Click here to switch to the map view.

The map label for this gene is purU [H]

Identifier: 238027291

GI number: 238027291

Start: 1846225

End: 1847226

Strand: Direct

Name: purU [H]

Synonym: bglu_1g16780

Alternate gene names: 238027291

Gene position: 1846225-1847226 (Clockwise)

Preceding gene: 238027290

Following gene: 238027292

Centisome position: 47.26

GC content: 73.85

Gene sequence:

>1002_bases
GTGACCCGCAACGAAACCCTGATCGATTCCCCGCACGCGCGCCGTCACGACGACGCCGCGCAGGTGCTGGCCCGCGTGCG
CGGCCGGGCCGCCGCGCCCGCGGGCCGCGAGTTCGTGCTGCGGCTGTCGTGCCCCGACAGCCGCGGCGTGGTGTACGCCG
TGTCGCGCGCGCTCTACGAGGCCGGCTGCAACATCGTCGACGCGCAGCAGTTCAGCGACTTCGACGCATGCGCCACGCCG
GCCGGCACCGACGGCACCGCCGCCGCGCCGGGCCGCTTCTTCATGCGCGTGCACCTCGAGGCGCCCGGCCGCGCCGCCGG
CCCCGAGGCGATCGCGCGGCTGCTCGACCCGCTGCGCCGCGACTACGACATGCAGATCGAGGTCCACGACGCCGGCTGGC
GGCCGCGCGCCGCGATCCTGGTGAGCCGCGAGGGCCATTGCCTGAACGACCTGATGTTCCGCCAGAGCGTGGGGCAGCTG
CCGGTGGAGATCGCCGCCGTGGTGTCGAACCACGAGGACCTGCGCGAGATGGCCGAGCGCTCGGGGCTCGCGTTCCACCA
CCTGCCGCTCGACGCCGCCGCGGGCGGCAAGCCGGCCCAGGAGGCACGCCTGCTCGGCCTGCTGGAGCGCGAGCGCGTGG
AGCTGGTGGTGCTCGCGCGCTACATGCAGATCCTCTCGCCCGAGCTGTGCGAGCGCCTGCGCGGGCGCGCGATCAACATC
CACCACAGCTTCCTGCCCAGCTTCAAGGGCGCGCAGCCGTACCGCCAGGCCCACGCGCGCGGCGTCAAGCTGATCGGCGC
GACGGCGCACTACGTGACCTCCGACCTCGACGAAGGGCCGATCATCGAGCAGGACGTCGAGCGCGTCGACCACGCGGCCG
GCCCGCGCGAGCTGGCCGCGATCGGCCGCGACATCGAATGCGTGGTGCTCGCGCGCGCGCTCAAGTGGCACTGCGAGCAT
CGCGTGCTGATGAACGGCGCGCGCACCGTCGTGTTCCGCTGA

Upstream 100 bases:

>100_bases
TCGCGGTGGCGAACGCGCTCGCCGCCTGGATCGCCCGCGACGACTTGCCGGTCGCGGGCATGGTGGTGCCGATCGGCATC
GGCTTTCCGGAGAACAACCT

Downstream 100 bases:

>100_bases
ACGCGGCTTCCCGTCCGGCCCTGCCGGATTTTCCGCCACCCGTCCTCGAACCCATCATGTCCGCCTATACCGAACAGACC
GTCCTCAGCGTCCATCACTG

Product: putative formyltetrahydrofolate deformylase protein

Products: NA

Alternate protein names: Formyl-FH(4) hydrolase [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MTRNETLIDSPHARRHDDAAQVLARVRGRAAAPAGREFVLRLSCPDSRGVVYAVSRALYEAGCNIVDAQQFSDFDACATP
AGTDGTAAAPGRFFMRVHLEAPGRAAGPEAIARLLDPLRRDYDMQIEVHDAGWRPRAAILVSREGHCLNDLMFRQSVGQL
PVEIAAVVSNHEDLREMAERSGLAFHHLPLDAAAGGKPAQEARLLGLLERERVELVVLARYMQILSPELCERLRGRAINI
HHSFLPSFKGAQPYRQAHARGVKLIGATAHYVTSDLDEGPIIEQDVERVDHAAGPRELAAIGRDIECVVLARALKWHCEH
RVLMNGARTVVFR

Sequences:

