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The map label for this gene is lysA [H]

Identifier: 238025969

GI number: 238025969

Start: 310161

End: 311432

Strand: Reverse

Name: lysA [H]

Synonym: bglu_1g02950

Alternate gene names: 238025969

Gene position: 311432-310161 (Counterclockwise)

Preceding gene: 238025970

Following gene: 238025963

Centisome position: 7.97

GC content: 69.97

Gene sequence:

>1272_bases
ATGACTCACCGCGCATTTGACTACGTCGACGGCACGCTGCACGCCGAAGGCATTCCGGCCGACAAGCTCGCCGACCACTT
CGACACGCCGCTCTACGTCTATTCGCGCGCCGCGCTGACGGCCGCGTACCAGGCCTATGCCAAGGCCTGCGAGGGCCGCC
GCGCGTCGCTCCACGTCGCCGTGAAGGCGAACAGCAACCTCGGCGTGCTGAACGTGTTCGCGCGGCTCGGCGCCGGCTTC
GACATCGTTTCGGGCGGCGAACTCGCGCGCGTGCTCGCCGCGGGCGGCAAGGCGGAGCACGTGGTGTTCTCGGGCGTGGC
CAAGAGCGCCGACGAGATGCGCCTCGCGCTCGAGGCCGGCGTCAAGTGCTTCAACGTCGAATCGGTGCCGGAGCTCGACC
GCCTCAACGCGGTGGCGGGCTCGCTCGGCAAGCGCGCGCCGGTCTCGCTGCGCGTGAACCCCGACGTCGATCCGAAGACG
CATCCGTACATCTCCACCGGCCTGAAGGCCAACAAGTTCGGCGTGGCGTTCGCCGACGCGCGCGCGACCTACCGCGCCGC
CGACGCGCTGCCGAACCTGCAGGTGGCCGGCATCGACTGCCACATCGGCTCGCAGATCACCGAGCTGAGCCCCTACCTCG
ACGCGCTCGACAAGGTGCTCGACCTGGTCGAGCAGATCGAGGCGGACGGCATCGCGATCCATCACGTCGACGTGGGCGGC
GGGCTCGGCATCACCTATGCCGACGAGACGCCGCCCGACATCGGCGCGTTCGTGCAGGCGCTGTTCGCGAAGCTCGACGC
GCGCGGCCATGGCCACCGCGAGCTGTGCTTCGAGCCGGGCCGCTCGCTGACCGGCAACGCCGGCATCCTGCTCACGCGCG
TCGAATTCCTGAAGCCGGGCGAGGAGAAGAACTTCGCGATCGTCGACGCGGGCATGAACGACCTGGCACGCCCGGCGATG
TACGAGGCCTATCACGCGATCGTGCCGGTCAGGCAGACCAGCGCGCATGCGAGCGCCGTCTACGACGTGGTCGGCCCGGT
CTGCGAGAGCGGCGACTGGCTCGGCCGCGAGCGCACGCTCGCGATCGCCGCGGGCGACCTGCTCGCGATCCGCTCGGCCG
GCGCCTACGGCTTCGCGATGAGCTCGAACTACAACACGCGCCCGCGCGCGGCCGAGGTGCTCGTCGACGGCCAGAACGCC
TATCTGGTGCGCCAGCGCGAAACCATCGCGAGCCTGTACGAGAACGAGGCGATCCTGCCCGAAGAGGCGTGA

Upstream 100 bases:

>100_bases
TCCGGCACCGGACGACGCGGCCGGCGCGTCACTGACGCTTTCGCCGTCGCTCGCCTCGCCGGGCGCGGCCTCCGACGCCA
CCCCCAATCGATGATCCCGG

Downstream 100 bases:

>100_bases
GCCGGGCCGGCGCGACGGCGCCGCGTCCATCGACGGCCCCGCAAAGCGATGCGTGTGAAGACGCATCGCTTTTTTCTTGG
CCGGCCTAGCCCGCGGCCCG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MTHRAFDYVDGTLHAEGIPADKLADHFDTPLYVYSRAALTAAYQAYAKACEGRRASLHVAVKANSNLGVLNVFARLGAGF
DIVSGGELARVLAAGGKAEHVVFSGVAKSADEMRLALEAGVKCFNVESVPELDRLNAVAGSLGKRAPVSLRVNPDVDPKT
HPYISTGLKANKFGVAFADARATYRAADALPNLQVAGIDCHIGSQITELSPYLDALDKVLDLVEQIEADGIAIHHVDVGG
GLGITYADETPPDIGAFVQALFAKLDARGHGHRELCFEPGRSLTGNAGILLTRVEFLKPGEEKNFAIVDAGMNDLARPAM
YEAYHAIVPVRQTSAHASAVYDVVGPVCESGDWLGRERTLAIAAGDLLAIRSAGAYGFAMSSNYNTRPRAAEVLVDGQNA
YLVRQRETIASLYENEAILPEEA

Sequences:

>Translated_423_residues
MTHRAFDYVDGTLHAEGIPADKLADHFDTPLYVYSRAALTAAYQAYAKACEGRRASLHVAVKANSNLGVLNVFARLGAGF
DIVSGGELARVLAAGGKAEHVVFSGVAKSADEMRLALEAGVKCFNVESVPELDRLNAVAGSLGKRAPVSLRVNPDVDPKT
HPYISTGLKANKFGVAFADARATYRAADALPNLQVAGIDCHIGSQITELSPYLDALDKVLDLVEQIEADGIAIHHVDVGG
GLGITYADETPPDIGAFVQALFAKLDARGHGHRELCFEPGRSLTGNAGILLTRVEFLKPGEEKNFAIVDAGMNDLARPAM
YEAYHAIVPVRQTSAHASAVYDVVGPVCESGDWLGRERTLAIAAGDLLAIRSAGAYGFAMSSNYNTRPRAAEVLVDGQNA
YLVRQRETIASLYENEAILPEEA
>Mature_422_residues
THRAFDYVDGTLHAEGIPADKLADHFDTPLYVYSRAALTAAYQAYAKACEGRRASLHVAVKANSNLGVLNVFARLGAGFD
IVSGGELARVLAAGGKAEHVVFSGVAKSADEMRLALEAGVKCFNVESVPELDRLNAVAGSLGKRAPVSLRVNPDVDPKTH
PYISTGLKANKFGVAFADARATYRAADALPNLQVAGIDCHIGSQITELSPYLDALDKVLDLVEQIEADGIAIHHVDVGGG
LGITYADETPPDIGAFVQALFAKLDARGHGHRELCFEPGRSLTGNAGILLTRVEFLKPGEEKNFAIVDAGMNDLARPAMY
EAYHAIVPVRQTSAHASAVYDVVGPVCESGDWLGRERTLAIAAGDLLAIRSAGAYGFAMSSNYNTRPRAAEVLVDGQNAY
LVRQRETIASLYENEAILPEEA

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=390, Percent_Identity=23.0769230769231, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1789203, Length=433, Percent_Identity=35.1039260969977, Blast_Score=164, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17562780, Length=360, Percent_Identity=23.8888888888889, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24586474, Length=389, Percent_Identity=25.4498714652956, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24586472, Length=345, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45013; Mature: 44882

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHRAFDYVDGTLHAEGIPADKLADHFDTPLYVYSRAALTAAYQAYAKACEGRRASLHVA
CCCCCCCCCCCEEECCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCEEEEEE
VKANSNLGVLNVFARLGAGFDIVSGGELARVLAAGGKAEHVVFSGVAKSADEMRLALEAG
EEECCCCCHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCEEEEEHHHCCHHHHHHHHHHC
VKCFNVESVPELDRLNAVAGSLGKRAPVSLRVNPDVDPKTHPYISTGLKANKFGVAFADA
CEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECC
RATYRAADALPNLQVAGIDCHIGSQITELSPYLDALDKVLDLVEQIEADGIAIHHVDVGG
HHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
GLGITYADETPPDIGAFVQALFAKLDARGHGHRELCFEPGRSLTGNAGILLTRVEFLKPG
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCEEEEEEHHHCCC
EEKNFAIVDAGMNDLARPAMYEAYHAIVPVRQTSAHASAVYDVVGPVCESGDWLGRERTL
CCCCEEEEECCCHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEE
AIAAGDLLAIRSAGAYGFAMSSNYNTRPRAAEVLVDGQNAYLVRQRETIASLYENEAILP
EEECCCEEEEECCCCEEEEECCCCCCCCCEEEEEEECCCEEEEEHHHHHHHHHHCCCCCC
EEA
CCC
>Mature Secondary Structure 
THRAFDYVDGTLHAEGIPADKLADHFDTPLYVYSRAALTAAYQAYAKACEGRRASLHVA
CCCCCCCCCCEEECCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCEEEEEE
VKANSNLGVLNVFARLGAGFDIVSGGELARVLAAGGKAEHVVFSGVAKSADEMRLALEAG
EEECCCCCHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCEEEEEHHHCCHHHHHHHHHHC
VKCFNVESVPELDRLNAVAGSLGKRAPVSLRVNPDVDPKTHPYISTGLKANKFGVAFADA
CEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECC
RATYRAADALPNLQVAGIDCHIGSQITELSPYLDALDKVLDLVEQIEADGIAIHHVDVGG
HHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
GLGITYADETPPDIGAFVQALFAKLDARGHGHRELCFEPGRSLTGNAGILLTRVEFLKPG
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCEEEEEEHHHCCC
EEKNFAIVDAGMNDLARPAMYEAYHAIVPVRQTSAHASAVYDVVGPVCESGDWLGRERTL
CCCCEEEEECCCHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEE
AIAAGDLLAIRSAGAYGFAMSSNYNTRPRAAEVLVDGQNAYLVRQRETIASLYENEAILP
EEECCCEEEEECCCCEEEEECCCCCCCCCEEEEEEECCCEEEEEHHHHHHHHHHCCCCCC
EEA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]