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The map label for this gene is livM [H]

Identifier: 238027294

GI number: 238027294

Start: 1850802

End: 1851785

Strand: Reverse

Name: livM [H]

Synonym: bglu_1g16810

Alternate gene names: 238027294

Gene position: 1851785-1850802 (Counterclockwise)

Preceding gene: 238027295

Following gene: 238027293

Centisome position: 47.4

GC content: 74.7

Gene sequence:

>984_bases
ATGACGCTCGTCACCAACCTCGGCCTGCTGTCGTTTCTCGCGCTGTCGGCCTACGTGCTGGCGATTGCCGGCGATTTCTC
GTTCGGCCAGCAGGCGCTGTTCGCGATCGGCGCCTACGCGGGCGCGTCGGCCACGGTGCTGGGCGGCTGGCCGCTCGGCG
CGGCGCTCGCGGTGGCCGCGGCCGCCGGCGCGCTGGCCGGCTGGCTGCTGCGCGCGGCCACGCTGCGGCTGTCGGGGCTG
CGCTTCTCGCTGGCGATGCTGGCCGCCGCCGAGACGATCCGCCAGTTGCTGCTGCTGATCCGCGTGCAGCGCCCCGGGCC
GGACGGCGAGCCGATCGGCCCGGGCGGCGACGAGGGCTTCGCCGGCATCCGCTACGTGTTCGAGCACGGCATGACGCCGG
CGCAGGTCGCGCTGATGGTCTGGGCCGCGCTCGGGCTGGTGCTCGTCGCGCTGGCAGGATTCGAGCGCACCCGCCGCGGC
CGCGCCTGGCGCATGGTGGGCGAGGACCCGGCGCTGGCCGCCGCGCTCGGCATCGACGCGCGGCGCGCCAAGCTCGCCGC
CGCCACGCTGGCCGGTGCCGTCGCCGCGCTCGGCGGCGCGCTCTACGCGCATTGCAGCACTTATATCGAACCCGACAACT
TCGACGTGATGATCGGCATCCACGGCCTGTCGTATGCGCTGATCGGCGGCCTCGGCTCGCCGTTCGGGCCCTTGCTCGGC
GTCGCGCTCGACCTCGGCCTGCTGGAAGGCACGCGCTTTTTTCACGGCTACCGGATGATCGCGTTCGGCGGGCTGGTCGC
CGGCCTGCTGGTGGTGCGCCCGCGCGGGCTCGTCGACGAGGCGCTGGTGGCGCGGCTCGGCGCGCTGCTGCCGCGCCGCG
CTTCAGGCCGGCCCCCGCCGGCGGCCTCGGGCTCGGCCGTAGCGCGCGTCTTTCACCCGGCTTCGCCCCCTACCCCCACC
TCCACCGATACGGAGCAAGCATGA

Upstream 100 bases:

>100_bases
TGTTCGCGGCACTCTGCGCCTGGCCGGGCGGCCTCGCCTCGCTGCTGCCGCGCAGGCTCGGGCGCGGCGCTGCCGCGCCG
GCCGACGGAGCCGCCCGCCC

Downstream 100 bases:

>100_bases
AACCGTCCCATCGCGCGCGTGCGCGCCGTCTGATCGTTGCTTTTTTTGAATCAATGATGGCGATCGTGCTGCTGATCGCT
CCGCTGTTCGCCAACGCGGC

Product: Inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MTLVTNLGLLSFLALSAYVLAIAGDFSFGQQALFAIGAYAGASATVLGGWPLGAALAVAAAAGALAGWLLRAATLRLSGL
RFSLAMLAAAETIRQLLLLIRVQRPGPDGEPIGPGGDEGFAGIRYVFEHGMTPAQVALMVWAALGLVLVALAGFERTRRG
RAWRMVGEDPALAAALGIDARRAKLAAATLAGAVAALGGALYAHCSTYIEPDNFDVMIGIHGLSYALIGGLGSPFGPLLG
VALDLGLLEGTRFFHGYRMIAFGGLVAGLLVVRPRGLVDEALVARLGALLPRRASGRPPPAASGSAVARVFHPASPPTPT
STDTEQA

Sequences:

>Translated_327_residues
MTLVTNLGLLSFLALSAYVLAIAGDFSFGQQALFAIGAYAGASATVLGGWPLGAALAVAAAAGALAGWLLRAATLRLSGL
RFSLAMLAAAETIRQLLLLIRVQRPGPDGEPIGPGGDEGFAGIRYVFEHGMTPAQVALMVWAALGLVLVALAGFERTRRG
RAWRMVGEDPALAAALGIDARRAKLAAATLAGAVAALGGALYAHCSTYIEPDNFDVMIGIHGLSYALIGGLGSPFGPLLG
VALDLGLLEGTRFFHGYRMIAFGGLVAGLLVVRPRGLVDEALVARLGALLPRRASGRPPPAASGSAVARVFHPASPPTPT
STDTEQA
>Mature_326_residues
TLVTNLGLLSFLALSAYVLAIAGDFSFGQQALFAIGAYAGASATVLGGWPLGAALAVAAAAGALAGWLLRAATLRLSGLR
FSLAMLAAAETIRQLLLLIRVQRPGPDGEPIGPGGDEGFAGIRYVFEHGMTPAQVALMVWAALGLVLVALAGFERTRRGR
AWRMVGEDPALAAALGIDARRAKLAAATLAGAVAALGGALYAHCSTYIEPDNFDVMIGIHGLSYALIGGLGSPFGPLLGV
ALDLGLLEGTRFFHGYRMIAFGGLVAGLLVVRPRGLVDEALVARLGALLPRRASGRPPPAASGSAVARVFHPASPPTPTS
TDTEQA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=282, Percent_Identity=30.4964539007092, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 33440; Mature: 33309

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLVTNLGLLSFLALSAYVLAIAGDFSFGQQALFAIGAYAGASATVLGGWPLGAALAVAA
CCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHH
AAGALAGWLLRAATLRLSGLRFSLAMLAAAETIRQLLLLIRVQRPGPDGEPIGPGGDEGF
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
AGIRYVFEHGMTPAQVALMVWAALGLVLVALAGFERTRRGRAWRMVGEDPALAAALGIDA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHCCCH
RRAKLAAATLAGAVAALGGALYAHCSTYIEPDNFDVMIGIHGLSYALIGGLGSPFGPLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHCCCCCHHHHHH
VALDLGLLEGTRFFHGYRMIAFGGLVAGLLVVRPRGLVDEALVARLGALLPRRASGRPPP
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCC
AASGSAVARVFHPASPPTPTSTDTEQA
CCCCCHHHHEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TLVTNLGLLSFLALSAYVLAIAGDFSFGQQALFAIGAYAGASATVLGGWPLGAALAVAA
CEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHH
AAGALAGWLLRAATLRLSGLRFSLAMLAAAETIRQLLLLIRVQRPGPDGEPIGPGGDEGF
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
AGIRYVFEHGMTPAQVALMVWAALGLVLVALAGFERTRRGRAWRMVGEDPALAAALGIDA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHCCCH
RRAKLAAATLAGAVAALGGALYAHCSTYIEPDNFDVMIGIHGLSYALIGGLGSPFGPLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHCCCCCHHHHHH
VALDLGLLEGTRFFHGYRMIAFGGLVAGLLVVRPRGLVDEALVARLGALLPRRASGRPPP
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCC
AASGSAVARVFHPASPPTPTSTDTEQA
CCCCCHHHHEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]