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The map label for this gene is nat [H]

Identifier: 238024800

GI number: 238024800

Start: 1837871

End: 1838743

Strand: Reverse

Name: nat [H]

Synonym: bglu_2g14380

Alternate gene names: 238024800

Gene position: 1838743-1837871 (Counterclockwise)

Preceding gene: 238024801

Following gene: 238024793

Centisome position: 65.03

GC content: 69.53

Gene sequence:

>873_bases
ATGTACGACGATCTGGATCTTCCGCACTACCTCGAACGCATCGGCTATCGCGGCAAGCCGGAGCCGACGCTCGAGGTGCT
GCGGCAACTGCATCGCCTGCATCCGCAGGCAATCGCCTTCGAGAATCTCGATTCGCTGAGCGGCTCGCCGGTGAAGCTCG
ACCTGCTGTCGATCACCGCCAAGATGGTCGCGCGGCGGCGCGGCGGCTACTGCTTCGAGCACAATCGGCTGTTCCATGCC
GCGCTCACCCGGATCGGTTTTGAGGTCACGCCGCTGCTCGCGCGCGTGCGCTGGCAGCAGGCGCCCGATGCCGTCACGCC
GCAGACGCACAAGCTGTTGTGCGTCGAGATCGGCGGCGAGAGCTGGTACGTGGACGTCGGGTTCGGCGCGGTCACGCAGA
CGGCGCCGCTCGCGGCCACGCCCGGCCTCGCGCAGGCCACCACGCACGGCGAGTACCGGATCGTCGCCGCGCCGGCGCCC
GCGGCTGGCGAATTCGACCTCGAATGCCGGACGGCGAAGGGCTGGCAGGCCGTCTATCGGTTCGGCACCAGGCGCGCCGA
GCGCGTCGATTACGACGTGGCGAACTGGTACGCCTCCACGCACCCCGATTCGAAGTTCGTCAACGACTTGATCGTGAGCC
GCGTGCTACCGGATGGGCGCGCCTCGCTGCTCAACGACGCACTGACGCTGCGCGACGCGAATGGCGCGGCCACTCACCAC
GAACGGTTCGCCGGTGCCACCGCGTGGGCCGCCTGCCTGACCGAGCGTTTCGGTCTCGAGCTGGGCGGCTTCGATATCGG
CGGCCTGTTCGCGCGCGTGCAGGCGCGCAGCGCGGCGCTCGACGCGCTGGCGCAGGCGCAATCGCCGCGCTGA

Upstream 100 bases:

>100_bases
GCGCCCAATGCCGCCGTCGCACTTCTGCGCCGGTCGCCGCGTGGTGCTAAGGTAGGGGCGGCCGTCGGGCCGGCTCCTTC
TTCCACAGGCACGCACACGC

Downstream 100 bases:

>100_bases
CGGCGCGGGCCGGCGTGGTTCGCCAGCAGGGGCCGGCGCCGGGTCACACCTGCATCGACGGCACGTCCTTCATGCAGCGC
AGCGCGAACATCGAGCGGCT

Product: N-hydroxyarylamine O-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MYDDLDLPHYLERIGYRGKPEPTLEVLRQLHRLHPQAIAFENLDSLSGSPVKLDLLSITAKMVARRRGGYCFEHNRLFHA
ALTRIGFEVTPLLARVRWQQAPDAVTPQTHKLLCVEIGGESWYVDVGFGAVTQTAPLAATPGLAQATTHGEYRIVAAPAP
AAGEFDLECRTAKGWQAVYRFGTRRAERVDYDVANWYASTHPDSKFVNDLIVSRVLPDGRASLLNDALTLRDANGAATHH
ERFAGATAWAACLTERFGLELGGFDIGGLFARVQARSAALDALAQAQSPR

Sequences:

