Click here to switch to the map view.

The map label for this gene is hisI [H]

Identifier: 238026012

GI number: 238026012

Start: 356811

End: 357230

Strand: Direct

Name: hisI [H]

Synonym: bglu_1g03380

Alternate gene names: 238026012

Gene position: 356811-357230 (Clockwise)

Preceding gene: 238026011

Following gene: 238026013

Centisome position: 9.13

GC content: 66.67

Gene sequence:

>420_bases
ATGACGACGACACAGGCGGCGGCCCGCCCCGCGTGGCTCGACAAGGTCCGCTGGGACGCCAACGGCCTCGTGCCGGTGAT
CGCGCAGGAGGTCGGCACGAACGACGTGCTGATGTTCGCGTGGATGAACCGCGAGGCGCTCGCGAAGACCGTCGAGACGG
GCCGCGCGGTCTATTACTCGCGCTCGCGGCAGCGGCTCTGGTTCAAGGGCGAGGAGTCGGGGCACGTGCAGCACGTGCAT
GAGGTGCGGCTCGATTGCGACGAGGACGTGGTGCTGCTGAAGATCGACCAGGTGTCGGGCATCGCCTGCCACACCGGCCG
CCATTCCTGCTTTTTCCAGAAATTCGAGGGCACCGCCGAGGGCGGCGACTGGGTCGCCGTCGAGCCGGTGCTGAAAGATC
CCGAGCACATCTACAAATGA

Upstream 100 bases:

>100_bases
ACGCGGTGCTCGCGGCCAGCATCTTCCATTACGGCGAGCATACGGTCGGCGAGGCGAAGCGCTTCATGGCCGGGCGCGGC
ATTCCGGTGAGGCTCTGATC

Downstream 100 bases:

>100_bases
CGCAGACCACCAACGACACGCTGCTGCGCCTCGCGGCCGTGATCGACAGCCGCAAGGGCGGCGACCCCGAGCAATCCTAC
GTGTCGCGCCTATTCCACAA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 139; Mature: 138

Protein sequence:

>139_residues
MTTTQAAARPAWLDKVRWDANGLVPVIAQEVGTNDVLMFAWMNREALAKTVETGRAVYYSRSRQRLWFKGEESGHVQHVH
EVRLDCDEDVVLLKIDQVSGIACHTGRHSCFFQKFEGTAEGGDWVAVEPVLKDPEHIYK

Sequences:

>Translated_139_residues
MTTTQAAARPAWLDKVRWDANGLVPVIAQEVGTNDVLMFAWMNREALAKTVETGRAVYYSRSRQRLWFKGEESGHVQHVH
EVRLDCDEDVVLLKIDQVSGIACHTGRHSCFFQKFEGTAEGGDWVAVEPVLKDPEHIYK
>Mature_138_residues
TTTQAAARPAWLDKVRWDANGLVPVIAQEVGTNDVLMFAWMNREALAKTVETGRAVYYSRSRQRLWFKGEESGHVQHVHE
VRLDCDEDVVLLKIDQVSGIACHTGRHSCFFQKFEGTAEGGDWVAVEPVLKDPEHIYK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=92, Percent_Identity=45.6521739130435, Blast_Score=94, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319819, Length=107, Percent_Identity=34.5794392523364, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 15755; Mature: 15624

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTQAAARPAWLDKVRWDANGLVPVIAQEVGTNDVLMFAWMNREALAKTVETGRAVYYS
CCCCCCCCCCHHHHHEEECCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCEEEEE
RSRQRLWFKGEESGHVQHVHEVRLDCDEDVVLLKIDQVSGIACHTGRHSCFFQKFEGTAE
CCCCEEEEECCCCCCCEEEEEEECCCCCCEEEEEECCCCCEEEECCCCCEEEEECCCCCC
GGDWVAVEPVLKDPEHIYK
CCCEEEECCCCCCHHHHCC
>Mature Secondary Structure 
TTTQAAARPAWLDKVRWDANGLVPVIAQEVGTNDVLMFAWMNREALAKTVETGRAVYYS
CCCCCCCCCHHHHHEEECCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCEEEEE
RSRQRLWFKGEESGHVQHVHEVRLDCDEDVVLLKIDQVSGIACHTGRHSCFFQKFEGTAE
CCCCEEEEECCCCCCCEEEEEEECCCCCCEEEEEECCCCCEEEECCCCCEEEEECCCCCC
GGDWVAVEPVLKDPEHIYK
CCCEEEECCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA