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The map label for this gene is mutT [H]

Identifier: 238026144

GI number: 238026144

Start: 503136

End: 503576

Strand: Direct

Name: mutT [H]

Synonym: bglu_1g04740

Alternate gene names: 238026144

Gene position: 503136-503576 (Clockwise)

Preceding gene: 238026143

Following gene: 238026153

Centisome position: 12.88

GC content: 73.92

Gene sequence:

>441_bases
ATGAGCGCGGCCGCCGACACCGCCGCGGGCGGCGCCGCGCCGCGCAAGGTCACCGAGGTCGCGGTCGGCGTGCTGGTGCG
GCCCGACGGCCGTTACCTGCTCGCGCAGCGGCCGGCCGGCAAGCCCTACGAGGGGTATTGGGAATTCCCGGGCGGCAAGC
TCGAGGCGGGCGAGAGCGTCGAGGCGGCGCTCGCGCGCGAACTGCACGAGGAGCTCGGGATCTCGGTCACGGCCTGCCGG
CGCTGGCATACGCTCGAGCACGACTACCCGCACGCCTACGTGCGGCTGTTCTTCTGCAAGGTCACGGACTGGGACGGCGA
GCCGCATAGCCGTGAAGGGCAGGCGCTCGCCTGGCAGGCGCTGCCGGTCGACGTCGCGCCGCTCTTGCCTGCGGCGCTGC
CCGTGCTCGAACTGCTTGCGCGCGAGGCGCAGGCGCGCTGA

Upstream 100 bases:

>100_bases
CGCGCGGCGACGCGCTGGTCTGGGCGCTCGAACGCGGCTCGCGCTCGGGACGCGTGGCGTGGCAATTCGCGCGCGATCGC
GCCGGCCGCGGGGAGCCGGC

Downstream 100 bases:

>100_bases
GCGGGTTTGTCCGGGAGCCGGCCCGGCCCGCGGGCCGTCCGCCGGCTCGGAGCGGGCGTTAGTCGTCGCGGCCCGAGCGG
CCGTCCGGCTGGCCATTCGC

Product: pyrophosphatase, NUDIX family

Products: 8-Oxo-Dgmp; Pyrophosphate. [C]

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 146; Mature: 145

Protein sequence:

>146_residues
MSAAADTAAGGAAPRKVTEVAVGVLVRPDGRYLLAQRPAGKPYEGYWEFPGGKLEAGESVEAALARELHEELGISVTACR
RWHTLEHDYPHAYVRLFFCKVTDWDGEPHSREGQALAWQALPVDVAPLLPAALPVLELLAREAQAR

Sequences:

>Translated_146_residues
MSAAADTAAGGAAPRKVTEVAVGVLVRPDGRYLLAQRPAGKPYEGYWEFPGGKLEAGESVEAALARELHEELGISVTACR
RWHTLEHDYPHAYVRLFFCKVTDWDGEPHSREGQALAWQALPVDVAPLLPAALPVLELLAREAQAR
>Mature_145_residues
SAAADTAAGGAAPRKVTEVAVGVLVRPDGRYLLAQRPAGKPYEGYWEFPGGKLEAGESVEAALARELHEELGISVTACRR
WHTLEHDYPHAYVRLFFCKVTDWDGEPHSREGQALAWQALPVDVAPLLPAALPVLELLAREAQAR

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=127, Percent_Identity=35.4330708661417, Blast_Score=83, Evalue=7e-18,
Organism=Escherichia coli, GI1788056, Length=126, Percent_Identity=41.2698412698413, Blast_Score=77, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 15895; Mature: 15764

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAADTAAGGAAPRKVTEVAVGVLVRPDGRYLLAQRPAGKPYEGYWEFPGGKLEAGESV
CCCCCCCCCCCCCCHHHHHHHEEEEECCCCCEEEEECCCCCCCCCEEECCCCCCCCCCHH
EAALARELHEELGISVTACRRWHTLEHDYPHAYVRLFFCKVTDWDGEPHSREGQALAWQA
HHHHHHHHHHHHCCEEEHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCEEEEEE
LPVDVAPLLPAALPVLELLAREAQAR
CCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAAADTAAGGAAPRKVTEVAVGVLVRPDGRYLLAQRPAGKPYEGYWEFPGGKLEAGESV
CCCCCCCCCCCCCHHHHHHHEEEEECCCCCEEEEECCCCCCCCCEEECCCCCCCCCCHH
EAALARELHEELGISVTACRRWHTLEHDYPHAYVRLFFCKVTDWDGEPHSREGQALAWQA
HHHHHHHHHHHHCCEEEHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCEEEEEE
LPVDVAPLLPAALPVLELLAREAQAR
CCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Oxo-Dgtp; H2O [C]

Specific reaction: 8-Oxo-Dgtp + H2O = 8-Oxo-Dgmp + Pyrophosphate. [C]

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8244038 [H]