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The map label for this gene is yvaG [H]

Identifier: 238025106

GI number: 238025106

Start: 2209110

End: 2209904

Strand: Direct

Name: yvaG [H]

Synonym: bglu_2g17650

Alternate gene names: 238025106

Gene position: 2209110-2209904 (Clockwise)

Preceding gene: 238025105

Following gene: 238025110

Centisome position: 78.13

GC content: 68.68

Gene sequence:

>795_bases
ATGCAGATCAACCTCACTGGCAGGATCGCCCTCGTGACCGCATCCACCGGCGGCATCGGCTATGCCATCGCGGCGGGCCT
AGCGCGCGCGGGCGCGACGCTGATCCTCAACGGCCGTAGCGACACCTCGGTCAACGCGGCGCTGGCCACGCTGCGCTCGT
CGGTACCTGGCGTGAACGCCTCCGGCATCGCGGCCGACCTGTCCGGCGCAGCCGGCGTCGGGGAGCTGACCGAGGCGGCA
CCGACCGTGGACATCCTCGTCAACAACGCCGGCATCTACGGACCGAAGCCGTTCTTCGACATCGACGACGAGGAATGGGA
GCGTTACTTCCAGACCAACGTGATGTCGGGCGTGCGGCTCTCGCGCCACTACCTGCCGCGAATGATGGAGCGCGACTGGG
GCCGGGTGGTATTCATCTCGTCGGAATCGGCGCTGAACATCCCGGCCGACATGATCCAGTACGGCTTCTCGAAGACGGCC
CAGCTGTCGATCGCACGCGGCCTCGCGAAACTCGCGGCCGGCACCGGCGTGACGGTCAACTCGGTGCTGCCGGGGCCGAC
CATGTCGGACGGCGTGAAGGCGATGCTGAAGGACAGCGCCGACCGGCAGGGCAAGACGGTGGACGAGGTGGCGGTGGAAT
TCGTGCGCACCCAGCGCCCCAGCTCGATCCTGCAGCGTCCGGCGACCACCGAGGAAGTGGCGAATCTGGTGGTGTACGTG
TGCTCGGCGCAGGCCTCGGCAACCACCGGCGCCGCGCTGCGCGTGGACGGCGGGGTGGTCGACACGCTGGCCTAG

Upstream 100 bases:

>100_bases
GTCCGGTGATTCGTCTAAGCTGATCCGTCCCATTGTCGAGCGTGCCGCGCCGGTCGCGTCACGTCTCGTGTTCTCGCTCC
CTTTCCGGAACCCGACACTC

Downstream 100 bases:

>100_bases
TGCGGGCCGCCGCGCCGGTGGTTCGCGCATGCGGCGCGAGCCGCGCGGTCATGAATGCGCGGCCGCGAGTTCGCCGCAAC
CGGCGTGCTGGCAAGGTGTT

Product: D-beta-hydroxybutyrate dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MQINLTGRIALVTASTGGIGYAIAAGLARAGATLILNGRSDTSVNAALATLRSSVPGVNASGIAADLSGAAGVGELTEAA
PTVDILVNNAGIYGPKPFFDIDDEEWERYFQTNVMSGVRLSRHYLPRMMERDWGRVVFISSESALNIPADMIQYGFSKTA
QLSIARGLAKLAAGTGVTVNSVLPGPTMSDGVKAMLKDSADRQGKTVDEVAVEFVRTQRPSSILQRPATTEEVANLVVYV
CSAQASATTGAALRVDGGVVDTLA

Sequences:

