCTCGCGAAGATGCTGCATACCCACATCTCGCTCAACAACACGCGGCTCGTCGCGCTGCT
CGAGCAGGCCTCCGGGCAACTGCTCGGGCAGCATCTGGCGCTCTGGGAGGCGATCCGCGCGCGCCGGCCCGAGGACGCGC
GGCGGCTGATGCTCGAACACATCGGCTTCGTCTGGCAGCGGCTCGAACCGGAGCTGCCGGTGACGATGCTATGA

Upstream 100 bases:

>100_bases
ACCGATGGCCGCCATGATCGACAGCGGTGCGACATTCCGGCAAACTGGTACGACCAGTTTATGCGCCCCGACCGGCACCG
CTTCCCATGACATTCTTCTG

Downstream 100 bases:

>100_bases
GCCACGCCCGCCTGCGAGCGCATCCGGCGGCGCCGTCGCTTGCCCGATCCACGTCCACGTTCACCGATCCGATGACGCCA
TGAGTTCCCTGCTGATCCGC

Product: GntR-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MKTLNQTERIVREIETQLIEGAWAPGQRIPGERKLAEAMGAARSTVRTALQRLVARGLLASRPMSGFYVSDRLQTGLISP
WRQLVSEHPELRPDMLEFRLMLEGTTAYLAAIRATDEDLARIEAVTDAMAVAHRAGDHAGGSRLDGDFHAALASASHNAM
LRHLQASLAKMLHTHISLNNTRLVALLEQASGQLLGQHLALWEAIRARRPEDARRLMLEHIGFVWQRLEPELPVTML

Sequences:

>Translated_237_residues
MKTLNQTERIVREIETQLIEGAWAPGQRIPGERKLAEAMGAARSTVRTALQRLVARGLLASRPMSGFYVSDRLQTGLISP
WRQLVSEHPELRPDMLEFRLMLEGTTAYLAAIRATDEDLARIEAVTDAMAVAHRAGDHAGGSRLDGDFHAALASASHNAM
LRHLQASLAKMLHTHISLNNTRLVALLEQASGQLLGQHLALWEAIRARRPEDARRLMLEHIGFVWQRLEPELPVTML
>Mature_237_residues
MKTLNQTERIVREIETQLIEGAWAPGQRIPGERKLAEAMGAARSTVRTALQRLVARGLLASRPMSGFYVSDRLQTGLISP
WRQLVSEHPELRPDMLEFRLMLEGTTAYLAAIRATDEDLARIEAVTDAMAVAHRAGDHAGGSRLDGDFHAALASASHNAM
LRHLQASLAKMLHTHISLNNTRLVALLEQASGQLLGQHLALWEAIRARRPEDARRLMLEHIGFVWQRLEPELPVTML

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=219, Percent_Identity=35.6164383561644, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1790032, Length=203, Percent_Identity=33.0049261083744, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1789353, Length=229, Percent_Identity=30.5676855895196, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI48994955, Length=231, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1790780, Length=245, Percent_Identity=29.3877551020408, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 26395; Mature: 26395

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLNQTERIVREIETQLIEGAWAPGQRIPGERKLAEAMGAARSTVRTALQRLVARGLLA
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRPMSGFYVSDRLQTGLISPWRQLVSEHPELRPDMLEFRLMLEGTTAYLAAIRATDEDLA
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHH
RIEAVTDAMAVAHRAGDHAGGSRLDGDFHAALASASHNAMLRHLQASLAKMLHTHISLNN
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TRLVALLEQASGQLLGQHLALWEAIRARRPEDARRLMLEHIGFVWQRLEPELPVTML
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKTLNQTERIVREIETQLIEGAWAPGQRIPGERKLAEAMGAARSTVRTALQRLVARGLLA
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRPMSGFYVSDRLQTGLISPWRQLVSEHPELRPDMLEFRLMLEGTTAYLAAIRATDEDLA
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHH
RIEAVTDAMAVAHRAGDHAGGSRLDGDFHAALASASHNAMLRHLQASLAKMLHTHISLNN
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TRLVALLEQASGQLLGQHLALWEAIRARRPEDARRLMLEHIGFVWQRLEPELPVTML
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]