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The map label for this gene is purA1 [H]

Identifier: 238027082

GI number: 238027082

Start: 1607251

End: 1608597

Strand: Direct

Name: purA1 [H]

Synonym: bglu_1g14610

Alternate gene names: 238027082

Gene position: 1607251-1608597 (Clockwise)

Preceding gene: 238027081

Following gene: 238027083

Centisome position: 41.14

GC content: 66.74

Gene sequence:

>1347_bases
ATGTCTGCCAGCGCAGTGAATGTGACTCCCGGGCGCAATGTCGTCGTCGTGGGAACCCAGTGGGGAGATGAAGGCAAGGG
CAAGATCGTCGACTGGCTGACGGACCACGCGCAAGGCGTCGTTCGTTTCCAAGGCGGTCACAACGCCGGGCACACGCTCA
TCATCGGCGGCAAGAAAACCATCTTGCGCCTCATTCCTTCCGGCATCATGCGCGCGGGCGTGGCCTGCTACATCGGCAAC
GGCGTCGTGCTGTCGCCCGAGGCGCTGTTCAAGGAAATCGGCGAACTCGAGGAAGCCGGGCTCGACGTCCAGTCGCGGCT
GTTCATTTCCGAGGCCGCCACGCTGATCCTGCCGTACCACGTCGCGATCGACCAGGCGCGCGAGGCGCGCCGCGGCGCCG
ACAAGATCGGCACCACGGGCCGCGGCATCGGCCCGGCCTACGAGGACAAGGTGGGCCGCCGCGCGCTGCGCGTGCAGGAC
CTGTTCGACGCGAAGACCTTCGCCGACCGTCTGCGCGACAATCTCGATTTCCACAACTTCGTGCTGACCCAGTATCTCGG
CGGCGCGGCTGTCGATTTCCAGGCGACGCTCGACACCATGCTCGGTTACGTCGATCGTCTCAAGCCGATGGTCACGGACG
TCTCGCGGCGCCTGTACGACGCGAACAACGCCGGCCAGAACCTGCTGTTCGAAGGCGCGCAGGGTACGCTGCTCGACATC
GACCACGGCACCTATCCGTTCGTCACGTCGAGCAACTGCGTGGCCGGCGCGGCCACGTCGGGTGCCGGCATCGGCCCGCA
GAAGCTCAACTACATCCTCGGCATCACCAAGGCCTACTGCACGCGCGTCGGCGCTGGCCCGTTCCCGAGCGAACTGTACG
ACGCGGACAATCCCGCGCGCCAGAGCCCGGTCGGCGTCACGCTGGCCAACGTCGGCAAGGAGTTCGGTTCGGTCACGGGC
CGCCCGCGCCGCACCGGCTGGCTCGACGCGGCTGCGCTGCGCCGTTCGATCCAGATCAACGGCGTATCGGGCCTCTGCAT
GACCAAGCTCGATGTGCTCGACGGCCTCGACGAAGTCCAGCTCTGCGTCGGCTACAAGATCGACGGCAAGGACGTGGACC
TGCTGCCGCGCGGCGCGGCCGACGTCGCACGCTGTGAGCCGGTCTACGAAACGTTTGGCGGCTGGAAGGAAAGCACGGTG
GGCATCGATTCGTGGGAGGCGCTGCCGGCCAACGCGCAGGCTTACCTGACGCGCGTGCAGGAAGTGGCCGGCGTGCCGAT
CGACATGGTGTCGACCGGCCCCGATCGCGACGAAACGATCCTGCTGCGCCATCCGTTCAAGGTCTGA

Upstream 100 bases:

>100_bases
TGCCTTGTCGTCGGCGCGAAGCCGTTGAAGCGAAACGGAAAAATTCGGAACCCGCGCCGAACCTATGTAGAATACGTTTT
TAACCAGCTAACGAATCAAC

Downstream 100 bases:

>100_bases
TTGCACGATGACGCAAACCAATCACGGCGCGCCGATCGCGATGGCCGATCCGCGCAACGACGACAAGAACCTCTGGGTCG
GCTGGGACGAATATCATCGG

Product: adenylosuccinate synthetase

Products: NA

Alternate protein names: AMPSase 1; AdSS 1; IMP--aspartate ligase 1 [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSASAVNVTPGRNVVVVGTQWGDEGKGKIVDWLTDHAQGVVRFQGGHNAGHTLIIGGKKTILRLIPSGIMRAGVACYIGN
GVVLSPEALFKEIGELEEAGLDVQSRLFISEAATLILPYHVAIDQAREARRGADKIGTTGRGIGPAYEDKVGRRALRVQD
LFDAKTFADRLRDNLDFHNFVLTQYLGGAAVDFQATLDTMLGYVDRLKPMVTDVSRRLYDANNAGQNLLFEGAQGTLLDI
DHGTYPFVTSSNCVAGAATSGAGIGPQKLNYILGITKAYCTRVGAGPFPSELYDADNPARQSPVGVTLANVGKEFGSVTG
RPRRTGWLDAAALRRSIQINGVSGLCMTKLDVLDGLDEVQLCVGYKIDGKDVDLLPRGAADVARCEPVYETFGGWKESTV
GIDSWEALPANAQAYLTRVQEVAGVPIDMVSTGPDRDETILLRHPFKV

Sequences:

>Translated_448_residues
MSASAVNVTPGRNVVVVGTQWGDEGKGKIVDWLTDHAQGVVRFQGGHNAGHTLIIGGKKTILRLIPSGIMRAGVACYIGN
GVVLSPEALFKEIGELEEAGLDVQSRLFISEAATLILPYHVAIDQAREARRGADKIGTTGRGIGPAYEDKVGRRALRVQD
LFDAKTFADRLRDNLDFHNFVLTQYLGGAAVDFQATLDTMLGYVDRLKPMVTDVSRRLYDANNAGQNLLFEGAQGTLLDI
DHGTYPFVTSSNCVAGAATSGAGIGPQKLNYILGITKAYCTRVGAGPFPSELYDADNPARQSPVGVTLANVGKEFGSVTG
RPRRTGWLDAAALRRSIQINGVSGLCMTKLDVLDGLDEVQLCVGYKIDGKDVDLLPRGAADVARCEPVYETFGGWKESTV
GIDSWEALPANAQAYLTRVQEVAGVPIDMVSTGPDRDETILLRHPFKV
>Mature_447_residues
SASAVNVTPGRNVVVVGTQWGDEGKGKIVDWLTDHAQGVVRFQGGHNAGHTLIIGGKKTILRLIPSGIMRAGVACYIGNG
VVLSPEALFKEIGELEEAGLDVQSRLFISEAATLILPYHVAIDQAREARRGADKIGTTGRGIGPAYEDKVGRRALRVQDL
FDAKTFADRLRDNLDFHNFVLTQYLGGAAVDFQATLDTMLGYVDRLKPMVTDVSRRLYDANNAGQNLLFEGAQGTLLDID
HGTYPFVTSSNCVAGAATSGAGIGPQKLNYILGITKAYCTRVGAGPFPSELYDADNPARQSPVGVTLANVGKEFGSVTGR
PRRTGWLDAAALRRSIQINGVSGLCMTKLDVLDGLDEVQLCVGYKIDGKDVDLLPRGAADVARCEPVYETFGGWKESTVG
IDSWEALPANAQAYLTRVQEVAGVPIDMVSTGPDRDETILLRHPFKV

Specific function: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP [H]

COG id: COG0104

COG function: function code F; Adenylosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylosuccinate synthetase family [H]

Homologues:

Organism=Homo sapiens, GI22748717, Length=440, Percent_Identity=41.8181818181818, Blast_Score=331, Evalue=9e-91,
Organism=Homo sapiens, GI34577063, Length=443, Percent_Identity=38.3747178329571, Blast_Score=305, Evalue=7e-83,
Organism=Homo sapiens, GI40316944, Length=405, Percent_Identity=40.4938271604938, Blast_Score=296, Evalue=4e-80,
Organism=Escherichia coli, GI1790620, Length=437, Percent_Identity=59.7254004576659, Blast_Score=532, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI25146553, Length=439, Percent_Identity=39.8633257403189, Blast_Score=310, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI25146555, Length=436, Percent_Identity=39.9082568807339, Blast_Score=310, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6324109, Length=437, Percent_Identity=40.2745995423341, Blast_Score=320, Evalue=2e-88,
Organism=Drosophila melanogaster, GI21356033, Length=456, Percent_Identity=38.3771929824561, Blast_Score=310, Evalue=1e-84,

Paralogues:

None

Copy number: 940 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018220
- InterPro:   IPR001114 [H]

Pfam domain/function: PF00709 Adenylsucc_synt [H]

EC number: =6.3.4.4 [H]

Molecular weight: Translated: 48033; Mature: 47902

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS01266 ADENYLOSUCCIN_SYN_1 ; PS00513 ADENYLOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASAVNVTPGRNVVVVGTQWGDEGKGKIVDWLTDHAQGVVRFQGGHNAGHTLIIGGKKT
CCCCEEEECCCCCEEEEEECCCCCCCCCCHHHHHHCCCEEEEEECCCCCCCEEEECCHHH
ILRLIPSGIMRAGVACYIGNGVVLSPEALFKEIGELEEAGLDVQSRLFISEAATLILPYH
HHHHHHHHHHHCCEEEEECCCEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEHH
VAIDQAREARRGADKIGTTGRGIGPAYEDKVGRRALRVQDLFDAKTFADRLRDNLDFHNF
HHHHHHHHHHHCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VLTQYLGGAAVDFQATLDTMLGYVDRLKPMVTDVSRRLYDANNAGQNLLFEGAQGTLLDI
HHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEC
DHGTYPFVTSSNCVAGAATSGAGIGPQKLNYILGITKAYCTRVGAGPFPSELYDADNPAR
CCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCC
QSPVGVTLANVGKEFGSVTGRPRRTGWLDAAALRRSIQINGVSGLCMTKLDVLDGLDEVQ
CCCCCEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHEEEECCCCCHHHHHHHHHCCCCCEE
LCVGYKIDGKDVDLLPRGAADVARCEPVYETFGGWKESTVGIDSWEALPANAQAYLTRVQ
EEEEEEECCCCCCCCCCCCHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHH
EVAGVPIDMVSTGPDRDETILLRHPFKV
HHHCCCEEEECCCCCCCCEEEEECCCCC
>Mature Secondary Structure 
SASAVNVTPGRNVVVVGTQWGDEGKGKIVDWLTDHAQGVVRFQGGHNAGHTLIIGGKKT
CCCEEEECCCCCEEEEEECCCCCCCCCCHHHHHHCCCEEEEEECCCCCCCEEEECCHHH
ILRLIPSGIMRAGVACYIGNGVVLSPEALFKEIGELEEAGLDVQSRLFISEAATLILPYH
HHHHHHHHHHHCCEEEEECCCEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEHH
VAIDQAREARRGADKIGTTGRGIGPAYEDKVGRRALRVQDLFDAKTFADRLRDNLDFHNF
HHHHHHHHHHHCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VLTQYLGGAAVDFQATLDTMLGYVDRLKPMVTDVSRRLYDANNAGQNLLFEGAQGTLLDI
HHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEC
DHGTYPFVTSSNCVAGAATSGAGIGPQKLNYILGITKAYCTRVGAGPFPSELYDADNPAR
CCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCC
QSPVGVTLANVGKEFGSVTGRPRRTGWLDAAALRRSIQINGVSGLCMTKLDVLDGLDEVQ
CCCCCEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHEEEECCCCCHHHHHHHHHCCCCCEE
LCVGYKIDGKDVDLLPRGAADVARCEPVYETFGGWKESTVGIDSWEALPANAQAYLTRVQ
EEEEEEECCCCCCCCCCCCHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHH
EVAGVPIDMVSTGPDRDETILLRHPFKV
HHHCCCEEEECCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA