Click here to switch to the map view.

The map label for this gene is serS [H]

Identifier: 238026472

GI number: 238026472

Start: 881560

End: 882861

Strand: Direct

Name: serS [H]

Synonym: bglu_1g08160

Alternate gene names: 238026472

Gene position: 881560-882861 (Clockwise)

Preceding gene: 238026471

Following gene: 238026473

Centisome position: 22.57

GC content: 67.43

Gene sequence:

>1302_bases
ATGCTCGACATCCAGTTGCTGCGCAAAGACCTCGACGGCGTTGCCAAGCGCCTCGCCGATCGCGGCTACATCCTCGACGT
CGCCGCGTTCTCCTCGCTCGAGGCCGAACGCCGCGCGATCCAGACCCGCACCGAGGAACTGCAGGCACGCCGCAACAGCC
TGTCCAAGCAGATCGGCGCGATGAAGGGGCGGGGCGAGGACACCTCGGCCGTGATGGCCGAGGTGGGCGGGATCGGCGAC
GAAATGAAGGCGTCGGCCGCGAAGCTCGACGAGATCCAGAGTGCGATGTCGGAACTGATGCTCGGCATGCCGAACCTCGC
GCACGAGAGCGTGCCGGTGGGCGCCGACGAAGCCGGCAACGTCGAGGTGCGCCGCTGGGGCACGCCGCGCGCGTTCGATT
TCGAGGTGCGCGACCACGTCGACGTCGGCACTCCGCTCGGCCTCGATTTCGAGACCGGCGCGAAGCTGTCCGGCGCGCGC
TTCACGATGCTGCGCGGCCCGATCGCGCGCCTGCACCGTGCGCTCGCGCAGTTCATGATCGACACCCACACCCAGCAGCA
CGGGTACACCGAGACCTACACGCCGTACATCGTGAACCCGGACATCCTGCGTGGCACCGGCCAACTGCCGAAGTTCGCCG
ACGACATGTTCCGAGTGGAGAAGGGCGGCGGCGAGAACACCGTCACGCAGTACCTGATCTCGACCTCCGAGATCACGCTG
ACCAACACCGTGCGCGAGTCGATCCTCGATGCGGCCGAGCTGCCCGTCAAGCTGACCGCGCATTCGCCGTGCTTTCGCTC
CGAGGCCGGCGCCTATGGGCGCGACACGCGCGGCATGATCCGCCAGCACCAGTTCGACAAGGTAGAGATGGTGCAGGTGA
CGGCACCCGACGCGTCGTATGCGGCGCTCGAGGAAATGGTCGGCCACGCGGAGGCGATCCTGCAAAAGCTCGAACTGCCT
TACCGGGTGGTCACGCTCTGCACCGGCGACATGGGCTTCTCGGCCGCGAAGACCTACGACCTCGAAGTCTGGCTGCCCGC
GCAGAACACCTATCGCGAGATCTCCAGCTGCTCGAACACCGAGTCGTTCCAGGCGCGGCGCATGCAGGCGCGCTTTCGCA
ACGCACAGGGCAAGCCCGAGCTCGTGCATACGCTGAACGGTTCGGGGCTCGCGGTGGGCCGCACGCTCGTGGCCGTGCTC
GAGAACTACCAGAACGCCGACGGTTCGGTAACGGTGCCGGCCGCGCTGCGTCCGTACCTGGGTGGACTCGACACGATTGC
GGCGCCGAACGCCGCGGCCTGA

Upstream 100 bases:

>100_bases
GCCGGCCGGAATCGTCGCGTGCTTCGCCTCGGGCGGCAGCCGGCAGCGCCGCGCGGTGCGTTAGAATTCGCCTTTCACAC
AACGATTCTCCGGTCCTCCC

Downstream 100 bases:

>100_bases
ACGCGCGCAACGCATGCGCAGCGCCGGCAACGGCGATTCGCTCGTGCGGCACGCGACGCAAAGTTTTTTGCGGAAAGGAC
TTGGAAGTTTGAAAAGAGTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLDIQLLRKDLDGVAKRLADRGYILDVAAFSSLEAERRAIQTRTEELQARRNSLSKQIGAMKGRGEDTSAVMAEVGGIGD
EMKASAAKLDEIQSAMSELMLGMPNLAHESVPVGADEAGNVEVRRWGTPRAFDFEVRDHVDVGTPLGLDFETGAKLSGAR
FTMLRGPIARLHRALAQFMIDTHTQQHGYTETYTPYIVNPDILRGTGQLPKFADDMFRVEKGGGENTVTQYLISTSEITL
TNTVRESILDAAELPVKLTAHSPCFRSEAGAYGRDTRGMIRQHQFDKVEMVQVTAPDASYAALEEMVGHAEAILQKLELP
YRVVTLCTGDMGFSAAKTYDLEVWLPAQNTYREISSCSNTESFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPAALRPYLGGLDTIAAPNAAA

Sequences:

>Translated_433_residues
MLDIQLLRKDLDGVAKRLADRGYILDVAAFSSLEAERRAIQTRTEELQARRNSLSKQIGAMKGRGEDTSAVMAEVGGIGD
EMKASAAKLDEIQSAMSELMLGMPNLAHESVPVGADEAGNVEVRRWGTPRAFDFEVRDHVDVGTPLGLDFETGAKLSGAR
FTMLRGPIARLHRALAQFMIDTHTQQHGYTETYTPYIVNPDILRGTGQLPKFADDMFRVEKGGGENTVTQYLISTSEITL
TNTVRESILDAAELPVKLTAHSPCFRSEAGAYGRDTRGMIRQHQFDKVEMVQVTAPDASYAALEEMVGHAEAILQKLELP
YRVVTLCTGDMGFSAAKTYDLEVWLPAQNTYREISSCSNTESFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPAALRPYLGGLDTIAAPNAAA
>Mature_433_residues
MLDIQLLRKDLDGVAKRLADRGYILDVAAFSSLEAERRAIQTRTEELQARRNSLSKQIGAMKGRGEDTSAVMAEVGGIGD
EMKASAAKLDEIQSAMSELMLGMPNLAHESVPVGADEAGNVEVRRWGTPRAFDFEVRDHVDVGTPLGLDFETGAKLSGAR
FTMLRGPIARLHRALAQFMIDTHTQQHGYTETYTPYIVNPDILRGTGQLPKFADDMFRVEKGGGENTVTQYLISTSEITL
TNTVRESILDAAELPVKLTAHSPCFRSEAGAYGRDTRGMIRQHQFDKVEMVQVTAPDASYAALEEMVGHAEAILQKLELP
YRVVTLCTGDMGFSAAKTYDLEVWLPAQNTYREISSCSNTESFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPAALRPYLGGLDTIAAPNAAA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=469, Percent_Identity=32.6226012793177, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI8923421, Length=417, Percent_Identity=29.7362110311751, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI225579074, Length=333, Percent_Identity=33.033033033033, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=61.5384615384615, Blast_Score=548, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17539260, Length=342, Percent_Identity=35.0877192982456, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17542084, Length=334, Percent_Identity=29.0419161676647, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=406, Percent_Identity=31.7733990147783, Blast_Score=213, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6321799, Length=386, Percent_Identity=30.5699481865285, Blast_Score=189, Evalue=6e-49,
Organism=Drosophila melanogaster, GI24581334, Length=470, Percent_Identity=31.7021276595745, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI17737985, Length=344, Percent_Identity=29.6511627906977, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47269; Mature: 47269

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIQLLRKDLDGVAKRLADRGYILDVAAFSSLEAERRAIQTRTEELQARRNSLSKQIGA
CCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGRGEDTSAVMAEVGGIGDEMKASAAKLDEIQSAMSELMLGMPNLAHESVPVGADEAGN
HCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPRAFDFEVRDHVDVGTPLGLDFETGAKLSGARFTMLRGPIARLHRALAQFMI
EEEEECCCCCEEEEEHHCCCCCCCCCCCCCCCCCCCCCCEEHHHHCHHHHHHHHHHHHHH
DTHTQQHGYTETYTPYIVNPDILRGTGQLPKFADDMFRVEKGGGENTVTQYLISTSEITL
HHHHHHCCCCCCCCCEEECCHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCEEE
TNTVRESILDAAELPVKLTAHSPCFRSEAGAYGRDTRGMIRQHQFDKVEMVQVTAPDASY
HHHHHHHHHHHHHCCEEEECCCCCHHCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHH
AALEEMVGHAEAILQKLELPYRVVTLCTGDMGFSAAKTYDLEVWLPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHCCCC
ESFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPAALRPYL
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEECHHHHHHH
GGLDTIAAPNAAA
CCCHHHCCCCCCC
>Mature Secondary Structure
MLDIQLLRKDLDGVAKRLADRGYILDVAAFSSLEAERRAIQTRTEELQARRNSLSKQIGA
CCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGRGEDTSAVMAEVGGIGDEMKASAAKLDEIQSAMSELMLGMPNLAHESVPVGADEAGN
HCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPRAFDFEVRDHVDVGTPLGLDFETGAKLSGARFTMLRGPIARLHRALAQFMI
EEEEECCCCCEEEEEHHCCCCCCCCCCCCCCCCCCCCCCEEHHHHCHHHHHHHHHHHHHH
DTHTQQHGYTETYTPYIVNPDILRGTGQLPKFADDMFRVEKGGGENTVTQYLISTSEITL
HHHHHHCCCCCCCCCEEECCHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCEEE
TNTVRESILDAAELPVKLTAHSPCFRSEAGAYGRDTRGMIRQHQFDKVEMVQVTAPDASY
HHHHHHHHHHHHHCCEEEECCCCCHHCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHH
AALEEMVGHAEAILQKLELPYRVVTLCTGDMGFSAAKTYDLEVWLPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHCCCC
ESFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPAALRPYL
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEECHHHHHHH
GGLDTIAAPNAAA
CCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA