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The map label for this gene is gmk [H]

Identifier: 238026486

GI number: 238026486

Start: 895610

End: 896284

Strand: Direct

Name: gmk [H]

Synonym: bglu_1g08300

Alternate gene names: 238026486

Gene position: 895610-896284 (Clockwise)

Preceding gene: 238026485

Following gene: 238026487

Centisome position: 22.93

GC content: 67.11

Gene sequence:

>675_bases
ATGACCGAATCGAACCGAGACGCGCACGCGCTGCATGCCGGCGCGTATCCCGGCAACCTGTTCATGGTGGTGGCCCCGTC
GGGCGCCGGCAAGTCGACGCTCGTGAACGCGCTGCTCGCGCAGGACGACGAGATCCGCCTGTCGATCTCGTACACGACGC
GCAAGCCGCGCCCGGGCGAGCAGGACGGCGAGCACTATCACTTCACGAGCGTCGAGGACTTCCGCGCGCGCCATGCGGCG
CACGAATTCCTCGAAAGCGCCGAGGTGCACGGCAACTACTACGGCACCTCGCGCGTCTGGATCGAGGAGCAGATGGCGAG
CGGGCGCGACGTACTGCTCGAGATCGACTGGCAGGGCGCGCAGCAGGTCAAGAAGCAGTTCCGCAACGCGGTCGGGATCT
TCATCCTGCCGCCCTCGCTCGCGGCCCTCGAGGAACGTCTGAAGAAACGCGGCCAGGACGAGCCGAACGTGATCACGCGG
CGCCTGCTCGCAGCGGGCAGCGAGATCGCGCACGCTTCCGAGGCCGAATACGTGGTGATCAACGAGCACTTCGACACGGC
ACTGGCCGAGTTGCGGCGCATCGTGGCCGCCACGCGGCTGCGCTTCGCCTCGCAATACGCACGCCACACCGAGCTTTTCA
TCGAGCTCGGCATCCATCTCCCGCACGCCGAGTGA

Upstream 100 bases:

>100_bases
CTCGAAGGCGGCCGCCAAGGAGCTGGCCGACGCATCGATGGCGCTCAAGCTGCTGATCGAGCAGATGCGTGAGCAAGTGC
AAAACCTGGAGTAACGCAAG

Downstream 100 bases:

>100_bases
AGGCGAGGGACGAGGGACATAAGGTAGAATAGCCAACATATTCAGAAGGAACACCCACCATGGCTCGCATTACCGTCGAA
GACTGCCTGAAGCAGATCCC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MTESNRDAHALHAGAYPGNLFMVVAPSGAGKSTLVNALLAQDDEIRLSISYTTRKPRPGEQDGEHYHFTSVEDFRARHAA
HEFLESAEVHGNYYGTSRVWIEEQMASGRDVLLEIDWQGAQQVKKQFRNAVGIFILPPSLAALEERLKKRGQDEPNVITR
RLLAAGSEIAHASEAEYVVINEHFDTALAELRRIVAATRLRFASQYARHTELFIELGIHLPHAE

Sequences:

>Translated_224_residues
MTESNRDAHALHAGAYPGNLFMVVAPSGAGKSTLVNALLAQDDEIRLSISYTTRKPRPGEQDGEHYHFTSVEDFRARHAA
HEFLESAEVHGNYYGTSRVWIEEQMASGRDVLLEIDWQGAQQVKKQFRNAVGIFILPPSLAALEERLKKRGQDEPNVITR
RLLAAGSEIAHASEAEYVVINEHFDTALAELRRIVAATRLRFASQYARHTELFIELGIHLPHAE
>Mature_223_residues
TESNRDAHALHAGAYPGNLFMVVAPSGAGKSTLVNALLAQDDEIRLSISYTTRKPRPGEQDGEHYHFTSVEDFRARHAAH
EFLESAEVHGNYYGTSRVWIEEQMASGRDVLLEIDWQGAQQVKKQFRNAVGIFILPPSLAALEERLKKRGQDEPNVITRR
LLAAGSEIAHASEAEYVVINEHFDTALAELRRIVAATRLRFASQYARHTELFIELGIHLPHAE

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=39.4285714285714, Blast_Score=127, Evalue=6e-30,
Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=39.4285714285714, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=39.4285714285714, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI262118259, Length=140, Percent_Identity=31.4285714285714, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI4505237, Length=140, Percent_Identity=31.4285714285714, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI262118255, Length=140, Percent_Identity=31.4285714285714, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI262118263, Length=140, Percent_Identity=31.4285714285714, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI38570142, Length=195, Percent_Identity=27.6923076923077, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI21361598, Length=198, Percent_Identity=25.2525252525253, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=49.7512437810945, Blast_Score=204, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI193203132, Length=180, Percent_Identity=35, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17508835, Length=180, Percent_Identity=35, Blast_Score=109, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=39.010989010989, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21356141, Length=180, Percent_Identity=39.4444444444444, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24640542, Length=132, Percent_Identity=28.030303030303, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI45554481, Length=132, Percent_Identity=28.030303030303, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI85724806, Length=132, Percent_Identity=28.030303030303, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI116007136, Length=132, Percent_Identity=28.030303030303, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45554489, Length=132, Percent_Identity=28.030303030303, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 25108; Mature: 24977

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESNRDAHALHAGAYPGNLFMVVAPSGAGKSTLVNALLAQDDEIRLSISYTTRKPRPGE
CCCCCCCCCEEECCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCC
QDGEHYHFTSVEDFRARHAAHEFLESAEVHGNYYGTSRVWIEEQMASGRDVLLEIDWQGA
CCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEECCEEEEEEHHHCCCCEEEEEECCCCH
QQVKKQFRNAVGIFILPPSLAALEERLKKRGQDEPNVITRRLLAAGSEIAHASEAEYVVI
HHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCEEEE
NEHFDTALAELRRIVAATRLRFASQYARHTELFIELGIHLPHAE
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCC
>Mature Secondary Structure 
TESNRDAHALHAGAYPGNLFMVVAPSGAGKSTLVNALLAQDDEIRLSISYTTRKPRPGE
CCCCCCCCEEECCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCC
QDGEHYHFTSVEDFRARHAAHEFLESAEVHGNYYGTSRVWIEEQMASGRDVLLEIDWQGA
CCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEECCEEEEEEHHHCCCCEEEEEECCCCH
QQVKKQFRNAVGIFILPPSLAALEERLKKRGQDEPNVITRRLLAAGSEIAHASEAEYVVI
HHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCEEEE
NEHFDTALAELRRIVAATRLRFASQYARHTELFIELGIHLPHAE
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA