Click here to switch to the map view.

The map label for this gene is moaA [H]

Identifier: 238026593

GI number: 238026593

Start: 1014929

End: 1016041

Strand: Reverse

Name: moaA [H]

Synonym: bglu_1g09390

Alternate gene names: 238026593

Gene position: 1016041-1014929 (Counterclockwise)

Preceding gene: 238026594

Following gene: 238026592

Centisome position: 26.01

GC content: 68.82

Gene sequence:

>1113_bases
ATGTCCCAACGCATCATCCCGGTCACCGACGTCAGCGGCATTCCGGATATCTCCGGCACGCCGTTCGCGCCGAGCGGCAT
CCTGCGCGACACCCTCGCGCGGCCGCTGCGGGATCTGCGCATCTCGGTCACCGATCGCTGCAACTTCCGCTGCGTCTACT
GCATGCCGCGCGACGTGTTCGACAAGGACTATCCGTTCCTGCCGCACAGCGCGCTGCTCTCGCTCGAGGAGCTCGAACGC
GTGGCGCGCCTCTTCGTCGCGCACGGCGTCGAGAAGATTCGCATCACCGGCGGCGAGCCGCTGCTGCGCAAGAACCTCGA
GTTCCTGATCGAACGGCTCGCGCGGATGCAAACGGTGGGCGGCCATCCGCTCGACCTGACGCTGACGACCAACGGCTCGC
TGCTCGCGCGCAAGGCGCGCAGCCTGCGCGACGCGGGTCTGACGCGCGTCACGGTCAGCCTCGACGCGCTCGATGATGCG
CTGTTTCGTCGCATGAACGACGCCAACTTCGCGAGCGCCGACGTGCTGGAAGGGATCTTCGCCGCACAGGACGCCGGGCT
CGCTCCGGTCAAGGTCAACATGGTGGTCAAGCGCGGCACCAACGACGCCGAGATCGTGCCGATGGCGCGCCGCTTCAAGG
GCACCGGCATCGTGCTGCGCTTCATCGAATACATGGACGTGGGCACCTCGAACGGCTGGGACATGACCGACGTGCTGCCG
TCGGCCGAGGTGCTCGAACGGATCGACGCGCAATTCCCGCTCGTGCCGCTCGAGGCGCACTCGGCGGCCGAGACCGCGCA
GCGCTGGGGCTATGCGGACGGCAGCGGCGAGATCGGCCTGATCTCGAGCGTCACGCGCGCGTTCTGCGGCGCCTGCACGC
GCGCGCGGCTGTCGACCGAAGGCAAGCTCTATCTGTGCCTGTTCGGCTCCTCCGGCCACGACCTGCGCGCCCTGCTGCGC
AATGGCGCCACCGATGCGCAAATCGCGACCGCGATCGCGCGGATCTGGCAGGCGCGCGACGACCGCTATTCGCAACTGCG
CGGCACCGCGCAGGCCGGGCAGCGCGCCGATGCCGCCGCGCCCCGCGTCGAAATGTCGTATATCGGTGGCTGA

Upstream 100 bases:

>100_bases
TCTGTGCTCTTTTCCTAGGGGTTTGCGTGCGCCGGCCCGATCGGCCGCTTGCCGTTAAAATAACGGTCTGGTCGTCTTTC
CCGAACGGGCCTCCGTCACC

Downstream 100 bases:

>100_bases
GCGCCGCCGCCCCCGATGTCCATGATCGCACCCGCGCCCTTGCCCGGTGACGCCACCCGCCAGTTGACCGGCCTGCTGCT
GGCCGGCGGCCGGGGTTCGC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MSQRIIPVTDVSGIPDISGTPFAPSGILRDTLARPLRDLRISVTDRCNFRCVYCMPRDVFDKDYPFLPHSALLSLEELER
VARLFVAHGVEKIRITGGEPLLRKNLEFLIERLARMQTVGGHPLDLTLTTNGSLLARKARSLRDAGLTRVTVSLDALDDA
LFRRMNDANFASADVLEGIFAAQDAGLAPVKVNMVVKRGTNDAEIVPMARRFKGTGIVLRFIEYMDVGTSNGWDMTDVLP
SAEVLERIDAQFPLVPLEAHSAAETAQRWGYADGSGEIGLISSVTRAFCGACTRARLSTEGKLYLCLFGSSGHDLRALLR
NGATDAQIATAIARIWQARDDRYSQLRGTAQAGQRADAAAPRVEMSYIGG

Sequences:

>Translated_370_residues
MSQRIIPVTDVSGIPDISGTPFAPSGILRDTLARPLRDLRISVTDRCNFRCVYCMPRDVFDKDYPFLPHSALLSLEELER
VARLFVAHGVEKIRITGGEPLLRKNLEFLIERLARMQTVGGHPLDLTLTTNGSLLARKARSLRDAGLTRVTVSLDALDDA
LFRRMNDANFASADVLEGIFAAQDAGLAPVKVNMVVKRGTNDAEIVPMARRFKGTGIVLRFIEYMDVGTSNGWDMTDVLP
SAEVLERIDAQFPLVPLEAHSAAETAQRWGYADGSGEIGLISSVTRAFCGACTRARLSTEGKLYLCLFGSSGHDLRALLR
NGATDAQIATAIARIWQARDDRYSQLRGTAQAGQRADAAAPRVEMSYIGG
>Mature_369_residues
SQRIIPVTDVSGIPDISGTPFAPSGILRDTLARPLRDLRISVTDRCNFRCVYCMPRDVFDKDYPFLPHSALLSLEELERV
ARLFVAHGVEKIRITGGEPLLRKNLEFLIERLARMQTVGGHPLDLTLTTNGSLLARKARSLRDAGLTRVTVSLDALDDAL
FRRMNDANFASADVLEGIFAAQDAGLAPVKVNMVVKRGTNDAEIVPMARRFKGTGIVLRFIEYMDVGTSNGWDMTDVLPS
AEVLERIDAQFPLVPLEAHSAAETAQRWGYADGSGEIGLISSVTRAFCGACTRARLSTEGKLYLCLFGSSGHDLRALLRN
GATDAQIATAIARIWQARDDRYSQLRGTAQAGQRADAAAPRVEMSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=338, Percent_Identity=35.7988165680473, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI116734668, Length=338, Percent_Identity=35.7988165680473, Blast_Score=202, Evalue=3e-52,
Organism=Escherichia coli, GI1786999, Length=345, Percent_Identity=35.0724637681159, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI32566329, Length=361, Percent_Identity=32.9639889196676, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI32566331, Length=323, Percent_Identity=33.4365325077399, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17561210, Length=347, Percent_Identity=32.8530259365994, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI28574488, Length=329, Percent_Identity=32.8267477203647, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI28574490, Length=318, Percent_Identity=33.3333333333333, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 40424; Mature: 40293

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQRIIPVTDVSGIPDISGTPFAPSGILRDTLARPLRDLRISVTDRCNFRCVYCMPRDVF
CCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEECCCCEEEEEECCHHHC
DKDYPFLPHSALLSLEELERVARLFVAHGVEKIRITGGEPLLRKNLEFLIERLARMQTVG
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCC
GHPLDLTLTTNGSLLARKARSLRDAGLTRVTVSLDALDDALFRRMNDANFASADVLEGIF
CCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHH
AAQDAGLAPVKVNMVVKRGTNDAEIVPMARRFKGTGIVLRFIEYMDVGTSNGWDMTDVLP
HHCCCCCCEEEEEEEEECCCCCCCEEHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHCC
SAEVLERIDAQFPLVPLEAHSAAETAQRWGYADGSGEIGLISSVTRAFCGACTRARLSTE
CHHHHHHHCCCCCEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
GKLYLCLFGSSGHDLRALLRNGATDAQIATAIARIWQARDDRYSQLRGTAQAGQRADAAA
CCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHCHHHHCCCCCCCC
PRVEMSYIGG
CCEEEEECCC
>Mature Secondary Structure 
SQRIIPVTDVSGIPDISGTPFAPSGILRDTLARPLRDLRISVTDRCNFRCVYCMPRDVF
CCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEECCCCEEEEEECCHHHC
DKDYPFLPHSALLSLEELERVARLFVAHGVEKIRITGGEPLLRKNLEFLIERLARMQTVG
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCC
GHPLDLTLTTNGSLLARKARSLRDAGLTRVTVSLDALDDALFRRMNDANFASADVLEGIF
CCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHH
AAQDAGLAPVKVNMVVKRGTNDAEIVPMARRFKGTGIVLRFIEYMDVGTSNGWDMTDVLP
HHCCCCCCEEEEEEEEECCCCCCCEEHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHCC
SAEVLERIDAQFPLVPLEAHSAAETAQRWGYADGSGEIGLISSVTRAFCGACTRARLSTE
CHHHHHHHCCCCCEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
GKLYLCLFGSSGHDLRALLRNGATDAQIATAIARIWQARDDRYSQLRGTAQAGQRADAAA
CCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHCHHHHCCCCCCCC
PRVEMSYIGG
CCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]