>Translated_333_residues
MTRNETLIDSPHARRHDDAAQVLARVRGRAAAPAGREFVLRLSCPDSRGVVYAVSRALYEAGCNIVDAQQFSDFDACATP
AGTDGTAAAPGRFFMRVHLEAPGRAAGPEAIARLLDPLRRDYDMQIEVHDAGWRPRAAILVSREGHCLNDLMFRQSVGQL
PVEIAAVVSNHEDLREMAERSGLAFHHLPLDAAAGGKPAQEARLLGLLERERVELVVLARYMQILSPELCERLRGRAINI
HHSFLPSFKGAQPYRQAHARGVKLIGATAHYVTSDLDEGPIIEQDVERVDHAAGPRELAAIGRDIECVVLARALKWHCEH
RVLMNGARTVVFR
>Mature_332_residues
TRNETLIDSPHARRHDDAAQVLARVRGRAAAPAGREFVLRLSCPDSRGVVYAVSRALYEAGCNIVDAQQFSDFDACATPA
GTDGTAAAPGRFFMRVHLEAPGRAAGPEAIARLLDPLRRDYDMQIEVHDAGWRPRAAILVSREGHCLNDLMFRQSVGQLP
VEIAAVVSNHEDLREMAERSGLAFHHLPLDAAAGGKPAQEARLLGLLERERVELVVLARYMQILSPELCERLRGRAINIH
HSFLPSFKGAQPYRQAHARGVKLIGATAHYVTSDLDEGPIIEQDVERVDHAAGPRELAAIGRDIECVVLARALKWHCEHR
VLMNGARTVVFR

Specific function: Produces Formate From Formyl-Tetrahydrofolate. Provides The Major Source Of Formate For The Purt-Dependent Synthesis Of 5'-Phosphoribosyl-N-Formylglycinamide (Fgar) During Aerobic Growth. Has A Role In Regulating The One-Carbon Pool. [C]

COG id: COG0788

COG function: function code F; Formyltetrahydrofolate hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=165, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI209869995, Length=165, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI209869993, Length=165, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1787483, Length=303, Percent_Identity=39.9339933993399, Blast_Score=208, Evalue=3e-55,
Organism=Escherichia coli, GI1788846, Length=189, Percent_Identity=29.6296296296296, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17567511, Length=153, Percent_Identity=35.9477124183007, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24582400, Length=189, Percent_Identity=29.6296296296296, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002376
- InterPro:   IPR004810 [H]

Pfam domain/function: PF00551 Formyl_trans_N [H]

EC number: =3.5.1.10 [H]

Molecular weight: Translated: 36692; Mature: 36561

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRNETLIDSPHARRHDDAAQVLARVRGRAAAPAGREFVLRLSCPDSRGVVYAVSRALYE
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHH
AGCNIVDAQQFSDFDACATPAGTDGTAAAPGRFFMRVHLEAPGRAAGPEAIARLLDPLRR
HCCCEEEHHHCCCCHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHC
DYDMQIEVHDAGWRPRAAILVSREGHCLNDLMFRQSVGQLPVEIAAVVSNHEDLREMAER
CCCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHH
SGLAFHHLPLDAAAGGKPAQEARLLGLLERERVELVVLARYMQILSPELCERLRGRAINI
CCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCEEEE
HHSFLPSFKGAQPYRQAHARGVKLIGATAHYVTSDLDEGPIIEQDVERVDHAAGPRELAA
EHHHCCCCCCCCHHHHHHHCCEEEEECHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHH
IGRDIECVVLARALKWHCEHRVLMNGARTVVFR
HCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure 
TRNETLIDSPHARRHDDAAQVLARVRGRAAAPAGREFVLRLSCPDSRGVVYAVSRALYE
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHH
AGCNIVDAQQFSDFDACATPAGTDGTAAAPGRFFMRVHLEAPGRAAGPEAIARLLDPLRR
HCCCEEEHHHCCCCHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHC
DYDMQIEVHDAGWRPRAAILVSREGHCLNDLMFRQSVGQLPVEIAAVVSNHEDLREMAER
CCCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHH
SGLAFHHLPLDAAAGGKPAQEARLLGLLERERVELVVLARYMQILSPELCERLRGRAINI
CCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCEEEE
HHSFLPSFKGAQPYRQAHARGVKLIGATAHYVTSDLDEGPIIEQDVERVDHAAGPRELAA
EHHHCCCCCCCCHHHHHHHCCEEEEECHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHH
IGRDIECVVLARALKWHCEHRVLMNGARTVVFR
HCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7543100 [H]