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The map label for this gene is ilvR [H]

Identifier: 238025295

GI number: 238025295

Start: 2446923

End: 2447834

Strand: Direct

Name: ilvR [H]

Synonym: bglu_2g19690

Alternate gene names: 238025295

Gene position: 2446923-2447834 (Clockwise)

Preceding gene: 238025290

Following gene: 238025306

Centisome position: 86.55

GC content: 63.27

Gene sequence:

>912_bases
ATGCACAACTTCGTCCCCGATCTGCGCCAGTGGTACTACTTCGTCGCTGTCGCCGAGGAGCGGCATTTCGGTCGAGCCGC
CGTGCGCCTGTCCATGACTCAGCCCCCTCTCTCACAGGCGATTCGCTCGCTGGAGCGCGAGCTCGGCGTCATGTTGTTTG
CCCGCACGAACCGCACGGTCACGCTCACTGCGGTCGGCGAAGCATTGCTCCCCGAGGTCCGTAAGCTACTGAGCGCGGCC
GAGGCGCTTCCCCCGCTGGCGCAGAGTCTCGCGCGGGGCGAGAGCGGGAGCCTGTCGCTGGCGTTTGTGTCAATTGCCGA
CTATGGCCTGCTCCCATTGCTGCTACGCGAGTTCGGCGCGCGCTATCCGCTGGTGCGGTTGCACCTCACCGAGGCCACCA
GCGATGTGCAAATCGACGCGCTGGTGGCCGGCCAGATCGACGCGGGATTGATCGTCCCGCCAGTGCCGCCCCGCTACTCT
TCGGAGCTGTCGTACCTGCCGGTCCTCAGGGAGCCGTTGGTGCTCGCGATACCGGCCGCCGAATCGGATGCGGCCGAGGA
CGTGCCGATTCATCTGGCAGAAGTTGCCGAGCTCCCGCTCGTGATTTTCCCGCGGCGCCTTGCGCCAAATTTTTACGATT
CGATCATGGAATGCTACCGCGTTGCGGGCGTGGTTCCGCGGATTGGCCAAGAAGCGATCCAGATGCAGACGATCGTCAGC
CTCGTTTCCGCCGGCATCGGTGTGGCCGTGGTTCCGCAATCACTGCGAAACTTGCGACGCACGGGCGTCATCTACCGCCC
GATCGCACACGAACCGTTCATCGTCGAAACCGGCTTGGCATGGCGAAAAGCCGACACCGGACATGTGTTGACCAGTTTTA
TCAATATCGTGCAAACCCTGACGTCCAGGTAA

Upstream 100 bases:

>100_bases
GTTCGTCCCGGAGCCGCGTCCGAACCAGCGCGGCCACGTCAAATGCACGACCGCCGCCTGTCCAATCATTTTCTCATCGC
CTTCAGACGTATTTCAAAAA

Downstream 100 bases:

>100_bases
TGCAGGCGCAAGCGAGCCAGGCGCCGGTTTGGTCGCGGGGCCGCGGCCCATGGCGCGGCACGCGCGCGAATCGTGCGGAC
CGCCGCAGACGGGGATGGCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Isoleucine biosynthesis transcriptional activator [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MHNFVPDLRQWYYFVAVAEERHFGRAAVRLSMTQPPLSQAIRSLERELGVMLFARTNRTVTLTAVGEALLPEVRKLLSAA
EALPPLAQSLARGESGSLSLAFVSIADYGLLPLLLREFGARYPLVRLHLTEATSDVQIDALVAGQIDAGLIVPPVPPRYS
SELSYLPVLREPLVLAIPAAESDAAEDVPIHLAEVAELPLVIFPRRLAPNFYDSIMECYRVAGVVPRIGQEAIQMQTIVS
LVSAGIGVAVVPQSLRNLRRTGVIYRPIAHEPFIVETGLAWRKADTGHVLTSFINIVQTLTSR

Sequences:

>Translated_303_residues
MHNFVPDLRQWYYFVAVAEERHFGRAAVRLSMTQPPLSQAIRSLERELGVMLFARTNRTVTLTAVGEALLPEVRKLLSAA
EALPPLAQSLARGESGSLSLAFVSIADYGLLPLLLREFGARYPLVRLHLTEATSDVQIDALVAGQIDAGLIVPPVPPRYS
SELSYLPVLREPLVLAIPAAESDAAEDVPIHLAEVAELPLVIFPRRLAPNFYDSIMECYRVAGVVPRIGQEAIQMQTIVS
LVSAGIGVAVVPQSLRNLRRTGVIYRPIAHEPFIVETGLAWRKADTGHVLTSFINIVQTLTSR
>Mature_303_residues
MHNFVPDLRQWYYFVAVAEERHFGRAAVRLSMTQPPLSQAIRSLERELGVMLFARTNRTVTLTAVGEALLPEVRKLLSAA
EALPPLAQSLARGESGSLSLAFVSIADYGLLPLLLREFGARYPLVRLHLTEATSDVQIDALVAGQIDAGLIVPPVPPRYS
SELSYLPVLREPLVLAIPAAESDAAEDVPIHLAEVAELPLVIFPRRLAPNFYDSIMECYRVAGVVPRIGQEAIQMQTIVS
LVSAGIGVAVVPQSLRNLRRTGVIYRPIAHEPFIVETGLAWRKADTGHVLTSFINIVQTLTSR

Specific function: Positively regulates the expression of the ilvD gene while negatively autoregulating its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=282, Percent_Identity=38.6524822695035, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1788887, Length=296, Percent_Identity=33.445945945946, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI2367136, Length=270, Percent_Identity=31.8518518518519, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1790399, Length=278, Percent_Identity=29.4964028776978, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI145693105, Length=258, Percent_Identity=26.3565891472868, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI157672245, Length=235, Percent_Identity=32.7659574468085, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787806, Length=295, Percent_Identity=25.7627118644068, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788748, Length=246, Percent_Identity=28.0487804878049, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786713, Length=297, Percent_Identity=28.6195286195286, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790208, Length=252, Percent_Identity=30.1587301587302, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787530, Length=246, Percent_Identity=26.4227642276423, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1788297, Length=257, Percent_Identity=26.4591439688716, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787589, Length=137, Percent_Identity=36.4963503649635, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081904, Length=212, Percent_Identity=29.2452830188679, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI48994962, Length=69, Percent_Identity=49.2753623188406, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87082132, Length=151, Percent_Identity=32.4503311258278, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788296, Length=239, Percent_Identity=26.3598326359833, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33213; Mature: 33213

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNFVPDLRQWYYFVAVAEERHFGRAAVRLSMTQPPLSQAIRSLERELGVMLFARTNRTV
CCCCCHHHHHHEEHEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHCEEEEEECCCEE
TLTAVGEALLPEVRKLLSAAEALPPLAQSLARGESGSLSLAFVSIADYGLLPLLLREFGA
EEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEEEHHHCCHHHHHHHHHCC
RYPLVRLHLTEATSDVQIDALVAGQIDAGLIVPPVPPRYSSELSYLPVLREPLVLAIPAA
CCCEEEEEEECCCCCEEEEEEEECCCCCCEECCCCCCCCCCCCCCCHHHCCCEEEEEECC
ESDAAEDVPIHLAEVAELPLVIFPRRLAPNFYDSIMECYRVAGVVPRIGQEAIQMQTIVS
CCCCCCCCCCHHHHHHCCCCEEECHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVSAGIGVAVVPQSLRNLRRTGVIYRPIAHEPFIVETGLAWRKADTGHVLTSFINIVQTL
HHHCCCCCEEHHHHHHHHHHCCEEEECCCCCCEEEECCCCEECCCCHHHHHHHHHHHHHH
TSR
HCC
>Mature Secondary Structure
MHNFVPDLRQWYYFVAVAEERHFGRAAVRLSMTQPPLSQAIRSLERELGVMLFARTNRTV
CCCCCHHHHHHEEHEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHCEEEEEECCCEE
TLTAVGEALLPEVRKLLSAAEALPPLAQSLARGESGSLSLAFVSIADYGLLPLLLREFGA
EEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEEEHHHCCHHHHHHHHHCC
RYPLVRLHLTEATSDVQIDALVAGQIDAGLIVPPVPPRYSSELSYLPVLREPLVLAIPAA
CCCEEEEEEECCCCCEEEEEEEECCCCCCEECCCCCCCCCCCCCCCHHHCCCEEEEEECC
ESDAAEDVPIHLAEVAELPLVIFPRRLAPNFYDSIMECYRVAGVVPRIGQEAIQMQTIVS
CCCCCCCCCCHHHHHHCCCCEEECHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVSAGIGVAVVPQSLRNLRRTGVIYRPIAHEPFIVETGLAWRKADTGHVLTSFINIVQTL
HHHCCCCCEEHHHHHHHHHHCCEEEECCCCCCEEEECCCCEECCCCHHHHHHHHHHHHHH
TSR
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8113165; 11259647 [H]