>Translated_290_residues
MYDDLDLPHYLERIGYRGKPEPTLEVLRQLHRLHPQAIAFENLDSLSGSPVKLDLLSITAKMVARRRGGYCFEHNRLFHA
ALTRIGFEVTPLLARVRWQQAPDAVTPQTHKLLCVEIGGESWYVDVGFGAVTQTAPLAATPGLAQATTHGEYRIVAAPAP
AAGEFDLECRTAKGWQAVYRFGTRRAERVDYDVANWYASTHPDSKFVNDLIVSRVLPDGRASLLNDALTLRDANGAATHH
ERFAGATAWAACLTERFGLELGGFDIGGLFARVQARSAALDALAQAQSPR
>Mature_290_residues
MYDDLDLPHYLERIGYRGKPEPTLEVLRQLHRLHPQAIAFENLDSLSGSPVKLDLLSITAKMVARRRGGYCFEHNRLFHA
ALTRIGFEVTPLLARVRWQQAPDAVTPQTHKLLCVEIGGESWYVDVGFGAVTQTAPLAATPGLAQATTHGEYRIVAAPAP
AAGEFDLECRTAKGWQAVYRFGTRRAERVDYDVANWYASTHPDSKFVNDLIVSRVLPDGRASLLNDALTLRDANGAATHH
ERFAGATAWAACLTERFGLELGGFDIGGLFARVQARSAALDALAQAQSPR

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649128, Length=245, Percent_Identity=31.0204081632653, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI237649126, Length=245, Percent_Identity=31.0204081632653, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI237649124, Length=245, Percent_Identity=31.0204081632653, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI237649122, Length=245, Percent_Identity=31.0204081632653, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI237649119, Length=245, Percent_Identity=31.0204081632653, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI42741671, Length=245, Percent_Identity=31.0204081632653, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI237649009, Length=245, Percent_Identity=31.0204081632653, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI237649132, Length=245, Percent_Identity=31.0204081632653, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI237649130, Length=245, Percent_Identity=31.0204081632653, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI116295260, Length=245, Percent_Identity=29.7959183673469, Blast_Score=91, Evalue=9e-19,
Organism=Escherichia coli, GI1787736, Length=280, Percent_Identity=36.0714285714286, Blast_Score=157, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 31847; Mature: 31847

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDDLDLPHYLERIGYRGKPEPTLEVLRQLHRLHPQAIAFENLDSLSGSPVKLDLLSITA
CCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHCHHHCCCCCEEEHHHHHHH
KMVARRRGGYCFEHNRLFHAALTRIGFEVTPLLARVRWQQAPDAVTPQTHKLLCVEIGGE
HHHHHHCCCEEEECCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCC
SWYVDVGFGAVTQTAPLAATPGLAQATTHGEYRIVAAPAPAAGEFDLECRTAKGWQAVYR
EEEEECCCCCHHCCCCCCCCCCCHHHCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHHH
FGTRRAERVDYDVANWYASTHPDSKFVNDLIVSRVLPDGRASLLNDALTLRDANGAATHH
HHCHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHEEECCCCCCHHH
ERFAGATAWAACLTERFGLELGGFDIGGLFARVQARSAALDALAQAQSPR
HHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYDDLDLPHYLERIGYRGKPEPTLEVLRQLHRLHPQAIAFENLDSLSGSPVKLDLLSITA
CCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHCHHHCCCCCEEEHHHHHHH
KMVARRRGGYCFEHNRLFHAALTRIGFEVTPLLARVRWQQAPDAVTPQTHKLLCVEIGGE
HHHHHHCCCEEEECCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCC
SWYVDVGFGAVTQTAPLAATPGLAQATTHGEYRIVAAPAPAAGEFDLECRTAKGWQAVYR
EEEEECCCCCHHCCCCCCCCCCCHHHCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHHH
FGTRRAERVDYDVANWYASTHPDSKFVNDLIVSRVLPDGRASLLNDALTLRDANGAATHH
HHCHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHEEECCCCCCHHH
ERFAGATAWAACLTERFGLELGGFDIGGLFARVQARSAALDALAQAQSPR
HHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]