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The map label for this gene is glyA1 [H]

Identifier: 238026344

GI number: 238026344

Start: 733448

End: 734695

Strand: Direct

Name: glyA1 [H]

Synonym: bglu_1g06780

Alternate gene names: 238026344

Gene position: 733448-734695 (Clockwise)

Preceding gene: 238026334

Following gene: 238026345

Centisome position: 18.78

GC content: 66.43

Gene sequence:

>1248_bases
ATGTTTGACAGAGCCCAAAGCACCATCGCGAACGTCGATCCCGACCTCTGGCAGGCGATCCAGCAGGAGAACCAGCGCCA
GGAAGATCACATCGAGCTGATCGCCTCCGAGAACTACACGAGCCCGGCGGTGATGGCCGCGCAGGGCTCGCAGCTGACCA
ACAAGTATGCCGAGGGCTATCCCGGCAAGCGCTACTACGGCGGCTGCGAATACGTGGACGTGGTCGAGCAACTGGCGATC
GACCGGGTCAAGGCGCTGTTCGGCGCGCAAGCGGCCAACGTGCAGCCGAACTCGGGCTCGCAGGCCAACCAGGGCGTGTT
CTTCGCGATGCTCAAGCCGGGCGACACGATCATGGGCATGAGCCTGGCGCACGGCGGGCACCTCACGCACGGCTCGCCGG
TGAACATGTCGGGCAAGTGGTTCAACGTGGTGAGCTACGGCCTGGACGAAAGCGAGGACATCGACTACGAGGCGGCCGAT
CGGCTCGCGCAGGAGCACAAGCCGAAGATGATCGTGGCGGGGGCCTCGGCATTCGCGCTGAAGATCGACTTCGAGCGCCT
GGCGAAGATCGCGAAGTCGGTGGGCGCGTACCTGATGGTGGACATGGCGCACTACGCGGGGCTGATCGCGGCTGGGGTGT
ATCCGAACCCGGTGCCGCACGCGGACTTCGTGACGACGACCACGCACAAGAGCCTGCGCGGGCCGCGCGGCGGCGTGATT
CTGATGAAGTCGGAGTACGAGAAGCCGATCAACTCGGCGATTTTCCCCGGGATTCAGGGCGGCCCGCTGATGCACGTGAT
CGCGGCGAAGGCGGTGGCGTTCAAGGAAGCGGGCTCGGCGGAATTCAAGGCGTACCAGCAGCAGGTGGTGGAGAACGCGC
GGGTGCTGGCGCAGACGCTGGTCAAGCGCGGGCTGCGGATCGTGTCCGGGCGCACGGAAAGCCACGTGATGCTGGTGGAC
CTGCAGGCGAAGAAGATCACGGGCAAGGCGGCGGAAGCGGCGCTGGGCGCGGCGCACATCACGGTGAACAAGAACGCGAT
CCCGAACGACCCGGAGAAGCCGTTCGTGACGAGCGGGATTCGTCTGGGCTCGCCGGCGATGACGACGCGCGGGTTCGGCA
CGAAGGAGGCGGAGATCGTGGGCAACCTGATCGCGGACGTGCTGGACAATCCGGAGGACGCGGCCACGCTGGAGCGCGTG
CGCGCGCAGGTGGCCGAGCTGACCCGGCAGTTCCCGGTCTACCGCTGA

Upstream 100 bases:

>100_bases
CGTCAACCGGATACTTCCGCCACGTCGGGCTGGCCATTCCGCCAGCAACGCAATGTACTCGGCCGCCCCGGTCAACCTGT
ACACACTTAACGGAAACCGT

Downstream 100 bases:

>100_bases
TCGGTCATGCGCTGTCCGTTCTGCCGGCACGACGACACGCAGGTGGTGGATTCGCGCGTGTCCGAGGACGGCGCCGCGAT
TCGCCGGCGCCGCCGCTGCT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MFDRAQSTIANVDPDLWQAIQQENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKALFGAQAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLDESEDIDYEAAD
RLAQEHKPKMIVAGASAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKSEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEAGSAEFKAYQQQVVENARVLAQTLVKRGLRIVSGRTESHVMLVD
LQAKKITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFGTKEAEIVGNLIADVLDNPEDAATLERV
RAQVAELTRQFPVYR

Sequences:

>Translated_415_residues
MFDRAQSTIANVDPDLWQAIQQENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKALFGAQAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLDESEDIDYEAAD
RLAQEHKPKMIVAGASAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKSEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEAGSAEFKAYQQQVVENARVLAQTLVKRGLRIVSGRTESHVMLVD
LQAKKITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFGTKEAEIVGNLIADVLDNPEDAATLERV
RAQVAELTRQFPVYR
>Mature_415_residues
MFDRAQSTIANVDPDLWQAIQQENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKALFGAQAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLDESEDIDYEAAD
RLAQEHKPKMIVAGASAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKSEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEAGSAEFKAYQQQVVENARVLAQTLVKRGLRIVSGRTESHVMLVD
LQAKKITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFGTKEAEIVGNLIADVLDNPEDAATLERV
RAQVAELTRQFPVYR

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=454, Percent_Identity=40.7488986784141, Blast_Score=333, Evalue=1e-91,
Organism=Homo sapiens, GI261862350, Length=454, Percent_Identity=40.7488986784141, Blast_Score=333, Evalue=1e-91,
Organism=Homo sapiens, GI261862348, Length=454, Percent_Identity=40.7488986784141, Blast_Score=333, Evalue=1e-91,
Organism=Homo sapiens, GI19923315, Length=454, Percent_Identity=40.7488986784141, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI261862346, Length=453, Percent_Identity=40.1766004415011, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI22547186, Length=428, Percent_Identity=41.3551401869159, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI22547189, Length=386, Percent_Identity=41.4507772020725, Blast_Score=273, Evalue=3e-73,
Organism=Escherichia coli, GI1788902, Length=414, Percent_Identity=63.2850241545894, Blast_Score=539, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI25144732, Length=400, Percent_Identity=45, Blast_Score=339, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI25144729, Length=400, Percent_Identity=45, Blast_Score=338, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6319739, Length=415, Percent_Identity=45.7831325301205, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323087, Length=433, Percent_Identity=42.4942263279446, Blast_Score=330, Evalue=3e-91,
Organism=Drosophila melanogaster, GI24640005, Length=455, Percent_Identity=41.7582417582418, Blast_Score=349, Evalue=2e-96,
Organism=Drosophila melanogaster, GI221329721, Length=455, Percent_Identity=41.7582417582418, Blast_Score=349, Evalue=2e-96,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 44796; Mature: 44796

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDRAQSTIANVDPDLWQAIQQENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCHHHHHHHCCCHHHHHHHHHHHCCCHHHEEEEECCCCCCCEEEECCCCHHHHHHHCCC
PGKRYYGGCEYVDVVEQLAIDRVKALFGAQAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLDESEDIDYEAADRLAQEHKPKMIVAGASAFAL
EECCCCCCCCCCCCCCCCCEEEHEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCEEEE
KIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKSEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEAGSAEFKAYQQQVVENARVLAQTL
EECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLQAKKITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGI
HHCCCEEECCCCCCEEEEEEECHHHHCCHHHHHHHCEEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGTKEAEIVGNLIADVLDNPEDAATLERVRAQVAELTRQFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFDRAQSTIANVDPDLWQAIQQENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCHHHHHHHCCCHHHHHHHHHHHCCCHHHEEEEECCCCCCCEEEECCCCHHHHHHHCCC
PGKRYYGGCEYVDVVEQLAIDRVKALFGAQAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLDESEDIDYEAADRLAQEHKPKMIVAGASAFAL
EECCCCCCCCCCCCCCCCCEEEHEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCEEEE
KIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKSEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEAGSAEFKAYQQQVVENARVLAQTL
EECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLQAKKITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGI
HHCCCEEECCCCCCEEEEEEECHHHHCCHHHHHHHCEEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGTKEAEIVGNLIADVLDNPEDAATLERVRAQVAELTRQFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA