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The map label for this gene is proY [H]

Identifier: 238024529

GI number: 238024529

Start: 1447859

End: 1449235

Strand: Direct

Name: proY [H]

Synonym: bglu_2g11350

Alternate gene names: 238024529

Gene position: 1447859-1449235 (Clockwise)

Preceding gene: 238024525

Following gene: 238024551

Centisome position: 51.21

GC content: 68.55

Gene sequence:

>1377_bases
ATGAAGCATCTGCAGCGCCACCTCGGCGCGCGTCACATCCGTTTTCTCGCCCTCGGCTCGGCAATCGGCACCGGCCTCTT
CTACGGCTCGGCCTCGGCGATACAGCTCGCCGGCCCCGCCGTGATCCTCGCTTACATGATCGGCGGCGCGGCCGTCTACA
TGGTCATGCGCGCGCTCGGCGAAATGGCCGTGCGCGATCCCGTGTCCGGTTCGTTCGGCCAGTACGCCACCGACAATCTC
GGCCCGTTCGCGGGCTTCATCACCGGCTGGACCTACACGCTGGAGATGGTGATCGTCGCGATCGCCGACGTCACGGCGTT
CGGCATCTACATGGGCTTCTGGTTTCCCGGCGTGCCGCAGTGGATCTGGGTGCTCGCGATCGTCACGATCCTCTGCGGGC
TCAACCTCTGCCACGTGAAGGTGTTCGGCGAGCTCGAATTCTGGCTCTCGATCGTCAAGGTCGTGGCGATCGGCGCGATG
ATCGCGGGCGGCGTCGTGATCCTGCTGGCCGGCATGCGGCTGAGCGCGCAGCATGACGCGCCGGCGCTGTCGAACCTCTG
GTCGCACGGCGGCTTCCTGCCCCACGGGGTGAGCGGCCTGATCGAATCGCTGGCGGTGGTGATCTTCGCCTACGGCGGCA
TCGAGGTGATCGGCATGAGCGCGGGCGAGGCCAAGCATCCCGAGCGCGTGCTGCCGCGCGCGATCAACACCGTGCCGATG
CGCATCCTGCTGTTCTACGTGCTGACCATGGTGGTGCTGATGTCGATCTTCCCGTGGACCGGCATCGGCACGAGCGGCAG
CCCGTTCGTGACGATCTTCTCGGCGCTCGGCGTGCGCTCGGCCGCCACGATCCTGAACCTGGTGGTGATCAGCGCCGCGA
TCTCGGCGATCAACAGCGACATCTTCGGCGCGGGCCGCATGATGTACGGCATGGCGCGCCAGGGCCAGGCCTCGCCCAGC
TTCGCGGCCACCTCGCGGCACGGCGTGCCCTACGTGACGGTGCTCGTGATGACGGCCGCGCTGCTGGTGGGCGTGCTGCT
GAACTACCTGATGCCGAAGGACGTGTTCCAGACCGTGGCCGCGATCGCCACCTTCGCGACGGTCTGGGTCTGGCTGATGA
TCCTGCTCTCGCAGATGGCCATGCGCCGGCGCCTCACGCGCGACGAGGTCGCGGCGCTGAGGTTTCGCGTCCCGCTCTGG
CCGGTGGGGCCGGCGCTCGCGATCGCGTTCATGCTGTTCGTGGTGACGGTGATCGGCTGGTTCGCCGAGACCCGCGTCGC
GCTGTACGTGGGCCTGGCCTGGCTCGCCGCGCTCGGCGTGGCCTGGCTGCTGCGCCAGCGCTCGGCGCCGCTGCAACCGA
GCCGCCCGGAGCGCTGA

Upstream 100 bases:

>100_bases
CCGCCTGCGTTGGTAAGATGGGTGGCCGTCCGAACCTGTCTAGACAAGCTCGGGCGCGCTCGCCCCGAGGCCTCCCCGCG
ACACCCACTCCGGAGTCTTG

Downstream 100 bases:

>100_bases
GCGCGGGCACCCCGCCGCCCGCGCCCGGAACGCGATGCGGGCGGCACGGGCGGCGCCGCTCGAACCTCAGGCCGCCTGCA
GCACCCCGGCGCCGGTCGCG

Product: proline-specific permease ProY

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MKHLQRHLGARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYMIGGAAVYMVMRALGEMAVRDPVSGSFGQYATDNL
GPFAGFITGWTYTLEMVIVAIADVTAFGIYMGFWFPGVPQWIWVLAIVTILCGLNLCHVKVFGELEFWLSIVKVVAIGAM
IAGGVVILLAGMRLSAQHDAPALSNLWSHGGFLPHGVSGLIESLAVVIFAYGGIEVIGMSAGEAKHPERVLPRAINTVPM
RILLFYVLTMVVLMSIFPWTGIGTSGSPFVTIFSALGVRSAATILNLVVISAAISAINSDIFGAGRMMYGMARQGQASPS
FAATSRHGVPYVTVLVMTAALLVGVLLNYLMPKDVFQTVAAIATFATVWVWLMILLSQMAMRRRLTRDEVAALRFRVPLW
PVGPALAIAFMLFVVTVIGWFAETRVALYVGLAWLAALGVAWLLRQRSAPLQPSRPER

Sequences:

>Translated_458_residues
MKHLQRHLGARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYMIGGAAVYMVMRALGEMAVRDPVSGSFGQYATDNL
GPFAGFITGWTYTLEMVIVAIADVTAFGIYMGFWFPGVPQWIWVLAIVTILCGLNLCHVKVFGELEFWLSIVKVVAIGAM
IAGGVVILLAGMRLSAQHDAPALSNLWSHGGFLPHGVSGLIESLAVVIFAYGGIEVIGMSAGEAKHPERVLPRAINTVPM
RILLFYVLTMVVLMSIFPWTGIGTSGSPFVTIFSALGVRSAATILNLVVISAAISAINSDIFGAGRMMYGMARQGQASPS
FAATSRHGVPYVTVLVMTAALLVGVLLNYLMPKDVFQTVAAIATFATVWVWLMILLSQMAMRRRLTRDEVAALRFRVPLW
PVGPALAIAFMLFVVTVIGWFAETRVALYVGLAWLAALGVAWLLRQRSAPLQPSRPER
>Mature_458_residues
MKHLQRHLGARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYMIGGAAVYMVMRALGEMAVRDPVSGSFGQYATDNL
GPFAGFITGWTYTLEMVIVAIADVTAFGIYMGFWFPGVPQWIWVLAIVTILCGLNLCHVKVFGELEFWLSIVKVVAIGAM
IAGGVVILLAGMRLSAQHDAPALSNLWSHGGFLPHGVSGLIESLAVVIFAYGGIEVIGMSAGEAKHPERVLPRAINTVPM
RILLFYVLTMVVLMSIFPWTGIGTSGSPFVTIFSALGVRSAATILNLVVISAAISAINSDIFGAGRMMYGMARQGQASPS
FAATSRHGVPYVTVLVMTAALLVGVLLNYLMPKDVFQTVAAIATFATVWVWLMILLSQMAMRRRLTRDEVAALRFRVPLW
PVGPALAIAFMLFVVTVIGWFAETRVALYVGLAWLAALGVAWLLRQRSAPLQPSRPER

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=320, Percent_Identity=27.1875, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI110347453, Length=332, Percent_Identity=26.5060240963855, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI4507047, Length=345, Percent_Identity=25.2173913043478, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1786602, Length=446, Percent_Identity=59.1928251121076, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI1786302, Length=450, Percent_Identity=42, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1786789, Length=448, Percent_Identity=40.8482142857143, Blast_Score=351, Evalue=7e-98,
Organism=Escherichia coli, GI1790653, Length=455, Percent_Identity=38.9010989010989, Blast_Score=342, Evalue=3e-95,
Organism=Escherichia coli, GI48994972, Length=438, Percent_Identity=41.324200913242, Blast_Score=323, Evalue=1e-89,
Organism=Escherichia coli, GI87081915, Length=399, Percent_Identity=39.5989974937343, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI87081708, Length=456, Percent_Identity=35.3070175438597, Blast_Score=281, Evalue=7e-77,
Organism=Escherichia coli, GI1789017, Length=413, Percent_Identity=36.319612590799, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI1788480, Length=432, Percent_Identity=34.4907407407407, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI87081869, Length=194, Percent_Identity=23.7113402061856, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87082023, Length=410, Percent_Identity=22.6829268292683, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17531343, Length=356, Percent_Identity=25.8426966292135, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17532491, Length=427, Percent_Identity=22.9508196721311, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17540018, Length=418, Percent_Identity=25.3588516746411, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324061, Length=444, Percent_Identity=32.4324324324324, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6320772, Length=443, Percent_Identity=31.1512415349887, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324553, Length=387, Percent_Identity=31.5245478036176, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6324924, Length=444, Percent_Identity=29.2792792792793, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324059, Length=445, Percent_Identity=30.1123595505618, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6324990, Length=355, Percent_Identity=32.9577464788732, Blast_Score=163, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6322892, Length=413, Percent_Identity=27.8450363196126, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6319824, Length=438, Percent_Identity=26.2557077625571, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320717, Length=398, Percent_Identity=25.3768844221106, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320251, Length=397, Percent_Identity=27.455919395466, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319542, Length=396, Percent_Identity=26.2626262626263, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321629, Length=406, Percent_Identity=25.615763546798, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6321053, Length=427, Percent_Identity=25.9953161592506, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319543, Length=398, Percent_Identity=25.3768844221106, Blast_Score=136, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6322967, Length=405, Percent_Identity=27.4074074074074, Blast_Score=126, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6319608, Length=366, Percent_Identity=26.775956284153, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324981, Length=404, Percent_Identity=26.2376237623762, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320364, Length=499, Percent_Identity=23.6472945891784, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24667468, Length=334, Percent_Identity=25.748502994012, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24666159, Length=336, Percent_Identity=25.5952380952381, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221512776, Length=336, Percent_Identity=25.5952380952381, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI161077963, Length=333, Percent_Identity=26.1261261261261, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49241; Mature: 49241

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLQRHLGARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYMIGGAAVYMVMRALG
CCHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMAVRDPVSGSFGQYATDNLGPFAGFITGWTYTLEMVIVAIADVTAFGIYMGFWFPGVPQ
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
WIWVLAIVTILCGLNLCHVKVFGELEFWLSIVKVVAIGAMIAGGVVILLAGMRLSAQHDA
HHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCC
PALSNLWSHGGFLPHGVSGLIESLAVVIFAYGGIEVIGMSAGEAKHPERVLPRAINTVPM
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
RILLFYVLTMVVLMSIFPWTGIGTSGSPFVTIFSALGVRSAATILNLVVISAAISAINSD
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFGAGRMMYGMARQGQASPSFAATSRHGVPYVTVLVMTAALLVGVLLNYLMPKDVFQTVA
HHHCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AIATFATVWVWLMILLSQMAMRRRLTRDEVAALRFRVPLWPVGPALAIAFMLFVVTVIGW
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
FAETRVALYVGLAWLAALGVAWLLRQRSAPLQPSRPER
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKHLQRHLGARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYMIGGAAVYMVMRALG
CCHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMAVRDPVSGSFGQYATDNLGPFAGFITGWTYTLEMVIVAIADVTAFGIYMGFWFPGVPQ
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
WIWVLAIVTILCGLNLCHVKVFGELEFWLSIVKVVAIGAMIAGGVVILLAGMRLSAQHDA
HHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCC
PALSNLWSHGGFLPHGVSGLIESLAVVIFAYGGIEVIGMSAGEAKHPERVLPRAINTVPM
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
RILLFYVLTMVVLMSIFPWTGIGTSGSPFVTIFSALGVRSAATILNLVVISAAISAINSD
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFGAGRMMYGMARQGQASPSFAATSRHGVPYVTVLVMTAALLVGVLLNYLMPKDVFQTVA
HHHCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AIATFATVWVWLMILLSQMAMRRRLTRDEVAALRFRVPLWPVGPALAIAFMLFVVTVIGW
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
FAETRVALYVGLAWLAALGVAWLLRQRSAPLQPSRPER
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]