>Translated_264_residues
MQINLTGRIALVTASTGGIGYAIAAGLARAGATLILNGRSDTSVNAALATLRSSVPGVNASGIAADLSGAAGVGELTEAA
PTVDILVNNAGIYGPKPFFDIDDEEWERYFQTNVMSGVRLSRHYLPRMMERDWGRVVFISSESALNIPADMIQYGFSKTA
QLSIARGLAKLAAGTGVTVNSVLPGPTMSDGVKAMLKDSADRQGKTVDEVAVEFVRTQRPSSILQRPATTEEVANLVVYV
CSAQASATTGAALRVDGGVVDTLA
>Mature_264_residues
MQINLTGRIALVTASTGGIGYAIAAGLARAGATLILNGRSDTSVNAALATLRSSVPGVNASGIAADLSGAAGVGELTEAA
PTVDILVNNAGIYGPKPFFDIDDEEWERYFQTNVMSGVRLSRHYLPRMMERDWGRVVFISSESALNIPADMIQYGFSKTA
QLSIARGLAKLAAGTGVTVNSVLPGPTMSDGVKAMLKDSADRQGKTVDEVAVEFVRTQRPSSILQRPATTEEVANLVVYV
CSAQASATTGAALRVDGGVVDTLA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=262, Percent_Identity=32.4427480916031, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI5031737, Length=261, Percent_Identity=31.0344827586207, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI33667109, Length=245, Percent_Identity=32.2448979591837, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI126723191, Length=186, Percent_Identity=33.8709677419355, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI126723750, Length=263, Percent_Identity=28.8973384030418, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI66933014, Length=259, Percent_Identity=25.4826254826255, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI210032110, Length=185, Percent_Identity=28.6486486486486, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI40807363, Length=167, Percent_Identity=29.3413173652695, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI7705925, Length=263, Percent_Identity=27.3764258555133, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4504505, Length=270, Percent_Identity=22.5925925925926, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=265, Percent_Identity=32.8301886792453, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082100, Length=268, Percent_Identity=30.2238805970149, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787905, Length=266, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788459, Length=260, Percent_Identity=31.1538461538462, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1790717, Length=263, Percent_Identity=27.3764258555133, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786812, Length=257, Percent_Identity=28.7937743190661, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI2367175, Length=259, Percent_Identity=30.1158301158301, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI2367365, Length=256, Percent_Identity=27.734375, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787820, Length=182, Percent_Identity=30.7692307692308, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789208, Length=278, Percent_Identity=23.7410071942446, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=26.4367816091954, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87082160, Length=264, Percent_Identity=23.1060606060606, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1789378, Length=260, Percent_Identity=28.8461538461538, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=262, Percent_Identity=30.1526717557252, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17561402, Length=266, Percent_Identity=27.4436090225564, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=30.46875, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71994604, Length=258, Percent_Identity=30.6201550387597, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193204405, Length=191, Percent_Identity=35.0785340314136, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI115534694, Length=263, Percent_Identity=29.6577946768061, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=269, Percent_Identity=27.5092936802974, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=190, Percent_Identity=30.5263157894737, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=259, Percent_Identity=28.1853281853282, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=270, Percent_Identity=29.2592592592593, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=192, Percent_Identity=24.4791666666667, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=269, Percent_Identity=28.6245353159851, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=267, Percent_Identity=26.9662921348315, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=265, Percent_Identity=26.4150943396226, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562990, Length=265, Percent_Identity=27.1698113207547, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=191, Percent_Identity=23.0366492146597, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21355319, Length=267, Percent_Identity=30.3370786516854, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24644339, Length=259, Percent_Identity=28.957528957529, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=29.4117647058824, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28571526, Length=261, Percent_Identity=29.1187739463602, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24643142, Length=258, Percent_Identity=27.1317829457364, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24639444, Length=260, Percent_Identity=27.3076923076923, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27463; Mature: 27463

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQINLTGRIALVTASTGGIGYAIAAGLARAGATLILNGRSDTSVNAALATLRSSVPGVNA
CEEEEEEEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCC
SGIAADLSGAAGVGELTEAAPTVDILVNNAGIYGPKPFFDIDDEEWERYFQTNVMSGVRL
CCCEECCCCCCCCCHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SRHYLPRMMERDWGRVVFISSESALNIPADMIQYGFSKTAQLSIARGLAKLAAGTGVTVN
HHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEE
SVLPGPTMSDGVKAMLKDSADRQGKTVDEVAVEFVRTQRPSSILQRPATTEEVANLVVYV
CCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHE
CSAQASATTGAALRVDGGVVDTLA
ECCCCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MQINLTGRIALVTASTGGIGYAIAAGLARAGATLILNGRSDTSVNAALATLRSSVPGVNA
CEEEEEEEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCC
SGIAADLSGAAGVGELTEAAPTVDILVNNAGIYGPKPFFDIDDEEWERYFQTNVMSGVRL
CCCEECCCCCCCCCHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SRHYLPRMMERDWGRVVFISSESALNIPADMIQYGFSKTAQLSIARGLAKLAAGTGVTVN
HHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEE
SVLPGPTMSDGVKAMLKDSADRQGKTVDEVAVEFVRTQRPSSILQRPATTEEVANLVVYV
CCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHE
CSAQASATTGAALRVDGGVVDTLA
ECCCCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]